Effects of long-term pioglitazone treatment on peripheral and central markers of aging. by Eric M Blalock, Jeremiah T Phelps, Tristano Pancani, James L Searcy, Katie L Anderson, John C Gant, Jelena Popovic, Margarita G Avdiushko, Don A Cohen, Kuey-Chu Chen, Nada M Porter, Olivier Thibault

“…Finally, a combination of microarray analyses on hippocampal tissue and serum-based multiplex cytokine assays revealed that age-dependent inflammatory increases were not reversed by PIO.<h4>Conclusions</h4>While current research efforts continue to identify the underlying processes responsible for the progressive decline in cognitive function seen during normal aging, available medical treatments are still very limited. …”
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Cr doping modification for tribological behavior of Cr/a-C multilayer coatings against PEEK under diverse operational conditions by Xiaohui Zhou, Yingpeng Zhang, Hao Li, Li Cui, Wei Yang, Aiying Wang, Peng Guo, Peiling Ke

“…Considering the increasing demand for wear-resistant materials used for various frictions with dynamic sealing parts, we employed hybrid magnetron sputtering technology to fabricate Cr/amorphous carbon (a-C) multilayered coatings with and without Cr doping for comparison. …”
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Sarcopenia in Rheumatic Diseases: A Hidden Issue of Concern by Eleni C. Pardali, Markos Klonizakis, Dimitrios G. Goulis, Sousana K. Papadopoulou, Christos Cholevas, Constantinos Giaginis, Christina Tsigalou, Dimitrios P. Bogdanos, Maria G. Grammatikopoulou

“…The present narrative review seeks to explore the methods used to assess sarcopenia in patients with RDs, its prevalence among them, and the challenges faced by the affected individuals, while critically assessing the appropriateness and limitations of current sarcopenia assessment tools in the context of RDs.…”
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The lack of evidence-based management in electrical storm: a scoping review by Pouya Motazedian, Graeme Prosperi-Porta, Marie-Eve Mathieu, Nickolas Beauregard, William Knoll, Nicholas Quinn, Simon Parlow, Pietro Di Santo, Omar Abdel-Razek, Richard Jung, Nikola Kolobaric, William Barbour, David Nelson, Trevor Simard, Jacob C. Jentzer, Rebecca Mathew, George A. Wells, F. Daniel Ramirez, Benjamin Hibbert

“…The use of sedation for ES was exclusively studied in the context of mechanical ventilation. There was an increase in the number of ES studies over time, but sample sizes remained small and unchanged. …”
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A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise‐Induced Hearing Loss Therapy by Jiawen Li, Zhuowen Hao, Fangzi Ke, Zhihui Liu, Weilong Wang, Sihui Wen, Fan Wu, Bowen Xu, Miao He, Shengyu Zou, Xiong Chen, Jingfeng Li, Zuhong He

“…Teriparatide (PTH1‐34) exerts antioxidant properties in the context of osteoporosis. Thus, in the current study, a multifunctional thermosensitive nanodelivery system is developed, based on the unique anatomical structure of the inner ear, to load and sustain the release of PTH1‐34 to alleviate hair cell damage. …”
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Rubinstein-Taybi syndrome with ganglioneuroblastoma: a case report and literature review by Jiaji Zhou, Tang Dan, Lan Zeng, Fu Xiong, Guanghuan Pi, Ai Chen, Haiting Liu, Shuyao Zhu

“…However, the association between CREBBP variants and an increased risk of tumors remains unknown, despite multiple reports of tumor comorbidities related to RSTS. …”
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Facilitating active participation in anticoagulant decisions in advanced kidney disease: co-production of a question prompt list by Kathrine Parker, Abigail Needham, Jecko Thachil, Sandip Mitra, Penny Lewis

“…Currently, there are no support tools for people with chronic kidney disease regarding anticoagulant therapy decisions. …”
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Energy recovery analysis through numerical simulations of steam injection in continental shale oil reservoirs by Maryelin Josefina Briceño Montilla, Shouding Li, Zhaobin Zhang, Yanzhi Hu, Jianming He, Zheng Bo, Xiao Li

“…However, optimizing energy utilization to maximize hydrocarbon production remains a significant challenge, particularly in the context of current energy limitations. This study compares two steam injection strategies using a thermal-flow-chemical (TFC) simulator to assess energy recovery efficiency. …”
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Intelligent Monitoring and Treatment System of Heavy Metal Contaminated Soil Based on Artificial Bee Colony Algorithm and Edge Computing Nanotechnology by Ke Hu, Dongdong Li, Xiaolei Cui, Donghua Hu, Junliang Chen, Shaopeng Zhuan, Hao Chang, Yaping Zhang, Tingting An, Juqin Zhang

“…Abstract The CGABC algorithm improves the convergence speed of the algorithm by crossing the solution generated by the neighborhood search of bees with the current global optimal solution. By selecting reasonable cross-operation coefficients to balance the algorithm's global optimization ability and local search ability, and adding random interference terms to increase population diversity. …”
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Advances in Oncolytic Viral Therapy in Melanoma: A Comprehensive Review by Ayushi Garg, Rohit Rao, Felicia Tejawinata, Gazi Amena Noor Shamita, McKay S. Herpel, Akihiro Yoshida, Gordon Goolamier, Jessica Sidiropoulos, Iris Y. Sheng, Salim-Tamuz Abboud, Luke D. Rothermel, Nami Azar, Ankit Mangla

“…From the historical use of wild viruses to the sophisticated use of genetically modified viruses in the current era, oncolytic virus therapy has evolved tremendously in the last two decades. …”
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Determining the Cost-Effectiveness of Home Care: A Scoping Review by Katerina Gousia, Hansel Teo, Stacey Rand, Florin Vadean

“… Context: The demand for long-term care services provided at home (home care) has increased over time. …”
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Interpersonal counselling for adolescent depression delivered by youth mental health workers without core professional training: the ICALM feasibility RCT by Jon Wilson, Viktoria Cestaro, Eirini Charami-Roupa, Timothy Clarke, Aoife Dunne, Brioney Gee, Sharon Jarrett, Thando Katangwe-Chigamba, Andrew Laphan, Susie McIvor, Richard Meiser-Stedman, Jamie Murdoch, Thomas Rhodes, Carys Seeley, Lee Shepstone, David Turner, Paul Wilkinson

“…However, alterations to the referral pathways did not increase the number of referrals made to the study. …”
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Evaluation of pre-exposure vaccine effectiveness against mpox during the 2022–2023 mpox outbreak in the Madrid region (Spain): a test-negative design by José Francisco Barbas del Buey, Jesús Íñigo Martínez, Marcos Alonso García, Andrés Aragón Peña, Laura Montero Morales, Araceli Arce Arnáez

“…Introduction An appropriate vaccination approach is critical to control the current outbreak of mpox but there is little research providing information on its effectiveness, particularly under circumstances of limited vaccine availability.Methods Pre-exposure vaccination campaign in the Madrid region, with the modified vaccinia Ankara-Bavarian Nordic was indicated in the risk groups from 18 July 2022.To evaluate the vaccine effectiveness (VE) of a dose of third-generation smallpox vaccine against mpox in the context of pre-exposure prophylaxis, a population-based indirect cohort study (Broome method) also known as test-negative design (TND) was conducted in the Madrid region (6 751 251 inhabitants). …”
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Study on the influence of load and sliding speed on the friction behavior of electrodeposited Ni–SiC composite coatings by Pao-Chang Huang, An-Yu Cheng, Chih-Cheng Chou, Jung-Sen Huang, Zi-An Wang, Kung-Hsu Hou

“…Increasing sliding speed significantly reduced wear and coefficient of friction (COF), attributed to the formation of a continuous tribo-oxidative layer. …”
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Norbornenic anhydride as versatile additive optimizing interphases to enable high-performance LiNi0.8Co0.1Mn0.1O2/Li batteries by Fujie Yang, Zihao Yang, Qiujie Huang, Pipi Wang, Chong Mao, Zhanqiang Li, Huiyang Li, Xudong Chen

“…A LiǁLi symmetric cell with NA exhibits excellent cycling stability at a current density of 1.0 mA cm−2 for cycling 400 h. …”
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Neurobiological and therapeutic landmarks of depression associated with Alzheimer’s disease dementia by Ilinca Untu, Michael Davidson, Gabriela-Dumitrita Stanciu, Jonathan Rabinowitz, Jonathan Rabinowitz, Romeo-Petru Dobrin, Diana-Sabina Vieru, Bogdan-Ionel Tamba, Bogdan-Ionel Tamba

“…These mechanisms likely contribute to the acceleration of neurodegeneration in AD and the onset or worsening of depressive symptoms. Current therapeutic approaches remain largely nonspecific, with a lack of targeted therapies that address the unique pathophysiological context of depression in AD. …”
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Emergency response mobile 3D printing system: A case study in rapid manufacturing of polyurethane foam bridges by Jingwen Liang, Zhuo Zeng, Penglin Wang, Zhongxu Wang, Shifeng Wen, Yan Zhou, Cheng Zhou

“…In the context of increasing global natural disasters, the 72-hour golden rescue window imposes three critical requirements on rapid construction technologies: timeliness, multi-hazard adaptability, and systemic support. …”
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Modelling the efficiency of technological management of agricultural enterprises in economic security by Mykola Vovk, Tetyana Zubro, Elvin Omarov, Bohdan Kolomiiets, Volodymyr Hnydiuk

“…The purpose of this study is to develop a model for assessing the efficiency of technological management of agricultural enterprises in the context of ensuring economic security. The study also focuses on the analysis of key factors affecting the efficiency of technological processes, and on the development of tools for improving management technologies in the context of modern economic challenges and risks. …”
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Control Shift by Theodora Chatzi Rodopoulou

“…The aim of this dissertation is to explore the potential of enhancement of the Industrial Heritage Reuse through the identification and analysis of its influencing Aspects, under the light of the contemporary theoretical conservation concepts, the current demands of the field of practice and the rising challenges of the 21st century context. …”
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A novel proof of concept approach towards generating reference microplastic particles by Simon D.J. Oster, Paul E. Bräumer, Daniel Wagner, Max Rösch, Martina Fried, Vinay K.B. Narayana, Eva Hausinger, Helena Metko, Eva C. Vizsolyi, Matthias Schott, Christian Laforsch, Martin G.J. Löder

“…Currently, the variety of analytical methods used in microplastic research result in data of different quality. …”
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