OPTIMIZATION OF IMID-BASED THERAPIES by Murat Çınarsoy

“…In this case, it is clear that multiple myeloma treatment optimization cannot be achieved by considering multiple myeloma treatment only as applying the appropriate drug combination.In order to ensure the optimization of IMID-based therapies, it is necessary to take a broad perspective.This perspective should include the correct selection of the patient to be treated with IMID, the development and implementation of IMID forms that will increase patient compliance, the use of techniques to predict the development of resistance, side effect management during treatment, preventing the increase in disease burden with appropriate maneuvers by following the disease burden after treatment, and drug-free follow-up.It is recommended to avoid thalidomide in the presence of peripheral neuropathy, to prefer other agents instead of lenalidomide in the presence of renal function loss, and to avoid pomalidomide in patients with COPD.Nex-20, a once-monthly subcutaneous formulation of lenalidomide, is expected to be an important breakthrough in improving patient compliance.Prediction of which patients will develop resistance will be very useful in order to have the best treatment outcomes.Calculation of miRNA risk scores, measurement of lenalidomide metabolite levels in urine, measurement of cereblon levels in blood, or immunohistochemical detection of cereblon levels are some of the methods currently being tried to predict disease resistance.Patients who develop anemia should be treated with erythropoietin, skin reactions should be treated with steroids and antihistamines, diarrhea should be treated with loperamide and colestyramine, and in general, the drug should be discontinued and the same dose or a lower dose should be insisted upon.An important part of treatment is maintenance therapy with lenalidomide. …”
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Advances and challenges in the production and use of native bacteria as plant probiotics in agronomic applications: A Mexican review by Rincón-Molina Clara Ivette, Manzano-Gómez Luis Alberto, García-Pérez Luis Galdino, Rincón-Molina Francisco Alexander, Rincón-Rosales Reiner

“…This review addresses key research questions: 1) What is the historical context and current status of biofertilizer use in Mexico? …”
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Clinical Leadership and Integration of Triple Bottom Line for Planetary Health by Wasim Alamgir, Hina Shan

“…The healthcare community, clinicians, and hospital management are well-placed to play a vital role as change agents with Health in All Policies approach by protecting health during the current climate crises. An eco-friendly, equitable, interprofessional, and transdisciplinary approach is required to create a resilient healthcare sector that works harmoniously with nature while coping with increasing disease burdens and challenges to healthcare infrastructure. …”
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Leishmaniasis in Greece: Prospects of transitioning to a One Health surveillance system by Emmanouil Alexandros Fotakis, Dimitris Papamichail, Sofia Boutsini, Eleni Patsoula, Takis Panagiotopoulos

“…Conversely, the existing CanL surveillance governance and the lack of systematic entomological surveillance constitute important drawbacks. Moreover, the current context of public health and animal health financial constraints in Greece may impede a strategic OH transition in leishmaniasis surveillance. …”
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Model-based analysis of the impact of an eco-scheme premium on the climate protection potential of short rotation coppice in Baden-Württemberg by Cecilia Roxanne Geier, Elisabeth Angenendt, Enno Bahrs, Jan Weik, Christian Sponagel

“…Our findings suggested that increasing the premium to €400 ​ha−1 ​yr−1 could offset up to 1.5% of the current agricultural GHG emissions of BW. …”
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Correlation of Calibration Parameters for HPGe Detector Efficiency Based on Monte Carlo Simulation by LI Yan1, SHAN Chenyu2, GU Weiguo1, WANG Dezhong1

“…The study primarily focused on addressing the limitations of current calibration methods by proposing more efficient alternatives. …”
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Simulation of Spatial and Temporal Patterns of Suitable Wintering Habitat for Hooded Crane (<i>Grus monacha</i>) Under Climate and Land Use Change Scenarios by Zeng Jiang, Mingqin Shao, Jianying Wang

“…In the context of global warming and intensified human activities, the loss and fragmentation of species habitats have been exacerbated. …”
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Role of Interleukins in Type 1 and Type 2 Diabetes by Roha Asif, Ammara Khalid, Tolga Mercantepe, Aleksandra Klisic, Sana Rafaqat, Saira Rafaqat, Filiz Mercantepe

“…While their diagnostic and therapeutic potential is increasingly recognized, future research must address current limitations through isoform-specific targeting, context-aware interventions, and validation in large-scale, human cohorts. …”
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THE ROLE OF INNOVATIONS IN IMPROVING LABOR PRODUCTIVITY IN AGRICULTURAL ENTERPRISES by Lala Fagail Mahmudova, Kamala Vagif Azizova, Elnara Shamsi Mammadova, Samira Rasim Seyidova

“…Therefore, studying ways to increase labor productivity in agricultural enterprises is particularly important. …”
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A retrospective assessment of COVID-19 vulnerability index indicators and mortality rates pre-COVID-19 (2018–2020) and during COVID-19 (2020–2022) in a health and demographic surve... by Takwanisa Machemedze, Chodziwadziwa Whiteson Kabudula, Jean Juste Harrisson Bashingwa, Beth A. Tippett Barr, Nellie Myburgh, Sana Mahtab, Cleopas Hwinya, Stephen Tollman, Ziyaad Dangor, Shabir A. Madhi

“…Conclusions All-cause mortality during the COVID-19 era was significantly higher than the pre- COVID-19 period, with the increase observed across all vulnerability tertiles. …”
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Fatores que potencializam a participação e comunicação dos estudantes de ensino superior na modalidade a distância / Factors that enhance the participation and communication of hig... by Paula Santos Orofino, Adson Nogueira Alves, Raphael Sigolo Ruas Gonçalves, Vitor da Silva Palacios, Mônica Cristina Garbin

“…Além de proporcionar aos estudantes uma participação mais ativa nesse processo comunicacional no âmbito da educação a distância considerando que o processo de ensino e de aprendizagem ocorrem de forma mediada, colaborativa e por meio de interações sociais no bojo da sociedade do conhecimento. /// The increase in the offer of distance learning higher education courses is a growing reality that requires a careful look at how communication takes place between those involved. …”
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Pesticide Residues in Fruits and Vegetables from Cape Verde: A Multi-Year Monitoring and Dietary Risk Assessment Study by Andrea Acosta-Dacal, Ricardo Díaz-Díaz, Pablo Alonso-González, María del Mar Bernal-Suárez, Eva Parga-Dans, Lluis Serra-Majem, Adriana Ortiz-Andrellucchi, Manuel Zumbado, Edson Santos, Verena Furtado, Miriam Livramento, Dalila Silva, Octavio P. Luzardo

“…Food safety concerns related to pesticide residues in fruits and vegetables have increased globally, particularly in regions where monitoring programs are scarce or inconsistent. …”
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Application of Jane Jacobs’ Theory in the Analysis of the Borders of Territory Monitoring in Urban Spaces from Citizens’ Points of View in Bandar Abbas by Amirhamzeh Shahbazi, Esmaeil zakerimnabi, Alireza Shahbazi

“…The city exhibits a heterogeneous and multicultural context characterized by both modern influences and traditional customs that have persisted over time. …”
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CREATING PUBLIC OPINION AND DEVELOPING SPATIAL CITIZENSHIP THROUGH MAPS: THE CASE OF ZARAGOZA, SPAIN by María ZÚÑIGA-ANTÓN, María SEBASTIÁN LÓPEZ, Rafael DE MIGUEL GONZÁLEZ, Ángel PUEYO CAMPOS

“… The current context of social transformation and urban changes increases the need for updated knowledge of living spaces. …”
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Scouting emerging AI applications in fashion heritage and archival practices by Greta Rizzi, Daria Casciani

“…These reflections are accompanied by a broader reconsideration of how memory is constructed and mediated in the contemporary context, increasingly shaped by human–AI collaboration.…”
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Trade Risk Society—Understanding Trade Policymaking in the 2020s by Christopher M. Dent

“…It is argued this pattern of initiatives are indicative of a paradigm shift in trade policy norms emerging in an increasingly volatile and contested world that can be best understood in a trade risk society context.…”
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Surface displacements induced by underground activities from 2014 to 2019 in the former Lorraine coalfield, northeastern France by Modeste Guillaume, Gunzburger Yann, Conin Marianne, Diallo Maniang

“…Given this particular context, combination of historical and recent subsurface activities, it is useful to characterise the current induced surface displacements in the area. …”
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Designing and explaining the political behavior model of managers in government organizations by Mehdi Izadi, Amir Hoshang Nazarpuri, Reza Sepahvand, Hojat Vahdati, Mohammad Hakak

“…Abstract The purpose of the current research is to design and explain the political behavior model of managers in government organizations. …”
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Construction and Evaluation of Scenarios as a Learning Strategy through Modelling-Simulation by Juan Luis Peñaloza Figueroa, Carmen Vargas Perez

“…From a systemic perspective and in the context of an increasing generalization in the use of new technologies and the change in the educational paradigm -which emphasizes guided and autonomous learning-, the learning strategy should be routed to join logical reasoning and instrumental skills (software). …”
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Improving health-promoting workplaces through interdisciplinary approaches. The example of WISEWORK-C, a cluster of five work and health projects within Horizon-Europe by Deborah De Moortel, Michelle C Turner, Ella Arensman, Alex Binh Vinh Duc Nguyen, Víctor Gonzalez

“…Poorly designed or managed workplaces are associated with increased risks of musculoskeletal disorders (MSD), stress, burnout, and long-term sickness absence (3). …”
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