Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and <i>Trypanosoma cruzi</... by Gabriela Alves de Souza, Lorrane de Souza Chaves, Afonso Santine M. M. Velez, Jorge Lucas F. Lacerda, Paulo Pitasse-Santos, Jayane Clys Conceição dos Santos, Otávio Augusto Chaves, Carlos Serpa, Raphael do Carmo Valente, Leonardo Marques da Fonseca, Marcos André Rodrigues da Costa Santos, Jhenifer Santos dos Reis, Carlos Antônio do Nascimento Santos, Lucia Mendonça-Previato, Jose Osvaldo Previato, Celio Geraldo Freire-de-Lima, Debora Decoté-Ricardo, Leonardo Freire-de-Lima, Marco Edilson Freire de Lima

“…<b>Background: </b>Anticancer therapies represent the primary treatment option for a significant number of cancer patients globally; however, many of these treatments are associated with severe side effects as they target molecular structures present in both cancerous and healthy cells. In a similar context, the treatment of Chagas disease, a neglected tropical illness, is hindered by the high toxicity of the currently available drugs. …”
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Understanding data and information needs for palliative cancer care to inform digital health intervention development in Nigeria, Uganda and Zimbabwe: protocol for a multicountry q... by Richard Harding, Bassey Ebenso, Adlight Dandadzi, Eve Namisango, Kehinde Okunade, Kennedy Bashan Nkhoma, Omolola Salako, David Akeju, Olaitan Soyannwo, Elizabeth Namukwaya, Elizabeth Nabirye, Lovemore Mupaza, Emmanuel Luyirika, Henry Ddungu, Z Mike Chirenje, Michael I Bennett, Matthew J Allsop

“…However, there is currently a lack of any theoretical underpinning or data to understand stakeholder drivers for digital health components in this context. …”
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Epigenetic therapeutics to overcome resistance against immune checkpoint inhibitors (ICI) in hepatocellular carcinoma (HCC): a proof-of-concept clinical trial by Stephen Chan, Alfred Cheng, Nick La Thangue, David Kerr

“…However, resistance to ICI is increasingly encountered in clinical practice in HCC patients. …”
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Novel Nanozyme-Based Multicomponent in situ Hydrogels with Antibacterial, Hypoxia-Relieving and Proliferative Properties for Promoting Gastrostomy Tube Tract Maturation by Xiao F, Yan B, Yuan T, He Y, Zhang X, He X, Peng W, Xu Y, Cao J

“…The antibacterial efficiency of the MO-HPA1.0 group on E. coli and S. aureus increased by about 40.1% and 55.6% respectively, compared to the MO-HPA0.5 group. …”
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Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway by Xiao Li, Mengna Cui, Long Xu, Qie Guo

“…ObjectiveSorafenib, a multikinase inhibitor, is currently the standard treatment for advanced liver cancer. …”
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A Comparative Study of the Extraction Methods for the Simultaneous Detection of NPS Groups from Urine by M. Kuloglu Genc, S. Mercan, C. Bulut, Z. Turkmen

“…A total of 1,127 NPS have been reported worldwide as of 2022. The increasing chemical diversity and unprecedented substance numbers of NPS make this phenomenon even more difficult to detect, monitor and understand analytically. …”
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An in-depth understanding of stakeholders’ experiences about their participation in the co-production of ‘Maze Out’: a serious game for the treatment of eating disorders by Maria Mercedes Guala, Aida Bikic, Kim Bul, David Clinton, Anette Søgaard Nielsen, Helene Nygaard Nielsen, Martina Scarpelli, Luciana Schneider, Regina Christiansen

“…Abstract Background Co-production is increasingly used in mental health research and clinical settings. …”
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Trade-Off Between Growth Regimes in <i>Chlorella vulgaris</i>: Impact on Carotenoid Production by Patrícia Acosta Caetano, Pricila Pinheiro Nass, Mariany Costa Deprá, Tatiele Casagrande do Nascimento, Eduardo Jacob-Lopes, Leila Queiroz Zepka

“…With the increasing awareness of socio-environmental issues, a global trend has emerged emphasizing the valorization of natural ingredients that promote health and well-being within sustainable production systems, such as microalgae-based carotenoids. …”
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Factors Related to Health Resilience in Students Affected by Disaster at Campus Graha Ananda Palu by Sadli Syam, Muhammad Sabri Syahrir, Muhammad Aji Satria, Iin Irawati

“…Follow stages disaster in Palu City, when these are the people affected disaster in Palu City now currently in phase recovery going to resilience, namely restore normal condition and strengthen Power stand public to disaster. …”
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Methods for the health technology assessment of complex interventions: a protocol for a scoping review by Tracy Merlin, Abdolvahab Baghbanian, Drew Carter, Shuhong Wang

“…Introduction In healthcare policy and economic literature, research on the health technology assessment (HTA) of complex interventions (CIs) is becoming increasingly important. In many developed countries, HTA guides decision-making to help achieve greater value for money when funding health care. …”
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Fuel cell technologies in the automotive sector: A focus on proton exchange membrane and Alkaline fuel cells by Vijay Bhooshan Kumar, Aakash Collin, M. Gopi Sankar, Kanakasabapathi Subramanian

“…The automotive industry currently relies heavily on internal combustion engine (ICE) technology, which consumes large amounts of fossil fuels and significantly contributes to global environmental degradation and the ongoing energy crisis. …”
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Implementation of a community-based LC-UV drug checking service: promising preliminary findings on feasibility and validity by Nicolas Fabresse, Eurydice Papias, Alma Heckenroth, Victor Martin, Daniel Allemann, Perrine Roux

“…Abstract Background The increasing diversity of psychoactive substances on the unregulated drug market poses significant health, psychological, and social risks to people who use drugs (PWUD). …”
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Expanding a primary care nurse practitioner fellowship to support rural and underserved pediatric patients in the US by Aaron Carpenter, Catherine Haut, Sarah Wawrzynski, Stacey Bachman, Lisa Kelly

“… Context: A significant shortage of primary care and mental healthcare providers currently exists in the US and is predicted to worsen, emphasizing the imperative for mental health training and collaboration within primary care settings, especially in rural and underserved areas. …”
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Epidemiology of Horsepox. The New Aspects by L. F. Stovba, A. A. Petrov, S. A. Melnikov, O. V. Chukhralia, N. K. Cherniкova, S. V. Borisevich

“…Although horsepox is currently considered extinct, its pathogen may persist in unknown reservoirs. …”
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Ductus Venosus Agenesis in Monochorionic Twin Pregnancies Complicated by Fetal Growth Restriction: When to Deliver? by Eleonora Torcia, Alessandra Familiari, Elvira Passananti, Giulia di Marco, Federica Romanzi, Mariarita Trapani, Daniela Visconti, Antonio Lanzone, Elisa Bevilacqua

“…Fetuses with ADV are at increased risk for congenital cardiac disease, heart failure, and fetal growth restriction (FGR). …”
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Medical embryology and regenerative medicine: research and applications in clinical practice by Julia Soczyńska, Julia Soczyńska, Wiktor Gawełczyk, Wiktor Gawełczyk, Patrycja Obrycka, Patrycja Obrycka, Mateusz Żołyniak, Mateusz Żołyniak, Adrian Muzyka, Adrian Muzyka, Krzysztof Majcherczyk, Krzysztof Majcherczyk, Julia Papierkowska, Julia Papierkowska, Sławomir Woźniak

“…Taking this progress a step further, the ability to introduce stem cells into damaged tissues, thereby facilitating the formation of functional structures, has led to the growing interest in organoids -three-dimensional models that replicate key functions of real organs. Organoids are currently applied not only in drug screening but are also gaining increasing attention for their role in cancer therapy research. …”
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Toxicity of ivermectin to bed bugs (Cimex hemipterus) and risk factors associated with infestation in Kwale County, coastal Kenya by Tobias Odongo, Isaiah Omondi, Caroline Wanjiku, Miguel Okoko, Caroline Kiuru, Mercy Kariuki, Isaac Ringera, Bruno Otieno, Festus Mure, Joanna Furnival-Adams, Almudena Sanz Gutierrez, Rachel Otuko, Nelly Regina Rabinovich, Joseph Mwangangi, Carlos Chaccour, Marta Ferreira Maia

“…Ivermectin, an endectocide known to impact various neglected tropical diseases and hematophagous arthropods, is currently being assessed for malaria vector control. …”
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A collaborative approach to advancing research and training in Public Health Data Science—challenges, opportunities, and lessons learnt by Elisha Abade, Wondwossen Mulugeta, Idah Orowe, Getachew Hailemariam, Patrick Weke, Rahel Bekele, Isabelle Zaugg, Jeff Goldsmith, Tiffany Sanchez, Kiros Berhane

“…However, there is a severe lack of well-trained data scientists and home-grown educational programs to enable context-specific training. The lack of human capacity and resources for public health data analysis as well as the dire need to use modern technology for better understanding and possible intervention cannot be dealt with currently available educational programs and computing infrastructure, demanding a great deal of collaboration and investments within Africa and with the Global North This paper describes processes undertaken to establish sustainable research training programs and to train a new generation of data scientists with knowledge, mentoring, professional skills, and research immersion. …”
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Hermetia illucens oil vs. hydrogenated palm fat in dairy cow nutrition: effects on digestive parameters, oxidative stress, and milk production performance by Lara Rastello, Laura Gasco, Mauro Coppa, Mathieu Gerbelle, Stefania Colombini, Marco Battelli, Paola Badino, Luca Vernetti-Prot, Pablo G. Toral, Alberto Brugiapaglia, Giulia Gardini, Vanda Malfatto, Isabelle Constant, Alessandro Galli, Christophe Trespeuch, Manuela Renna

“…Abstract Background Scant information is currently available on the use of insect oils in ruminant diets. …”
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Analysis of the influence of the microbial load of poultry facilities on the development of keel “mins” in turkeys by R. I. Fedyniak, R. A. Peleno

“…Instead, an imbalance can lead to the development of specific pathologies in the bird. Currently, in the conditions of industrial poultry farming, studying the influence of the microbial environment of poultry houses on the health and development of birds is a relevant and important topic of scientific research. …”
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