Impaired plasma membrane calcium ATPase activity and mitochondrial dysfunction contribute to calcium dysregulation in Fabry disease-related painful neuropathy by Francesco Formaggio, Asia Pizzi, Cecilia Delprete, Davide Pasqualini, Isabella Mataloni, Roberto Rimondini, Ludovica Campolongo, Vincenzo Donadio, Anna Maria Ghelli, Rocco Liguori, Marco Caprini

“…The reduced activity was associated with a decrease of cytosolic pH which weakened the PMCA-dependent calcium extrusion. …”
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Flow and mixing of elongated particles in rotating drums of different sizes by Jinhua Song, Numan Naeem, Hu Fan, Guanhua Li, Maosong Li, Yu Guo, Jianzhong Lin, Jianzhong Lin, Jinxin Tie

“…For both monodisperse and binary particle systems, dynamic angle of repose is determined mainly by a Froude number Fr, measuring the ratio of centrifugal force to gravitational force on a particle, while it is insensitive to scale-up ratio α, defined as the ratio of cross-sectional areas of the current drum to the reference one. Average particle velocity and contact force generally increase with both Froude number and scale-up ratio. …”
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An Agent-Based Simulation and Optimization Approach for Sustainable Urban Logistics: A Case Study in Lisbon by Renan Paula Ramos Moreno, Rui Borges Lopes, Ana Luísa Ramos, José Vasconcelos Ferreira, Diogo Correia, Igor Eduardo Santos de Melo

“…This study examines the PDP-TW in an urban logistics context using an integrated approach that combines an agent-based simulation model and an optimization model. …”
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IAE-CDNet: A Remote Sensing Change Detection Network for Buildings With Interactive Attention-Enhanced by Zhaoyang Han, Linlin Zhang, Qingyan Meng, Chongchang Wang, Wenxu Shi, Maofan Zhao

“…Currently, the development of deep learning has had a positive impact on remote sensing image change detection tasks, but many current methods still face challenges in effectively processing global and local features, especially in the task of building change detection in high-resolution images containing complex scenes. …”
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What happens between first symptoms and first acute exacerbation of COPD – observational study of routine data and patient survey by Alex Bottle, Alex Adamson, Xiubin Zhang, Benedict Hayhoe, Jennifer K Quint

“…Most patients were offered the flu jab. Older patients, current smokers and those with other conditions such as heart failure had higher risk of an acute exacerbation. …”
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Effects of ultrasonic vibration on residual stress distribution and local mechanical properties of AA6061/Ti6Al4V dissimilar joints by resistance spot welding by Mohan He, Qian Wang, Yingjun He, Jinxiang Wang, Ninshu Ma, Yuanxun Wang

“…The maximum load of welding nugget region increased from 19.6 N to 22.3 N, and the elongation obtained 10% increase. …”
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Variation and prognostic potential of the gut antibiotic resistome in the FINRISK 2002 cohort by Katariina Pärnänen, Matti O. Ruuskanen, Guilhem Sommeria-Klein, Ville Laitinen, Pyry Kantanen, Guillaume Méric, Camila Gazolla Volpiano, Michael Inouye, Rob Knight, Veikko Salomaa, Aki S. Havulinna, Teemu Niiranen, Leo Lahti

“…Resistance was linked not only to prior use of antibiotics, as anticipated, but also to frequent consumption of fresh vegetables and poultry, two food groups previously reported to contain antibiotic-resistant bacteria. Interestingly, resistance was not linked to the consumption of high-fat and high-sugar foods, but was consistently higher in females and urban high-income individuals, who currently have generally lower mortality rates. …”
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Synthesis, structure, and visible-light-driven activity of o-YbFeO3/h-YbFeO3/CeO2 photocatalysts by Sofia M. Tikhanova, Lev A. Lebedev, Svetlana A. Kirillova, Maria V. Tomkovich, Vadim I. Popkov

“…It was found that nanocrystalline components were chemically and phase-pure, uniformly spatially distributed over the nanocomposite, and had multiple contacts with each other. Based on this fact and the established electronic structure of the nanocomposite components, the formation of I-type heterojunction with the participation of o-YbFeO3 (Eg = 2.15 eV), h-YbFeO3 (Eg = 2.08 eV), and CeO2 (Eg = 2.38 eV) was shown, the presence of which increased photocatalytic activity of the resulting nanocomposite. …”
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Mapping evidence of spinal manipulation therapy for headaches in South Africa: a scoping review of grey literature by Keseri Padayachy, Ismail Fatima, Morris Kahere, Alister du Rose, Katherine A. Pohlman

“…Abstract Objective Spinal manipulative therapy (SMT) has been demonstrated to be an effective management approach for primary headaches; however, current literature often excludes data from South Africa (SA). …”
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Cost-utility of aripiprazole once-monthly versus paliperidone palmitate once-monthly injectable for schizophrenia in China. by Yiping An, Gang Fang, Zhipeng Pi, Yumeng Zhang, Wei Li, Jinxi Ding

“…A cost-effectiveness threshold (CET) of 0.51 times China's 2023 gross domestic product (GDP) (US$ 6,394.536) was used to judge the economics of intervention.<h4>Results</h4>The current price of AOM in China is relatively high (US$418.140). …”
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“They tossed me up like a ball”: informal settlement residents’ experiences in accessing healthcare in Kampala, Uganda by Julia Dickson-Gomez, Kirsten Beyer, Arthur Kiconco, Ronald Anguzu, Agnes Nyabigambo

“…The focus group interviews indicated that private healthcare systems have created incentives to draw resources away from already depleted public healthcare systems, further decreasing access to the most vulnerable. Conclusions Our study reveals important and substantial gaps in the current healthcare system in Uganda. …”
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Comparison of Bone Mineral Density in Lumbar Spine and Fracture Rate among Eight Drugs in Treatments of Osteoporosis in Men: A Network Meta-Analysis. by Ling-Xiao Chen, Zhi-Rui Zhou, Yu-Lin Li, Guang-Zhi Ning, Tian-Song Zhang, Di Zhang, Shi-Qing Feng

“…<h4>Context</h4>The preferred treatment for osteoporosis in men is debated, and pairwise meta-analysis cannot obtain hierarchies of these treatments.…”
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Analysis of Adaptation of Students Studying under the Flipped Classroom Model to the Conditions of Distance Learning by G. R. Chaynikova

“…At the same time, it is necessary to keep in mind the importance of pedagogical support in the context of e-learning.…”
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Insulin Modulates NK Cell Activity in Liver Fibrosis MASH Patients via the STING Pathway by Johnny Amer, Ahmad Salhab, Amiram Ariel, Rifaat Safadi

“…While STING is well-established in various immune cells, its role in natural killer (NK) cells, particularly within the context of liver fibrosis, remains inadequately explored. …”
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Establishing priorities for future land conservation to maximise biodiversity conservation and other ecosystem services in the Tilarán Mountains of Costa Rica by Lindsay Stallcup, Matthew D. Moran, Doris Rojas, Erich Mata

“…The opportunity to connect currently protected areas to one another through effective biological corridors still remains, possibly through conservation partnerships with landowners or direct land purchase, but time could be short as increasing development and changing land-use patterns threaten to further isolate habitats in the MAB.…”
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Exposure to secondhand smoke from cigarettes and secondhand aerosol from tobacco and nicotine products in indoor and outdoor public spaces in the European Union: a cross-sectional... by Anthony A Laverty, Ariadna Feliu, Filippos T Filippidis, Constantine I Vardavas, Cristina Martínez, Charis Girvalaki, Armando Peruga, Charlotte Xin Li, Pin-Chun Wang, Cornel Radu Loghin

“…Introduction In December 2024, the Council of the European Union (EU) adopted a recommendation to expand regulations on the use of nicotine-containing products both in indoor settings and specific outdoor areas. …”
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Effect of temperature on corrosion behaviors of copper in high-level nuclear waste disposal environment by Tianyu Wang, Chengtao Li, Lijun Song, Xiang Cai, Jian Chen, Zhilin Chen, Qichao Zhang, Yishan Jiang, Yanxin Qiao

“…The results showed that the increase in temperature can accelerate both cathodic and anodic reactions, thereby increasing the corrosion current density. …”
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Standalone ultrasound-based highly visualized volumetric spine imaging for surgical navigation by Xinben Hu, Tianjian Liu, Zhengyuan Zhang, Xuan Xiao, Lin Chen, Gao Wei, Yunjiang Wang, Keji Yang, Haoran Jin, Yongjian Zhu

“…Abstract Current navigation systems employing intraoperative CT have been applied in spinal interventions for accurate and visualized guidance. …”
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Screen-printed Carbon Electrode from Coconut Shell Activated Carbon Modified with Ferrocene for Cobalt Detection by Muhammad Farhan, Eddy Heraldy, Abu Masykur, Muhammad A. Munir, Fitria Rahmawati

“…The cyclic voltammetry analysis found that 10% Fc on SPCE provides the highest current density compared to 20% and 30%. Meanwhile, the 2 mV s-1 scanning rate reveals a more defined anodic and cathodic peak than 3 mV s-1 and 5 mV s‑1. …”
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Genetic Diversity and Mutation Frequency Databases in Ethnic Populations: Systematic Review by Shumaila Khan, Mahmood Alam, Iqbal Qasim, Shahnaz Khan, Wahab Khan, Orken Mamyrbayev, Ainur Akhmediyarova, Nurzhan Mukazhanov, Zhibek Alibiyeva

“…The review also addressed standardization and data quality challenges prevalent in current NEMDBs. ResultsThe analysis of 42 NEMDBs revealed significant issues, with 70% (29/42) lacking standardized data formats and 60% (25/42) having notable gaps in the cross-comparison of genetic variations, and 50% (21/42) of the databases contained incomplete or outdated data, limiting their clinical utility. …”
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