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Substance P- and Insulin-like Growth Factor 1-derived Tetrapeptides for Neurotrophic Keratopathy Related to Leprosy: A Clinical Trial
Published 2025-03-01“…Although leprosy is bacteriologically curable, there is currently no efficient treatment. Eye drops containing tetrapeptides, phenylalanine-glycine-leucine-methionine-amide (FGLM-NH2) and serine-serine-serine-arginine (SSSR), derived from substance P and insulin-like growth factor 1, are clinically efficacious in the treatment of corneal epithelial disorders caused by neurotrophic keratopathy. …”
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2242
The role of judicial authorities in criminal proceedings for political crimes in the Stalinist period: modern historiography
Published 2019-11-01“…Currently, PhD theses, covering an increasing number of regions of Russia, are being defended actively. …”
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2243
A methionine/aspartate-rich synthetic peptide delineated from N-terminal region of nucleophosmin protein effectively protects against cadmium-induced toxicity
Published 2025-05-01“…The molecular mechanism of Cd cytotoxicity is complicated and still not well understood, and treatment options for Cd cytotoxicity are lacking. Currently, only a limited number of Cd-targeted proteins have been identified. …”
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2244
Identifying studies evaluating susceptibility factors for chemical health assessments: A case study focused on methylmercury developmental neurotoxicity
Published 2025-03-01“…However, at this time, Approach 1, involving the application of a dose–response filter, is currently recommended for identifying epidemiology papers with information on susceptibility factors.…”
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2245
Military and political security in the Arctic before and amidst the Ukrainian crisis
Published 2024-11-01“…This course has been reflected in a whole series of alliance’s military exercises, which, as shown in the article, are becoming increasingly extensive and regular year by year. The author concludes that the Ukrainian crisis has only laid bare the true aspirations of the NATO countries seeking to contain Russia in the Far North and refusing to consider its interests and build a constructive dialogue in the field of military and political security. …”
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2246
UML/OCL based design and the transition towards temporal object relational database with bitemporal data
Published 2020-05-01“…In software modeling, UML (Unified modeling language) receives increasing attention from designers of real-time systems in software development. …”
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2247
Melt‐Processable and Electrospinnable Shape‐Memory Hydrogels
Published 2024-12-01“…Abstract Due to their ability to adapt to subtle changes in response to various external and internal stimuli, smart hydrogels have become increasingly popular in research and industry. However, many currently available hydrogels suffer from poor processability and inferior mechanical properties. …”
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2248
Effects of Dynamic Agrivoltaics on Containerized Raspberry Plants: Results of the First Season
Published 2025-03-01“…The protection from the DAV reduced mean air temperature by 1.8°C and increased mean relative humidity by 7.3% in comparison to the CTL. …”
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2249
G‐space versus E‐space: Are hornets (Hymenoptera: Vespidae) at equilibrium with honeybees in Asia?
Published 2024-07-01“…We found that Vespa velutina currently exhibits a moderate geographic niche overlap (G‐space) of 0.63 with both honeybee species. …”
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2250
Prevalence of viral DNA in high-grade serous epithelial ovarian cancer and correlation with clinical outcomes.
Published 2023-01-01“…<h4>Introduction</h4>Currently 11 infectious agents are classified as carcinogenic but the role of infectious agents on outcomes of epithelial ovarian cancer is largely unknown.…”
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2251
Mapping the global distribution and conservation status of oases—ecosystems of pivotal biocultural relevance
Published 2025-02-01“…However, less than 0.5% of their total area is currently under protection, making oases one of the least conserved ecosystems worldwide. …”
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2252
Prompt closure versus gradual weaning of extraventricular drainage for hydrocephalus in adult patients with aneurysmal subarachnoid haemorrhage: a systematic review protocol with m...
Published 2019-10-01“…Sparse data exist on the recommendation of cessation strategy and patients are currently being treated on the basis of personal experience and expert opinion. …”
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2253
Prioritization of potential drug targets for diabetic kidney disease using integrative omics data mining and causal inference
Published 2025-08-01“…Diabetic kidney disease (DKD) with increasing global prevalence lacks effective therapeutic targets to halt or reverse its progression. …”
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2254
Evidence of Transmission Capability in UK <i>Culex pipiens</i> for Japanese Encephalitis Virus (JEV) Genotype I and Potential Impact of Climate Change
Published 2025-06-01“…Japanese encephalitis virus (JEV) is a mosquito-borne orthoflavivirus and a major cause of human encephalitis throughout Asia, although it is currently not reported in Europe. To assess the potential impact of climate change, such as increased temperatures, and the potential for native <i>Cx. pipiens</i> to transmit JEV genotype I in the United Kingdom (UK), we have investigated vector competence at two different temperatures. …”
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2255
Forensic Investigation of Stainless Steel 316 Hydrogen-Membrane and Ammonia-Cracking Reactors Through Mechanical Testing
Published 2025-05-01“…We examined samples of reactor walls exposed to hydrogen-containing atmospheres for >100 and ~1000 h at elevated temperatures during hydrogen separation and ammonia cracking. …”
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2256
Tax planning: organization features at enterprise
Published 2017-08-01“…The research determines the need for studying the «cloud» technologies as the method of saving company’s resources and increasing the efficiency of processing accounting data. …”
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2257
Trial in absentia and the modern international criminal procedure
Published 2023-04-01“…The practice of these courts demonstrates a very inconsistent application and not always convincing interpretation of the rights of the accused in general and the right to be tried in his presence. Currently, this practice is trying to change the previously formed trend towards increasingly severe restrictions on exceptions to the right of the accused to be tried in his presence.…”
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2258
Ginseng and its functional components in non-alcoholic fatty liver disease: therapeutic effects and multi-target pharmacological mechanisms
Published 2025-04-01“…BackgroundNon-alcoholic fatty liver disease (NAFLD) is a common type of chronic liver disease and its incidence is increasing. Its disease progression is closely related to non-alcoholic steatohepatitis and liver fibrosis. …”
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2259
Modern ideas about the causes, pathogenesis and innovative areas of therapy for asthenic syndrome in clinical practice
Published 2024-11-01“…The most common tool for diagnosing AS is currently the Multidimensional Fatigue Inventory (MFI-20) questionnaire, and the L. …”
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2260
Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis
Published 2025-02-01“…LC-treated hiPSC-CM cultures and LC-containing spheroids presented structural and functional defects including: (1) decreased levels and subcellular disorganization of sarcomeric protein alpha-actinin; (2) abnormal accumulation of calcium handling SERCA2a protein; (3) impaired contractility of spheroids and altered calcium transients. …”
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