A Novel Mutation of VPS33B Gene Associated with Incomplete Arthrogryposis-Renal Dysfunction-Cholestasis Phenotype by Eleni Agakidou, Charalampos Agakidis, Marios Kambouris, Nicoleta Printza, Maria Farini, Elina Vourda, Spyridon Gerou, Kosmas Sarafidis

“…This is the first published VPS33B mutation in an ARC patient of Greek origin. The current case adds to the spectrum of ARC-associated VPS33B mutations and provides evidence supporting the existence of incomplete ARC phenotype. …”
Get full text

EQ-5D Based Utility Values for Adults with Chronic Obstructive Pulmonary Disease: A Systematic Review, Meta-Analysis, and Meta-Regression by Natasha Salant, Syed Mohiuddin, Yuanyuan Zhang, Lynda Ayiku, Kusal Lokuge, Paul Jacklin, Lesley Owen

“…Moayeri et al. published a systematic review and meta-analysis of utilities (EQ-5D) in COPD in June 2016. The current study investigated changes in mean utilities in more recent studies thereafter, exploring heterogeneity in utilities across diverse clinical and study characteristics. …”
Get full text

Factors Affecting Medical Device-Related Pressure Injuries in Intensive Care Units by Fatma Ali, Sahar Mohammad, Dalia Ameen

“… Context: Medical device-related pressure injuries (MDRPI) are a common complication that can occur in critically ill patients and require medical devices in the intensive care unit. …”
Get full text

Traumatic Brain Injury and Genetic Risk for Alzheimer’s Disease Impact Cerebrospinal Fluid β-Amyloid Levels in Vietnam War Veterans by Jena N. Moody, Erica Howard, Kate E. Nolan, Sarah Prieto, Mark W. Logue, Jasmeet P. Hayes

“…This relationship may be stronger with increasing TBI severity (p = 0.05). Overall, TBI was associated with lower Aβ42/40, indicating greater amyloid deposition in the brain, in the context of greater polygenic risk for AD. …”
Get full text

Unravelling the myriad physiologic roles of transthyretin: critical considerations for treating transthyretin amyloidosis by Morie A. Gertz, Mandar A. Aras, Nicole Bart, Thomas H. Brannagan, Jan M. Griffin, Amy R. Kontorovich, Andrew M. Rosen

“…While a link between low TTR and severe disease and mortality is well established, it remains unclear whether long-term TTR suppression via ATTR therapies increases risk of disease. Clinical decisions in ATTR, however, should reflect the current understanding of the roles of TTR and the patient’s clinical history.Conclusion TTR serves vital physiologic roles across organ systems. …”
Get full text

Potential protective association of the AA genotype and a allele of CXCR4 rs2228014 polymorphism with COVID-19 severity in adult egyptians by Osama H. Korayem, Amr E. Ahmed, Mohamed H. Meabed, Doaa M. Magdy, Wafaa M. Abdelghany

“…Several genetic factors have been implicated in diverse responses to SARS-CoV-2 infection, such as the C-X-C chemokine receptor 4 (CXCR4) rs2228014 polymorphism, which has been previously studied in various diseases but has not been explored in the context of COVID-19 severity. The current study aimed to assess the association between the rs2228014 polymorphism in the CXCR4 gene and the severity of COVID-19, which has not been previously reported. …”
Get full text

Private, non-profit, and plantation: Oil palm smallholders in management-assistance programs vary in socio-demographics, attitudes, and management practices. by Valentine J Reiss-Woolever, Wakhid Wakhid, Muhammad Ikhsan, Jean-Pierre Caliman, Muhammad Naim, Elfina N Azmi, Sharyn Shufiyan, John Howes, Reza Azmi, Ying Ying Lim, Siti Zulaikah Abdul Jan, Isaac Barrock, Badrul Azhar, Julia Drewer, Caroline Ward, Joshua A Jones, Sarah H Luke, Edgar C Turner, Purnama Hidayat, Damayanti Buchori

“…Awareness of the effects of palm oil production on ecosystems and human communities has increased drastically in recent years, with ever louder calls for the private and public sector to develop programs to support sustainable cultivation by smallholder farmers. …”
Get full text

Lithologically constrained velocity–density relationships and vertical stress gradients in the North Alpine Foreland Basin, SE Germany by P. Obermeier, F. Duschl, M. C. Drews

“…In SE Germany, the North Alpine Foreland Basin (NAFB) is a well-studied sedimentary basin, which was extensively explored for oil and gas in the last century and which is currently explored and exploited for deep geothermal energy. …”
Get full text

Cervical ripening at home or in hospital during induction of labour: the CHOICE prospective cohort study, process evaluation and economic analysis by Mairead Black, Cassandra Yuill, Mairi Harkness, Sayem Ahmed, Linda Williams, Kathleen A Boyd, Maggie Reid, Amar Bhide, Neelam Heera, Jane Huddleston, Neena Modi, John Norrie, Dharmintra Pasupathy, Julia Sanders, Gordon C S Smith, Rosemary Townsend, Helen Cheyne, Christine McCourt, Sarah Stock

“…However, there was substantial uncertainty with the adjusted analysis consistent with a 74% decrease in the risk through to an 81% increase. qCHOICE Important aspects of service users’ experience of home cervical ripening were quality of information provided, support and perception of genuine choice. …”
Get full text

Ethical implications related to processing of personal data and artificial intelligence in humanitarian crises: a scoping review by Tino Kreutzer, James Orbinski, Lora Appel, Aijun An, Jerome Marston, Ella Boone, Patrick Vinck

“…Ethical risks, particularly from artificial intelligence (AI) data processing, are increasingly recognized yet inadequately addressed by current humanitarian data protection guidelines. …”
Get full text

Precision livestock farming in buffalo species: a sustainable approach for the future by Roberta Matera, Federica Pierro, Matteo Santinello, Antonio Iraci Fuintino, Giovanmaria Pacelli, Tomas Norton, Gianluca Neglia

“…The increasing global demand for animal-derived foods in a climate-changing context requires innovative strategies to enhance farm efficiency and sustainability. …”
Get full text

戶外教育課程評估指標建構之研究 Indicators for Evaluating Outdoor Education Curricula by 鄭智明 Chi Meng Cheang, 陳美燕 Mei-Yen Chen, 郭雄軍 Husing-Chun Kuo

“…The outdoor education model explored in the current study was developed on the basis of experiential learning. …”
Get full text

Investigating The Performance Of Local And Indigenous Businesses In Times Of Economic Recession With Emphasis On Developing The Capabilities Of Cooperatives In Sistan And Baluchest... by Ali Asghar Tabavar, Abdoulnaser Derakhshan, Sahar Arefi

“…In this regard, a cooperative in the country can be a solution to overcome the existing unfavorable economic and social conditions, including the weakness in creating employment for young people and social capital, economic stagnation, and environmental problems in the country. The purpose of the current research is to investigate the performance of local and local businesses in the economic recession with an emphasis on the development of the capabilities of cooperatives. …”
Get full text

The Palliative Care in Patients with Oncological Diseases - a New Medical and Therapeutic Approach by Catalina FLORESCU, Octavian VASILIU, Dan PRELIPCEANU

“…The life expectancy increase in patients with cancer requires more attention to the quality of life and mental health status of this population. …”
Get full text

Japan’s Economy: Reforms and Growth Strategies by Yana Valeryevna Dyomina, Marina Gamilovna Mazitova

“…The return on capital and labor has decreased. There was a shortage in the labor market within the country due to the aging population, decreasing birth rate, traditions of the Japanese family (women leaving the labor market after marriage), strict migration policy, etc. …”
Get full text

Integrating Palliative Care and Heart Failure: the PalliatHeartSynthesis realist synthesis by Tracey McConnell, Carolyn Blair, Geoff Wong, Claire Duddy, Clare Howie, Loreena Hill, Joanne Reid

“…Our realist analysis developed and refined 6 overarching context–mechanism–outcome configurations and 30 sub context–mechanism–outcome configurations. …”
Get full text

Playing towards Motivation: Gamification and University Students in Physical Activity! by Victor Javier Sotos-Martinez, Salvador Baena-Morales, Manuel Sanchez-De Miguel, Alberto Ferriz-Valero

“…There is currently concern about the decrease in physical activity participation among university students. …”
Get full text

Problems in preparation of legally binding documents for oncological and palliative patients and their solutions by P. G. Gabay, B. Sh. Kamolov

“…To consider problems arising when an oncological or palliative patient decides to dispose of their property and to suggest solutions to these problems.Materials and methods. An analysis of the current normative legal acts and legal precedents in the Russian Federation in the context of property disposal by severely ill patients was performed. …”
Get full text

Internalized Stigma of Mental Illness and Its Relation with Self- Esteem and Social Support among Psychiatric Patients by Amany A. Mohamed

“… Context: Mentally ill patients challenging dual difficulties that are illness and stigma. …”
Get full text

Exploring efficacy of spiritual-based interventions (SBIs) in addressing depressive symptoms among cardiac patients in MENA region: a scoping review by Rizwana Amin

“…The results showed that SBIs are related to a decrease in depression symptomology and enhancement of psychological wellbeing. …”
Get full text