Approaches to clinical development of combination medicines in the Russian Federation and the Eurasian Economic Union in view of the requirements of the current legislation by A. V. Dobrovolskiy

“…In recent years, there has been an increasing interest in the development of combination medicines (fixed drug combinations) containing two or more active ingredients in a single dosage form. …”
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A Dynamic Interval Auto-Scaling Optimization Method Based on Informer Time Series Prediction by Yu Ding, Chenhao Li, Zhengong Cai, Xinghao Wang, Bowei Yang

“…Currently, widely used responsive auto-scaling methods, such as Kubernetes HPA, exhibit certain lags due to the startup time costs of containers and Pods. …”
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A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosisResearch in context by Jeremy S. Lum, Mikayla L. Brown, Natalie E. Farrawell, Rachael Bartlett, Christen G. Chisholm, Jody Gorman, Anthony Dosseto, Florian Dux, Lachlan E. McInnes, Heath Ecroyd, Luke McAlary, Peter J. Crouch, Paul S. Donnelly, Justin J. Yerbury

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Frequency of weight and body composition increases in advanced non‐small cell lung cancer patients during first line therapy by Philip Bonomi, Hita Moudgalya, Sandra L. Gomez, Palmi Shah, Sanjib Basu, Marta Batus, Levi B. Martinka, Ahmed Abdelkader, Iphigenia Tzameli, Sonia Cobain, Susie Collins, Edmund J. Keliher, Danna M. Breen, Roberto A. Calle, Mary Jo Fidler, Jeffrey A. Borgia

“…One cohort received the current standard of care (CSOC), which consisted of immunotherapy and newer chemotherapy regimens, and the other cohort was treated with the former standard of care (FSOC), consisting only of older platinum‐containing regimens. …”
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Significantly Increased Aqueous Solubility of Piperine via Nanoparticle Formulation Serves as the Most Critical Factor for Its Brain Uptake Enhancement by Li J, Leung SSY, Chan EHY, Jiang C, Ho ETY, Zuo Z

“…The PIP NPs could significantly increase the aqueous solubility of piperine from 0.04 mg/mL to 52.31± 0.9 mg/mL and release piperine with a 12.83-fold higher rate than that from piperine suspension. …”
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Increasing uptake of self-management education programmes for type 2 diabetes in primary care: the Embedding research programme including an RCT by Melanie J Davies, Shona Agarwal, Danielle H Bodicoat, Alan Brennan, Simon Dixon, Helen Eborall, Agnieszka Glab, Laura J Gray, Michelle Hadjiconstantinou, Lisa Huddlestone, Nicky Hudson, Anju Keetharuth, Kamlesh Khunti, Caroline Kristunas, Graham Martin, Alison Northern, Mike Patterson, Daniel Pollard, Rebecca Pritchard, Sally Schreder, Jane Speight, Bernie Stribling, Jackie Sturt, Jess Turner, Christina Weis

“…However, most people do not attend these programmes. Objective Increase type 2 diabetes self-management programme attendance. …”
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Evaluating the potential impact of rubella-containing vaccine introduction on congenital rubella syndrome in Afghanistan, Dem. Republic of Congo, Ethiopia, Nigeria, and Pakistan: A... by Sebastian A Rodriguez-Cartes, Yiwei Zhang, Maria E Mayorga, Julie L Swann, Benjamin T Allaire

“…However, COD, NGA, and ETH must increase their current routine vaccination coverage to reduce CRS incidence significantly. …”
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Impact of Hall current on radiative Ree-Eyring nanofluid flow across rectangular frame with Joule and viscous dissipation effects by Saira Yousaf, Zahir Shah, Muhammad Rooman, Mansoor H Alshehri, Atta Ullah, Elisabeta Antonescu, Narcisa Vrinceanu

“…With this motive, the current study investigates the constant, incompressible flow of nanofluids containing copper nanoparticles suspended in ethylene glycol and water, within a rectangular framework. …”
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Pharmacoeconomic evaluation of first-line combination therapy with immunotherapy drugs and platinum-containing chemotherapy in adult patients with metastatic non-squamous non-small... by S. К. Zyryanov, I. N. Dyakov

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SUPEROxIDE DISMUTASE AS A COMPONENT OF ANTIOxIDANT THERAPY: CURRENT STATE OF THE ISSUE AND PROSPECTS. A LITERATURE REVIEW by T. A. Pushkina, E. S. Tokayev, T. S. Popova, E. N. Borodina

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Effect of Current Density on Structure and Hardness of the MAO Film on 7N01 Aluminum Alloy Surface for Water Pump by WEI Si-yuan, LIU Zhi-ying

“…The hardness of the MAO film prepared with the current density of 1 A/dm2 was 158.3 HV. When the current density increased, the hardness of the film was also improved. …”
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Evaluation of four KCNMA1 channelopathy variants on BK channel current under CaV1.2 activation by Ria L. Dinsdale, Andrea L. Meredith

“…Only the N999S mutation produced an increase in BK current in both micro- and nano-domains using square voltage commands and was also detectable in BK current evoked by a neuronal action potential within a microdomain. …”
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Households willingness to pay for improved solid waste management by S. Akhtar, A.S. Ahmad, M.I. Qureshi, S. Shahraz

“…The area lacks frequent collection of waste containers. Therefore, there is a need for upgradation of storage and collection facilities in terms of increase in collection efficiency and rates, introduction of recycling facility and segregation of waste at source. …”
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Study on the Electrochemical Corrosion Resistance Behavior of 20 and L245NS Steels in Simulated Low Sulfur - Containing and CO₂ - Saturated Oilfield Sewage by GAO Wen - ling, GAO Jia - xi, YIN Zhi - fu, YANG Chao - chao

“…Results showed that corrosion current density of 20 and L245NS steels decreased and charge transfer resistance increased in low sulfur conditions compared to those in sulfur - free conditions. …”
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Bioconvective MHD flow of hybrid alumina-silver-water nanofluid across a moving needle containing gyrotactic microorganisms with Cattaneo-Christov heat and mass flux model by Utpal Jyoti Das, Deepjyoti Mali

“…The current study contains a steady laminar bioconvective magnetohydrodynamic (MHD) flow involving water (H2O)-based hybrid nanofluid composed of silver (Ag) and alumina oxide (Al2O3) as nanoparticles. …”
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Chaperonin containing TCP1 subunit 6A may activate Notch and Wnt pathways to facilitate the malignant behaviors and cancer stemness in oral squamous cell carcinoma by Yangyi Chen, Yongge Chen, Weixian Liu

“…The current study aimed to investigate the impact of CCT6A on OSCC cell malignant behaviors and stemness and to explore its potentially interreacted pathways. …”
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Influence of Compressive Strength and Steel-Tube Thickness on Axial Compression Performance of Ultra-High-Performance Concrete-Filled Stainless-Steel Tube Columns Containing Coarse... by Wenrui Li, Mengqi Zhu, Guo Li, Yang Hu, Bei Wang, Yongfei Cao, Wenting He, Haiyang Li, Zhaopeng Tang, Yingda Zhang

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Expert opinion on the current conceptual, clinical and therapeutic aspects of disease related malnutrition and muscle loss: a multidisciplinary perspective by Mutlu Doganay, Meltem Gulhan Halil, Cetin Kaymak, Ugur Selek, Mehmet Akif Topcuoglu, Suayib Yalcin

“…Therefore, the proposed expert opinion aimed to address the current conceptual, clinical and therapeutic aspects of DRM and muscle loss from a multidisciplinary perspective in certain risk groups (geriatric patients, cancer patients, patients with neurodegenerative disorders and critically ill patients) and to address the utility of targeted specific nutritional interventions, specifically the high protein nutritional supplements containing β-hydroxy-β-methylbutyrate (HMB) and vitamin D, in terms of potential beneficial effects in preserving and reversing muscle loss beyond meeting nutritional requirements.…”
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Studies of the Belukha glacier plexus in the context of global glacio-climatic monitoring (on the 100th anniversary of the first ascent of the Belukha Mountain) by V. S. Revyakin

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Regular Nonsteroidal Anti-Inflammatory Drug Use Increases Stress Fracture Risk in the General Population: A Retrospective Case-Control Study by Alexandra Ciuciu, Christopher Mulholland, Michael A. Bozzi, Chris C. Frymoyer, Leonardo Cavinatto, David Yaron, Marc I. Harwood, Jeremy D. Close, Christopher J. Mehallo, Ryan E. Tomlinson

“…Subjects diagnosed with stress fractures had a statistically significant increase in both current use (p=0.03) and regular use (p=0.04) of ibuprofen/naproxen/celecoxib as compared to control subjects. …”
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