Unraveling the complex role of microglia in Alzheimer’s disease: amyloid β metabolism and plaque formation by Sho Takatori, Mayuna Kondo, Taisuke Tomita

“…Conversely, we explore findings that challenge this view, such as microglial depletion experiments resulting in unchanged or decreased Aβ accumulation. We propose that the contribution of microglia to Aβ metabolism is context-dependent, varying with disease progression, genetic background, and experimental conditions. …”
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Characterizing dengue transmission in rural areas: A systematic review. by Olivia Man, Alicia Kraay, Ruth Thomas, James Trostle, Gwenyth O Lee, Charlotte Robbins, Amy C Morrison, Josefina Coloma, Joseph N S Eisenberg

“…We conducted a systematic review to synthesize research on dengue in rural areas and apply this knowledge to summarize aspects of rurality used in current epidemiological studies of DENV transmission given changing and mixed environments. …”
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CIS Countries Foreign Economic Activity — from Challenges to New Opportunities by M. S. Goncharov

“…Aim and tasks. To identify current trends and issues in foreign trade, the international financial system, and the investment activity of CIS member states, and to provide recommendations that contribute to sustainable economic development and strengthened mutual cooperation.Methods. …”
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Unlocking the hidden forces: deformation and associated stress distribution in the present-day Geneva Basin and Jura fold-and-thrust belt by Sandra Borderie, Jon Mosar, Adeline Marro, Louis Hauvette

“…If current seismicity indicates that the Geneva Basin is tectonically active, few data regarding the state of stress in the area are currently available. …”
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Effectiveness of Nursing Intervention Protocol on Nurses’ Performance and Patients’ Self-Care after Cataract Surgery by Amal S. Taha

“… Context: Cataract is the leading cause of poor vision worldwide. …”
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Social Skills Training Program and its Effect on Quality of Life and Stigma among Patients with Schizophrenia by Samah Ali, Amal Awad, Hanaa Ewise, Shimaa Adam

“… Context: Schizophrenia is a severe mental disorder that significantly disrupts an individual's social interactions, work performance, and overall quality of life. …”
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Therapeutic potential of microRNAs in neurological disorders: mechanisms, biomarkers, and emerging therapeutic strategies by Sourav Pal, Subhajit Mandal

“…We also explore the future of miRNA research in the context of precision medicine, highlighting the importance of targeted delivery, safety optimization, and integration of patient-specific molecular profiles. …”
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Theoretical Research on the Shear Mechanical Properties and Size Effect of Recycled Concrete Beams Without Stirrups by Chunyang Liu, Guangkai Zhou, Hao Wang, Yilin Wang

“…As a new type of building material with great potential, recycled concrete is playing a vital role in the context of the current construction industry’s pursuit of sustainable development. …”
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Overcoming immunosuppression in cancer: how ketogenic diets boost immune checkpoint blockade by Victoria E. Stefan, Daniela D. Weber, Roland Lang, Barbara Kofler

“…., high-fat low-carbohydrate diets, have been shown to have antiproliferative and immunomodulatory effects in various preclinical cancer studies. Here, we review current knowledge of the complex interplay of KDs and the anti-tumor immune response in the context of ICB therapy, to update our understanding of diet-induced immunometabolic reprogramming in cancer. …”
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Horticultural performance and QTL mapping of snap bean (Phaseolus vulgaris L.) populations with organic and conventional breeding histories by Hayley E. P. Richardson, Ryan M. King, Joel Davis, James R. Myers

“…IntroductionImproving crop cultivars for use on organic farms is pertinent, as current elite germplasm is less resilient within the more variable context of organic farm environments. …”
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Neutrophil-to-Lymphocyte ratio as surrogate for JAK2V617F suppression and event-free survival in polycythemia vera by Tiziano Barbui, Arianna Ghirardi, Victoria Empson, Francesca Fenili, Giuseppe Gaetano Loscocco, Annalisa Condorelli, Alessandra Iurlo, Daniele Cattaneo, Elena Rossi, Valerio De Stefano, Paola Guglielmelli, Christoph Klade, Heinz Gisslinger, Alessandro Rambaldi, Joseph M. Scandura, Alessandro Maria Vannucchi

“…Abstract Chronic systemic inflammation is a key driver of polycythemia vera (PV) progression, but the immunomodulatory effects of current treatments remain poorly defined. The neutrophil-to-lymphocyte ratio (NLR) is an accessible biomarker of systemic inflammation proven in other contexts, but its role in monitoring PV disease activity has not been established. …”
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Hypoxia-inducible factor-1α promotes tubulointerstitial fibrosis via the upregulation of Muc4 by Zhong-Tang Li, Xin-Hui Hu, Wei-Jie Ni, Zuo-Lin Li, Bi-Kun Huang, Yu Zhang, A-Feng Miao, Jing-Yuan Cao

“…Furthermore, MUC4 overexpression in the context of HIF-1α knockout was positively correlated with increased ECM protein expression and TIF. …”
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Job insecurity, work passion, and work–life balance in diverse work arrangements by Chantell Ribas, Gerhard H. Rabie, Karina Mostert, Leon De Beer

“…Orientation: The coronavirus disease 2019 (COVID-19) pandemic shifted work settings, revealing gaps in current literature on how work arrangements affect employee experiences and well-being. …”
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Impaired plasma membrane calcium ATPase activity and mitochondrial dysfunction contribute to calcium dysregulation in Fabry disease-related painful neuropathy by Francesco Formaggio, Asia Pizzi, Cecilia Delprete, Davide Pasqualini, Isabella Mataloni, Roberto Rimondini, Ludovica Campolongo, Vincenzo Donadio, Anna Maria Ghelli, Rocco Liguori, Marco Caprini

“…The obtained results suggest that other transport proteins participate in Ca2+ homeostasis in FD and their dysfunction may be directly involved in nociception. In this context, plasma-membrane Ca2+ ATPases exhibited reduced activity in FD, leading to an increased resting [Ca2+]i in sensory neurons. …”
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Ethnozootechnical Perspectives on the Decline of Traditional Knowledge About Local Goat and Sheep Breeds in the Semi-Arid Region of Paraíba, Brazil by Raissa C. Silva, Marilene N. Melo, Carlos F. T. de Oliveira, José V. Cardoso, Luis A. C. Cevallos, Laura L. da Rocha, Janaina K. G. Arandas, Maria N. Ribeiro

“…The conservation of local breeds plays a strategic role in maintaining genetic variability, ensuring adaptive responses to environmental challenges, and preserving the cultural and socioeconomic structures of traditional communities. In this context, this study explores the potential disappearance of traditional knowledge about local breeds from an ethnozootechnical perspective. …”
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Iran's Media Diplomacy Challenges in Tourism Marketing by Fateme Asgharian Kari, Sajad Ferdowsi

“…Abstract The current research was conducted with the aim of identifying the challenges of Iran's media diplomacy in tourism marketing. …”
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Assessing Immunization Coverage and the Negative Impact of Local Vaccine Production Cessation in Ecuador by Esteban Ortiz-Prado, Lissette Carolina Villacreses-Brito, Jorge Vasconez-Gonzalez, Cristina Anabel Jacome, Marlon Arias-Intriago, Juan S. Izquierdo-Condoy

“…Mann–Whitney U tests were conducted to compare vaccination coverage during the periods of local production (2004–2013) and post-production cessation (2014–2023). Historical context and policy implications were also evaluated to provide a comprehensive perspective. …”
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Effect of social perspectives in the relationship between suicidal ideation and depression among young women in slums of Kampala, Uganda by Charles Natuhamya, Enid Nabukalu, Matthew Lyons, Kevin B. Gittner, Jane Palmier, Rachel Culbreth, Monica H. Swahn

“…TOPOWA is a multi-component, prospective cohort study examining the mechanistic pathways of mental illness in the context of social determinants of mental health and lived experience among young women aged 18 to 24 years living in the urban slums of Kampala. …”
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Jian-Pi-Gu-Shen-Hua-Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis by Shuquan Lv, Lirong Fan, Xiaoting Chen, Xiuhai Su, Li Dong, Qinghai Wang, Yuansong Wang, Hui Zhang, Huantian Cui, Shufang Zhang, Lixin Wang

“…Diabetic nephropathy (DN), one of the most frequent complications of diabetes mellitus, is a leading cause of end-stage renal disease. However, the current treatment methods still cannot effectively halt the progression of DN. …”
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Study of Different Recycling Approaches for Gypsum-Based Composites with Recycled Rubber Aggregates by Daniel Ferrández, Alicia Zaragoza-Benzal, Evangelina Atanes-Sánchez, Beatriz Merillas, Ricardo Mateus, Paulo Santos

“…Therefore, this research outlines the potential of gypsum recycling with recycled rubber aggregates, thus promoting the circularity of construction products and decreasing the building’s environmental footprint. This represents a novelty compared to current studies, which are more oriented towards recycling and recovery of waste from conventional plasterboards.…”
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