Impaired plasma membrane calcium ATPase activity and mitochondrial dysfunction contribute to calcium dysregulation in Fabry disease-related painful neuropathy by Francesco Formaggio, Asia Pizzi, Cecilia Delprete, Davide Pasqualini, Isabella Mataloni, Roberto Rimondini, Ludovica Campolongo, Vincenzo Donadio, Anna Maria Ghelli, Rocco Liguori, Marco Caprini

“…The obtained results suggest that other transport proteins participate in Ca2+ homeostasis in FD and their dysfunction may be directly involved in nociception. In this context, plasma-membrane Ca2+ ATPases exhibited reduced activity in FD, leading to an increased resting [Ca2+]i in sensory neurons. …”
Get full text

Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…We collected front-line national and international healthcare professional perspectives on best practice, current practice and explanations for implementation gaps between ‘best’ and ‘current’ practice (WP1, phase 2). …”
Get full text

Turkey’s Nuclear Energy Ambitions: Past Efforts, Present Strategies, and Future Directions by Muhammed Cihat Mercan, Ali İhsan Aygün

“…Nuclear power plants, popularized by the promise of decreasing dependency on foreign resources and providing supply security, meet 10% of the world’s energy needs as of 2023. …”
Get full text

Alpha Helices Are More Robust to Mutations than Beta Strands. by György Abrusán, Joseph A Marsh

“…The rapidly increasing amount of data on human genetic variation has resulted in a growing demand to identify pathogenic mutations computationally, as their experimental validation is currently beyond reach. …”
Get full text

Load Forecasting in Electrical Grids: Analysis of Methods and their Trends by Kyryk V.V., Shatalov Y.O.

“…The results show that, although increasingly complex models are being developed, their accuracy gain remains inconsistent in different application contexts, provided that a single-type architecture is used. …”
Get full text

Understanding Social Engineering Victimisation on Social Networking Sites: A Comprehensive Review of Factors Influencing User Susceptibility to Cyber-Attacks by Saad S. Alshammari, Ben Soh, Alice Li

“…This systematised analysis emphasises the limitations in current research and identifies future research directions in order to deepen the understanding of the factors influencing SEV. …”
Get full text

Be AIware! An AI Competency Model for K-12 Education by Lana Sattelmaier, Jan Pawlowski

“…The rapid emergence of generative artificial intelligence (GAI) is reshaping educational contexts, creating an urgent need for K–12 systems to adapt. …”
Get full text

Therapy, Pain & Training by Jendrusch G, Henke T, Schnell D, Platen P

“…However, athletes are at increased risk for eye injuries caused by high-velocity objects e.g. balls or physical contact with opponents. …”
Get full text

Teaching English Oral Expressionand Listening Comprehension at the Department ofLetters and English Language, University of Constantine 1: Past and Present Ups and Downs by Youcef BEGHOUL

“…It also suggests some solutions for a more practical teaching of these two crucial skills in a pedagogical context characterized by ever decreasing linguistic and cultural levels and more and more overcrowded classes.…”
Get full text

miR-34a-5p modulation of polycystic ovary syndrome via targeting the NOTCH signaling pathway by Kexin Zhang, Xiaomeng Wang, Fang Liu, Hong Lin, Yan Wang, Min Zhao, Xiaofei Wang, Yijing Chu, Lin Xu

“…Conversely, inhibiting miR-34a-5p resulted in an increase in cell growth and a decrease in programmed cell death. …”
Get full text

Wildlife law and policy by S. Bertouille

“…Van Gossum et al. (2010) developed the RAA by merging current smart regulation theory with the policy arrangement approach and the policy learning concept. …”
Get full text

Residential Buildings at Climate Crossroads: Insights from Portugal for South European Energy Performance by Alexandre Castro, Sandra Sorte, Vera Rodrigues, Nelson Martins

“…Results indicate substantial regional variations, with significant increases in cooling demands and corresponding reductions in heating needs, exposing limitations in the regulatory climate files currently used in energy certification processes. …”
Get full text

Perceptions of AI competence in social and healthcare services: Readiness, reliance and realism by Tuuli Turja, Outi Ahonen

“… Artificial intelligence (AI) is transforming the health and social service environment through increasingly advanced and autonomous digital solutions. …”
Get full text

PULSE: A modular framework for predictive energy efficiency in heterogeneous data centers by Daniel Flores-Martin, Felipe Lemus-Prieto, Juan A. Rico-Gallego

“…The platform fills a gap in current research by offering a user-friendly, modular, and adaptive solution that empowers operators to model, predict, and improve data center energy performance with minimal technical expertise. …”
Get full text

Document-Level Neural TTS Using Curriculum Learning and Attention Masking by Sung-Woong Hwang, Joon-Hyuk Chang

“…During synthesis, the document-level text is synthesized using only the necessary contexts of the current time step and masking the rest through an attention-masking mechanism. …”
Get full text

Advances in research on SATB2 and its role in tumor development by Ge Cheng, Chi Tian, Waner Wang, Yangyang Zhou, Xiaoqing Wang, Lei Zhang

“…Understanding its precise mechanisms in these contexts can pave the way for future advancements in therapeutic strategies. …”
Get full text

Unlocking the potential of global greenhouse gas mitigation by reducing food loss and waste by Suraj Negi, Liang-Shih Fan, Hyunook Kim, Taira Hidaka, Aishwarya Rani, Shu-Yuan Pan

“…Food loss and waste (FLW) are significant yet under-addressed contributors to global greenhouse gas (GHG) emissions, and the effectiveness of current FLW mitigation policies and valorization technologies remains insufficiently explored. …”
Get full text

‘Just because something works doesn’t mean it can’t be improved’: an ethnographic analysis of the health system in Black Panther’s Wakanda by Jennifer Jackson, Carla Ferreira, Samantha Perry, Carla Ginn, Melissa Scott, Elke Jaibeeh Barah, Zahra Upal, Krista Phelps, Carol Mei, Haneul Woo, Megan Tung, Farida Gadimova, Alexandra Ewanyshyn, Twyla Ens

“…The emergence of COVID-19 (SARS-CoV-2) has introduced significant global challenges for healthcare systems, healthcare professionals and patients. This current climate creates an opportunity to learn from equitable health systems and move toward making fundamental changes to healthcare systems. …”
Get full text

Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…Understanding of the mechanisms underlying productive HEV infection remains incomplete and would benefit from technological advances improving current model systems. Methods: We exploited transposon-mediated random insertion and selection of viable clones to identify sites in the HEV open reading frame 2 (ORF2) protein, corresponding to the viral capsid, allowing for the insertion of reporter sequences in a functional context. …”
Get full text

Opportunities and practices supporting responsive health care for forced migrants: lessons from transnational practice and a mixed-methods systematic review by Amy Robinson, Protus Musotsi, Ziaur Rahman A Khan, Laura Nellums, Bayan Faiq, Kofi Broadhurst, Gisela Renolds, Michael Pritchard, Andrew Smith

“…Conclusion Our study poses important questions around local and national capacity to dismantle some of the structures, institutional behaviours and ideas that affirm the current experience of healthcare contexts for forced migrants. …”
Get full text