Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and <i>Trypanosoma cruzi</... by Gabriela Alves de Souza, Lorrane de Souza Chaves, Afonso Santine M. M. Velez, Jorge Lucas F. Lacerda, Paulo Pitasse-Santos, Jayane Clys Conceição dos Santos, Otávio Augusto Chaves, Carlos Serpa, Raphael do Carmo Valente, Leonardo Marques da Fonseca, Marcos André Rodrigues da Costa Santos, Jhenifer Santos dos Reis, Carlos Antônio do Nascimento Santos, Lucia Mendonça-Previato, Jose Osvaldo Previato, Celio Geraldo Freire-de-Lima, Debora Decoté-Ricardo, Leonardo Freire-de-Lima, Marco Edilson Freire de Lima

“…<b>Background: </b>Anticancer therapies represent the primary treatment option for a significant number of cancer patients globally; however, many of these treatments are associated with severe side effects as they target molecular structures present in both cancerous and healthy cells. In a similar context, the treatment of Chagas disease, a neglected tropical illness, is hindered by the high toxicity of the currently available drugs. …”
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“Locality – Adaptation” Research of Hydropower Resettlement Communities in the Jinsha River Basin: A Case Study of Ludila Hydropower Station by Fang WANG, Zhuoqi LI, Haoyi XU, Jiaqi YAN

“…ObjectiveWithin human – environment systems, river basins constitute the earliest geographical units of human activity and currently represent the most critical zones of strained human – environment interactions. …”
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On the added value of sequential deep learning for the upscaling of evapotranspiration by B. Kraft, B. Kraft, B. Kraft, J. A. Nelson, S. Walther, F. Gans, U. Weber, G. Duveiller, M. Reichstein, W. Zhang, M. Rußwurm, D. Tuia, M. Körner, Z. Hamdi, M. Jung

“…</p> <p>Our findings highlight non-linear model responses to biases in the training data and underscore the need for improved upscaling methodologies, which could be achieved by increasing the amount and quality of training data or by the extraction of more-targeted features representing spatial variability. …”
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Regulatory culture and architectural project by Mario Losasso

“…They are attentive to a quality that does not depend on construction solutions or on techno-typological, morphological or physical-chemical characteristics, but which is linked to a system of needs to be satisfied, the outcome of the interaction between construction and cultural, socio-economic and environmental context. Today’s regulatory landscape has expanded, increasing sensitivities to environmental challenges, health and the qualities of living space. …”
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Conceptualization of Policies, Strategies and Programs for Poverty Alleviation in Iran: A Qualitative Study by Hassan Danaeefard, Morteza Nabavi, Faramarz Nasri, Seyed Mohammad Javad Sajjadi Nezhad

“…., were created to help alleviate poverty in the country.The Research Center of the Islamic Council has stated in a report that the poverty line rate has been increasing since 2011 and has reached from 19.4% to 30/4% in 2021. …”
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Studying the Requirement of Water Police to Control Groundwater Resources in the Villages Iij, Jovin and Soufiabad of Sorkheh - Semnan by Peyman Akbarzadeh, Mohammadreza Yazdani, Shima Nikoo

“…Besides, farm cultivation with high water need can increase water consumption causing stress on the water resources in the study area. …”
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Group-based interventions to reduce gambling involvement among male football fans: a synopsis of findings from a feasibility study by Gerda Reith, Blair Biggar, Chris Bunn, Manuela Deidda, Craig Donnachie, Frankie Graham, Cindy Gray, Nicola Greenlaw, Kate Hunt, Matthew Philpott, Neil Platt, Robert D Rogers, John Rooksby, Sally Wyke, Heather Wardle

“…Football Fans and Betting was most successful in feasibility delivery when it was delivered within grassroots and local community contexts. Conclusions In the current climate of gambling industry penetration into professional football, promoting a gambling harms prevention intervention proved an insurmountable challenge. …”
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Territories -in- between by Alexander Wandl

“… There is an increasing body of literature suggesting that the conventional idea of a gradual transition in spatial structure from urban to rural does not properly reflect contemporary patterns of urban development and their potential for sustainable development. …”
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Aspiring to Higher Education? Choice, complexity and confidence in secondary students’ decision-making by Zeta Williams-Brown, Matt Smith, David Thompson, Gavin Rhoades

“…This article reports on a programme designed to encourage young people who are currently in secondary school (age range 11-18) to apply to university. …”
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The Concept of Sovereignty Through Space and Time by Ksenia Radchenkova

“…The study shows that the trajectories of the concept evolution in Russia and China are becoming increasingly divergent from the European line of development that aims at limiting state sovereignty. …”
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Analysis of Outdoor and Indoor Radon Concentration Time Series Recorded with RadonEye Monitors by Peter Bossew, Eleonora Benà, Scott Chambers, Miroslaw Janik

“…Consumer-grade economical radon monitors are becoming increasingly popular in private and institutional use, in the contexts of both Citizen Science and traditional research. …”
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A second horizon scan of biogeography: Golden Ages, Midas touches, and the Red Queen by Michael N Dawson, Jan C. Axmacher, Carl Beierkuhnlein, Jessica L. Blois, Bethany A. Bradley, Anna F. Cord, Jürgen Dengler, Kate S. He, Lawrence R. Heaney, Roland Jansson, Miguel D. Mahecha, Corinne Myers, David Nogués-Bravo, Anna Papadopoulou, Björn Reu, Francisco Rodríguez-Sánchez, Manuel J. Steinbauer, Alycia Stigall, Mao-Ning Tuanmu, Daniel G. Gavin

“…., advances in genetics, remote sensing, modeling) that promote studies with increasing detail and at increasing scales; disciplinary breadth is being diversified (e.g., by developments in paleobiogeography and microbiology) and integrated through the transfer of approaches and sharing of theory (e.g., spatial modeling and phylogenetics in evolutionary–ecological contexts). …”
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Wanderings of the nomadic subject: on becoming, relationality and interdependency as a space of subject's autonomy in education by Jolanta Rzeźnicka-Krupa

“…It aims to show the most important theoretical assumptions of contemporary philosophical currents, which create different contexts for rethinking and reconfiguring both discursive and material aspects of human subjectivity, difference, identity, relations between different entities or, finally, practices of producing knowledge and arranging educational reality. …”
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Letter to readers by Francesca Gorini

“…The evolution of educational technologies and their impact on the educational system is, also, a topic that personally involves me, having dedicated part of my research job in exploring which skills are essential to preserve and develop in order to interact appropriately with AI – a tool which is becoming increasingly pervasive even in teaching and educational contexts. …”
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Deadline-Aware Scheduling Perspectives in Industrial Wireless Networks: A Comparison between IEEE 802.15.4 and Bluetooth by Mario Collotta, Giovanni Pau, Gianfranco Scatà

“…In industrial contexts, most of process control applications use wired communication networks. …”
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Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection by Carrie L. Butler, Nicole M. Valenzuela, Kimberly A. Thomas, Elaine F. Reed

“…This review highlights what is currently known about the clinical context of pre and posttransplant antibodies, antibody characteristics that influence AMR, and the paths after donor specific antibody production (no rejection, subclinical rejection, and clinical dysfunction with AMR).…”
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Energy-driven circular design in the built environment: rethinking architecture and infrastructure by Williams Chibueze Munonye, George Oche Ajonye

“…This study explores the integration of energy-driven circular design principles within the built environment, aiming to foster sustainable, low-carbon cities and buildings. Currently as urbanization accelerates and environmental concerns heighten, the need for circular economy practices that promote energy efficiency, resource optimization, and waste reduction becomes increasingly urgent. …”
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Curious Travellers: New Journeys for the Home Tour by Mary-Ann Constantine

“…The creation of new editions continues to generate new topics and research questions, including Anglophone/Celtic-language interactions; the writings of women tourists; the role of material objects (specimens and souvenirs) and of visual culture in knowledge exchange and production. Increasingly, project researchers are relating their work to broader global contexts of colonialism and environmental history. …”
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Trends of compressive word formation in modern Russian language by Natalia A. Nikolina

“…The increasing frequency of contaminated formations in modern Russian speech is revealed. …”
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Does Beta Explain Global Equity Market Volatility – Some Empirical Evidence by Radosław Kurach

“…In the subsidiary outcomes of our verification procedure, we argue that country betas are time-varying and that currently, global factors are the dominant source of equity market volatility. …”
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