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The prognostic value of serum apolipoprotein A1 levels in elderly patients with de novo SARS-CoV-2 omicron infection
Published 2025-07-01“…Additionally, we observed a significant increase in C-reactive protein (CRP) and beta-2 microglobulin (β2-MG) levels in individuals with decreased ApoA1 levels. …”
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242
Cervical ripening at home or in hospital during induction of labour: the CHOICE prospective cohort study, process evaluation and economic analysis
Published 2024-12-01“…However, there was substantial uncertainty with the adjusted analysis consistent with a 74% decrease in the risk through to an 81% increase. qCHOICE Important aspects of service users’ experience of home cervical ripening were quality of information provided, support and perception of genuine choice. …”
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243
What do we know about digital public debate? Technological affordances and democratic dilemmas
Published 2025-06-01“…We illustrate the resulting six types of participation through a review of empirical studies based in the Nordic context. We summarise what we currently know about digital public debate in a key democratic dilemma: increasing digital participation goes hand in hand with decreasing institutional trust.…”
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244
ChatGPT's perspectives on real numbers, straight lines, and probability—A quantitative study on the influence of prompting
Published 2025-07-01“…The use of appropriate prompts can significantly increase or decrease the occurrence of perspectives. …”
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245
Impaired plasma membrane calcium ATPase activity and mitochondrial dysfunction contribute to calcium dysregulation in Fabry disease-related painful neuropathy
Published 2025-09-01“…The obtained results suggest that other transport proteins participate in Ca2+ homeostasis in FD and their dysfunction may be directly involved in nociception. In this context, plasma-membrane Ca2+ ATPases exhibited reduced activity in FD, leading to an increased resting [Ca2+]i in sensory neurons. …”
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246
Wildlife law and policy
Published 2012-11-01“…Van Gossum et al. (2010) developed the RAA by merging current smart regulation theory with the policy arrangement approach and the policy learning concept. …”
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247
Large Language Model Applications for Health Information Extraction in Oncology: Scoping Review
Published 2025-03-01“…Comparing the studies published in 2022‐2024 versus 2019‐2021, both the total number of studies (18 vs 6) and the proportion of studies using prompt engineering increased (5/18, 28% vs 0/6, 0%), while the proportion using fine-tuning decreased (8/18, 44.4% vs 6/6, 100%). …”
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248
Consequences, costs and cost-effectiveness of workforce configurations in English acute hospitals
Published 2025-07-01“…These findings lend support to policy initiatives aimed at increasing the supply of RNs. Study registration This study is registered as Current Controlled Trials ClinicalTrials.gov NCT04374812. …”
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249
Evaluation of Urban Composite Carbon Sink Value: A Case Study of Shenyang
Published 2025-01-01“…The proportion of carbon sink value contributed by vegetation and soil decreased from 43.61% and 46.15% in 2003 to 34.70% and 36.62% respectively, whereas the proportion contributed by buildings increased from 10.24% to 28.70%.ConclusionThe important contribution of urban space to carbon sinks in terrestrial ecosystems should not be ignored. …”
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250
GBD: incidence rates and prevalence of anxiety disorders, depression and schizophrenia in countries with different SDI levels, 1990–2021
Published 2025-05-01“…Data were categorized into 5-year age groups and 95% uncertainty intervals (UI) were calculated to account for data variability.ResultsIn countries with different SDI levels, the age-standardized average annual percentage change (AAPC) in the incidence of anxiety were all shown to be increasing, and there were large gender differences between the different SDI levels, with a maximum of 0.97 (0.76–1.18) for females in countries with a high SDI level, Age-standardized more rates per 100,000 people in high SDI countries, from 658.87 in 1990 to 841.56 in 2021, and the largest gender differences in countries with a low to moderate SDI level, with AAPCs for males and females of 0.04 (0.04–0.05), 0.86 (0.63–1.09); for depression, only the countries with medium-high SDI levels were statistically significant compared to the countries with medium-low SDI levels, with AAPCs of 0.05 (0.04–0.07), 0.04 (0.04–0.05); for schizophrenia in addition to the AAPCs of the countries with medium-high SDI levels showed an increase of 0.16 (0.13–0.18); the rest decreased.ConclusionThis study highlights the current status of global incidence and prevalence of mental disorders and examines the complex interactions between the period of onset and cohort of onset of mental disorders using APC modeling, with differences in gender differences in mental disorders in countries with different SDIs, and significant differences in countries with low to medium SDI levels, requiring further exploration of the mechanisms by which socio-economic development influences gender-specific mental health. …”
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251
高敏感特質中高齡學習者面對數位學習壓力及疫情焦慮之學習滿意度與後疫情調適:復原力之中介效果 Learning Satisfaction and Post-Pandemic Adaptation in Highly Sensitive Middle-aged and Elderly Learners in the Face of Digital Learni...
Published 2025-03-01“…In 2020, due to the COVID-19 pandemic, the number of people suffering from depression increased by 25.6% globally (Santomauro et al., 2021). …”
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252
Anatomic and mechanical considerations in restoring volume of the face with use of hyaluronic acid fillers with a novel layered technique
Published 2014-01-01“…Context: Facial fillers have revolutionized the field of cosmetic facial rejuvenation as it has become the prime sought - after rejuvenation procedure offering youthful, 3-dimensional look with minimal invasiveness. …”
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253
Coordinated regulation of timing and strength of synaptic outputs by adrenergic receptors through control of action potentials in Purkinje cells
Published 2025-07-01“…We demonstrate that Purkinje cell axons exhibit negative control of action potentials in amplitude and conduction velocity by β-adrenergic receptors in a manner dependent on the axonal length through specific reduction of axonal Na+ currents. On the other hand, β-adrenergic receptors increased presynaptic release probability without changing the amount of readily releasable vesicles in axon terminals of Purkinje cells. …”
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254
Circle of Security - Parenting: A Systematic review on Effectiveness of use of the parent training program within Multi-problem Families
Published 2021-01-01“…Introduction: Circle of Security-parenting (COS-p) is a simplified, relationship-based programme with the intention of developing parents’ observation and inferential skills related to understanding their child’s needs, increasing sensitivity to their child, aiding in emotional regulation, as well as decreasing any of their negative attributions to their child. …”
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255
MHD analysis of couple stress nanofluid through a tapered non-uniform channel with porous media and slip-convective boundary effects
Published 2025-05-01“…Moreover, the synergistic effects of thermophoresis and Brownian motion result in a substantial elevation of fluid temperature, enhancing thermal energy transfer throughout the system. Increasing wall slip parameter diminishes the friction between the fluid and the channel walls, facilitating smoother fluid flow and decreasing thermal resistance. …”
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256
Genotypes and spatial configurations of public art museums in Japan
Published 2025-07-01“…The social role of museums has continued to shift according to evolving social, economic, and cultural contexts. The transition from a single exhibition educational role to a more diversified role presents challenges in terms of the spatial configuration of museums, thereby highlighting areas for broadening the current understanding of spatial layouts. …”
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257
International Labor Migration and Its Transformative Effects on Political Landscapes Across Central Asian Nations
Published 2025-07-01“…This study concludes that any reduction in migratory activities, decreased inflows of remittance funds, or diminished organic inclination toward closer ties among migrants would result in both increased political volatility within Central Asia and weakened Russian leverage over the area.…”
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258
Molecular mechanisms underlying Tao-Hong-Si-Wu decoction treating hyperpigmentation based on network pharmacology, Mendelian randomization analysis, and experimental verification
Published 2024-12-01“…Context Hyperpigmentation, a common skin condition marked by excessive melanin production, currently has limited effective treatment options.Objective This study explores the effects of Tao-Hong-Si-Wu decoction (THSWD) on hyperpigmentation and to elucidate the underlying mechanisms.Materials and methods We employed network pharmacology, Mendelian randomization, and molecular docking to identify THSWD’s hub targets and mechanisms against hyperpigmentation. …”
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259
Neutrophil-to-Lymphocyte ratio as surrogate for JAK2V617F suppression and event-free survival in polycythemia vera
Published 2025-08-01“…Abstract Chronic systemic inflammation is a key driver of polycythemia vera (PV) progression, but the immunomodulatory effects of current treatments remain poorly defined. The neutrophil-to-lymphocyte ratio (NLR) is an accessible biomarker of systemic inflammation proven in other contexts, but its role in monitoring PV disease activity has not been established. …”
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260
Unveiling biomarkers via plasma metabolome profiling for diabetic macrovascular and microvascular complications
Published 2025-08-01“…As for reverse MR, DN was relevant to decreased level of serum ratio of docosahexaenoic acid to total fatty acids (OR = 0.97, 95% CI 0.95–0.99, P = 0.019), increased level of the ratio of triglycerides to total lipids in very large VLDL (OR = 1.03, 95% CI 1.01–1.05, P = 0.019), and pyruvate (OR = 1.03, 95% CI 1.01–1.05, P = 0.046). …”
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