EstablishINg the best STEp-up treatments for children with uncontrolled asthma despite INhaled corticosteroids (EINSTEIN): protocol for a systematic review, network meta-analysis a... by Ian Sinha, Dyfrig A Hughes, Michelle Maden, Stephen Turner, Sofia Cividini, Sarah Donegan, Giovanna Culeddu, Katie Rose, Olive Fulton, Catrin Tudur Smith

“…Treatment with a low-dose ICS, however, fails to control asthma symptoms in around 10%–15% of children and this places the individual at increased risk for an asthma attack. At present, there is no clear preferred treatment option for a child whose asthma is not controlled by low-dose ICS and international guidelines currently recommend at least three treatment options. …”
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Dealing with Complexity – Knowledge, design, and management of the built environment by Cesare Sposito, Francesca Scalisi

“…How do we place knowledge and learning into a system to better understand the current era’s multidimensional, fundamental, and global issues in their irreducible complexity? …”
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Comparative chromium adsorptive capacity of different low-cost materials using fixed bed column by Asma Shakeel, Inayat Mustafa Khan, Faheem Jeelani, Mukhtar Iderawumi Abdulraheem, Salma Imam Sulaiman, Mohmad Auyoub Bhat, Javid Ahmad Bhat, Tahir Sheikh, Rakshanda Anayat, Syed Andleeba Jan, Mehnaz Shakeel, Mohd. Tariq, Arifullah Mohammed, Tabarak Malik

“…Abstract The accessibility of pure water is crucial for various human activities and is increasingly in demand due to the growing global population. …”
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Reims antique, acquis et perspectives by Magalie Cavé, Philippe Rollet, Régis Bontrond

“…This article adopts an approach designed to assess the current state of acquired knowledge and developed hypotheses relative to the spatial organization of the city, enriching both with the most recent research developments. …”
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Application of dry electrodes in supercapacitors and lithium-ion batteries by Guolei ZHANG, Keliang ZHANG, Yabin AN, Chen LI, Guanwei LIU, Xianzhong SUN, Changzhou YUAN, Kai WANG, Xiong ZHANG, Yanwei MA

“…Finally, the challenges and issues in the current use of dry electrodes in supercapacitors and lithium-ion batteries are summarized, along with proposed future directions. …”
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Mineralogy and sulfide mineral chemistry of Khabr iron ore, Southwest of Baft (Southeast of Sanandaj-Sirjan Zone) by Mohammad Boomeri, Habib Biabangard, Somayeh Dehghani Soltani, Azadeh Bordbar

“…Discussion and Results  The iron mineralization occurs at the contact of carbonate rocks and phyllite and schists. …”
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Consequences, costs and cost-effectiveness of workforce configurations in English acute hospitals by Peter Griffiths, Christina Saville, Jane Ball, David Culliford, Jeremy Jones, Francesca Lambert, Paul Meredith, Bruna Rubbo, Lesley Turner, Chiara Dall’Ora

“…Study registration This study is registered as Current Controlled Trials ClinicalTrials.gov NCT04374812. …”
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SOLPS-ITER simulation of W limiter start-up on ITER by Y. Zhang, A.A. Pshenov, R.A. Pitts, X. Bonnin, M. Dubrov, Y. Gribov, A. Kirschner, C. Baumann, S. Brezinsek, J. Romazanov, Chaofeng Sang, Dezhen Wang

“…To assess this impact, a large database of SOLPS-ITER simulations of the hydrogen (H) plasmas in contact with the tungsten (W) limiter has been constituted, including transport of all individual W charge states up to a given cut-off. …”
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Solid waste management service chain and sanitation safety: a case study of existing practice in Addis Ababa, Ethiopia by Shegaw Fentaye Sisay, Sirak Robele Gari, Sirak Robele Gari, Argaw Ambelu

“…Additionally, 85% of households used storage and transport containers that had leaks, potentially leading to contamination and infection. …”
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Hermetia illucens oil vs. hydrogenated palm fat in dairy cow nutrition: effects on digestive parameters, oxidative stress, and milk production performance by Lara Rastello, Laura Gasco, Mauro Coppa, Mathieu Gerbelle, Stefania Colombini, Marco Battelli, Paola Badino, Luca Vernetti-Prot, Pablo G. Toral, Alberto Brugiapaglia, Giulia Gardini, Vanda Malfatto, Isabelle Constant, Alessandro Galli, Christophe Trespeuch, Manuela Renna

“…Abstract Background Scant information is currently available on the use of insect oils in ruminant diets. …”
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Analysis of the influence of the microbial load of poultry facilities on the development of keel “mins” in turkeys by R. I. Fedyniak, R. A. Peleno

“…Instead, an imbalance can lead to the development of specific pathologies in the bird. Currently, in the conditions of industrial poultry farming, studying the influence of the microbial environment of poultry houses on the health and development of birds is a relevant and important topic of scientific research. …”
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Effectiveness of virtual fencing in a mountain environment and its impact on heifer behaviour and welfare by P. Fuchs, C.M. Pauler, M.K. Schneider, C. Umstätter, C. Rufener, B. Wechsler, R.M. Bruckmaier, M. Probo

“…Video cameras recorded animal reactions upon virtual fence contact. Grass height was measured to estimate forage availability in the currently grazed paddocks. …”
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Herd immunity to hepatitis A virus in the Saint Petersburg and Leningrad Region by A. Yu. Popova, A. Yu. Gorbunova, Yu. V. Ostankova, S. A. Egorova, D. E. Reingardt, A. R. Ivanova, A. N. Schemelev, I. V. Drozd, O. B. Zhimbaeva, E. M. Danilova, A. M. Milichkina, E. B. Ezhlova, A. A. Melnikova, N. S. Bashketova, L. V. Buts, A. A. Totolian

“…Acute HA accounted for the largest share in the structure of acute viral hepatitis morbidity – 61%, and in comparison, with 2010, its specific weight increased 1.3 times (55% – in 2010). Currently, there is no specific treatment for HA. …”
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Structure, conservation and health implications of urban wild meat value chains: A case study of Lagos, Nigeria by Samuel N. Akpan, Pim van Hooft, Anise N. Happi, Ralph Buij, Frank van Langevelde, Elizabeth A.J. Cook, James M. Hassell, Dawn M. Zimmerman, Sherrill P. Masudi, Christian T. Happi, Lian F. Thomas

“…Conservation and public health interventions should be node-specific and gender-sensitive, targeting the dry seasons when actors' activities peak, and risks of human-wild meat contact are greater. There is need for the re-assessment of the conservation statuses of West Africa's wildlife species to reflect current realities foisted by wild meat trade.…”
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Combined TNF-α and OX40L targeting as a new treatment option for hidradenitis suppurativa by Thomas Leeuw, PhD, Deimantė Šimaitė, PhD, Karen Heyninck, PhD, Clement Levin, PhD, Sigrid Cornelis, PhD, Youssef Hijazi, PhD, Heidi Rommelaere, PhD, Thomas Kreutzberg, PhD, Peter Florian, DVM, Markus Kohlmann, PhD, Theresa-Charlotte Brembach, PhD, Frank Nestle, MD, FmedSci, Kerstin Wolk, PhD, Robert Sabat, MD, PhD, Matthias Herrmann, PhD

“…Conclusion: OX40-OX40L interaction is a key pathogenetic feature in HS, and patients with HS might benefit from combined TNF-α/OX40L blockade by SAR442970, which is currently investigated in a clinical phase 2 trial.…”
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HIV-1 suppression and rare dolutegravir resistance in antiretroviral-experienced people with HIV in Liberia by James Soka Moses, Alice K. Pau, Safia Kuriakose, Greg Grandits, Cavan Reilly, Brad T. Sherman, Weizhong Chang, Lisheng Dai, Muhammad A. Khan, Helene Highbarger, Moses Mannah, Johnathan McCullough, Carla Chorley, Isaac Morlu, Joseph Dorbor, Ophelia Talweh Bongolee, Rebecca Slewion, Esther Akpa, Barthalomew Wilson, April L. Poole, Stacy L. Kopka, Tracey Miller, Cecelia J. Nuta, Christina Lindan, David Glidden, Jeffrey N. Martin, Kumblytee L. Johnson, Robin L. Dewar, Ian Wachekwa, Stephen A. Migueles

“…Abstract Background Increasingly, persons with HIV in Liberia are receiving antiretroviral therapy containing the integrase strand-transfer inhibitor (InSTI) dolutegravir (DTG), but the prevalence of and factors associated with virologic failure and HIV drug resistance (HIVDR) remain unknown. …”
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CREATING THE KULTUK POLYGON FOR EARTHQUAKE PREDICTION: VARIATIONS OF (234U/238U) AND 87SR/86SR IN GROUNDWATER FROM ACTIVE FAULTS AT THE WESTERN SHORE OF LAKE BAIKAL by S. V. Rasskazov, E. P. Chebykin, A. M. Ilyasova, E. N. Vodneva, I. S. Chuvashova, S. A. Bornyakov, A. K. Seminsky, S. V. Snopkov, V. V. Chechel'nitsky, N. A. Gileva

“…Determinations of (234U/238U) in groundwater samples are used for monitoring current deformations in active faults (parentheses denote activity ratio units). …”
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Making temporary homes by Marjolein Overtoom

“…The main finding was that the concept of home could benefit housing design. Current building guidelines do not include the user-perspective, which is of importance to residents. …”
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Microvesicles Derived from Human Embryonic Neural Stem Cells Inhibit the Apoptosis of HL-1 Cardiomyocytes by Promoting Autophagy and Regulating AKT and mTOR via Transporting HSP-70 by Lei Zhang, Jianyi Gao, Tianyan Chen, Xiang Chen, Xianyan Ji, Kai Ye, Jiahong Yu, Bin Tang, Yusheng Wei, Hong Xu, Jiabo Hu

“…Additionally, hESC-NSC-derived MVs contained high levels of heat shock protein 70 (HSP-70), which can increase the level of HSP-70 in cells. …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…This paper describes the current transplant system’s use of subjective evaluation criteria, particularly psychosocial support and compliance. …”
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