Immunological and physiological changes of exercise-released lactate on tumors: an important and new research window by Amir Hossein Ahmadi Hekmatikar, Arsham Entesari, Hossein Shirvani

“…In the cancer immune cycle, the immune checkpoint PD-1 and its ligand PD-L1 collaborate to facilitate immune escape and promote tumor progression (Keir et al., 2008). In this context, a study revealed that lactate can enhance the expression of PD-L1 on tumor cells, suggesting that lactate may have a protective effect against tumors by increasing PD-L1 expression (Feng et al., 2017). …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…This paper describes the current transplant system’s use of subjective evaluation criteria, particularly psychosocial support and compliance. …”
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“Locality – Adaptation” Research of Hydropower Resettlement Communities in the Jinsha River Basin: A Case Study of Ludila Hydropower Station by Fang WANG, Zhuoqi LI, Haoyi XU, Jiaqi YAN

“…ObjectiveWithin human – environment systems, river basins constitute the earliest geographical units of human activity and currently represent the most critical zones of strained human – environment interactions. …”
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On the added value of sequential deep learning for the upscaling of evapotranspiration by B. Kraft, B. Kraft, B. Kraft, J. A. Nelson, S. Walther, F. Gans, U. Weber, G. Duveiller, M. Reichstein, W. Zhang, M. Rußwurm, D. Tuia, M. Körner, Z. Hamdi, M. Jung

“…However, together with the non-temporal FCN model, they exhibited a larger ensemble spread than XGBoost, and they yielded lower global ET estimates than what is currently understood. XGBoost showed a smaller ensemble spread compared to neural networks, in particular when conditions were poorly represented in the training data, but it was more sensitive to the covariate setup. …”
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Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and <i>Trypanosoma cruzi</... by Gabriela Alves de Souza, Lorrane de Souza Chaves, Afonso Santine M. M. Velez, Jorge Lucas F. Lacerda, Paulo Pitasse-Santos, Jayane Clys Conceição dos Santos, Otávio Augusto Chaves, Carlos Serpa, Raphael do Carmo Valente, Leonardo Marques da Fonseca, Marcos André Rodrigues da Costa Santos, Jhenifer Santos dos Reis, Carlos Antônio do Nascimento Santos, Lucia Mendonça-Previato, Jose Osvaldo Previato, Celio Geraldo Freire-de-Lima, Debora Decoté-Ricardo, Leonardo Freire-de-Lima, Marco Edilson Freire de Lima

“…<b>Background: </b>Anticancer therapies represent the primary treatment option for a significant number of cancer patients globally; however, many of these treatments are associated with severe side effects as they target molecular structures present in both cancerous and healthy cells. In a similar context, the treatment of Chagas disease, a neglected tropical illness, is hindered by the high toxicity of the currently available drugs. …”
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Early Warning and Assessment of Chinese Marathon Events' Exposure to High Temperature under Climate Warming by Yu Dandan, Shi Yong, Chen Shuman, Mei Yuru

“…In recent years, the number of marathons in China has expanded rapidly, but the impact of high-temperature weather has become more apparent. Current high-temperature early warning systems lack tailored thresholds and unified standards for sports scenarios. …”
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Regulatory culture and architectural project by Mario Losasso

“…They are attentive to a quality that does not depend on construction solutions or on techno-typological, morphological or physical-chemical characteristics, but which is linked to a system of needs to be satisfied, the outcome of the interaction between construction and cultural, socio-economic and environmental context. Today’s regulatory landscape has expanded, increasing sensitivities to environmental challenges, health and the qualities of living space. …”
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The Structural Model of Happiness Based on Mindfulness with Mediator Role of Emotional Intelligence, Self-Compassion and Resilience by Mohammad Reza Tamannai far, Faezeh Taraffo

“…Moreover, the indirect effect of mindfulness on happiness was significant in that mindfulness leads to an increase in resilience by enhancing emotional intelligence and self-compassion, while it improves happiness by increasing resilience. …”
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Conceptualization of Policies, Strategies and Programs for Poverty Alleviation in Iran: A Qualitative Study by Hassan Danaeefard, Morteza Nabavi, Faramarz Nasri, Seyed Mohammad Javad Sajjadi Nezhad

“…., were created to help alleviate poverty in the country.The Research Center of the Islamic Council has stated in a report that the poverty line rate has been increasing since 2011 and has reached from 19.4% to 30/4% in 2021. …”
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Improving health-promoting workplaces through interdisciplinary approaches. The example of WISEWORK-C, a cluster of five work and health projects within Horizon-Europe by Deborah De Moortel, Michelle C Turner, Ella Arensman, Alex Binh Vinh Duc Nguyen, Víctor Gonzalez

“…New survey shows the mental health of European workers is increasingly at risk. https://www.etui.org/news/new-survey-shows-mental-health-european-workers-increasingly-risk 7. …”
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Group-based interventions to reduce gambling involvement among male football fans: a synopsis of findings from a feasibility study by Gerda Reith, Blair Biggar, Chris Bunn, Manuela Deidda, Craig Donnachie, Frankie Graham, Cindy Gray, Nicola Greenlaw, Kate Hunt, Matthew Philpott, Neil Platt, Robert D Rogers, John Rooksby, Sally Wyke, Heather Wardle

“…Football Fans and Betting was most successful in feasibility delivery when it was delivered within grassroots and local community contexts. Conclusions In the current climate of gambling industry penetration into professional football, promoting a gambling harms prevention intervention proved an insurmountable challenge. …”
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Interpersonal counselling for adolescent depression delivered by youth mental health workers without core professional training: the ICALM feasibility RCT by Jon Wilson, Viktoria Cestaro, Eirini Charami-Roupa, Timothy Clarke, Aoife Dunne, Brioney Gee, Sharon Jarrett, Thando Katangwe-Chigamba, Andrew Laphan, Susie McIvor, Richard Meiser-Stedman, Jamie Murdoch, Thomas Rhodes, Carys Seeley, Lee Shepstone, David Turner, Paul Wilkinson

“…However, alterations to the referral pathways did not increase the number of referrals made to the study. …”
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Territories -in- between by Alexander Wandl

“… There is an increasing body of literature suggesting that the conventional idea of a gradual transition in spatial structure from urban to rural does not properly reflect contemporary patterns of urban development and their potential for sustainable development. …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…Support for the diversity of carers of eating disorders (fathers, partners, siblings) in different cultural contexts across the spectrum of eating disorders The current model of carers support is designed for parents (particularly mothers) of white, highly educated patients with AN. …”
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Biological contingency and adaptation to celibacy among girls aged 35 and over in Yazd city by Ahmad Kalateh Sadati, Fatemeh Jafari Naeimi, Sara Sadeghieh, Zahra Sadeghian Moghadam

“…This phenomenon varies across different decades and contexts, influenced by social and cultural conditions, which can impart diverse meanings and biological patterns. …”
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Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection by Carrie L. Butler, Nicole M. Valenzuela, Kimberly A. Thomas, Elaine F. Reed

“…This review highlights what is currently known about the clinical context of pre and posttransplant antibodies, antibody characteristics that influence AMR, and the paths after donor specific antibody production (no rejection, subclinical rejection, and clinical dysfunction with AMR).…”
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Does Beta Explain Global Equity Market Volatility – Some Empirical Evidence by Radosław Kurach

“…In the subsidiary outcomes of our verification procedure, we argue that country betas are time-varying and that currently, global factors are the dominant source of equity market volatility. …”
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Incomplete epidemiological transition in Kazakhstan: changes in the structure of life expectancy and causes of death by А. Алдангаркызы, М. Денисенко

“… This article examines Kazakhstan's epidemiological transition, focusing on shifts in mortality patterns and life expectancy within the context of socioeconomic and demographic influences. …”
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Progress of arylacetamide deacetylase research in metabolic diseases by Liu Yang, Zhe-Zhen Liao, Li Ran, Xin-Hua Xiao

“…It plays a significant role in drug metabolism, lipid metabolism, and the pathogenesis of various diseases. In the context of drug metabolism, AADAC is vital for ensuring the safety of ester-based drugs. …”
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A novel RNN architecture to improve the precision of ship trajectory predictions by Martha Dais Ferreira, Jessica N. A. Campbell

“…Currently, the Ornstein-Uhlenbeck (OU) model is considered the state-of-the-art for STP. …”
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