Scientific and Regulatory Lessons Learnt on Building a Chemistry, Manufacturing, and Controls (CMC) Package for COVID-19 Variant Vaccine Updates in the EU—A Regulator’s Perspective... by Ragini Shivji, Elena Grabski, Veronika Jekerle

“…The pace at which variants emerge challenges the technical feasibility to make adapted vaccines available in a suitable timeframe and in sufficient quantities. Despite the current absence of a clear-cut seasonal spread for COVID-19, the EU regulatory approach thus far is a pragmatic approach following a pathway similar to that of seasonal influenza. …”
Get full text

Phylogenetic Groups and Antimicrobial Resistance among Uropathogenic Escherichia coli Isolates from Hospitalized Patients in Tehran by Mana Talebi Farahani, Mohammad Karim Rahimi, Mehdi Goudarzi

“…Background: The presence of Escherichia coli among uropathogens is increasing significantly worldwide. It accounts for a considerable amount of morbidity and high medical costs and also can lead to mortality. …”
Get full text

IoT Device Identification Techniques: A Comparative Analysis for Security Practitioners by Ashley Andrews, George Oikonomou, Simon Armour, Paul Thomas, Thomas Cattermole

“…As the Internet of Things (IoT) continues to grow, networks are increasingly at risk from vulnerable devices that allow access to attackers. …”
Get full text

N-Acetyl-cysteine and Mechanisms Involved in Resolution of Chronic Wound Biofilm by Xin Li, Jane Kim, Jiabin Wu, Alaa’ I Ahamed, Yinsheng Wang, Manuela Martins-Green

“…Chronic wounds are a major global health problem with the presence of biofilm significantly contributing to wound chronicity. Current treatments are ineffective in resolving biofilm and simultaneously killing the bacteria; therefore, effective biofilm-resolving drugs are needed. …”
Get full text

Policies and guidelines supporting the sustainability of human milk donation to milk banks in Switzerland: a document analysis by Christelle Kaech, Tracy Humphrey, Catherine Kilgour, Céline Julie Fischer Fumeaux, Claire de Labrusse

“…Globally, despite an increasing number of human milk banks, the demand for donor milk exceeds the supply, and access remains inequitable and insufficient. …”
Get full text

Non-linear oral bioavailability and clinical pharmacokinetics of high-dose Andrographis paniculata ethanolic extract: relevant dosage implications for COVID-19 treatment by Phanit Songvut, Jaratluck Akanimanee, Tawit Suriyo, Nanthanit Pholphana, Nuchanart Rangkadilok, Duangchit Panomvana, Porranee Puranajoti, Jutamaad Satayavivad

“…These findings suggest that current extraction process of ethanolic extract may hinder its effectiveness. …”
Get full text

Stability and change in latent movement behaviour profiles during adolescence and links with future depressive symptoms by Christopher Knowles, Gavin Breslin, Angela Carlin, Kyle Paradis, Stephen Shannon

“…Transition patterns containing a period of minimal movement predicted worse depressive symptoms at ages 18 and 22. …”
Get full text

Copper homeostasis and neurodegenerative diseases by Yuanyuan Wang, Daidi Li, Kaifei Xu, Guoqing Wang, Feng Zhang

“…Copper is a potent oxidant that increases reactive oxygen species production and promotes oxidative stress. …”
Get full text

US Deterrence against Russia and China (based on strategic documents of J. Biden administration) by V. I. Batyuk

“…A closer examination of key strategic documents published in recent years shows that if from a political and military point of view, the US strategists come up with a generally rational list of measures aimed at countering the challenge, posed by Russia and China, from an ideological point of view they doggedly follow liberal-hegemonic premises that are increasingly inconsistent with current international political realities. …”
Get full text

TIM-3 teams up with PD-1 in cancer immunotherapy: mechanisms and perspectives by Zhuohong Yan, Chunmao Wang, Jinghong Wu, Jinghui Wang, Teng Ma

“…Among these candidates, T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is considered a promising target. …”
Get full text

Spatio-temporal changes of water quality variables in a highly disturbed river by Z. Abdollahi, A. Kavian, S.H.R. Sadeghi

“…Many rivers in developing countries are unhealthy because they contain harmful physical, chemical and biological agents. …”
Get full text

Brownian motion effects and thermophoresis on heat transmission mechanism of hybrid nano liquid flow over a stretched wedge surface by Sharanayya Swami, Suresh Biradar, Jagadish V Tawade, Vediyappan Govindan, Haewon Byeon, Busayamas Pimpunchat

“…The current study observes the impact of thermophoresis, Brownian motion, and magnetic fields on the flow and heat transfer properties of a hybrid nanofluid containing Al2O3, CuO, and ethylene glycol over a wedge-shaped surface undergoing horizontal stretching. …”
Get full text

Descriptive, analytical and molecular epidemiology of pancreatic cancer by O. V. Shangina, D. M. Maximovich, D. G. Zaridze

“…The purpose of the study was to present current data on the role of lifestyle and heredity factors in the etiology of pancreatic cancer (PC). …”
Get full text

Identification of widely conserved biosynthetic gene cluster involved in pigment production of Bacillus subtilis by Rune Overlund Stannius, Christopher A. Dunlap, Estelle Morvan, Mélanie Berbon, Sophie Lecomte, Antoine Loquet, Ákos T. Kovács

“…This study describes the chemical and biological features of a new class of SM BGC, which we hope will serve to improve the current BGC discovery pipelines in Bacilli.IMPORTANCEIdentification of novel microbial secondary metabolites (SMs) and their biosynthetic gene cluster (BGC) has become increasingly difficult, especially in Bacilli, as the tools for screening and genome mining are dependent on clear function or similarity to already known BGCs. …”
Get full text

A Systematic Review Examining the Association of Falls With Diabetes‐Related Foot Ulcers by Mike Wu, Mallika Sinha, Chanika Alahakoon, Kristen S. Barratt, Shivshankar Thanigaimani, Jonathan Golledge

“…A meta‐analysis showed high heterogeneity between studies (I2 = 95%) and an increased risk of falls in people with DFU (risk ratio 2.25 and 95% CI 1.05–4.84). …”
Get full text

Potato Peels as an Adsorbent for Heavy Metals from Aqueous Solutions: Eco-Structuring of a Green Adsorbent Operating Plackett–Burman Design by Marwa El-Azazy, Ahmed S. El-Shafie, Ahmed A. Issa, Maetha Al-Sulaiti, Jawaher Al-Yafie, Basem Shomar, Khalid Al-Saad

“…Treatment of wastewater is becoming a concern of an increasing prominence. Trace amounts of toxic metalloids and heavy metals (HMs) would contaminate large volumes of water. …”
Get full text

Changes in the structure and properties of graphene oxide surfaces during reduction and modification by M. T. Kartel, K. V. Voitko, Y. Grebelna, S. V. Zhuravskyi, K. Ivanenko, T. V. Kulyk, S. M. Makhno, Yu. I. Sementsov

“… The aim of the current study was to find changes in the structure and state of the surface of graphene oxide (GO) under the conditions of its reduction and modification by hetero atoms of nitrogen and amino acids. …”
Get full text

Enhancing road safety of PLEVs by novel vehicle concepts: A comprehensive investigation on regulations, accident statistics, and perception of riders in Europe by Michelangelo-Santo Gulino, Susanna Papini, Giovanni Zonfrillo, Peter Miklis, Thomas Unger, Dario Vangi

“…The rise of Personal Light Electric Vehicles (PLEVs), including electric bicycles and electric kick scooters, represents a relevant trend in current urban mobility. PLEVs offer economic, social, and environmental advantages, making them increasingly attractive for short-distance travel. …”
Get full text

Effects of Dynamic Agrivoltaics on Containerized Raspberry Plants: Results of the First Season by Perrine Juillion, Candice Tranchant, Kaoutar Nadi, Jimmy Noel, Benoit Valle, Jérôme Chopard, Gerardo Lopez, Camille Crevat, Xavier Bunker, Damien Fumey

“…The protection from the DAV reduced mean air temperature by 1.8°C and increased mean relative humidity by 7.3% in comparison to the CTL. …”
Get full text

Mobile-Based Women’s Sexual Health Education Application: Providing a Content Model by Maryam Jahanbakhsh, Mahnaz Noroozi, Majid Jangi, Fateme Ghadiri Kofrani

“…The evidence suggests that mobile phone-based applications can be a suitable tool to improve education in the field of sexual health. Therefore, in the current research, the design of the content model of the mobile phone-based application with an emphasis on diseases transmitted through sexual contact and functional disorders of women has been discussed. …”
Get full text