Anti-tumor efficacy and safety of AEV01 in preclinical glioblastoma and hepatocellular carcinoma models by Indrani Biswas, Senthilathiban Daisy Precilla, Aravinda Kumar, M. M. Sekhar, Renu Medasani, T. S. Anitha

“…AEV01, a specialized lipophilic extract derived from the roots of Picrorhiza kurroa, has shown promise as a potential anti-cancer agent. In this context, the current study aimed to evaluate the anti-tumor efficacy and safety profile of AEV01 both in vitro and in vivo in GB and HCC models. …”
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Crosstalk between ferroptosis and innate immune in diabetic kidney disease: mechanisms and therapeutic implications by Jinyang Wang, Haonan Shi, Ye Yang, Xueli Gong

“…This review presents an overview of ferroptosis within the context of DKD, beginning with its core mechanisms and delving into its potential roles in DKD progression. …”
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Protective graphene oxide layers for enhanced stability of copper cathodes in zinc-ion energy storage systems by Nikos Κavousanos, Ricardo Santamaría Ramirez, Athanasia Kostopoulou, Konstantinos Brintakis, Emmanuel Stratakis, Dimitra Vernardou

“…However, this enhancement led in a slight initial drop in capacitance, attributed to the increased resistance of Zn+2 interactions with the cathode.…”
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Blood-based biomarkers in mild behavioral impairment: an updated overview by Efthalia Angelopoulou, Xenia Androni, Chiara Villa, Alexandros Hatzimanolis, Nikolaos Scarmeas, Sokratis Papageorgiou

“…A growing number of studies have recently begun to explore the relationship between MBI and several blood-based biomarkers associated with Alzheimer’s disease (AD) pathology, neurodegeneration, as well as systemic metabolic and inflammatory dysregulation. In this context, MBI has been associated with lower plasma Aβ42/Αβ40 ratio, higher plasma phosphorylated tau at threonine 181 (p-tau181), increased neurofilament light chain (NfL) levels, as well as disturbances in metabolic markers, including homocysteine, insulin and ferritin, suggesting a multifaceted neurobiological basis for this syndrome. …”
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The Role of Extracellular Vesicles in Aging and Age-Related Disorders by Bharathi Hassan Ganesh, Himabindu Padinjarathil, Ramya Lakshmi Rajendran, Prasanna Ramani, Prakash Gangadaran, Byeong-Cheol Ahn

“…Mitochondrial malfunction and increased oxidative stress are major contributors for the aging process. …”
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Assessment of Health-Oriented Layout and Perceived Density in High-Density Public Residential Areas: A Case Study of Shenzhen by Guangxun Cui, Menghan Wang, Yue Fan, Fei Xue, Huanhui Chen

“…The authors attempt to go beyond current regulations to propose tailored solutions for Shenzhen’s high-density context, improving spatial efficiency and residential comfort in future public housing designs. …”
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Objects of forensic documentary science by V. S. Sezonov

“…The scientific novelty lies in the establishment of promising areas for the development of an innovative methodology for conducting forensic document examination in the context of the use of special technical means and the methodology for the use of modern software products. …”
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Crop simulation models as decision tools to enhance agricultural system productivity and sustainability – a critical review by Koushik Banerjee, Suman Dutta, Sumanta Das, Rahul Sadhukhan

“…Feeding the growing global population necessitates increased agricultural production, yet agriculture remains a vulnerable sector facing significant challenges from limited land resources, environment, and climatic constraints. …”
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The frequent variant A57F in the GNE gene in patients from Russia has Finno-Ugric Mari origin by Dmitrii Subbotin, Sofya Ionova, Andrey Marakhonov, Elena Saifullina, Artem Borovikov, Leila Akhmadeeva, Polina Chausova, Oksana Ryzhkova, Rena Zinchenko, Sergey Kutsev, Aysylu Murtazina

“…According to our study, the estimated age of the mutation’s spread is 160.46 years (95% CI: 45.55–244.14).DiscussionBy comparing the information gathered with historical data on migration patterns in the Middle Volga region and estimating the age of the variant’s dissemination, we propose hypotheses regarding its origin and the pathways through which it spread. In the current context of increased rate of interethnic marriages, investigating the spread of common pathogenic variants from historically isolated populations is important for molecular genetic diagnosis. …”
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NFT UNDER CONDITIONS OF CRITICAL TRANSFORMATIONS IN THE DIGITAL ASSET MARKET by Svitlana Volosovych, Mariia Nezhyva, Іgor Napadovskyi

“…The article presents an analysis of the NFT market with a focus on its structural changes. The current state of the non-fungible token market is characterised by a shift from speculation to increased utility of NFTs in various sectors. …”
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The CeHRes Roadmap 2.0: Update of a Holistic Framework for Development, Implementation, and Evaluation of eHealth Technologies by Hanneke Kip, Nienke Beerlage-de Jong, Lisette J E W C van Gemert-Pijnen, Saskia M Kelders

“… To ensure that an eHealth technology fits with its intended users, other stakeholders, and the context within which it will be used, thorough development, implementation, and evaluation processes are necessary. …”
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Publishing Identifiable Patient Photographs in the Digital Age: Focus Group Study of Patients, Doctors, and Medical Students by Marija Roguljić, Dina Šimunović, Ivan Buljan, Marija Franka Žuljević, Antonela Turić, Ana Marušić

“…Additionally, it sought to identify key areas for future research, particularly in the context of online, open-access articles. …”
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Tuberculosis mortality and drug resistance among patients under TB treatment before and during COVID-19 in Burundi: a case–control study by Arnaud Iradukunda, Fentabil Getnet, Emmanuel Nene Odjidja

“…Conclusion TB mortality increased during the COVID-19 pandemic, particularly among MDR-TB patients. …”
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Elevated levels of Letm1 drives mitochondrial dysfunction and cardiomyocyte stress-mediated apoptosis in cultured cardiomyocytes by Anushka Deshpande, Leo Weirauch, Tapan Kumar Baral, Marco Steier, Ankush Borlepawar, Manju Kumari, Lucia S. Kilian, Karsten Richter, Elke Hammer, Derk Frank, Constanze Schmidt, Norbert Frey, Ashraf Y. Rangrez

“…Although genetic alterations in Letm1 are linked to cardiomyopathies, its specific contributions to cardiac pathophysiology, particularly in the context of ischemic heart disease, remain poorly defined. …”
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Adipokines as Cardioprotective Factors: BAT Steps Up to the Plate by Keely McLeod, Victoria Datta, Scott Fuller

“…The molecules secreted specifically by BAT have been termed “batokines”, and currently available evidence supports the notion that batokines exert favorable metabolic effects on multiple organ systems. …”
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Technical, forensic and organisational aspects of work with Monero cryptocurrency by V. V. Nosov, O. V. Manzhai, V. O. Kovtun

“…The forensic, organisational and technical features of law enforcement agencies' work with the Monero cryptocurrency in the context of pre-trial investigation and operational search activities are analysed. …”
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Infinity war: Trichomonas vaginalis and interactions with host immune response by Giulia Bongiorni Galego, Tiana Tasca

“…Endosymbi-osis: Mycoplasma hominis increased cytotoxicity, growth, and survival rate of the parasite. …”
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Smart Campus Tools by Bart Valks

“…The main research question is: How can smart campus tools optimally contribute to the match between demand for and supply of space, both on the current campus and on the future campus? To answer the research question, this PhD dissertation explores the use of Smart campus tools in Dutch and international contexts, at universities and other organisations. …”
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Complementary Strategy of Maternal Immunization with RSVpreF Vaccine and Monoclonal Antibodies for the Prevention of Respiratory Syncytial Virus Among Italian Infants: A Cost-Effec... by Barbara Polistena, Fabio Midulla, Giovanni Sotgiu, Daniela d’Angela, Roberto Di Virgilio, Federico Spandonaro

“…The strategy results cost-saving: the complementary strategy saves € 6.0 mil and € 8.4 mil per year in the NHS and in the Societal perspective, respectively; the complementary strategies of maternal vaccination plus nirsevimab also prove to have significant benefits versus the monoclonal antibody alone, providing a decrease equal to 941 annual hospitalizations (−9.0%), 6 years of life recovered, and an increase of 20 QALYs. …”
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Insomnia, Cognitive Impairment, or a Combination of Both, Alter Lipid Metabolism Due to Changes in Acylcarnitine Concentration in Older Persons by Selma Karime Castillo-Vazquez, Berenice Palacios-González, Marcela Vela-Amieva, Isabel Ibarra-González, Ricardo Morales, Paola García-delaTorre, Sergio Sánchez-García, Carmen García-Peña, Ricardo Reyes-Chilpa, Raúl Hernán Medina-Campos, Jessica Hernández-Pineda, Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura

“…Results: Our results show that insomnia increases the concentration of acylcarnitines (C10, C8, C14, C12:1, C18:1 and C18) as compared to CI group, while older persons with CI show a decrease the concentration of the acylcarnitines C16, C10 and C8. …”
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