From the bakery to the brain business: developing inducible yeast models of human neurodegenerative disorders by Alejandro Ocampo, Antoni Barrientos

“…The models would increase their significance if they were based on continuous and tightly regulated gene expression systems for both activation and levels of expression. …”
Get full text

A theory and analysis of the impact of gas in the dynamical behavior of the molten salt research reactor leading to the computation of the "gas coefficients of reactivity" [version... by Kevin Clarno, Terry Price, Ondrej Chvala

“…Background Molten salt reactors, and other types of circulating, liquid fueled, nuclear reactors contain a certain amount of gas entrained in their liquid nuclear fuel. …”
Get full text

Precolumn Derivatization High-Performance Liquid Chromatography for Determination of Perfluorocarboxylic Acids in Catalytic Degradation Solutions by Liping Yang, Binbin Sun, Haochen Cui, Lingyan Zhu, Guoqiang Shan

“…There are a lot of measurement requests in currently increasing degradation studies of PFCAs, which usually rely on expensive liquid chromatography-mass spectrometry (LC-MS). …”
Get full text

Identification, Cloning, and Expression of L-Amino Acid Oxidase from Marine Pseudoalteromonas sp. B3 by Zhiliang Yu, Ning Zhou, Hua Qiao, Juanping Qiu

“…Several solutions are currently being conducted in our lab to increase its expression level.…”
Get full text

Genetic diversity of the Plasmodium falciparum GTP-cyclohydrolase 1, dihydrofolate reductase and dihydropteroate synthetase genes reveals new insights into sulfadoxine-pyrimethamin... by Anna Turkiewicz, Emilia Manko, Colin J Sutherland, Ernest Diez Benavente, Susana Campino, Taane G Clark

“…Amplifications are more likely to be present in isolates with a greater accumulation of pfdhfr and pfdhps substitutions (median of 1 additional mutations; P<0.00001), and there was evidence that the frequency of pfgch1 variants may be increasing in some African populations, presumably under the pressure of SP for chemoprophylaxis and anti-folate containing antibiotics used for the treatment of bacterial infections. …”
Get full text

Determination of Microbial Properties of Freeze Dried Traditional Cheese by Tuba Büyüksırıt Bedir, Hakan Kuleaşan

“…Various technologies are currently being used for the drying of cheese and efforts are still being made to develop new methods. …”
Get full text

Global Secular Trend of Gonadal Size in Men: Review and Analysis of Publications by A. Yu. Seroukhov, A. A. Afoko, I. E. Mamaev

“…Notwithstanding the general increase in world population, there is a steady decline in birth rate. …”
Get full text

Graded Roll‐to‐Roll Slot Die Coating for High‐Throughput Catalyst Layer Studies by George Pätzold, Maximilian Maier, Lukas Löttert, Anna T. S. Freiberg, Prof. Dr. Simon Thiele, Dr. Dominik Dworschak

“…Many of these systems are based on substrates coated with thin layers containing catalyst, ionomer or support material like carbon. …”
Get full text

Engineered extracellular vesicles for delivering functional Cas9/gRNA to eliminate hepatitis B virus cccDNA and integration by Wanjia Zeng, Liwei Zheng, Yukun Li, Jing Yang, Tianhao Mao, Jing Zhang, Yanna Liu, Jing Ning, Ting Zhang, Hongxin Huang, Xiangmei Chen, Fengmin Lu

“…Our results demonstrated that engineered EVs containing Cas9/gRNA and VSV-G can effectively reduce viral antigens and cccDNA levels in the HBV-replicating and infected cell models. …”
Get full text

Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration by Andjela Sekulic, Sarah M. Herr, Kelly Mulfaul, Inga-Marie Pompös, Silvia Winkler, Carola Dietrich, Benedikt Obermayer, Robert F. Mullins, Thomas Conrad, Peter F. Zipfel, Florian Sennlaub, Christine Skerka, Olaf Strauß

“…Polymorphisms in complement factor-H increase, while absence of factor-H-related protein-1 (FHR1) decreases the AMD risk, currently explained by their opposing relationship. …”
Get full text

Soil Decomposer Can Regulate the Legacy Effect of Photodegradation on Forest Marcescent Litter Decomposition, but Emerging Microplastics Disrupt This by Kai Tian, Xin Wang, Rumeng Ye, Yingqi Wang, Zhicheng Chen, Xiaojing Liu, Wenxia Wang, Lunguang Yao

“…ABSTRACT Photodegradation—photochemical mineralization of standing litters—often exerts a legacy effect aiding biodegradation in soil (PLE), which is overlooked in deciduous forests containing marcescent leaves. Meanwhile, increasing anthropogenic microplastics have deposited in forests, how they would affect the PLE on subsequent litter bio‐decomposition is currently unknown. …”
Get full text

Cytomegalovirus-Specific T Cells from Third-Party Donors Successfully Treated Refractory Cytomegalovirus Retinitis after Unrelated Umbilical Cord Blood Transplantation by Na Li, Guangyu Sun, Lihua Zhu, Kang Ding, Huilan Liu, Xiaoyu Zhu, Baolin Tang, Wen Yao, Xiang Wan, Liangquan Geng, Ping Qiang, Kaidi Song, Changcheng Zheng, Zimin Sun, Juan Tong

“…Umbilical cord blood (UCB) transplants (UCBTs) are becoming increasingly common in the treatment of a variety of hematologic and nonhematologic conditions. …”
Get full text

Evolution of taxis responses in virtual bacteria: non-adaptive dynamics. by Richard A Goldstein, Orkun S Soyer

“…We currently lack a full understanding of the different pathway structures and dynamics and how this integration is achieved. …”
Get full text

Spaciotemporal distribution characteristics of glacial lakes and the factors influencing the Southeast Tibetan Plateau from 1993 to 2023 by Yu Mingwei, Guo Yonggang, Zhang Jian, Li Feng, Su Libin, Qin Deshun

“…However, given the backdrop of a slight increase in precipitation and a gradual increase in temperature, the proliferation of glacial lakes is projected to accelerate predominantly in Nyingchi City’s eastern and western regions.…”
Get full text

Safety of a change of specifications of phytosterols/phytostanols as a novel food pursuant to Regulation (EU) 2015/2283 by EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Monika Neuhäuser‐Berthold, Helle Katrine Knutsen, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Wolfgang Gelbmann, Harry J. McArdle

“…Regarding the maximum limit of the specification parameter ‘other sterols/stanols’, the applicant asks for an increase from currently less than 3% to less than 7% to better reflect and cover the natural composition and proportions of sunflower‐based phytosterols/phytostanols, noting that the existing specifications have been established largely based on the NF when sourced from soy. …”
Get full text

Optimizing enzyme thermostability by combining multiple mutations using protein language model by Jiahao Bian, Pan Tan, Ting Nie, Liang Hong, Guang‐Yu Yang

“…It showed a 10.19°C increase in the melting temperature and an ~655‐fold increase in the half‐life at 58°C. …”
Get full text

Ipomoea batatas (L.) Lam. cultivation in the conditions of light culture in vitro and ex vitro by E. A. Kalashnikova, R. N. Kirakosyan, A. V. Gushchin, K. G. Abubakarov, N. N. Sleptsov, S. K. Temirbekova, A. P. Glinushkin, O. V. Meleshina, N. Ya. Rebouh, M. M. Tareeva

“…Interest in this substance is justified by its valuable properties – it is a good immunomodulator, cleanses the body of toxins, radionuclides, "bad" cholesterol, promotes the assimilation of useful trace elements necessary for human life. Inulin is contained in plants such as jerusalem artichoke, chicory, as well as in sweet potatoes, the popularity of which is increasing every year. …”
Get full text

Clinical and laboratory assessment of the effect of hygiene products on the condition of periodontal tissues and hard tooth tissues in the treatment of caries by indirect method by I. A. Belenova, V. A. Mitronin, Z. A. Filippova, V. I. Khryachkov, M. S. Vasilyeva, N. A. Protsenko

“…According to statistics, the widespread use in modern dental practice of indirect restoration methods in the treatment of caries of the frontal group of teeth leads to an increase in the incidence of marginal periodontal disease. …”
Get full text

How do patients, medical assistants and physicians accept and experience tablet-based cognitive testing by medical assistants in general practice? - A qualitative study by Kristin Rolke, Carolin Rosendahl, Klaus Weckbecker, Alexander Hanke, Michael Wagner, Leon Nissen, Lara Marie Reimer, Stephan Jonas, Philipp Schaper, Jochen René Thyrian, Florian Schweizer, Judith Tillmann

“…Abstract Background Approximately 1.8 million people with dementia live in Germany and the number is expected to increase in the coming years. Between 360,000 and 440,000 new cases are diagnosed each year. …”
Get full text

Perceptions of family physicians in Istanbul about e-cigarettes as smoking cessation aids: a qualitative study by Melis Selamoglu, Ayse Emel Onal, Bircan Erbas, Selma Karabey, Meryem Merve Oren, Mahmut Talha Ucar, Chris Barton

“…Abstract Background Family physicians (FPs) are the first point of contact for people who smoke who are seeking to quit smoking in Türkiye. …”
Get full text