Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Results Our findings showed that CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs-PTX significantly suppressed NOTCH1 and SF3B1 expression in PBMCs and BMMCs isolated from CLL cases in comparison with the untreated samples, leading to increased leukemic cell sensitivity to PTX and decreased the proliferative capacity of leukemic cells. …”
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Latest trends on interplay of autophagy, adipose tissue, and gut microbiota in obesity-related metabolic disorders by Claudette Butoyi, Muhammad Asad Iqbal, Isaac Duah Boateng

“…Conversely, pharmacologically induced Atg, exemplified by rapamycin administration, enhances insulin sensitivity by 15–25 % in rodent models. (2) Alterations in gut microbial composition, characterized by a 40 % decrease in Bacteroidetes and an increase in Firmicutes, correlate with elevated visceral adiposity and systemic inflammation. …”
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Longitudinal analysis of local government spending on adult social care and carers’ subjective well-being in England by Yanan Zhang, Matthew R Bennett, Sue Yeandle

“…Objectives Reform of England’s social care system is repeatedly discussed in the context of increasing demand, rising costs and austere policies that have decreased service provision. …”
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HORMONE IMBALANCE AS A MANIFESTATION OF STRESS IN THE FORMATION OF OLIGOMENORRHEA IN TEENAGE GIRLS by В. Диннік, О. Диннік, С. Новохатська

“…At OM onset, nearly 20% of participants exhibited low E2 levels. With increased disease duration (years 2–3), the proportion of adolescents with low E2 decreased while those with elevated E2 increased. …”
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Changes in the Species Composition and Structure of Large-Diameter Trees Along a Narrow Latitudinal Gradient in Subtropical China by Mengxian Li, Fei Huang, Xiaorong Jia

“…Additionally, species composition homogeneity decreased (based on PCoA and MRPP analysis), age-class structures became more complex, and the proportion of tropical genera gradually declined, whereas temperate genera increased. …”
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Impact of metabolic-associated fatty liver disease on the cholesterol efflux capacity of high-density lipoproteins in adolescents with type 2 diabetes by José Antonio Orozco Morales, José Antonio Orozco Morales, Aída Xochitl Medina Urrutia, Margarita Torres Tamayo, Margarita Torres Tamayo, Juan Reyes Barrera, Esteban Jorge Galarza, Juan Gabriel Juárez Rojas, Pilar Dies Suarez, Nahum Méndez Sánchez, Nahum Méndez Sánchez, Luis Enrique Díaz Orozco, Luis Enrique Díaz Orozco, Lubia Velázquez-López, Patricia Medina Bravo, Patricia Medina Bravo

“…In the population with DM2 and MAFLD, we did not observe a decrease in CEC. Initially we found a slight elevation of CEC in adolescents with DM2, however, with the increase in liver fat, a little decrease is observed, which could explain a probable metabolic phenomenon, since the physicochemical composition and distribution of the particles is associated with the percentage of liver fat. …”
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Evaluation of Total Electron Content Prediction Using Three Ionosphere‐Thermosphere Models by O. Verkhoglyadova, X. Meng, A. J. Mannucci, J.‐S. Shim, R. McGranaghan

“…We evaluate the prediction of TEC decreases and increases. Our results indicate that physics‐based modeling during storms shows promise in TEC prediction with multiday lead time.…”
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A Sociological study of the Relationship between Smartphone Addiction and Phubbing Case Study18-29 Year Old Females of Ramhormoz City by Ali Boudaghi, Ali Hossein Hosseinzadeh, Sayedeh Sara Mousavi Moghadam

“…In recent years, along with the digital transition and the increase of smart phone users, phubbing, as an emerging phenomenon, has drawn the attention of scholars and experts. …”
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‘It was a joint plan we worked out together’. How the I-WOTCH programme enabled people with chronic non-malignant pain to taper their opioids: a process evaluation by Martin Underwood, Kate Seers, Charles Abraham, Harbinder Kaur Sandhu, Vivien P Nichols, Sam Eldabe, Alleyne Sharisse, Balasubramanian Shyam, Betteley Lauren, Booth Katie, Carnes Dawn, D Furlan Andrea, Haywood Kirstie, Iglesias Urrutia C Paola, Lall Ranjit, Manca Andrea, Mistry Dipesh, Noyes Jennifer, Rahman Anisur, Shaw Jane, KY Tang Nicole, Taylor Stephanie, Tysall Colin, Underwood Martin, J Withers Emma

“…Background The Improving the Wellbeing of people with Opioid Treated CHronic pain (I-WOTCH) randomised controlled trial found that a group-based educational intervention to support people using strong opioids for chronic non-malignant pain helped a significant proportion of people to stop or decrease opioid use with no increase in pain-related disability. …”
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Introducing the non-invasive prenatal test for trisomy 21 in Belgium: a cost-consequences analysis by Mattias Neyt, Frank Hulstaert, Wilfried Gyselaers

“…The objective is to estimate the consequences of introducing NIPT for the detection of T21.Methods A cost-consequences analysis was performed presenting the impact on benefits, harms and costs. Context-specific real-world information was available to set up a model reflecting the current screening situation in Belgium. …”
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Financial security of Ukraine in debt burden: Assessment and forecasting by Fedir Zhuravka, Yuriy Petrushenko, Svitlana Chorna, Bohdana Huriy, Inessa Yarova, Olga Pankiv, Wojciech Duranowski

“…Regression modeling demonstrated a clear negative correlation between the amount of external debt and the level of financial security, with each increase in the debt burden being accompanied by a decrease in the integral index. …”
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Impact of frailty in older people on health care demand: simulation modelling of population dynamics to inform service planning by Bronagh Walsh, Carole Fogg, Tracey England, Sally Brailsford, Paul Roderick, Scott Harris, Simon Fraser, Andrew Clegg, Simon de Lusignan, Shihua Zhu, Francesca Lambert, Abigail Barkham, Harnish Patel, Vivienne Windle

“…Prescriptions increased with increasing age in both Fit and Mild frailty categories but decreased in moderate and severe categories. …”
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Unveiling biomarkers via plasma metabolome profiling for diabetic macrovascular and microvascular complications by Zhixi Li, Yuhan Ren, Feng Jiang, Kai Zhang, Xuan Meng, Yingfeng Zheng, Mingguang He

“…As for reverse MR, DN was relevant to decreased level of serum ratio of docosahexaenoic acid to total fatty acids (OR = 0.97, 95% CI 0.95–0.99, P = 0.019), increased level of the ratio of triglycerides to total lipids in very large VLDL (OR = 1.03, 95% CI 1.01–1.05, P = 0.019), and pyruvate (OR = 1.03, 95% CI 1.01–1.05, P = 0.046). …”
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Insomnia, Cognitive Impairment, or a Combination of Both, Alter Lipid Metabolism Due to Changes in Acylcarnitine Concentration in Older Persons by Selma Karime Castillo-Vazquez, Berenice Palacios-González, Marcela Vela-Amieva, Isabel Ibarra-González, Ricardo Morales, Paola García-delaTorre, Sergio Sánchez-García, Carmen García-Peña, Ricardo Reyes-Chilpa, Raúl Hernán Medina-Campos, Jessica Hernández-Pineda, Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura

“…Results: Our results show that insomnia increases the concentration of acylcarnitines (C10, C8, C14, C12:1, C18:1 and C18) as compared to CI group, while older persons with CI show a decrease the concentration of the acylcarnitines C16, C10 and C8. …”
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Complementary Strategy of Maternal Immunization with RSVpreF Vaccine and Monoclonal Antibodies for the Prevention of Respiratory Syncytial Virus Among Italian Infants: A Cost-Effec... by Barbara Polistena, Fabio Midulla, Giovanni Sotgiu, Daniela d’Angela, Roberto Di Virgilio, Federico Spandonaro

“…The strategy results cost-saving: the complementary strategy saves € 6.0 mil and € 8.4 mil per year in the NHS and in the Societal perspective, respectively; the complementary strategies of maternal vaccination plus nirsevimab also prove to have significant benefits versus the monoclonal antibody alone, providing a decrease equal to 941 annual hospitalizations (−9.0%), 6 years of life recovered, and an increase of 20 QALYs. …”
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Protocol for a randomized controlled trial of patient–portal–based screening for substance use among people with HIV by Eric Roessler, Daniela Zimmer, Jon Grant, Harold Pollack, Basmattee Boodram, Jessica Schmitt, Jessica Schmitt, Eleanor Friedman, Jade Pagkas-Bather, Jade Pagkas-Bather, Russell A. Brewer, Jessica Ridgway, Neda Laiteerapong, Neda Laiteerapong

“…To provide additional context, we briefly describe the overall ePORTAL HIV-S project.MethodsThis project will utilize a culturally tailored approach to increase patient portal use among PLWH in our health system via a community health worker (CHW)-led initiative. …”
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高敏感特質中高齡學習者面對數位學習壓力及疫情焦慮之學習滿意度與後疫情調適：復原力之中介效果 Learning Satisfaction and Post-Pandemic Adaptation in Highly Sensitive Middle-aged and Elderly Learners in the Face of Digital Learni... by 王雅鈴 Ya-Ling Wang, 張伶瑜 Lin-Yu Chang, 羅淇文 Chi-Wen Luo, 林郁文 Yu-Wen Lin

“…In 2020, due to the COVID-19 pandemic, the number of people suffering from depression increased by 25.6% globally (Santomauro et al., 2021). …”
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Multidisciplinary approach to the diagnosis of disorders of coagulation system in childrenwith various pathologies by O. B. Gordeeva, M. S. Karaseva, D. E. Lavretsky, M. A. Babaikina, N. D. Vashakmadze, M. A. Soloshenko, G. V. Revunenkov, E. A. Abashidze, M. V. Egorova

“…The problem of correct in time diagnostics has the socially significant nature. Currently, international consensus and national protocols for the treatment and prevention of venous thromboembolism are regularly reviewing. …”
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Transformation of trading patterns in global agricultural markets by V. V. Stroev, E. N. Smirnov

“…The analysis of international trade is conducted in the context of the need to ensure food security and counteract various exogenous shocks (decreasing crop yields, escalating geopolitical conflicts, food crises). …”
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Re-use of Building Products in the Netherlands by Loriane Icibaci

“…These characteristics indicated to influence (increase) housing survivability. Especially in the West, where most activities in the national housing stock are concentrated, the increase of private single-family houses influences overall housing survivability in the Netherlands (particularly when the pre-1946 group gradually decreases). …”
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