Scientific and Regulatory Lessons Learnt on Building a Chemistry, Manufacturing, and Controls (CMC) Package for COVID-19 Variant Vaccine Updates in the EU—A Regulator’s Perspective... by Ragini Shivji, Elena Grabski, Veronika Jekerle

“…The experience gained from the vaccine adaptations, combined with a continuous early regulator-developer scientific discussion, permits increasingly greater predictability for timing and positive regulatory outcomes. …”
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Phylogenetic Groups and Antimicrobial Resistance among Uropathogenic Escherichia coli Isolates from Hospitalized Patients in Tehran by Mana Talebi Farahani, Mohammad Karim Rahimi, Mehdi Goudarzi

“…Background: The presence of Escherichia coli among uropathogens is increasing significantly worldwide. It accounts for a considerable amount of morbidity and high medical costs and also can lead to mortality. …”
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Copper homeostasis and neurodegenerative diseases by Yuanyuan Wang, Daidi Li, Kaifei Xu, Guoqing Wang, Feng Zhang

“…Copper is a potent oxidant that increases reactive oxygen species production and promotes oxidative stress. …”
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Spatio-temporal changes of water quality variables in a highly disturbed river by Z. Abdollahi, A. Kavian, S.H.R. Sadeghi

“…Many rivers in developing countries are unhealthy because they contain harmful physical, chemical and biological agents. …”
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Identification of widely conserved biosynthetic gene cluster involved in pigment production of Bacillus subtilis by Rune Overlund Stannius, Christopher A. Dunlap, Estelle Morvan, Mélanie Berbon, Sophie Lecomte, Antoine Loquet, Ákos T. Kovács

“…This study describes the chemical and biological features of a new class of SM BGC, which we hope will serve to improve the current BGC discovery pipelines in Bacilli.IMPORTANCEIdentification of novel microbial secondary metabolites (SMs) and their biosynthetic gene cluster (BGC) has become increasingly difficult, especially in Bacilli, as the tools for screening and genome mining are dependent on clear function or similarity to already known BGCs. …”
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Effects of long-term pioglitazone treatment on peripheral and central markers of aging. by Eric M Blalock, Jeremiah T Phelps, Tristano Pancani, James L Searcy, Katie L Anderson, John C Gant, Jelena Popovic, Margarita G Avdiushko, Don A Cohen, Kuey-Chu Chen, Nada M Porter, Olivier Thibault

“…Finally, a combination of microarray analyses on hippocampal tissue and serum-based multiplex cytokine assays revealed that age-dependent inflammatory increases were not reversed by PIO.<h4>Conclusions</h4>While current research efforts continue to identify the underlying processes responsible for the progressive decline in cognitive function seen during normal aging, available medical treatments are still very limited. …”
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A Systematic Review Examining the Association of Falls With Diabetes‐Related Foot Ulcers by Mike Wu, Mallika Sinha, Chanika Alahakoon, Kristen S. Barratt, Shivshankar Thanigaimani, Jonathan Golledge

“…A meta‐analysis showed high heterogeneity between studies (I2 = 95%) and an increased risk of falls in people with DFU (risk ratio 2.25 and 95% CI 1.05–4.84). …”
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Marketing Logistics and its Digitalization by Iryna Polishchuk, Yuriy Dovhan, Iryna Kramar, Larysa Dovhan, Oksana Yakushevska

“…The purpose of the article is to highlight the historical process of forming marketing logistics as a modern management concept and the current trends in its digitalization. The theoretical foundations of marketing logistics summarized in this work will facilitate the integration of digital technologies into marketing logistics, improve business processes, and support the sustainable development of companies in the context of dynamic changes in the global market. …”
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The Direction of Indonesia’s Legal Policy on the ASEAN Mutual Legal Assistance Treaty in Criminal Matters: A Path to Law Reform in Cross-Border Crime Enforcement in Southeast Asia... by Ridwan Arifin, Rodiyah Rodiyah, Waspiah Waspiah, Asyaffa Ridzqi Amandha, Elizabeth Yunita Krisnawati, Tirta Sandi, Michael Timothy Napitupulu

“…The urgency of this research is underscored by the increasing prevalence of transnational crimes in Southeast Asia, exacerbated by advancements in technology and globalization. …”
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Energy recovery analysis through numerical simulations of steam injection in continental shale oil reservoirs by Maryelin Josefina Briceño Montilla, Shouding Li, Zhaobin Zhang, Yanzhi Hu, Jianming He, Zheng Bo, Xiao Li

“…However, optimizing energy utilization to maximize hydrocarbon production remains a significant challenge, particularly in the context of current energy limitations. This study compares two steam injection strategies using a thermal-flow-chemical (TFC) simulator to assess energy recovery efficiency. …”
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Advances in Oncolytic Viral Therapy in Melanoma: A Comprehensive Review by Ayushi Garg, Rohit Rao, Felicia Tejawinata, Gazi Amena Noor Shamita, McKay S. Herpel, Akihiro Yoshida, Gordon Goolamier, Jessica Sidiropoulos, Iris Y. Sheng, Salim-Tamuz Abboud, Luke D. Rothermel, Nami Azar, Ankit Mangla

“…Oncolytic viruses are a unique form of immunotherapy that uses live viruses to infect and lyse tumor cells to release the elusive neoantigen picked up by the antigen-presenting cells, thus increasing the chances of an immune response against cancer. …”
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Optical Identification of Plasmodium falciparum Malarial Byproduct for Parasite Density Estimation by Jerry Opoku-Ansah, Moses Jojo Eghan, Benjamin Anderson, Johnson Nyarko Boampong, Raymond Edziah, Peter Osei-Wusu Adueming, Charles Lloyd Yeboah Amuah

“…Empirical computation of ratio of the ODs for the blood absorption bands revealed reduction in the ODs with increasing PD. Multispectral images containing uninfected red blood cells (u-RBCs) and P. falciparum‐infected red blood cells (i-RBCs) on unstained blood smear slides exhibited spectrally determined decrease in both reflected and scattered pixel intensities and increase in transmitted pixel intensities with increasing PD. …”
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T cell epitope content comparison using EpiCC correlates with vaccine efficacy against heterologous porcine reproductive and respiratory syndrome virus type 2 strains by J. Mark Hammer, Andres H. Gutierrez, Lucas Huntimer, Benjamin Gabriel, William D. Martin, Sabine E. Hammer, Tobias Käser, Anne S. De Groot

“…While vaccines are available, they are not entirely effective, and the introduction of modified live virus vaccines (MLV) has contributed to an increase in the rate of viral evolution. While vaccines induce humoral responses that may contribute to immunity against PRRSV, vaccines containing T cell epitopes that are well-matched to circulating strains are believed to be more likely to induce protective effects upon challenge or field exposure. …”
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Analysis of Herd Behavior in Industry Groups of the Tehran Stock Exchange by Yahya Ebrahimpour, Elham Nobahar, Parviz Mohamadzadeh

“…Over the past decade, the TSE has undergone significant growth, marked by a dramatic increase in the number of active trading codes and a sharp rise in their trading values, underscoring the necessity of examining herd behavior in this context. …”
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Analysis of Plasmids of the Klebsiella pneumoniae Complex Carrying a Cluster of Aerobactin Synthesis Genes as Presented in International Databases by V. V. Shapovalova, Р. S. Chulkova, V. A. Ageevets

“…It has been shown that an increase in virulence is associated with the acquisition of additional genetic material — a plasmid carrying a cluster of aerobactin genes. …”
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Herpetic infections in humans: modern approaches to etiopathogenetic therapy by D. S. Sukhanov, E. V. Timofeev, Yu. S. Alexeeva, S. N. Tretyakov, A. L. Korshunova

“…Viruses of the Herpesviridae family are DNA-containing viruses prone to latent lifelong persistence in various tissues of the body after primary infection. …”
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Versatile Gyroinclinometer Based on a Single Axis Angular Rate Sensor by Ya. I. Binder, I. A. Khazov

“…Introduction. Currently, the versatility and reliability of gyroscopic inclinometers (GI), more than accuracy, determine their configuration and design. …”
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Determination of Ethanol Content in Fuels with Phononic Crystal Sensor by N. V. Mukhin, A. Oseev, M. M. Kutia, E. S. Borodacheva, P. G. Korolev

“…In-line analysis of ethanol content in gasoline blends is currently one of the urgent needs of fuel industry. …”
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A group psychological intervention for postnatal depression in British mothers of South Asian origin – the ROSHNI-2 RCT by Nusrat Husain, Karina Lovell, Carolyn A Chew-Graham, Farah Lunat, Penny Bee, Matthias Pierce, Najia Atif, Saadia Aseem, Kamaldeep Bhui, Peter Bower, Traolach Brugha, Nasim Chaudhry, Akbar Ullah, Linda Davies, Nadeem Gire, Deepali Sharma, Jahanara Miah, Waqas Ahmed, Joe Kai, Ilyas Mirza, Jillian Morrison, Naeem Mohmed, Atif Rahman, Shanaya Rathod, Najma Siddiqi, Waquas Waheed, Christopher Williams, Nosheen Zaidi, Richard Emsley, Richard Morriss

“…An additional substudy was incorporated following the pandemic to explore the impact of other associated risk factors related to maternal mental health and specifically in the pandemic’s context. We aimed to increase the understanding of the pandemic-related impact on BSA women, including interpersonal violence (IPV) in their communities. …”
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New perspectives on heterogeneity in astrocyte reactivity in neuroinflammation by Daniel Evangelista Santos, Sarah Alexandra Silva Lima, Leticia Santos Moreira, Silvia Lima Costa, Clarissa de Sampaio Schitine

“…Astrocyte reactivity, previously considered uniform and functionally inactive, is currently a very diverse event in different inflammatory processes. …”
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