SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2 by Hyun-Ju Cho, Joy Smith, Christopher H Switzer, Eleni Louka, Rebecca L Charles, Oleksandra Prysyazhna, Ewald Schroder, Mariana Fernandez-Caggiano, Daniel Simoes de Jesus, Seda Eminaga, Xiaoke Yin, Xiaoping Yang, Steven Lynham, Manuel Mayr, Valle Morales, Katiuscia Bianchi, Vinothini Rajeeve, Pedro R Cutillas, Adam J Mead, Philip Eaton

“…SFX-01, an α-cyclodextrin-stabilized sulforaphane complex currently in clinical development, covalently adducts cysteine residues. …”
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Stellate ganglion blockade under ultrasound-guidance and the physiological responses in the rat by Robert M. N. Tran, Shaista Malik, Christopher Reist, Christopher Reist, Chad K. Oh, Najeebah Abdul-Musawir, Stephanie C. Tjen-A-Looi, Liang-Wu Fu, Theodore J. Baird, Anh T. Nguyen, Yiwei D. Gong, Zhi-Ling Guo

“…Ultrasound-guided SGB is currently adopted as a more effective and safer method in humans. …”
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Nanoindentation Simulation of Hardening Caused by Cr Precipitates in FeCr Alloy by WANG Shumin, HE Xinfu, CAO Jinli

“…By analyzing the dislocations, it is found that the dislocation length in Fe matrix containing Cr clusters decreases obviously, while the nucleation time of dislocations and the depth of indenter when dislocations nucleate slightly increase, indicating that the addition of Cr clusters slightly slows down the nucleation of dislocations and significantly hinders the expansion of dislocations in the matrix. …”

The effect of biofertilizer on water regime, intensity of photosynthesis and productivity of grain crops in the Steppe Pre-Urals by D. G. Fedorova, L. V. Galaktionov

“…Grain crops are of great food value, productivity of which largely depends on the water regime and assimilation activity of plants. The purpose of the current study was to determine the effect of biofertilizer on the parameters of the water regime, pigment, and gas composition of grain crops. …”
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Kavalactones support motivation to move during intensive training in males preparing for military special operations forces by Sheena Y. Smith, Carlos F. Aylwin, Tyler F. Daniels, Jennifer L. Greer, Laura J. Kunces, Loukia Lili, Stephen M. Phipps, Caleb M. Schmidt, Julian C. Schmidt, Michael A. Schmidt

“…Furthermore, the group taking kavalactones first never experienced a significant decrease in Move motivation state (lowest mean score 21.0, highest 28.6, all p ≥ 0.05), while the group receiving kavalactones in the last 2 weeks of the study had Move scores that were statistically lower than baseline (lowest mean score 8.6, highest 25.9, all p ≤ 0.05) at all time points but the last (p = 0.063) after 2 weeks of kavalactones exposure.Conclusions We report a novel finding that kavalactones may support performance by maintaining or rescuing the desire to expend energy in the context of significant physical and mental strain in well-conditioned individuals, even in a context of already normal cortisol, sleep, and mood.…”
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Producing Bacillus from the Ripe Bananas, Jackfruit Seeds and Sweet Potato Tubers by Solid Fermentation and its Effect on the Products' Biochemical Properties by Bruce Robin Nyamweha, Collins Muhangi, Lonah Nampwera, Athanasius Ssekyanzi, Cosmas Wacal, Jacob Kaingo, Martin Sserwadda, Wycliffe Tumwesigye, Sylvester Katuromunda

“…In addition to enriching the nutritional components of plant materials and preserving food, fermentation promotes the growth of beneficial microbes that play a role in human and animal health, especially in the digestive tract, commonly known as probiotics. Objectives: The current study investigated the fermentation of ripe banana, jackfruit seeds and sweet potato tubers to produce Bacillus subtilis and also examined the effect of fermentation on the biochemical properties of the plant materials used in the current study. …”
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Importance of Cheese Whey Processing: Supplements for Sports Activities – a Review by Patricia Fassina, Gabriela Quadros Nunes, Fernanda Scherer Adami, Márcia Inês Goettert, Claucia Fernanda Volken de Souza

“…Whey protein (WP) is a highly nutritious, commercially available alternative food source that is used primarily as a food supplement by athletes and physically active individuals to provide them with essential amino acids and bioactive peptides, and additional benefits have been attributed to WP consumption. In this context, the objective of this review was to explore current evidence regarding the consumption of different WP supplements in sports nutrition to elucidate their efficiency in affecting muscle hypertrophy, physical performance, response to muscle injury, weight loss, and body composition changes. …”
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Endogenous IL-1 in cognitive function and anxiety: a study in IL-1RI-/- mice. by Carol L Murray, Pauline Obiang, David Bannerman, Colm Cunningham

“…IL-1RI(-/-) mice also showed normal memory for visuospatial context in the contextual fear conditioning paradigm. …”
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The Immune Environment in Colorectal Adenoma: A Systematic Review by Ugne Silinskaite, Jurate Valciukiene, Matas Jakubauskas, Tomas Poskus

“…<b>Methods:</b> In this systematic review, we aim to provide a thorough analysis of the current research examining the immune infiltration patterns in sporadic colorectal adenoma tissues in the context of immune cell-based, cytokine-based, and other immunological factor-related changes along the conventional adenoma–carcinoma sequence. …”
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Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway by Xiao Li, Mengna Cui, Long Xu, Qie Guo

“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”
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Effects of wetting events on mass timber surface microbial communities and VOC emissions: implications for building operation and occupant well-being by Gwynne Á. Mhuireach, Susan Collins, Leslie Dietz, Patrick Finn Horve, Aurélie Laguerre, Dale Northcutt, Jason Stenson, Kevin Van Den Wymelenberg, Elliott Gall, Mark Fretz

“…IntroductionHumans have used wood as a construction material throughout history. Currently, mass timber products, such as cross-laminated timber (CLT), are becoming more popular as a structural material, since they are renewable and have a lower carbon footprint than concrete or steel. …”
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Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma by Jing Wang, Meng Song, Jinming Tang, Haoran Yue, Xiaoyang Guo, Zhan Chen, Xiaolan Shen, Mingbo Cao, Mingbo Cao

“…It is critical to investigate new biomarkers and prognostic variables because there are currently no early diagnostic indicators. Actin-related proteins (ARPs) are involved in transcriptional regulation, chromatin remodeling, and DNA repair—all processes that have been connected to the development of cancer. …”
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Nanostructured Strategies for Melanoma Treatment—Part I: Design and Optimization of Curcumin-Loaded Micelles for Enhanced Anticancer Activity by Valentina Paganini, Andrea Cesari, Silvia Tampucci, Patrizia Chetoni, Susi Burgalassi, Michele Lai, Giulia Sciandrone, Silvia Pizzimenti, Fabio Bellina, Daniela Monti

“…<b>Background/Objectives</b>: Melanoma is a pathology that affects a large part of the population, and the currently available therapies have many limitations, including the selective targeting of the site of action. …”
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Patterns of childhood trauma co-occurrence and its predictivity for suicidality: A machine learning approach by Wenbang Niu, Yi Feng, Shicun Xu, Xin Cui, Zhihao Ma, Yuanyuan Wang

“…The relationship between different CT patterns and suicidality remains largely undiscovered. The current study aims to identify distinct CT overlapping patterns and to explore their association with suicidality in a comprehensive multivariable context. …”
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Iran's Media Diplomacy Challenges in Tourism Marketing by Fateme Asgharian Kari, Sajad Ferdowsi

“…Abstract The current research was conducted with the aim of identifying the challenges of Iran's media diplomacy in tourism marketing. …”
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Role of the Fe₃O₄ mass ratio in Fe₃O₄-Fe nanoparticles with the core-shell structure on their anticancer activity <i>in vitro</i> by O. V. Bakina, A. S. Lozhkomoev, S. O. Kazantsev, A. V. Avgustinovich, S. G. Afanasyev, l. V. Spirina

“…Using the MTT test, it was found that nanoparticles containing 5 wt. Fe3O4, in the presence of which, at a concentration of 1 mg/ml, the number of living cells decreased to 16 % relative to the control. …”
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A novel system applying artificial intelligence in the identification of air leak sitesCentral MessagePerspective by Yuka Kadomatsu, MD, PhD, Megumi Nakao, PhD, Harushi Ueno, MD, Shota Nakamura, MD, PhD, Toyofumi Fengshi Chen-Yoshikawa, MD, PhD

“…Intraoperative leak site detection is the first step in decreasing the risk of leak-related postoperative complications. …”
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Accretion of the degenerate Fermi gas onto a Reissner-Nordström black hole by Ping Li, Jiang-he Yang, Siwei Xu

“…The expressions for the particle current density, the stress energy-momentum tensor, and three accretion rates are derived. …”
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Spectroscopic Evolution in Ice Analogs of Trans-Neptunian Objects Exposed to Ionizing Radiation. I. Visible Reflectance Spectra and Colors by Chaojiang Zhang, Jia Wang, Andrew M. Turner, Leslie A. Young, Ralf I. Kaiser

“…The spectral slopes of processed water ices are neutral and independent of the radiation dose, whereas those of ammonia decrease with the increasing radiation dose. When the carbon-containing molecules are mixed with water and ammonia, the reddening process is found to be neutralized. …”
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Towards Sustainable Building Materials: An Experimental Investigation into the Effect of Recycled Construction Waste Aggregate on the Properties of High-Performance Concrete by Radoslav Gandel, Jan Jerabek, Andrea Peknikova, Libor Topolář, Oldrich Sucharda

“…Initially, the properties of concrete containing both the natural and recycled aggregate types were characterized. …”
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