Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia by Armin Dozandeh-Jouybari, Fatemeh Mousavi-Mirkalaei, Saeid Taghiloo, Hossein Karami, Mohammad Naderisorki, Ehsan Zaboli, Mohammad Eslami-Jouybari, Tohid Kazemi, Hossein Asgarian-Omran

“…Following treatment, the proliferation of leukemic cells was significantly decreased and the apoptosis rate was significantly increased, which was more remarkable for venetoclax. …”
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Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Results Our findings showed that CL-NPs loaded with anti-NOTCH1/-SF3B1 siRNAs-PTX significantly suppressed NOTCH1 and SF3B1 expression in PBMCs and BMMCs isolated from CLL cases in comparison with the untreated samples, leading to increased leukemic cell sensitivity to PTX and decreased the proliferative capacity of leukemic cells. …”
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Assessment of Sexual Functions among Infertile Women by Azza A. Mohamed, Aziza A. Attia, Hanan A. Mahjoub

“… Context: Sexual function plays a vital role in the quality of life and is determined by both biological and psychosocial factors. …”
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Advancing Energy Transition: A Circular Economy Framework for Co-Optimizing Energy, Water, and Emissions in Low-Carbon Systems by Mohamed Elsir, Ameena Saad Al-Sumaiti, Mohamed Shawky El Moursi

“…Current models fail to address the dynamic interplay between RES, CC, and desalination, especially given the complexities of temperature-sensitive desalination processes and operational uncertainties. …”
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ISSUES AND TRENDS OF PROGRESS TOWARDS SUSTAINABLE DEVELOPMENT GOALS IN ROMANIA by Dumitru Florin FRONE, Simona FRONE

“…Monitoring SDG 12 in an EU context focuses on progress made in decoupling environmental impacts from economic growth, in decreasing energy consumption and in tackling waste generation and management. …”
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The Immune Environment in Colorectal Adenoma: A Systematic Review by Ugne Silinskaite, Jurate Valciukiene, Matas Jakubauskas, Tomas Poskus

“…<b>Methods:</b> In this systematic review, we aim to provide a thorough analysis of the current research examining the immune infiltration patterns in sporadic colorectal adenoma tissues in the context of immune cell-based, cytokine-based, and other immunological factor-related changes along the conventional adenoma–carcinoma sequence. …”
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Neutrophil-to-Lymphocyte ratio as surrogate for JAK2V617F suppression and event-free survival in polycythemia vera by Tiziano Barbui, Arianna Ghirardi, Victoria Empson, Francesca Fenili, Giuseppe Gaetano Loscocco, Annalisa Condorelli, Alessandra Iurlo, Daniele Cattaneo, Elena Rossi, Valerio De Stefano, Paola Guglielmelli, Christoph Klade, Heinz Gisslinger, Alessandro Rambaldi, Joseph M. Scandura, Alessandro Maria Vannucchi

“…Abstract Chronic systemic inflammation is a key driver of polycythemia vera (PV) progression, but the immunomodulatory effects of current treatments remain poorly defined. The neutrophil-to-lymphocyte ratio (NLR) is an accessible biomarker of systemic inflammation proven in other contexts, but its role in monitoring PV disease activity has not been established. …”
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The Effects of Intensification on Rural Teachers’ Work by Gloria Penrice

“…School organisational structures, school cultures, personal relationships within the school context, along with high self-imposed expectations can result in an increased workload and demands on teachers’ time. …”
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Ethnozootechnical Perspectives on the Decline of Traditional Knowledge About Local Goat and Sheep Breeds in the Semi-Arid Region of Paraíba, Brazil by Raissa C. Silva, Marilene N. Melo, Carlos F. T. de Oliveira, José V. Cardoso, Luis A. C. Cevallos, Laura L. da Rocha, Janaina K. G. Arandas, Maria N. Ribeiro

“…Two workshops were held to assess the diversity of breeds in the past landscape (PP) and current landscape (PA), using the Recall technique. …”
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Assessing Immunization Coverage and the Negative Impact of Local Vaccine Production Cessation in Ecuador by Esteban Ortiz-Prado, Lissette Carolina Villacreses-Brito, Jorge Vasconez-Gonzalez, Cristina Anabel Jacome, Marlon Arias-Intriago, Juan S. Izquierdo-Condoy

“…For BCG, median coverage decreased from 100% during the production period to 87.8% post-cessation (<i>p</i> < 0.0001). …”
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Jian-Pi-Gu-Shen-Hua-Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis by Shuquan Lv, Lirong Fan, Xiaoting Chen, Xiuhai Su, Li Dong, Qinghai Wang, Yuansong Wang, Hui Zhang, Huantian Cui, Shufang Zhang, Lixin Wang

“…Diabetic nephropathy (DN), one of the most frequent complications of diabetes mellitus, is a leading cause of end-stage renal disease. However, the current treatment methods still cannot effectively halt the progression of DN. …”
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Optimal Decision-Making in a Green Supply Chain Duopoly: A Comparative Analysis of Subsidy Strategies with Data-Driven Marketing by Yao Yao, Shaoqing Geng, Jianhui Chen, Feng Shen, Huajun Tang

“…In the current context of severe environmental challenges and climate change, the low-carbon green development model has become an international consensus. …”
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Evaluation of Total Electron Content Prediction Using Three Ionosphere‐Thermosphere Models by O. Verkhoglyadova, X. Meng, A. J. Mannucci, J.‐S. Shim, R. McGranaghan

“…The meanings of contingency table elements for the prediction performance are analyzed in the context of ionosphere modeling. Prediction success is between about 0.2 and 0.5 for weak ionospheric disturbances and decreases for strong disturbances. …”
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INTERNATIONAL EXPERIENCE AND TRENDS OF INNOVATIVE DEVELOPMENT OF ARCTIC TERRITORIES by M. Dudin, N. Ivashchenko

“…This approach is fundamentally fl awed and fraught with a number of threats, because other countries do not decrease, but only increase their interest in this issue; Territorial opposition to all those involved in the topic of causing instability in the Arctic region, but does not represent a real threat for the emergence of large-scale conflict. …”
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Innovative enterprise accounting reporting features by S.E. Pyrizhok, E.H. Melnyk

“…The article defines innovative enterprises' accounting reporting features, which reflect the specifics of their activity in the context of increased risk and has a risk-oriented direction of the generated information resource for management purposes. …”
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Turkey’s Role in Somalia’s Peace and Development Process by Oktay Bingöl

“…In this context, Turkey should review the current Somalia policy and develop a comprehensive strategy…”
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Latest trends on interplay of autophagy, adipose tissue, and gut microbiota in obesity-related metabolic disorders by Claudette Butoyi, Muhammad Asad Iqbal, Isaac Duah Boateng

“…Conversely, pharmacologically induced Atg, exemplified by rapamycin administration, enhances insulin sensitivity by 15–25 % in rodent models. (2) Alterations in gut microbial composition, characterized by a 40 % decrease in Bacteroidetes and an increase in Firmicutes, correlate with elevated visceral adiposity and systemic inflammation. …”
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Effectiveness of Nursing Intervention Protocol on Nurses’ Performance and Patients’ Self-Care after Cataract Surgery by Amal S. Taha

“… Context: Cataract is the leading cause of poor vision worldwide. …”
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Nutritional management of pediatric nephrotic syndrome regarding oxidative stress and antioxidant balance by Elena Jechel, Alin Horatiu Nedelcu, Felicia Dragan, Vasile Valeriu Lupu, Iuliana Magdalena Starcea, Adriana Mocanu, Solange Tamara Rosu, Violeta Streanga, Ruxandra Russu, Ginel Baciu, Ciprian Danielescu, Delia Lidia Salaru, Ionela Daniela Morariu, Olga Cirstea, Emil Anton, Ancuta Lupu

“…The analysis focuses on the molecular mechanisms by which oxidative stress contributes to the progression of renal dysfunction, the role of oxidative biomarkers in disease monitoring, and the ability of antioxidants to reduce the need for immunosuppressants and corticosteroids, thus contributing to the decrease in associated morbidity. The translational perspectives of antioxidant therapy are also discussed, in the context of the urgent need for effective adjuvant strategies with a safety profile superior to conventional therapies. …”
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Reducing mine water contamination at the local drainage facility of a kimberlite mine by N. P. Ovchinnikov

“…As Russian kimberlite mines reach their design capacity, the interval between cleaning cycles of the local drainage system’s water collectors has significantly decreased. Currently, at kimberlite mines, the cleaning of silted water collectors is routinely carried out using all available load–haul–dump (LHD) machines operated by the mine’s Mechanical and Power Service. …”
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