Effect of 5-fluorouracil on Pseudomonas aeruginosa: impact on virulence, biofilm formation, and bacterial growth by Amani A. Niazy, May M. Alrashed, Abdurahman A. Niazy

“…By placing the current evidence in context, we hope to guide further studies toward determining the clinical viability of 5-FU as a treatment option against this formidable pathogen.…”
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Comparative Assessment of Preventable Socioeconomic Damage in Different Approaches to the Prevention of Vaccine-Controlled Infections in the Framework of the National Vaccination S... by N. I. Briko, L. D. Popovich, A. Ya. Mindlina, O. I. Volkova, E. O. Kurilovich

“…Extending the five-component vaccine coverage to 60% of children in the 3-to 18-month age group will reduce losses to 20,215 years, saving 10,263 years of life (33.7% more than the current algorithm), and even more if coverage is close to 100%: annual losses will decrease to 2,134 years, which can provide 28,344 saved years of life (93% more than the current algorithm). …”
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Features of the bridge span performance when shifting the axis of the rail-sleeper grid by V. V. Korolev, A. A. Loktev, I. V. Shishkina, E. A. Gridasova

“…The joint work of the upper structure of the railway track and the supporting structures of the bridge crossing is an important condition for the normal operation of the railway section without various restrictions and additional work on the current maintenance and diagnostics of structural elements. …”
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Small Extracellular Vesicles with a High Sphingomyelin Content Isolated from Hypertensive Diabetic db/db Mice Inhibits Calcium Mobilization and Augments Amiloride-Sensitive Epithel... by Hunter Ramsay, Ling Yu, Faisal F. Alousi, Abdel A. Alli

“…Extracellular vesicles (EVs) contain bioactive lipids that play a key role in pathophysiology. …”
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Stillbirth in term and late term gestations in Stockholm during a 20-year period, incidence and causes. by Hanna Åmark, Christina Pilo, Ingela Hulthén Varli

“…<h4>Introduction</h4>The incidence of stillbirth has decreased marginally or remained stable during the past decades in high income countries. …”
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ANALISIS OF THE INFLUENCE OF THE MAIN PARAMETERS AND CONDITION OF WORK OF AIRCRAFT CESN ON THE EFFICENCY OF THEIR USE METHODS OF MATHEMATICAL MODELING by V. I. Troitsky

“…The analysis of the obtained dependences shows a fairly stable tendency to reduce errors of CESN with a decrease in navigation angles. This dependence is demonstrated graphically. …”
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Bedrock Controls on Water and Energy Partitioning by Robert S. Ehlert, W. Jesse Hahm, David N. Dralle, Daniella M. Rempe, Diana M. Allen

“…Bedrock water storage (Sbedrock), in addition to soil moisture, thus plays an important role in water cycling and should be accounted for in the context of surface energy balances and streamflow generation. …”
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Trends, Cycles and Seasonal Variations of Ukrainian Gross Domestic Product by Debesh Bhowmik

“…The article attempts to study trends, seasonal variations and cyclical fluctuations of Ukraine’s quarterly GDP at current prices. The period of the study is from the first quarter of 2010 to the first quarter of 2020. …”
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Modelling of wax deposition for waxy crude oil by ANSYS fluent by Salman Hadi Dahwal, Zarana Patel, Ashish Nagar

“…The crude oil utilized for the study contains 38% wax and has pour point of 36 °C. The fluid flow was 1 GPM and the inlet temperature was 333.15 K which decreases up to 298.15 K. …”
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Preventive and therapeutic effects of Nasturtium officinale hydroalcoholic extract on cyclophosphamide-induced testicular toxicity in rats by Hamideh Aboutalebi, fatemeh alipour, Alireza Ebrahimzadeh-Bideskan

“…Since the Nasturtium officinale L. hydroalcoholic extract (NOE) contains a wide range of phytochemicals with various biological functions, the current study was designed to explore the protective potential of NOE on testicular toxicity caused by Cy in rats.Materials and Methods: Forty-eight adult male Wistar rats were randomly allocated into eight groups (n=6): control, Cy [received a single dose of 75 mg/kg, intraperitoneal (i.p)], NOE+Cy (Prevention): received NOE 500 and 1000 mg/kg/day, orally for 21 consecutive days and on the last day received Cy, Cy+NOE (Treatment): received NOE 500 and 1000 mg/kg/day, orally for 7 days after Cy administration for 21 consecutive days, and NOE (500 and 1000 mg/kg/day). …”
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Assessing the Quality of Concrete Tunnel Lining Exposed to Tunnel Fire through Residual Compressive Strength by Husen Alhawat, R. Hamid, Shahrizan Baharom, M. R. Azmi, A. B. M. A. Kaish

“…Another concrete tunnel lining segment was constructed using concrete containing silica fume normally used in the current construction, coded as SPC concrete. …”
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The impacts of perceived overqualification on employee performance: A case of chefs by Gökhan ONAT, Duygu Eren

“…As a result of the analysis made with the data collected, it was found that perceived overqualification negatively and significantly affects employee performance. In this context, as a result of this study, it can be said that employee performance may increase or decrease if the overqualification observed in chefs increases or decreases. …”
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Computational markers show specific deficits for dyslexia and ADHD in complex learning settings by Yafit Gabay, Lana Jacob, Atil Mansour, Uri Hertz

“…Abstract The current study examined how individuals with neurodevelopmental disorders navigate the complexities of learning within multidimensional environments marked by uncertain dimension values and without explicit guidance. …”
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Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Overexpression of the splicing factor 3b subunit 1 (SF3B1) and neurogenic locus notch homolog protein 1 (NOTCH1) factors is typically found in chronic lymphocytic leukemia (CLL), leading to the development of chemotherapy resistance. Objective The current investigation aims to evaluate the chemosensitivity of CLL cells by blocking NOTCH1 and SF3B1 using chitosan lactate (CL) nanoparticles (NPs). …”
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Monitoring ground temperature and deformation of the cast-in-place footings in permafrost regions on the Qinghai‒Tibet Plateau by Chao-Wei Wang, Yan-Hui You, Bin Yao, Bin Liu, Pei-Heng Guo, Lei Guo, Xin-Bin Wang, Qi-Hao Yu

“…The long-term stability of the cast-in-place footings in permafrost regions has received much attention due to its climate sensitivity. The current research lacks long-term data validation, especially in the context of climate change. …”
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Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants... by J. C. vanMaanen, F. C. Bach, J. W. Snuggs, K. Ito, M. H. M. Wauben, C. L. Le Maitre, M. A. Tryfonidou

“…Modification of the CCL2 secretion seemed to be context dependent in the human explants: where EVs treatment stimulated CCL2 secretion but in the presence of IL‐1β this effect was counteracted. …”
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Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia by Armin Dozandeh-Jouybari, Fatemeh Mousavi-Mirkalaei, Saeid Taghiloo, Hossein Karami, Mohammad Naderisorki, Ehsan Zaboli, Mohammad Eslami-Jouybari, Tohid Kazemi, Hossein Asgarian-Omran

“…By elucidating the precise underlying mechanisms, these drugs could emerge as promising therapeutic options, particularly in the context of combination therapy for ALL.…”
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Impact of a Saline Soil Improvement Project on the Spatiotemporal Evolution of Groundwater Dynamic Field and Hydrodynamic Process Simulation in the Hetao Irrigation District by Yule Sun, Liping Wang, Zuting Liu, Yonglin Jia, Zhongyi Qu

“…Reducing irrigation to 80% of the current water supply of the Yellow River enables groundwater level stabilization (2.05 ± 0.12 m burial depth) within 5–7 years. …”
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NEW APPROACHES TO THERAPY OF CLASSICAL PH-NEGATIVE MYELOPROLIFERATIVE DISEASES: THE EXPERIENCE OF EARLY THERAPY WITH CEPEGINTERFERON ALPHA-2B by A. S. Polyakov, Y. A. Noskov, V. V. Tyrenko, A. S. Lapshova, A. V. Kovalev

“…The limitations of classical cytoreduction and current targeted therapy, as well as the conviction of most specialists in the impossibility of adequately containment of disease progression, continue to be the main factors that keep physicians from the early start of pathogenetic therapy.Objective: to study the efficacy and safety of cepeginterferon alpha-2b (cePEG-IFN alpha-2b) in early (non-risk-adjusted) therapy of classical Ph-negative myeloproliferative neoplasms in initial use and after therapy with other pegylated interferons (PEG-IFN).Materials and methods. …”
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EFFECT OF COVID-19 ON GASTROINTESTINAL TRACT AND LIVER, MANIFESTATIONS, PROGNOSIS, MECHANISMS, TREATMENT, AND CHALLENGES: A COMPREHENSIVE REVIEW by Subhan Haider, Awais Ahmed Uttra, Saniya Sohail, Ayesha Ghani, Furqan Ahmed

“…The typical signs and symptoms of coronavirus patients consist of cough, fever, lethargy, and shortness of breath (SOB). Objectives: The current review contains summarized and complete information on the effect of coronavirus on GIT, Liver and its manifestations, prognosis, mechanisms, treatment, and challenges. …”
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