Possibilities of metabolic surgery for the treatment of type 2 diabetes mellitus in patients with grade 1 alimentary obesity by Vladimir V. Salukhov, Nikita S. Ilinskii, Evgenii V. Vasil'ev, Ruslan T. Sardinov, Dmitrii V. Gladyshev

“…Many studies have demonstrated the high effectiveness of bariatric surgery in patients with grade 2–3 obesity and type 2 diabetes mellitus. Currently, surgery is one of the most effective ways to decrease body mass, to maintain long-term weight loss and to manage type 2 diabetes mellitus. …”
Get full text

Interference in melanoma CD248 function reduces vascular mimicry and metastasis by Cheng-Hsiang Kuo, Ya-Fang Wu, Bi-Ing Chang, Chao-Kai Hsu, Chao-Han Lai, Hua-Lin Wu

“…Abstract Background Tumor vascular mimicry is an emerging issue that affects patient survival while having no treatment at the current moment. Despite several factors implicated in vascular mimicry, little is known about stromal factors that modulate tumor microenvironment and shape malignant transformation. …”
Get full text

3D-printed resin for permanent/definitive restorations: meta-analysis for bond strength by Minjoo Ki, Marc Hayashi, Mijoo Kim

“…This meta-analysis aimed to synthesize the current knowledge on the adhesion of 3D-printed restorations to resin cements and identify areas for future research. …”
Get full text

Financial security of Ukraine in debt burden: Assessment and forecasting by Fedir Zhuravka, Yuriy Petrushenko, Svitlana Chorna, Bohdana Huriy, Inessa Yarova, Olga Pankiv, Wojciech Duranowski

“…This study aims to comprehensively assess the state’s financial security of Ukraine in the context of mounting debt and economic instability. …”
Get full text

Ramadan fasting and exercise combination therapy: A novel approach for osteoporosis prevention in ovariectomized rats by Tarfa Albrahim, Raghad Alangry, Raghad Alotaibi, Leen Almandil, Sara Alburikan, Hisham S. Aloudah, Mohammed Alahmed, Mohammed Alahmed, Mona Alonazi

“…This could be recommended as a lifestyle modification that is protective against osteoporosis, especially in the context of depleted estrogen hormone after menopause.…”
Get full text

Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…Understanding of the mechanisms underlying productive HEV infection remains incomplete and would benefit from technological advances improving current model systems. Methods: We exploited transposon-mediated random insertion and selection of viable clones to identify sites in the HEV open reading frame 2 (ORF2) protein, corresponding to the viral capsid, allowing for the insertion of reporter sequences in a functional context. …”
Get full text

Unlocking the potential of global greenhouse gas mitigation by reducing food loss and waste by Suraj Negi, Liang-Shih Fan, Hyunook Kim, Taira Hidaka, Aishwarya Rani, Shu-Yuan Pan

“…Food loss and waste (FLW) are significant yet under-addressed contributors to global greenhouse gas (GHG) emissions, and the effectiveness of current FLW mitigation policies and valorization technologies remains insufficiently explored. …”
Get full text

Morphological features of the poultry thymus by S. V. Huralska, N. V. Dyshliuk, S. S. Zaika, H. P. Hryshchuk, L. H. Yevtukh

“…In this context, there is a change in the ratio of cortical and cerebral substances, the growth of connective tissue stroma and adipose tissue. …”
Get full text

Long-term dynamics of forests with Pinus sibirica in the upper reaches of the River Kolva (Northern Pre-Urals, Russia) from 1938 to 2023 by Alexei A. Aleinikov, Vadim E. Aleksutin, Foma K. Vozmitel, Alexey N. Gunya

“…Due to the exceptionally slow regeneration following fires and logging activities, Pinus sibirica is absent in the forests formed over the studied period. The current federal legal restrictions prove ineffective as they target the preservation of forest stands containing over 30% of Pinus sibirica, while the majority of forests in the study area contain less proportion of this species. …”
Get full text

Understanding the effectiveness and underlying mechanisms of lifestyle modification interventions in adults with learning disabilities: a mixed-methods systematic review by Dikshyanta Rana, Sophie Westrop, Nishant Jaiswal, Evi Germeni, Arlene McGarty, Louisa Ells, Phillippa Lally, Michael McEwan, Craig Melville, Leanne Harris, Olivia Wu

“…Following this, the specific interacting contexts and underlying mechanisms were appraised, and the synthesis focused on developing context–mechanism–outcome configurations (CMOCs), which formed the basis of the emerging programme theory. …”
Get full text

Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…It is not known whether these issues persist in the current iQVIA CDM. The EAG assesses the cost-effectiveness of HCL and CSII + CGM. …”
Get full text

Arginine–NO pathway modulated energy metabolism in the hepatopancreas and muscle of female Litopenaeus vannamei by Haitao Fan, Xin Zhang, Yanan Yin, Lefei Jiao

“…Currently, the regulational effect of arginine on the energy metabolism is unknown in broodstock shrimp nutrition. …”
Get full text

Analysis of clinical and epidemiological interactions of phenol and phthalate levels in blood and urine with anamnestic and biochemical health measures during the formation of mult... by I. Yu. Torshin, O. A. Gromova, T. E. Bogacheva, A. N. Gromov

“…Integrated clinical and epidemiological studies into the clinical consequences of such effects are currently lacking.Objective: To identify patient history parameters that are significantly associated with blood and urine levels of phenols and urine levels of phthalates.Material and methods. …”
Get full text

Insomnia, Cognitive Impairment, or a Combination of Both, Alter Lipid Metabolism Due to Changes in Acylcarnitine Concentration in Older Persons by Selma Karime Castillo-Vazquez, Berenice Palacios-González, Marcela Vela-Amieva, Isabel Ibarra-González, Ricardo Morales, Paola García-delaTorre, Sergio Sánchez-García, Carmen García-Peña, Ricardo Reyes-Chilpa, Raúl Hernán Medina-Campos, Jessica Hernández-Pineda, Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura

“…Therefore, in the present study we aim to characterise metabolomic profiles of insomnia and CI alone in order to address a significant gap in current research regarding the pathways through which insomnia may lead to CI in older persons. …”
Get full text

Joint response of coal permeability and wettability to changes in organic matter induced by oxidation treatment by Baoxin ZHANG, Xuehai FU, Fanhua Bill ZENG, Ze DENG, Zhaobiao YANG, Junqiang KANG, Chaochao DUAN

“…The “high-quality” coal with significantly high permeability enhancement and decreased/smaller increased hydrophilicity after oxidation apparently obtains higher benefits under similar conditions. …”
Get full text

Bone marrow mesenchymal stem cell-derived exosomes alleviate DSS-induced inflammatory bowel disease in mice through inhibiting intestinal epithelial cell pyroptosis via delivery of... by Bihua Wu, Shuangyan Su, Xianyu Wang, Yuwei Li, Zhenghao Mei, Fenglin Lou, Le Guo

“…BackgroundInflammatory bowel disease (IBD), characterized by chronic intestinal inflammation and epithelial barrier dysfunction, remains a therapeutic challenge due to the limitations of current treatments, including drug resistance and invasive surgical risks. …”
Get full text

Optimizing in vitro slow-growth conservation media for garlic under ambient conditions: further implications for core set accessions by Ashwini Prashant Benke, DalasanuruChandregowda ManjunathaGowda, Vijay Mahajan, Digambar N. Mokat

“…Therefore, maintaining the crop’s genetic diversity in a suitable alternative form is crucial. The current study standardized the protocol for slow-growth conservation of garlic (in vitro) at an ambient temperature. …”
Get full text

Sustainable agriculture through nano-priming: Evaluating the role of biogenic manganese oxide nanoparticles in mitigating wastewater-induced stress in wheat (Triticum aestivum) by Aneeza ISHFAQ, Sabir HUSSAIN, Tanvir SHAHZAD, Muhammed SHAHID, Faisal MAHMOOD, Syed Raza HUSSAIN, Irfan HAIDRI, Imran KHAN, Mahmoud F. SELEIMAN, Muhammad Ahsan ASGHAR, Muhammad Fuad ANSHORI

“…Control included seeds without MnO-NP priming. The wastewater contained contaminants such as heavy metals and organic pollutants. …”
Get full text

Finerenone attenuates downregulation of the kidney GLP-1 receptor and glucagon receptor and cardiac GIP receptor in mice with comorbid diabetes by Duc Tin Tran, Emily S. H. Yeung, Lisa Y. Q. Hong, Harmandeep Kaur, Suzanne L. Advani, Youan Liu, Madiha Zahra Syeda, Sri Nagarjun Batchu, Andrew Advani

“…After 26 weeks, mice were fed a high fat diet containing finerenone (100 mg/kg diet) or high fat diet alone for a further 2 weeks. …”
Get full text

Protocol for a randomized controlled trial of patient–portal–based screening for substance use among people with HIV by Eric Roessler, Daniela Zimmer, Jon Grant, Harold Pollack, Basmattee Boodram, Jessica Schmitt, Jessica Schmitt, Eleanor Friedman, Jade Pagkas-Bather, Jade Pagkas-Bather, Russell A. Brewer, Jessica Ridgway, Neda Laiteerapong, Neda Laiteerapong

“…This will lay the groundwork for the second aim, the focus of the current manuscript, RCT to measure the effectiveness of a population health, patient portal-based substance use screening program. …”
Get full text