A Comparison of the 𝜶2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain by Sarah Nickolls, Hannah Mace, Rebecca Fish, Michelle Edye, Rachel Gurrell, Magnus Ivarsson, Tom Pitcher, Sachi Tanimoto-Mori, Denise Richardson, Catherine Sweatman, Janet Nicholson, Cameron Ward, John Jinks, Christine Bell, Kimberly Young, Huw Rees, Andrew Moss, Ross Kinloch, Gordon McMurray

“…GABAA receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. …”
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The incidence of influenza in pregnant women and the relevance of possible preventive measures by A. Z. Khashukoeva, T. E. Dmitrashko, Z. A. Beslangurova, D. M. Lyafisheva

“…Currently, despite significant advances in the development of medicine in general, and diagnostic and therapeutic approaches in particular, the problem of influenza is still extremely relevant. …”
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The use of innovative technologies in the production of culinary products in public catering enterprises by E. S. Franchenko, M. Yu. Tamova, T. A. Dzhum, R. A. Zhuravlev, K. K. Nikanov

“…The article provides an overview of the types of raw materials containing increased amounts of digestible iron, and describes modern technologies for the production of culinary products for people suffering from anemia. …”
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Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia by Armin Dozandeh-Jouybari, Fatemeh Mousavi-Mirkalaei, Saeid Taghiloo, Hossein Karami, Mohammad Naderisorki, Ehsan Zaboli, Mohammad Eslami-Jouybari, Tohid Kazemi, Hossein Asgarian-Omran

“…By elucidating the precise underlying mechanisms, these drugs could emerge as promising therapeutic options, particularly in the context of combination therapy for ALL.…”
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Research hotspots and trends in the application of diffusion tensor imaging in ischemic stroke: a bibliometric analysis (2003–2024) by Xu Chen, Xu Chen, Meifang Liu, Xiaolin Yang, Mengqi Yue, Haocheng Yu, Haiqiang Wang, Zirong Wang, Jing Shi, Jing Shi, Yong Qiu

“…However, the current study still needs to strengthen cross-regional cooperation, and higher quality and broader research is still necessary to lay the foundation for reaching the consensus of various experts.…”
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Improved lubricating and corrosion resistance of MAO coatings on ZK61 Mg alloy by co-doping with graphite and nano-zirconia by Chao Yang, Liyuan Sheng, Chaochao Zhao, Pinghu Chen, Wentai Ouyang, Daokui Xu, Yufeng Zheng, Paul K. Chu

“…Compared with doping with a single element, co-doping increases the content of ZrO2 and graphite in the MAO coating. …”
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Impacts of climatology error on evapotranspiration data merging over the intensively irrigated Haihe river basin, China by Yuxi Li, Xi Chen, Jianzhi Dong, Jianhong Zhou, Xin Tian, Man Gao

“…New hydrological insights for the region: Results demonstrate that current RS and reanalysis datasets of ERA5, PML, and ALEXI contain strong intra and inter-annual biases. …”
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Functionalized gold nanoflowers on carbon screen-printed electrodes: an electrochemical platform for biosensing hemagglutinin protein of influenza A H1N1 virus by Carlos Enrique Torres-Méndez, Sharmilee Nandi, Klara Martinovic, Patrizia Kühne, Yifan Liu, Sam Taylor, Maria Lysandrou, Maria Ines Berrojo Romeyro Mascarenhas, Viktoria Langwallner, Javier Enrique Sebastián Alonso, Ivana Jovanovic, Maike Lüftner, Georgia-Vasiliki Gkountana, David Bern, Abdul-Raouf Atif, Ehsan Manouchehri Doulabi, Gemma Mestres, Masood Kamali-Moghaddam

“…Differential pulse voltammetry was used to measure the change in current across the electrode as a function of H1 concentration. …”
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Ginkgo ketone ester tablets for the treatment of cognitive impairment associated with chemotherapy for breast cancer - a prospective cohort study by Jiajing Chen, Lixin Chen, Kexin Jiang, Dandan Wang, Chunyu Wu, Yuenong Qin, Sheng Liu

“…BackgroundChemotherapy-related cognitive impairment (CRCI) affects up to 75% of breast cancer patients during treatment, with 35% experiencing persistent post-treatment deficits. Current interventions show limited efficacy, creating urgent need for targeted therapies. …”
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Biostimulation through natural biological inputs on fruiting, nutrient availability and rhizosphere microbiome in legume intercropped ‘Sweet Charlie’ strawberry (Fragaria × Ananass... by Pramod Kumar, Rajeshwar Singh Chandel, Subhash Chander Verma, Nisha Sharma, Simran Saini, Rohit Bishist, Suman Lata

“…Liquid microbial culture of Jeevamrit contained cow dung-urine (pH-5.65, EC-0.23 dS/m) and was enriched with Azotobacter chroococcum, Pseudomonas species and actinobacteria. …”
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Highly sensitive multiplex PCR for convenient quantification and differentiation of canine Oomycota pathogens: Pythium insidiosum, Lagenidium giganteum f. caninum, and Paralagenidi... by Asfiha Tarannum, Subarna Barua, Leonel Mendoza, Raquel Vilela, Priscilla Barger, Terri Hathcock, Amelia White, Kelly Chenoweth, Chengming Wang

“…Interestingly, the developed multiplex Oomycota PCR revealed that 45.5% (40/88) of serum samples positive for anti-Pythium antibody contained Pythium DNA. Additionally, among 24 suspected anti-Pythium antibody-positive samples, 54.2% (13/24) tested positive for Pythium DNA, while 8.3% (2/24) contained Lagenidium DNA. …”
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Mycochemistry, antioxidant, anticancer activity, and molecular docking of compounds of F12 of ethyl acetate extract of Astraeus asiaticus with BcL2 and Caspase 3 by Swapan Kumar Ghosh, Koushik Pandey, Madhuparna Ghosh, Pradip Kumar Sur

“…Abstract Globally the current research is going for cancer disease management by different strategies as frequency and severity of this disease are increasing day by day. …”
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Fabrication of biodegradable silicon nitride 3D printed nanocomposite with enhanced mechanical and antimicrobial properties for bone tissue repair by Femi B. Alakija, David K. Mills

“…The porosity test showed that the addition of Si3N4 does not affect the porosity or cell attachment of the fabricated nanocomposites, while histological staining revealed increased calcium and mucopolysaccharides. The nanocomposite exhibited excellent mechanical properties, including higher flexural strength, hardness, and a lower contact angle after surface coating with protein. …”
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School-Based Online Surveillance of Youth: Systematic Search and Content Analysis of Surveillance Company Websites by Alison O'Daffer, Wendy Liu, Cinnamon S Bloss

“…ObjectiveThe two goals of this study were to (1) comprehensively identify school-based online surveillance companies currently in operation, and (2) collate and analyze company-described surveillance services, monitoring processes, and features provided. …”
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Prioritization of potential drug targets for diabetic kidney disease using integrative omics data mining and causal inference by Junyu Zhang, Jie Peng, Chaolun Yu, Yu Ning, Wenhui Lin, Mingxing Ni, Qiang Xie, Chuan Yang, Huiying Liang, Miao Lin

“…Diabetic kidney disease (DKD) with increasing global prevalence lacks effective therapeutic targets to halt or reverse its progression. …”
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Combined single- and dual-energy CT workflow for dose calculation in radiotherapy by Hella Sand, Jens Edmund, Ane Appelt, Patrick Wohlfahrt, Vicki Trier Taasti, Laurids Østergaard Poulsen, Jimmi Søndergaard, Martin Skovmos Nielsen

“…Background and purpose: Dual-energy computed tomography (DECT) is increasingly used in radiotherapy delineation due to its enhanced soft tissue contrast. …”
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Indonesian Nursing Educators’ Experiences with Developing Student-Centered Learning Methods by Vigdis Abrahamsen Grøndahl, Kirsti Lauvli Andersen, Ann Karin Helgesen, Asniar Asniar, Randi Martinsen, Riza Septiani, Dharina Baharuddin, Signe Rasch Woersaa, Anna Willman, Liv Berit Olsen

“…A three-year educational program for nursing educators in Indonesia was developed. The current study used a qualitative, descriptive design with a questionnaire containing four open-ended questions focusing on the educators’ experiences with developing student-active methods and conditions affecting this process. …”
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Research progress on the control of reactive elements in remelted ingots during the electroslag remelting process by Shengchao DUAN, Lifeng ZHANG

“…Additionally, the physical parameters of the slag system play a crucial role in determining the surface quality and solidification characteristics of the ingots. Current research on the physical parameters of remelting slag systems containing TiO2, SiO2, B2O3, and rare earth oxides has primarily focused on viscosity and crystallization behavior. …”
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Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Overexpression of the splicing factor 3b subunit 1 (SF3B1) and neurogenic locus notch homolog protein 1 (NOTCH1) factors is typically found in chronic lymphocytic leukemia (CLL), leading to the development of chemotherapy resistance. Objective The current investigation aims to evaluate the chemosensitivity of CLL cells by blocking NOTCH1 and SF3B1 using chitosan lactate (CL) nanoparticles (NPs). …”
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Neurology care and the long-term outcomes of atrial fibrillation-related ischaemic stroke in China: median 3-year outcome from a high volume academic tertiary hospital by Nan Wu, Lian Zhang, Minglong Chen, Qi Wan, Zidun Wang, Fengming Wu, Xiaoyuan Gao, Yilan Yang, Mingfang Li

“…Objectives The initial medical contact of patients with atrial fibrillation (AF) and ischaemic stroke is often performed by neurologists. …”
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