P22 | EXPLORING THE UNEXPECTED DUAL ROLE OF GARLIC DERIVATIVES IN REGULATING INVASIVENESS IN BREAST CANCER SUBTYPES

“…Interestingly, in TNBC cells we found a selective molecular subtype-dependent decrease of the invasive potential3, while a dual effect was shown in HER2+ cells, with reduced invasiveness after a short-term exposure, and a paradoxically enhanced invasive potential after prolonged treatment. …”
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Climate and human activities alter coupling of soil macro- and micronutrients: Evidence from a long-term experiment in typical steppes by Yi Zhou, Shenghua Chang, Xiaojuan Huang, Wenjun Wang, Fujiang Hou, Yanrong Wang, Zhibiao Nan

“…Our results showed decreases in soil Zn and Fe stocks, alongside increases in Cu, SOC, and STN stocks over time. …”
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Is social theory losing its relevance? A call for social impact and cocreation from dialogic sociology by Elisabeth Torras-Gómez, Mar Joanpere, Carmen Elboj, Mengna Guo, Esther Oliver, Ane Lopez de Aguileta, Marta Soler-Gallart

“…Abstract Currently, the interest in and use of social theory by policy-makers, organizations, and citizens have decreased worldwide. …”
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Brain endurance training as a strategy for reducing mental fatigue by Nathalie André, Michel Audiffren, Chris Englert

“…Initial evidence suggests that endurance athletes are more resilient to the decrease in the capacity and/or willingness to deploy mental effort induced by mental fatigue, though the results are mixed. …”
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NECROSIS AS A COMPLICATION OF LOCAL ANESTHESIA IN DENTISTRY by V.V. Lepsky, C. V. Osik

“…However, as a rule, most of the groups of painkillers contain vasoconstrictors of the cartridge, such as adrenaline hydrochloride, noradrenaline, although the last one is currently banned for use because of the complications that it can cause. …”
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G‐space versus E‐space: Are hornets (Hymenoptera: Vespidae) at equilibrium with honeybees in Asia? by Ehsan Rahimi, Chuleui Jung

“…We found that Vespa velutina currently exhibits a moderate geographic niche overlap (G‐space) of 0.63 with both honeybee species. …”
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MHD analysis of couple stress nanofluid through a tapered non-uniform channel with porous media and slip-convective boundary effects by P. Deepalakshmi, G. Shankar, E.P. Siva, D. Tripathi, O. Anwar Bég

“…The current research addresses the peristaltic transport mechanism that propels fluid through a conduit through rhythmic contraction and relaxation of the conduit walls, a phenomenon evident in numerous biological systems, including the gastrointestinal tract. …”
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Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…Trial registration This trial is registered as Current Controlled Trials ISRCTN21656568 (www.isrctn.com/ISRCTN21656568). …”
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The role of anifrolumab in reshaping the treatment landscape of extra-renal systemic lupus erythematosus by Fulvia Ceccarelli, Matteo Piga, Alessandra Bortoluzzi, Laura Coladonato, Micaela Fredi, Daniele Mauro, Chiara Tani, Luca Iaccarino

“…The 2023 guidelines of the European Alliance of Associations for Rheumatology now recommend lowering maintenance glucocorticoid doses to ≤5 mg/day to reduce long-term health risks, a decrease from the previous 7.5 mg/day threshold set in 2019. …”
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Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT by Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger

“…Modelling suggested that provision of oral tenofovir/emtricitabine pre-exposure prophylaxis increased human immunodeficiency virus testing, with anti-retroviral therapy initiation at diagnosis, and reductions in the level of condom-less sex, that each played an important role in decreasing human immunodeficiency virus incidence among men who have sex with men, and that the current human immunodeficiency virus incidence would have been double what it is if any one of them had not occurred. …”
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Lithologically constrained velocity–density relationships and vertical stress gradients in the North Alpine Foreland Basin, SE Germany by P. Obermeier, F. Duschl, M. C. Drews

“…Thereby, we observed an eastward decrease in vertical stress gradients, which correlates well with the geological configuration of the North Alpine Foreland Basin in SE Germany. …”
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Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…Guiding Distributive Justice: Capability Theory Capability theory is an account of justice opportunity that places a fundamental moral significance on individuals' ability to reach proper functioning and well-being.[52] Whether or not an individual can make use of a particular set of resources and convert them into a state of functioning depends on personal, sociopolitical, and environmental conditions ("conversion factors").[53] In this sense, liberty is not the absence of restraint from others or institutions but the freedom achieved through capability-enhancing relationships.[54] Within the context of bioethics, capability theory shifts focus toward creating circumstances by which individuals can direct their lives as they choose.[55] Acting in accordance with the principle of beneficence, peer-support specialists could enhance the capability of patients to be self-determined and autonomous, which would promote patient well-being and empowerment.[56] Those living with SMI, such as schizophrenia and bipolar disorder, are among the most disadvantaged in society, experiencing social and economic hardship related to their illness.[57] These individuals are often feared and rejected by others, which increases depression, lowers self-esteem, and engenders feelings of social isolation.[58] Compounding their challenges, especially for those facing structural inequalities, is insufficient access to appropriate mental health services supporting recovery.[59] Capability theory provides a sound justification for the resource distribution necessary to create and sustain a thriving network of peer-support specialists, to which those with SMI currently do not have access. …”
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Comparative abundance and diversity of populations of the Pseudomonas syringae and Soft Rot Pectobacteriaceae species complexes throughout the Durance River catchment from its Fren... by Morris, C.E., Lacroix, C., Chandeysson, C., Guilbaud, C., Monteil, C., Piry, S., Rochelle Newall, E., Fiorini, S., Van Gijsegem, F., Barny, M.A., Berge, O.

“…The dynamics of human and animal pathogens in catchments have been widely studied in a large variety of contexts allowing the optimization of disease risk reduction. …”
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Impact of frailty in older people on health care demand: simulation modelling of population dynamics to inform service planning by Bronagh Walsh, Carole Fogg, Tracey England, Sally Brailsford, Paul Roderick, Scott Harris, Simon Fraser, Andrew Clegg, Simon de Lusignan, Shihua Zhu, Francesca Lambert, Abigail Barkham, Harnish Patel, Vivienne Windle

“…Mean face-to-face appointments were generally similar within frailty categories across age groups, but with a notable decrease in appointments with older age in the severe category. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…This article examines the alignment of current predominant payment models of fee-for-service, capitation, and value-based payments with patient care ethics. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…This article examines the alignment of current predominant payment models of fee-for-service, capitation, and value-based payments with patient care ethics. …”
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Supporting antiretroviral therapy uptake and adherence: the SUPA research programme and RCT by Rob Horne, Caroline Sabin, Trudie Chalder, Vanessa Cooper, Lucy Campbell, Elizabeth Glendinning, Iris Mosweu, Paul McCrone

“…We interviewed 52 men and women from Black African and Caribbean communities in London who had been identified as having previous or current problems adhering to their medication. Two separate analyses were conducted. …”
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Health and economic evaluation of cytomegalovirus vaccination strategy among young women in China: a modelling study by Bin Zhang, Gang Qin, Jun-Tao Shu, You-Jia Wu, Yin-Hua Jiang, Yi-Wen Ge, Meng-Zhao Yin

“…The vaccine was assumed to have 50% coverage and 50% efficacy for the first 5 years, with efficacy gradually decreasing over the next 15 years, costing US$300 per treatment course. …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…This paper describes the current transplant system’s use of subjective evaluation criteria, particularly psychosocial support and compliance. …”
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