Transcriptomic analysis on pancreatic adenocarcinoma patients uncovers KRAS-mediated PPAR pathway alteration by Giuseppe Defazio, Federico Scolari, Sara Fancelli, Simone Polvani, Daniele Lavacchi, Lucia Picariello, Alessandro Tubita, Michaela Luconi, Lorenzo Antonuzzo, Lorenzo Antonuzzo, Andrea Galli, Serena Pillozzi

“…The incidence and mortality of pancreatic adenocarcinoma (PC) are expected to increase in the coming years, with survival rates remaining poor due to limited treatment options. …”
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Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances by Qiu Jiang, Jie Liu, Shan Huang, Xuan-Yue Wang, Xiaowei Chen, Guang-Hui Liu, Keqiang Ye, Weihong Song, Colin L. Masters, Jun Wang, Yan-Jiang Wang

“…Abstract In the context of global ageing, the prevalence of neurodegenerative diseases and dementia, such as Alzheimer’s disease (AD), is increasing. …”
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TRANSFORMING MUSIC EDUCATION IN UKRAINE: OPPORTUNITIES AND CHALLENGES IN CULTURAL AND ARTISTIC EDUCATION REFORM by Ihor ZAKUS, Nataliia LEBEDIEVA, Irma GVINIASHVILI, Viktoriya KORZHENOK, Dennis ADU

“… The article discusses the current challenges and prospects for developing music education in Ukraine while reforming the cultural and artistic sphere. …”
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Assessing Climate Change Impacts on Distribution Dynamics of Lysimachia Christinae in China Through MaxEnt Modeling by Yangzhou Xiang, Yuan Li, Ying Liu, Yingying Yuan, Suhang Li, Qiong Yang, Jinxin Zhang

“…However, in the context of the SSP5‐8.5 pathway, the retention rate significantly decreased to 64.77% by the 2090s, indicating greater habitat instability and expansion needs. …”
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Unraveling the complex role of microglia in Alzheimer’s disease: amyloid β metabolism and plaque formation by Sho Takatori, Mayuna Kondo, Taisuke Tomita

“…Conversely, we explore findings that challenge this view, such as microglial depletion experiments resulting in unchanged or decreased Aβ accumulation. We propose that the contribution of microglia to Aβ metabolism is context-dependent, varying with disease progression, genetic background, and experimental conditions. …”
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CIS Countries Foreign Economic Activity — from Challenges to New Opportunities by M. S. Goncharov

“…Aim and tasks. To identify current trends and issues in foreign trade, the international financial system, and the investment activity of CIS member states, and to provide recommendations that contribute to sustainable economic development and strengthened mutual cooperation.Methods. …”
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Unlocking the hidden forces: deformation and associated stress distribution in the present-day Geneva Basin and Jura fold-and-thrust belt by Sandra Borderie, Jon Mosar, Adeline Marro, Louis Hauvette

“…If current seismicity indicates that the Geneva Basin is tectonically active, few data regarding the state of stress in the area are currently available. …”
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Social Skills Training Program and its Effect on Quality of Life and Stigma among Patients with Schizophrenia by Samah Ali, Amal Awad, Hanaa Ewise, Shimaa Adam

“… Context: Schizophrenia is a severe mental disorder that significantly disrupts an individual's social interactions, work performance, and overall quality of life. …”
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Therapeutic potential of microRNAs in neurological disorders: mechanisms, biomarkers, and emerging therapeutic strategies by Sourav Pal, Subhajit Mandal

“…This review critically evaluates current therapeutic strategies for miRNA delivery in neurological disorders, focusing on advanced platforms such as nanocarriers, exosomes, viral vectors, and ligand-mediated systems designed to overcome the blood-brain barrier. …”
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From bench to bedside: nanomedicine development for intracerebral hemorrhage – exploring microenvironment, innovation, and translation by Gui Wan, Lingui Gu, Yangyang Chen, Yiqing Wang, Ye Sun, Zhenwei Li, Wenbin Ma, Xinjie Bao, Renzhi Wang

“…Finally, the progress of nanomedicines in clinical translation is analyzed, highlighting the challenges, opportunities, and future prospects for their application in the context of ICH. Graphical abstract…”
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Rebooting Master’s Programs in an Updated Higher Education System: Management Track by E. A. Kuklina

“…It is recommended that master’s programs be updated in accordance with the developed principles of reengineering: taking into account transformational mega-trends when developing program content; strengthening the management component in the curriculum structure; increasing the level of originality of content through the development of “professorial” courses and reflecting this in the KPI system; the possibility of reformatting the curriculum into a block-modular format; participation of employers in the implementation of the master’s training curriculum in order to solve pressing problems of the real sector of the economy; formation of scientific groups of students to carry out research on current research topics with the possibility of using the results obtained in preparing reports on design and analytical work and writing a final qualifying thesis. …”
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Tax regulation of enterprise R&D expenditures: special aspects and problems of regulation by T. A. Loginova

“…As a second step authors are performing the analysis of current rules related to tax accounting of R&D costs and intangibles in accordance with Tax Code of Russian Federation. …”
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Dynamic Analysis of the Interconnection of a Set of FPSO Units to an Onshore System via HVDC by Johnny Orozco Nivelo, Carlos A. Villegas Guerrero, Lúcio José da Motta, Marcos R. de Paula Júnior, José M.d. Carvalho Filho, Alex Reis, José Carlos Oliveira, José Mauro T. Marinho, Vinicius Z. Silva, Carlos A. C. Cavaliere

“…In an effort to restrict further increases in climate change, governments and companies are exploring ways to reduce greenhouse gas (GHG) emissions. …”
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Interactions Between Nanoparticles and Tomato Plants: Influencing Host Physiology and the Tomato Leafminer’s Molecular Response by Inzamam Ul Haq, Xiangyun Cai, Habib Ali, Muhammad Rehan Akhtar, Muhammad Adeel Ghafar, Moazam Hyder, Youming Hou

“…The current study illustrates the broader implications of nanoparticle use in agriculture, which is a sustainable pathway to increase crop resilience and productivity while reducing the impact of pests. …”
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Reducing long‐term use of benzodiazepine receptor agonists: In‐depth interview study with primary care stakeholders by Kristien Coteur, Sanne Peters, Pieter Jansen, Birgitte Schoenmakers, Marc Van Nuland

“…Although primary care professionals in this study found discontinuation of long‐term BZRA use relevant to the patient's health, many organisational and personal barriers were reported. Moreover, the current social and healthcare context is not empowering patients and professionals to reduce long‐term BZRA use for insomnia. …”
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Extraterritorial Human Rights Obligations in the Area of Climate Change: Why the European Union Should Take Them Seriously by Chiara Tea Antoniazzi

“…After exploring the wide array of EU climate measures and their extensive impacts on third countries and persons living therein, the Article offers an overview of the historical evolution and current state of ex-traterritorial human rights obligations in general and in the context of climate change specifically, pay-ing special attention to recent judicial and quasi-judicial developments. …”
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Subject composition of the state financial control system in ensuring budget security by O.S. Dyka, M.V. Bilyachenko, Y.Yu. Levytskyi

“…Subject composition of the state financial control system in ensuring budget security Ensuring budget security is of particular importance in the context of military challenges and in the process of post-war economic transformation of Ukraine. …”
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Job insecurity, work passion, and work–life balance in diverse work arrangements by Chantell Ribas, Gerhard H. Rabie, Karina Mostert, Leon De Beer

“…Orientation: The coronavirus disease 2019 (COVID-19) pandemic shifted work settings, revealing gaps in current literature on how work arrangements affect employee experiences and well-being. …”
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Overview on the development and application of the key concepts for decision-making in health care by Nicolás Flores Uribe, Diego Grandi Pincheira, Roberto Garnham Parra, Eva Madrid Aris, Nicolas Meza Concha

“…In this context, promoting knowledge dissemination through reliable sources and fostering health literacy among the general population is crucial. …”
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A MODEL OF THE ENGLISH-UKRAINIAN SUB-CORPUS OF TEXTS OF NATO, UN AND WTO OFFICIAL AND BUSINESS DOCUMENTS by Yuliya I. Demyanchuk

“…The model of the English-Ukrainian sub-corpus of official and business documents texts of NATO, UN, and WTO provides for a clear division into categories of homogeneous texts and a quick search for special terminology of international organizations, such as NATO, UN, and WTO, in the EUS. In the context of the texts analyzed in the current paper numerous separated words and expressions-identifiers can help to carry out search and refer to a relevant text in the sub-corpus. …”
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