Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia by Armin Dozandeh-Jouybari, Fatemeh Mousavi-Mirkalaei, Saeid Taghiloo, Hossein Karami, Mohammad Naderisorki, Ehsan Zaboli, Mohammad Eslami-Jouybari, Tohid Kazemi, Hossein Asgarian-Omran

“…Following treatment, the proliferation of leukemic cells was significantly decreased and the apoptosis rate was significantly increased, which was more remarkable for venetoclax. …”
Get full text

Credit Rationing Equilibrium Achievement in the Conditions of Digitalization by O. V. Lunyakov

“…The authors’ hypothesis is that the credit market has the potential to increase the return on a loan per currency unit of borrowers’ loans, and the current estimates of the of defaults borrowers’ probability, interest rates are “biased”. …”
Get full text

Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Results Our findings showed that CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs-PTX significantly suppressed NOTCH1 and SF3B1 expression in PBMCs and BMMCs isolated from CLL cases in comparison with the untreated samples, leading to increased leukemic cell sensitivity to PTX and decreased the proliferative capacity of leukemic cells. …”
Get full text

A phenomenological study of knowledge concealment in country water and sewage engineering company by Gholamreza Moghadasi, Hamidreza Rezaei Kelidbari, Mohammad Doostar

“…Abstract The purpose of the current research is to investigate the effective factors in hiding knowledge in the country's water and sewage engineering company. …”
Get full text

Multiomics-based analysis of the mechanism of ammonia reduction in Sphingomonas by Wang Mingcheng, Wang Mingcheng, Wang Mingcheng, Wang Mingcheng, Liu Daoqi, Xia Huili, Wang Gailing, Liu Chaoying, Guo Yanan, Guo Aizhen, Guo Aizhen, Guo Aizhen

“…These results suggested that under high ammonium sulfate level, the flux of purine and arginine metabolism pathways in Sphingomonas sp. Z392 might decrease, while the flux of nitrogen metabolism pathway might increase, resulting in increased nitrite content and NH3 release. …”
Get full text

Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins by Georgy Berezhnoy, Gyuntae Bae, Leonie Wüst, Claudia Schulte, Claire Cannet, Isabel Wurster, Milan Zimmermann, Alexander Jäck, Eike Jakob Spruth, Julian Hellmann-Regen, Sandra Roeske, Dominik Pürner, Wenzel Glanz, Fabian Maass, Felix Hufschmidt, Ingo Kilimann, Elisabeth Dinter, Okka Kimmich, Anna Gamez, Johannes Levin, Josef Priller, Oliver Peters, Michael Wagner, Alexander Storch, Paul Lingor, Emrah Düzel, Christoph van Riesen, Ullrich Wüllner, Stefan Teipel, Björn Falkenburger, Mathias Bähr, Inga Zerr, Gabor C. Petzold, Annika Spottke, Patricia Rizzu, Frederic Brosseron, Hartmut Schäfer, Thomas Gasser, Christoph Trautwein

“…Highlights from these comparisons include increased citrate and dimethylglycine with a decrease of creatinine and methionine in healthy controls and early PD group compared to GBA, PD late and recessive PD. …”
Get full text

Introduction of Vector-Borne Infections in Europe: Emerging and Re-Emerging Viral Pathogens with Potential Impact on One Health by Jacopo Logiudice, Maria Alberti, Andrea Ciccarone, Benedetta Rossi, Giorgio Tiecco, Maria Antonia De Francesco, Eugenia Quiros-Roldan

“…This review explores the spread of arboviruses in Europe, highlighting their historical context, current transmission dynamics, and their impact on public health.…”
Get full text

Endogenous IL-1 in cognitive function and anxiety: a study in IL-1RI-/- mice. by Carol L Murray, Pauline Obiang, David Bannerman, Colm Cunningham

“…IL-1RI(-/-) mice also showed normal memory for visuospatial context in the contextual fear conditioning paradigm. …”
Get full text

Characterizing dengue transmission in rural areas: A systematic review. by Olivia Man, Alicia Kraay, Ruth Thomas, James Trostle, Gwenyth O Lee, Charlotte Robbins, Amy C Morrison, Josefina Coloma, Joseph N S Eisenberg

“…In some rural areas, the force of infection appears to be increasing over time, as measured by increasing seroprevalence in children and thus likely decreasing age of first infection, suggesting that rural dengue transmission may be a relatively recent phenomenon. …”
Get full text

The 'Antiretrovirals, Sexual Transmission Risk and Attitudes' (ASTRA) study. Design, methods and participant characteristics. by Andrew Speakman, Alison Rodger, Andrew N Phillips, Richard Gilson, Margaret Johnson, Martin Fisher, Ed Wilkins, Jane Anderson, Rebecca O'Connell, Monica Lascar, Kazeem Aderogba, Simon Edwards, Jeffrey McDonnell, Nicky Perry, Lorraine Sherr, Simon Collins, Graham Hart, Anne M Johnson, Alec Miners, Jonathan Elford, Anna-Maria Geretti, William J Burman, Fiona C Lampe

“…In this context the ASTRA study was designed to investigate current sexual activity, and attitudes to HIV transmission risk, in a large unselected sample of HIV-infected patients under care in the UK. …”
Get full text

Bibliometric analysis of research trends and topic areas in traditional Chinese medicine therapy for lymphoma by Gaofeng Zhang, Yanmei Qin, Shaobing Liu, Xi Chen, Wenwen Zhang

“…Context Traditional Chinese Medicine (TCM) is effective as a cancer treatment modality. …”
Get full text

Regulating and mitigating the risks of youth sports betting in Ethiopia by S. Lijagegnehu Biru, K. Gemechis, R. Girma, Y.A. Zikargie

“…This analysis was complemented by a comprehensive literature review, comparative studies of international regulatory models (specifically the UK), and practical observations within the Ethiopian context. The findings revealed that the current regulatory focus on revenue generation inadequately addresses the profound social harms. …”
Get full text

Preparation of Electrode Materials from Iron Cobalt Oxide on Carbon Fiber Cloth used for Asymmetric Supercapacitors by Abeer A. Radhi, Sami I. Jafar Al-Rubaiey, Shaymaa Al-Rubaye

“…Moreover, the FCO-CFC nanocomposite electrode demonstrated exceptional cyclic stability, i.e., 66% retention of capacitance at a current density of 10 mA g-1 after a process of 1000 cycles and a current density of 10 mA g-1 at a surprisingly high specific capacitance of 225 F g-1 for a nanocomposite electrode. …”
Get full text

Consequences, costs and cost-effectiveness of workforce configurations in English acute hospitals by Peter Griffiths, Christina Saville, Jane Ball, David Culliford, Jeremy Jones, Francesca Lambert, Paul Meredith, Bruna Rubbo, Lesley Turner, Chiara Dall’Ora

“…These findings lend support to policy initiatives aimed at increasing the supply of RNs. Study registration This study is registered as Current Controlled Trials ClinicalTrials.gov NCT04374812. …”
Get full text

Word recognition during movement under simulated weather conditions. by Francisco Rocabado, Natasha Alonso-Bernal, Jon Andoni Duñabeitia

“…These findings demonstrate the utility of VR as an ecologically valid framework to investigate the complex interplay between environmental context and reading comprehension. In conclusion, the current study provides insights into how varying environmental conditions affect word recognition during movement.…”
Get full text

THE DEVELOPMENT OF THE FINANCIAL ENVIRONMENT OF NON-PROFIT ORGANIZATIONS IN RUSSIA by I. N. Molchanov, M. V. Shulgina

“…The paper analyzes the current practice of funding non-profit organizations in Russia compared with the foreign experience. …”
Get full text

Co-creation as a Methodology to Integrate Mental Health and Psychosocial Support and Peacebuilding by Yvonne Sliep, Marian Tankink, Friederike Bubenzer

“…The process includes exploring the context and current situation of a given country, as well as how participants would like to see integration unfold in the short and long term, acknowledging that integration can take on many forms. …”
Get full text

Federated learning assisted distributed energy optimization by Yuhan Du, Nuno Mendes, Simin Rasouli, Javad Mohammadi, Pedro Moura

“…Abstract The increased penetration of distributed energy resources and the adoption of sensing and control technologies are driving the transition from our current centralized electric grid to a distributed system controlled by multiple entities (agents). …”
Get full text

«If we do not worship idols, then we worship sin in every possible way»: The topoi of pagan sacrifice in a late 17th century sermon by A. I. Popovich

“…The works of Dimitry Rostovsky are also used to reconstruct the multidimensional context of polemics. These authors are united by their increased focus on contemporaneousness, and by their desire to offerthe listener/reader by means of homilies an ideal of salvation (including «everyday martyrdom»), contrasting it with «sacrifice to idols». …”
Get full text

PHYSICO-MECHANICAL PROPERTIES INVESTIGATION OF HEMPCRETE by Laurențiu ADAM, Dorina-Nicolina ISOPESCU

“…Food, energy and construction are the three main domains in which different uses of industrial hemp confirm the role and importance that agriculture has in human life. In the current context with an increased need for energy efficiency and environmental protection, the attention of scientists is directed towards the identification of ecological construction materials, and a sustainable way of life, where the circular economy must become part of people’s living habits. …”
Get full text