Value added medicines: what value repurposed medicines might bring to society? by Mondher Toumi, Cécile Rémuzat

“…Discussion & conclusions: There is currently a gap between increasing regulatory authority interest in capturing value added medicines’ benefits and the resistance of HTA bodies/payers, who tend to ignore this important segment of the pharmaceutical field. …”
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Standardized Loads Acting in Hip Implants. by Georg Bergmann, Alwina Bender, Jörn Dymke, Georg Duda, Philipp Damm

“…With the increasing success of hip joint replacements, the average age of patients has decreased, patients have become more active and their expectations of the implant durability have risen. …”
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Climate Change and Its Impact on Romanian Rural Tourism—A Review of Actionable Knowledge by Liliana Velea, Anisoara Irimescu, Roxana Bojariu, Zenaida Chitu

“…This makes tourism vulnerable to climate change through the direct effect of changes in the attractivity of climate conditions, in addition to the indirect effects due to the expected impacts on other associated socio-economic sectors. In this context, increasing rural tourism resilience to climate change is a complex issue which needs to consider adaptation measures focusing on tourism specifics in synergy with adaptation measures in related sectors (e.g., energy, land and water management, urbanization aspects). …”
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Research on Vehicle Route Optimization for Half-Open Multi-Energy Urban Distribution Considering Order Priority by Mingxuan Zhang

“…Aiming at the current problems of increasingly serious tailpipe pollution of urban distribution vehicles and irrational distribution route planning, we construct a fuel-electric hybrid multi-trip multi-center half-open joint distribution vehicle routing optimization model (F-EHOMTMDVRPOPTW) considering order priority and fuzzy time window, and introduce Tent chaotic mapping combined with an improved discrete sparrow search algorithm (DSSA) with stochastic key encoding strategy for solving. …”
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PUMPING PRESSURE AND FLOW RATE RELATIONSHIP TO REDUCE ENERGY CONSUMPTION IN IRRIGATION SYSTEMS by Esmeralda CHIORESCU

“…In the context of the current energy crisis, electricity consumption, especially by large consumers, must be reduced, rationally, without affecting the quality of services provided. …”
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MARKETING COMMUNICATION IN THE DIGITAL AGE by Olimpia OANCEA

“…Once companies have developed products and services, they must communicate the value and benefits of the offerings to current and potential customers. Consumers are changing. …”
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Progressive scale implementation for personal income tax as a necessary condition for ensuring social justice by N. Z. Zotikov

“…In the context of the current unfavorable demographic situation and external challenges due to Western sanctions, it is necessary to strengthen motivation to work, considering foreign positive experience to introduce a real and workable progressive scale of personal income taxation.…”
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Study on the mechanism of Dexmedetomidine’s effect on postoperative cognitive dysfunction in elderly people by Yuanbin Cai, Fan Yu, Wei Wu, Wurong Chen

“…In recent years, dexmedetomidine (DEX), a novel α2-adrenoceptor agonist, has been increasingly utilized in surgical anaesthesia for elderly patients, showing potential as both a preventive and therapeutic agent for POCD. …”
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Regulatory T Cell in Kidney Transplant: The Future of Cell Therapy? by Ahmad Matarneh, Meet Patel, Kinna Parikh, Amanda Karasinski, Gurwant Kaur, Vaqar Shah, Nasrollah Ghahramani, Naman Trivedi

“…The long-term use of immunosuppressive drugs following kidney transplantation increases the risk of life-threatening infections, malignancies, and, paradoxically, eventual allograft rejection. …”
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MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance by Ahsas Goyal, Muhammad Afzal, Kavita Goyal, Subbulakshmi Ganesan, Mukesh Kumari, S. Sunitha, Aniruddh Dash, Suman Saini, Mohit Rana, Gaurav Gupta, Haider Ali, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan

“…Carrying a variety of molecules, including microRNAs, small interfering RNAs, long non-coding RNAs, proteins, lipids, and DNA, these vesicles are positioned as promising cancer treatment options. Current studies have increasingly investigated the capacity of microRNAs as a strategic approach for combating malignancy. …”
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Supporting self-management with an internet intervention for low back pain in primary care: a RCT (SupportBack 2) by Adam W A Geraghty, Taeko Becque, Lisa C Roberts, Jonathan Hill, Nadine E Foster, Lucy Yardley, Beth Stuart, David A Turner, Gareth Griffiths, Frances Webley, Lorraine Durcan, Alannah Morgan, Stephanie Hughes, Sarah Bathers, Stephanie Butler-Walley, Simon Wathall, Gemma Mansell, Malcolm White, Firoza Davies, Paul Little

“…Some described the perceived limitations of the telephone method and lack of physical contact. Others felt that the telephone contact increased the activation of the participants. …”
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Consumers’ Attitudes Towards Whole Dried Figs Attributes: A Preliminary Study in Italy by Federica Monaco, Pietro De Marinis, Guido Sali

“…Concerns about the quality of Turkish supply in the EU market give chances to the Italian production to uphold quality standards and cope with the increasing demand. National consumption of dried figs is showcased in market reports and nutritional surveys, with insufficient insights on consumers’ preferences. …”
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Behavior and sustainability benefits of modular steel buildings by Ahed Habib, Ausamah Al Houri, Bashar Alibrahim, Maan Habib

“…Accordingly, this study aims to first perform a bibliometric analysis of current literature to identify key trends in the field, then discuss the existing findings in the literature, and finally conduct a critical sustainability assessment to place modular steel buildings within the context of the United Nations Sustainable Development Goals. …”
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Investigation of the Effects of Accessible Traffic Calming and Flow Improvement Applications on Traffic by Kadir Berkhan Akalın, Çağdaş Kara, Abdulkadir Özden

“…As a result of the analysis, it is revealed that the design of the roundabout with raised pedestrain crosswalks (RPC) which is one of the human-friendly traffic calming methods, both increases traffic safety in the areas where pedestrian traffic is heavy and provides flow improvement.…”
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Nanotechnology-Based Antimicrobial Surface-Coating Technologies and Their Potential Applications by Gökhan Gurur Gökmen, Duygu Kışla

“…In the production of nanoparticles, top-down approaches in which macro-sized materials were reduced to nano-sizes and bottom-up approaches in which atoms / molecules were increased to nano-sizes by different chemical reactions, are used. …”
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Identify the Challenges of Sustainable Agricultural Development in the South of Kerman Province by Omid Sharifi, Amir Afzali Gorouh, Mona Babaee

“…The use of unconditional production inputs to increase performance over the last decade which leads to the degradation of the environment and human health, has underscored the importance of sustainable agriculture and continued production along with the preservation of natural resources. …”
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MARITIME 4.0 AND EXPECTATIONS IN MARITIME SECTOR by Dursun Balkan

“…As the rapid development of communication and information technologies allows real-time transmission of information, the world is increasingly becoming a global society. In this context, the most developed countries are required to develop their own strategies to encourage the industrial sector to stay up to date and compete in a dynamic and volatile global market in order to maintain its competitive capacity. …”
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Review of Articles Published Between 2014 and 2023 on Toxic Leadership Using Bibliometric Analysis: Comparison of DergiPark and Web of Science Databases by Timur Köse, Duygu Toplu Yaşlıoğlu

“…This study is important for observing and evaluating the current state of toxic leadership literature. In addition, it may lead to future studies in the context of related variables.…”
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PECULIARITIES OF THE CRIME OF DRIVING A VEHICLE UNDER THE INFLUENCE OF PSYCHOACTIVE SUBSTANCES, PROVIDED BY ART. 336 PARA. (2) CP. THEORETICAL AND PRACTICAL ASPECTS by Alexandru STAN

“…In the current social and legal context, the crime provided by art. 336 para. (2) CP is increasingly common in the practice of criminal investigation bodies and courts. …”
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Measuring the Capacity of Organizations Innovation ‒ Major Process of Innovation Management by Dorin Maier, Livia Anastasiu, Roxana Sârbu, Thorsten Eidenmüller

“…The article approaches the problem of companies’ success in today’s economic context, characterized by a generalized market with increasing competitive and client requirements. …”
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