OPTIMIZATION OF IMID-BASED THERAPIES by Murat Çınarsoy

“…In this case, it is clear that multiple myeloma treatment optimization cannot be achieved by considering multiple myeloma treatment only as applying the appropriate drug combination.In order to ensure the optimization of IMID-based therapies, it is necessary to take a broad perspective.This perspective should include the correct selection of the patient to be treated with IMID, the development and implementation of IMID forms that will increase patient compliance, the use of techniques to predict the development of resistance, side effect management during treatment, preventing the increase in disease burden with appropriate maneuvers by following the disease burden after treatment, and drug-free follow-up.It is recommended to avoid thalidomide in the presence of peripheral neuropathy, to prefer other agents instead of lenalidomide in the presence of renal function loss, and to avoid pomalidomide in patients with COPD.Nex-20, a once-monthly subcutaneous formulation of lenalidomide, is expected to be an important breakthrough in improving patient compliance.Prediction of which patients will develop resistance will be very useful in order to have the best treatment outcomes.Calculation of miRNA risk scores, measurement of lenalidomide metabolite levels in urine, measurement of cereblon levels in blood, or immunohistochemical detection of cereblon levels are some of the methods currently being tried to predict disease resistance.Patients who develop anemia should be treated with erythropoietin, skin reactions should be treated with steroids and antihistamines, diarrhea should be treated with loperamide and colestyramine, and in general, the drug should be discontinued and the same dose or a lower dose should be insisted upon.An important part of treatment is maintenance therapy with lenalidomide. …”
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Justification of military neutrality of the Republic of Serbia at a time of erosion of neutrality in Europe by Kajtez Ilija, Starčević Srđan

“…Increase of NATO members, as well as abandoning neutrality under the influence of globalization and negative experiences of neutral countries in the 20th century, strengthens this assertion. …”
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Innovative Thermosensitive Composite Materials: Merging Poloxamer PF‐127 and Polysaccharides for Enhanced Functional Properties by Marcos Blanco‐López, Inmaculada deDios‐Pérez, Álvaro González‐Garcinuño, Antonio Tabernero, Eva Martín del Valle

“…Abstract Currently, new cancer treatment options are being developed following tumor resection surgery, with a focus on minimizing invasiveness and reducing systemic toxicity to lower the risk of recurrence. …”
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Assessing coupled human-flood interactions using LiDAR geostatistics and neighbourhood analyses by Morgan J. Breen, Abiy S. Kebede, Carola S. König

“…The paper integrates well-established methods from other spheres of flood risk assessment in a novel way to explore the currently poorly understood Safe Development Paradox (SDP) phenomenon in coastal settings. …”
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A Methodological Proposal for Determining Environmental Risk Within Territorial Transformation Processes by Marco Locurcio, Felicia Di Liddo, Pierluigi Morano, Francesco Tajani, Laura Tatulli

“…The built assets and the real estate sector play a key role in this context; indeed, being among the first ones to be exposed to the effects of climate change, they serve as a crucial tool for the implementation of governance strategies that are more focused on environmental issues. …”
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A novel RNN architecture to improve the precision of ship trajectory predictions by Martha Dais Ferreira, Jessica N. A. Campbell

“…Currently, the Ornstein-Uhlenbeck (OU) model is considered the state-of-the-art for STP. …”
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Efficiency and heat transport processes of low-temperature aquifer thermal energy storage systems: new insights from global sensitivity analyses by Luka Tas, Niels Hartog, Martin Bloemendal, David Simpson, Tanguy Robert, Robin Thibaut, Le Zhang, Thomas Hermans

“…Thick productive aquifer layers have been targeted first, as these are the most promising hydrogeological context for ATES. Regardless, there is currently an increasing trend to target more complex aquifers such as low-transmissivity and alluvial aquifers or fractured rock formations. …”
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The Impact of Social Responsibility Activities on Gaining Values by Sümeyye Koç

“…Social responsibility activities implemented within the scope of the project that has been carried out can be summed up as teacher candidates engaging in educational activities for the underprivileged, marking down the positive experiences that experienced teachers have had throughout their careers, meeting with secondary and high school students during social activities and informing them about the universities and departments they are currently enrolled in. The social responsibility activities in this project aim to increase teacher candidates' sense of responsibility. …”
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Analysis of Factors Influencing Millennial Consumers' Decision in Buying Halal Cosmetics by Novalini Jailani, Susminingsih, Hendri Hermawan Adinugraha, Fatimah Kari, Adib Muhammad

“… The market potential of the halal cosmetics is currently very promising and the use of cosmetics among millennials is increasing. …”
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Replacing penalties by V. Stepashin

“…It is important in the context of the topic and the possibility of a sentence of imprisonment as a substitute punishment in cases where the original purpose of the strict measures excluded. …”
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PROBLEMS AND PROSPECTS OF THE EUROPEAN REGIONAL ORDER by L. A. Dymova

“…Building a stable architecture of the European security system is one of the essential conditions of the European regional order, however contradicting approaches of the parties acknowledge that political and ideological barriers between the East and the West continue to exist. In the context of increasing security threats transatlantic partnership does not lose the relevance though the tough course of the US and its desire to reinforce its leadership in Europe often meets the extreme disapproval on the part of the Europeans. …”
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A reasoning based explainable multimodal fake news detection for low resource language using large language models and transformers by Hariharan RamakrishnaIyer LekshmiAmmal, Anand Kumar Madasamy

“…This trend has resulted in an increase in the number of available social media platforms, online news feeds, and news aggregator applications. …”
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<i>Xanthium strumarium</i> L.: chemical components and biological activity (review) by N. S. Popkov, V. D. Zamyslova, M. N. Povydysh

“…The problem of using Common Cocklebur in the context of modern evidence-based medicine is becoming increasingly important.Text. …”
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Space 4.0 – a common, democratic European space, part 2 by Ryszard S. Romaniuk, Piotr Orleański

“…The transformation is related to the need to maintain the changes in a reasonable legal system so as not to experience the „Wild West” again, this time in space. It is currently difficult to establish strict rules regarding the still distant colonization of Mars, but undoubtedly establishing rules for the use of the LEO area, i.e. the already crowded low Earth orbits, is becoming an increasingly urgent necessity. …”
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Online foreign language teaching: challenges and solutions by Inessa K. Batenina, Yuliya M. Orekhova

“…Currently the digitalization of language education is one of the global trends, which is reflected in the requirements of the modernized Federal State Educational Standards of vocational and higher education. …”
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Ukrainian encyclopedistics in wartime (based on the Encyclopedia of Modern Ukraine) (Scientific review paper) by Mykola Zhelezniak, Oleksandr Ishchenko

“…At the same time, they draw attention to the fact that paper encyclopedia publishing needs more funding than it currently has (in recent years, the shortage of funding has been compensated by reducing the quality of printing and the circulation of edition volumes). …”
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The impact of social capital and government support on farmers’ willingness to pay for road governance: a case study of rural road governance in China by Xiaoli Zhou, Mingyang Han, Yunxuan Wang

“…The global environmental governance landscape is currently confronted with complex and pressing challenges, while rural road environments play a crucial role in providing essential services to rural ecosystems, making them a key factor in the success or failure of governance. …”
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Faith-Based Domestic Violence Training: Building Community Responses with an Islamic Perspective in Palestine by Denise Ziya Berte, Fayez Mahamid

“…Using faith-based initiatives that correspond to the native culture of a community&nbsp;can increase motivation, ownership, and the opportunity for unique programming and&nbsp;innovative methodologies.…”
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Design of GIS-Based Attendance Application at SMA Santika East Jakarta by Mohammad Ikhsan Saputro, Santhi Pertiwi, Agung Suryatno, Dedi Setiadi, Abu Sopian, Agven Muharis Rifqi

“…One important aspect in human resource management (HR) in a school is employee attendance. Currently, for employee attendance at SMA Santika East Jakarta, the fingerprint attendance system is still used, which has shortcomings, such as the possibility of misuse of number codes that can lead to falsification of attendance. …”
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Exploring the role of identity, the other and negative attributions in conflict about biodiversity valuation by Thomas Fickel, Adrian Rothers, Juliette C. Young

“…Although they might negatively affect deliberative processes, they are currently barely recognised in value integration research. …”
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