NECROSIS AS A COMPLICATION OF LOCAL ANESTHESIA IN DENTISTRY by V.V. Lepsky, C. V. Osik

“…However, as a rule, most of the groups of painkillers contain vasoconstrictors of the cartridge, such as adrenaline hydrochloride, noradrenaline, although the last one is currently banned for use because of the complications that it can cause. …”
Get full text

Warming Yang,Promoting Blood Circulation and Inducing Diuresis in the treatment of diabetic nephropathy:a meta-analysis by WANG Lan, WANG Xiao-qin

“…Objective To evaluate the efficacy and safety of ’Warming Yang,Promoting Blood Circulation and Inducing Diuresis’ in the treatment of diabetic nephropathy(DN).Methods The used electronic databases contained foreign databases such as PubMed,EMBASE,Cochrane Library,and Chinese databases such as CNKI,SinoMed,Wanfang Data,CQVIP.The clinical data of "Warming Yang,Promoting Blood Circulation and Inducing Diuresis" in treatment of DN were collected comprehensively.The literature retrieval ended on April 1,2016,and the meta analysis of appropriate literature was processed by RevMan 5.3 software.Results The cases of randomized controlled trials totaled16 and the cases of DN patients totaled 1 107.The results of Meta analysis showed that compared to western medicine control group,the experimental group of integrated traditional Chinese medicine and western medicine,based on "Warming Yang and Benefiting Qi,Promoting Blood Circulation and Inducing Diuresis",perfonned better in the significant efficiency and total efficiency of the treatment of DN(RR=1.97,95%CI 1.50~2.59,Z = 4.86,P<0.01;RR=1.48,95%CI 1.35~1.62,Z=8.58,P<0.01),in the decrease of the serum creatinine(MD=-32.33,95%CI-58.20~-6.47,Z =2.45,P= 0.01),in the increase of high density lipoprotein(MD= 0.16,95%CI 0.09~0.23,Z =4.33,P<0.01),in the decrease of cholesterol,triglyceride,low density lipoprotein(MD=-0.82,95%CI 1.28~-0.36,Z = 3.49,P = 0.0005;MD=-0.40,95%CI-0.53~-0.26,Z=5.95,P<0.01;MD=-0.49,95%CI-0.76~-0.21,Z=3.46,P = 0.000 5),in the decrease of urinary protein(MD=-0.46,95%I-0.61~-0.31,Z=6.01,P<0.01),in the control of fasting blood glucose(MD=-0.34,95%CI-0.57~-0.12,Z = 3.00,P = 0.003),and performed the same in the decrease of the levels of tumor necrosis factor alpha(P= 0.33).Conclusions The current limited evidence suggests that the efficacy and safety of integrated traditional Chinese medicine and western medicine in the treatment of DN is better than the traditional protocols alone.…”
Get full text

Immuno‐Nanocomplexes Target Heterogenous Network of Inflammation and Immunity in Myocardial Infarction by Fan Su, Weifan Ye, Yi Shen, Yujie Xie, Chong Zhang, Qianyun Zhang, Zhengqi Tang, Meihua Yu, Yu Chen, Bin He

“…Abstract Despite the proceeds in the management of acute myocardial infarction (AMI), the current therapeutic landscape still suffers from limited success in the clinic. …”
Get full text

Dietary Erucic Acid Induces Fat Accumulation, Hepatic Oxidative Damage, and Abnormal Lipid Metabolism in Nile Tilapia (Oreochromis niloticus) by Dingfei Ma, Qiangwei Li, Yuanyuan Xie, Youqin Kong, Zhili Ding, Jinyun Ye, Chenglong Wu, Yan Liu

“…Feeding fish with diets containing EA (20 and 27 g/kg diet) significantly increased the malondialdehyde content. …”
Get full text

Information transparency as paradigm of the economic systems sustaina ble development by L. Orlova

“…As the instrument of management an information transparency index can be used when monitoring the current situation, forming strategy of development, control for key problems of the sustainable development strategy.…”
Get full text

Evaluating the impact of mine tailings wastes on the development of sustainable Ultra High Performance Fiber Reinforced concrete by Osama Zaid, Mohd Ahmed, Ahmed. M. Yosri, Talal. O. Alshammari

“…The workability tests show a decrease in flow spread from 274 mm in the control mix to 221 mm in the mix with 25% MTP and 100% MTS. …”
Get full text

Mixed-methods assessment of health and mental health characteristics and barriers to healthcare for Ebola survivors in Beni, Butembo and Katwa health zones of the Democratic Republ... by Lynn Lieberman Lawry, Nancy Stroupe Kannappan, Covadonga Canteli, William Clemmer

“…Trouble sleeping and anger were the strongest predictors of post-traumatic stress disorder, major depressive disorder (MDD), anxiety and suicide attempts with 3-fold to 16-fold increases in the odds of these disorders. There was a 71% decrease in the odds of MDD if current substance abuse (aOR 0.29; 95% CI 0.13 to 0.67; p&lt;0.01) was reported.Conclusions Specialised mental health services were limited. …”
Get full text

Mixture toxicity of tebuconazole and fluopyram to honeybee (Apis mellifera L.): Effects on survival, feeding and antioxidant defenses by Neama S. Saeed, Sayed A. Ahmed, Zeinab H. Ahmed, Abdulraouf M. Amro, Ibrahim A. Mohamed

“…However, there is a lack of information about their toxicological effects on honeybees (Apis mellifera L.). In the current study, the lethal and sub-lethal toxic effects of mixture tebuconazole + fluopyram were examined on A. mellifera workers. …”
Get full text

Development and characterization of in‐situ nickel aluminide reinforced Al‐Si matrix composites by stir casting by A. Saiyathibrahim, Vijaykumar S. Jatti, P. Dhanapal, Dhanesh G. Mohan

“…Abstract Aluminium matrix composites (AMCs) exhibit promising mechanical properties that are required for the aeronautical and automotive industries. In the current research, A413 (eutectic AlSi) alloy is employed as matrix material, and nickel based trialuminide (Al3Ni) with primary Si particles as reinforcements to manufacture aluminium matrix composites through the stir casting process. …”
Get full text

The impact of dropouts in scRNAseq dense neighborhood analysis by Alisa Pavel, Manja Gersholm Grønberg, Line H. Clemmensen

“…., cell pairs consistently being in the same cluster) decreases. This implies that sub-populations within cell types are increasingly difficult to identify under increasing dropout rates because observations are not consistently close.Our results challenge the current practice of using default clustering pipelines and the general assumption of identifiable local neighborhoods on high dropout data. …”
Get full text

Interleukin-35 impairs human NK cell effector functions and induces their ILC1-like conversion with tissue residency features by Valentin Picant, Lara Revol-Bauz, Laurie Tonon, Timothée Casini, Aurélien Voissière, Dominique Poujol, Emilie Picard, Céline Rodriguez, Cyril Degletagne, Emily Sible, Uzma Hasan, Anthony Ferrari, Christophe Caux, Nathalie Bendriss-Vermare

“…Abstract Natural Killer (NK) cells play pivotal immunological roles including direct cytotoxic effector function and secretion of inflammatory and immunomodulating cytokines. In the context of chronic inflammation, NK cell fitness decreases during disease progression through currently unknown mechanisms. …”
Get full text

HORMONE IMBALANCE AS A MANIFESTATION OF STRESS IN THE FORMATION OF OLIGOMENORRHEA IN TEENAGE GIRLS by В. Диннік, О. Диннік, С. Новохатська

“… Stress is currently the most significant factor contributing to reproductive function disorders and has become a major public health problem in the 21st century. …”
Get full text

NEW APPROACHES TO THERAPY OF CLASSICAL PH-NEGATIVE MYELOPROLIFERATIVE DISEASES: THE EXPERIENCE OF EARLY THERAPY WITH CEPEGINTERFERON ALPHA-2B by A. S. Polyakov, Y. A. Noskov, V. V. Tyrenko, A. S. Lapshova, A. V. Kovalev

“…The limitations of classical cytoreduction and current targeted therapy, as well as the conviction of most specialists in the impossibility of adequately containment of disease progression, continue to be the main factors that keep physicians from the early start of pathogenetic therapy.Objective: to study the efficacy and safety of cepeginterferon alpha-2b (cePEG-IFN alpha-2b) in early (non-risk-adjusted) therapy of classical Ph-negative myeloproliferative neoplasms in initial use and after therapy with other pegylated interferons (PEG-IFN).Materials and methods. …”
Get full text

Self-other distinction modulates the sense of self-agency during joint actions by Laura Zapparoli, Marika Mariano, Lucia Maria Sacheli, Tommaso Berni, Caterina Negrone, Carlo Toneatto, Eraldo Paulesu

“…We discuss these results considering current cognitive theories on motor awareness and interactions.…”
Get full text

Flourishing as a highly sensitive person: a mixed method study on the role of nature connectedness and chaotic home environment by Susan Carroll, Anna O’Brien, Francesca Lionetti, Anna O’Reilly, Annalisa Setti, Annalisa Setti

“…IntroductionTheories of Environmental Sensitivity postulate that those who are highly sensitive thrive in favourable contexts and are more disadvantaged by unfavourable ones; however, negative outcomes, instead of positive, are more often investigated. …”
Get full text

Vertical distribution of ¹³⁷Cs in soddy-podzolic sandy soil in grasslands and forests of the Bryansk region in 2015–2016 by V. P. Ramzaev, A. N. Barkovsky, K V. Varfolomeeva

“…With increasing depth, the activity concentration decreased and reached a minimum in the deepest layers. …”
Get full text

Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis by Mélanie Bézard, Jean-Sébastien Vartanian-Grimaldi, Julien Henri, Denisa Calin, Amira Zaroui, Mounira Kharoubi, Thibaud Damy, Onnik Agbulut, Ekaterini Kordeli

“…LC-treated hiPSC-CM cultures and LC-containing spheroids presented structural and functional defects including: (1) decreased levels and subcellular disorganization of sarcomeric protein alpha-actinin; (2) abnormal accumulation of calcium handling SERCA2a protein; (3) impaired contractility of spheroids and altered calcium transients. …”
Get full text

Large Language Model Applications for Health Information Extraction in Oncology: Scoping Review by David Chen, Saif Addeen Alnassar, Kate Elizabeth Avison, Ryan S Huang, Srinivas Raman

“…ObjectiveThis scoping review aims to map the current landscape, including definitions, frameworks, and future directions of LLMs applied to data extraction from clinical text in oncology. …”
Get full text

Real time intelligent garbage monitoring and efficient collection using Yolov8 and Yolov5 deep learning models for environmental sustainability by Mohammed M. Abo-Zahhad, Mohammed Abo-Zahhad

“…Nationally, governments have initiated several programs to improve cleanliness by developing systems that alert businesses when it’s time to empty the bins. Current research proposes an enhanced, accurate, real-time object detection system to address the problem of trash accumulating around containers. …”
Get full text

Consequences, costs and cost-effectiveness of workforce configurations in English acute hospitals by Peter Griffiths, Christina Saville, Jane Ball, David Culliford, Jeremy Jones, Francesca Lambert, Paul Meredith, Bruna Rubbo, Lesley Turner, Chiara Dall’Ora

“…Study registration This study is registered as Current Controlled Trials ClinicalTrials.gov NCT04374812. …”
Get full text