A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer by Gary Middleton, Helen L. Robbins, Peter Fletcher, Joshua Savage, Manita Mehmi, Yvonne Summers, Alastair Greystoke, Nicola Steele, Sanjay Popat, Pooja Jain, James Spicer, Judith Cave, Paul Shaw, David Gilligan, Danielle Power, Dean Fennell, Maya Bajracharya, David J. McBride, Uma Maheswari, Alexander M. Frankell, Charles Swanton, Andrew D. Beggs, Lucinda Billingham

“…Abstract There are no current stratified medicine options for STK11-deficient NSCLC. …”
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Innovating through tradition: kava-talanoa as a culturally aligned medico-behavioral therapeutic approach to amelioration of PTSD symptoms by S. Apo Aporosa, Dennis Itoga, Julia Ioane, Jan Prosser, Sione Vaka, Emily Grout, Martin J. Atkins, Mitchell A. Head, Jonathan D. Baker, Tanecia Blue, David H. Sanday, Mahonri W. Owen, Chris Murray, Karthik Sivanathan, Tua’ipulotu W. Cuthers, Anau Mesui-Henry, Mary-Jane McCarthy, James Bunn, Ifereimi Waqainabete, Helen Turner, Helen Turner, Helen Turner

“…Our core hypothesis is that, combined, kava-talanoa will outperform current standards of care in PTSD symptom management as a culturally augmented cognitive-behavioral group therapy intervention. …”
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Young TPI: empowering animal-free science among the next- generation of scientists by Marta G. Valverde, Marta G. Valverde, Fatima Zohra Abarkan, Fatima Zohra Abarkan, Rebecca Van Eijden, Rebecca Van Eijden, Julia M. L. Menon, Julia M. L. Menon, Nikolas Gaio, Nikolas Gaio, Aarti Ramchandran, Aarti Ramchandran, Victoria C. De Leeuw, Victoria C. De Leeuw

“…The Dutch government has promoted initiatives such as Transitie Proefdiervrije Innovatie (TPI) to make the public aware of the current situation. However, the transition towards animal-free innovations will span over more than two generations. …”
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Improving mesophilic anaerobic digestion of compostable packaging through efficient and versatile thermo-alkaline pre-treatment by Gaël Huet, Julie Lamarque, Florian Monlau, Valentin Puchelle, Cecilia Sambusiti, Juliana Catalina Suarez Murcia, Sandra Domenek, Florian Pion, Emmanuelle Gastaldi

“…In the current European regulatory context, which requires its Member States to collect biowaste separately with a view to its organic recovery, the co-processing of compostable food packaging with biowaste by mesophilic anaerobic digestion (AD) offers the dual opportunity of promoting its conversion into biogas while reducing plastic contamination of the environment. …”
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Construction of medical scientific data repositories in China: analysis of survey and recommendations by Jia Song, Jia Song, Chunqiu Li, Wirapong Chansanam

“…BackgroundIn the context of global open science trends, medical open-access repositories (OARs) promote transparency in research and facilitate the sharing of scientific data. …”
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Soundscape research in wind farms: A state-of-art review by Xinyan Xu, Huan Tong, Jian Kang

“…By reviewing these articles, this review found that current research related to the soundscape study of wind farms is still lacking, with more researchers focussing on wind power noise and its effects on the physical and psychological health of residents rather than on the influence of the integrated acoustic environment and context of wind farms on residents' perception. …”
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Pregnancy-related acute kidney injury leads to hypertension, reduced kidney function and cognitive impairment in postpartum rats by Ashley Griffin, Jamie Szczepanski, Shauna-Kay Spencer, Shauna-Kay Spencer, Lucia Solis, Teylor Bowles, Reanna Robinson, Jan M. Williams, Patrick B. Kyle, Kedra Wallace, Kedra Wallace

“…Both hypertensive disorders of pregnancy and Acute Kidney Injury (AKI) outside the context of pregnancy have been associated with an increased risk of developing Chronic Kidney Disease (CKD) and cognitive impairment. …”
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Genome-Wide DNA Methylation Analysis during Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Yangyang Cao, Haoqing Yang, Luyuan Jin, Juan Du, Zhipeng Fan

“…We found that the majority of cytosines in a CpG context were methylated in induced BMSCs. Our results also revealed that, along with the induced osteogenic differentiation in BMSCs, the average genomic methylation levels and CpG methylation in transcriptional factor regions (TFs) were increased, the CpG methylation level of various genomic elements was mainly in the medium-high methylation section, and CpG methylation levels in the repeat element had highly methylated levels. …”
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Multi-omics reveals total flavones from Abelmoschus manihot (L.) Medik. [Malvaceae] ameliorate MAFLD via PI3K/AKT/mTOR-mediated autophagy by Chao Lv, Chao Lv, Chao Lv, Chao Lv, Chao Lv, Lei Zhao, Jiani Hou, Hongyin Sun, Hongyin Sun, Hongyin Sun, Zhongsha Li, Zhongsha Li, Zhongsha Li, Zhongsha Li, Yuesong Wu, Yuesong Wu, Yuesong Wu, Yuesong Wu, Peizheng Shi, Yaping Xiao, Yunjin Xie, Yunjin Xie, Yunjin Xie, Yunjin Xie, Wei Su, Wei Su, Wei Su, Wei Su, Mingzhu Yin, Mingzhu Yin, Mingzhu Yin, Mingzhu Yin

“…Histological analysis demonstrated that TFA alleviated hepatic steatosis and fibrosis, with decreased levels of inflammatory cytokines and increased antioxidant markers. …”
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Evaluating the Constructive Alignment of Learning Objectives Within Haptics Simulation in the Dental Undergraduate Curriculum by Susha Rajadurai, Tapan Hebballi, Zahra Sharif, Guneet Kaur Kukreja, Ithar Derdour

“…This study seeks to explore whether the current learning objectives constructively align with our current haptics simulation curriculum – in the specific context of how well they are being met by year 1 undergraduate dental students. …”
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Absence of progression risk of chronic kidney disease in patients with urine protein-creatinine ratio below 500 mg/g: a cohort study with competing risk analysis by Jiang Bai, Lijuan Zhang, Jingkai Di, Wenyu Wang, Yawen Wu, Yun Zhou, Yun Zhou, Yun Zhou

“…The results of the Fine and Gray competing risk survival regression model showed the same trend.ConclusionIn patients with CKD and UPCR levels below 500 mg/g, there was no increased risk of CKD progression associated with the higher proteinuria levels.…”
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Validation of the Mild Behavioral Impairment Scale (MBI-S) for brief self-assessment of Mild Behavioral Impairment in people without dementia by Paula Hinkl, Elmar Graessel, Nicolas Rohleder, Peter Landendoerfer, Thomas Kuehlein, Natascha Lauer, Anna Pendergrass

“…It has high test economy and measures current neuropsychiatric symptoms and their intensity as a state criterion. …”
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Knowledge of Preconception Healthcare and Associated Factors: A Study among Mothers in Jinka Town, Southern Region, Ethiopia by Kassahun Fikadu Tesema, Tamirat Cheneka, Alemayehu Alemu, Mekonen Feyissa, Birhanu Birkaye, Hafiza Mohammed, Eleni Kidu, Getahun Wegaso, Biresaw Wasihun

“…Preconception healthcare is promising to improve the reproductive health status of women and couples if they receive care three months to two years before conception. In the current context of Ethiopia, however, preconception healthcare is overlooked in the continuum of care. …”
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A Novel CTC-Binding Probe: Enzymatic vs. Shear Stress-Based Detachment Approaches by Sophia Krakowski, Sara Campos, Henri Wolff, Gabi Bondzio, Felix Hehnen, Michael Lommel, Ulrich Kertzscher, Paul Friedrich Geus

“…The additional flow treatment did not increase the CTC detachment efficiency. <b>Conclusions</b>: It is feasible that the detachment efficiency can be further increased by a longer enzymatic incubation time or higher shear stress. …”
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Spiritual space: Hearing and experiencing the voice of God by Walter Firth

“…As scrutiny increases of what and how, such material is shared, used and taught, creating a space where the voice of God can speak into our current settings becomes increasingly vital. …”
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A critical analysis of the policy potential for sustainable agriculture in India by Neha Chauhan, Henrik von Wehrden

“…As per last census conducted (in 2011), 54.6% of India’s total population depends on agriculture as their primary livelihood. In this context, the current study emphases on ascertaining the major themes of the current policies being implemented in agriculture in India, while evaluating the potential of these policies in restructuring the agriculture into a more sustainable sector. …”
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Holiday Weight Change in a US College Student Sample: A Prospective Observational Cohort Study by Hannah B. Yoo, Casen Bigham, Tanisha Basu, Sharmin Akter, Tiffany Tsai, Alexis Brown, Sara Kiros, Shruthi Durai, Claire Brown, Martin Binks

“…Weight gain occurred alongside increases in lean mass but not body fat. Results provide important context to previous findings observing weight gain in college students and adults over the holiday season. …”
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The right to a view in Russia: History, legislation and future prospects by Polina N. Andreeva

“…The current landscape reveals significant legal gaps that hinder the protection of property owners’ interests. …”
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Investing in the future: an integrated model for analysing user attitudes towards Robo-advisory services with AI integration by Sandeep Singh, Atul Kumar

“…Filling these gaps will improve the knowledge of consumer behaviour in the context of Fintech adoption and develop the current research. …”
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Adherence to and factors moderating the implementation of childhood TB contact tracing guidelines in selected facilities in Ndola District, Zambia: a cross-sectional study by Elizabeth Kashindi, Patricia Maritim, Adam Silumbwe, Joseph M. Zulu, Gershom Chongwe, Patrick Kaonga, Choolwe Jacobs

“…Moderators of contact investigation guidelines were related to the provider and organizational context. With each additional year in a healthcare provider’s age, there was a corresponding 1.12 increase (AOR 1.12, 95% CI 1.03–1.22 P = 0.006) in adherence. …”
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