‘It was a joint plan we worked out together’. How the I-WOTCH programme enabled people with chronic non-malignant pain to taper their opioids: a process evaluation by Martin Underwood, Kate Seers, Charles Abraham, Harbinder Kaur Sandhu, Vivien P Nichols, Sam Eldabe, Alleyne Sharisse, Balasubramanian Shyam, Betteley Lauren, Booth Katie, Carnes Dawn, D Furlan Andrea, Haywood Kirstie, Iglesias Urrutia C Paola, Lall Ranjit, Manca Andrea, Mistry Dipesh, Noyes Jennifer, Rahman Anisur, Shaw Jane, KY Tang Nicole, Taylor Stephanie, Tysall Colin, Underwood Martin, J Withers Emma

“…Background The Improving the Wellbeing of people with Opioid Treated CHronic pain (I-WOTCH) randomised controlled trial found that a group-based educational intervention to support people using strong opioids for chronic non-malignant pain helped a significant proportion of people to stop or decrease opioid use with no increase in pain-related disability. …”
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Changes in the Species Composition and Structure of Large-Diameter Trees Along a Narrow Latitudinal Gradient in Subtropical China by Mengxian Li, Fei Huang, Xiaorong Jia

“…Additionally, species composition homogeneity decreased (based on PCoA and MRPP analysis), age-class structures became more complex, and the proportion of tropical genera gradually declined, whereas temperate genera increased. …”
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Thermal and radiative effects on unsteady MHD flow of Casson fluid past a rotating porous medium with variable mass diffusion by J. Prakash, A. Selvaraj, P. Ragupathi, Qasem M. Al-Mdallal, S. Saranya

“…The findings indicate that buoyancy forces imparted by the Grashof numbers considerably increase the velocity due to convection currents. However, the magnetic parameter counteracts velocity due to the Lorentz force while larger porosity increases fluid flow. …”
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Lifelong Learning and Employability in the Danube Region Countries: Influences and Correlations by Constanţa-Nicoleta Bodea, Maria-Iuliana Dascălu, Gordana Velikic, Stelian Stancu

“…The conclusions of the current study are particularly important in the Romanian context, as the employment rate of recent graduates is in a decreasing trend, but also for all the Danube Region ex-communist countries, which have to boost their employment rates as well, to assure their economical growth. …”
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Neurophysiological evidence of single-shot semantic mapping in the developing brain by Marina J. Vasilyeva, Veronika M. Knyazeva, Elena D. Artemenko, Elena A. Vershinina, Ekaterina S. Garbaruk, Ekaterina S. Garbaruk, Maria Yu Boboshko, Maria Yu Boboshko, Aleksander A. Aleksandrov, Yury Shtyrov, Yury Shtyrov

“…This process is to a large degree mediated by a neurocognitive mechanism known as «fast mapping» (FM) which allows the child to quickly map new words onto neural representations after even a single exposure to them, using context-driven inference. However, the neurophysiological bases of this mechanism are still poorly understood. …”
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Cluster-randomized trial of the implementation of the Responses to Illness Severity Quantification (RISQ) system in children with acute malnutrition 6 to 59 months of age in Ngouri... by Nancy M. Dale, Youssouf Djidita Hagre, Susan Shepherd, George Tomlinson, Stanley Zlotkin, Masra Ngaradoum, Mahmat Bechir, Marius Madjissem, Charles Tehoua, Christopher Parshuram

“…Abstract Background The Responses to Illness Severity Quantification (RISQ) System is a scientifically developed clinical decision support tool comprised of four parts: (1) a validated 7-item severity of illness score, (2) age-specific documentation forms, (3) context-relevant score-matched recommendations, and (4) implementation programming. …”
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Application of urinary peptide-biomarkers in trauma patients as a predictive tool for prognostic assessment, treatment and intervention timing by Gökmen Aktas, Felix Keller, Justyna Siwy, Agnieszka Latosinska, Harald Mischak, Jorge Mayor, Jan Clausen, Michaela Wilhelmi, Vesta Brauckmann, Stephan Sehmisch, Tarek Omar Pacha

“…CE-MS peptidome analysis identified 191 significantly altered peptides in severely injured patients. A consistent increase in the abundance of peptides from A1AT, AHSG, and HBA1 was observed, while peptides derived from PIGR and UROM were consistently decreased. …”
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High prevalence of the hotspot complement factor I p.Ile357Met pathogenic variant in Tunisian atypical hemolytic uremic syndrome patients: report of three new cases and review of t... by Asma Tajouri, Asma Tajouri, Asma Tajouri, Imen Ayadi, Imen Ayadi, Rimeh BenBrahim, Rimeh BenBrahim, Ikram Mami, Abir Boussetta, Hend Jlajla, Hend Jlajla, Yousr Zerzeri, Haifa Arbi Sassi, Jamila Ben Sassi, Hela Sahli, Lilia Laadhar, Lilia Laadhar, Tahar Gargah, Mohamed Karim Zouaghi, Maryam Kallel Sellami, Maryam Kallel Sellami

“…The recurrence of this variant in the Tunisian cohort led us to suggest that it could be characteristic of the Tunisian population.MethodsIn this context, we conducted the current study which included 8 adults and three children with suspected aHUS and decreased factor I levels, as well as one relative. …”
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Playing towards Motivation: Gamification and University Students in Physical Activity! by Victor Javier Sotos-Martinez, Salvador Baena-Morales, Manuel Sanchez-De Miguel, Alberto Ferriz-Valero

“…There is currently concern about the decrease in physical activity participation among university students. …”
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Adverse birth outcome research case definitions associated with maternal HIV and antiretroviral drug use in pregnancy: a scoping review by Kopano R. Dube, Shani T. de Beer, Kathleen M. Powis, Michael McCaul, Amy L. Slogrove

“…Abstract Background Adverse birth outcomes (preterm birth, low birth weight, small for gestational age, and stillbirth) seem to persist in infants born to people with HIV, even in the context of maternal antiretroviral therapy. However, findings have been disparate, inconclusive, and difficult to compare directly across settings, partly owing to variable outcome definitions. …”
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International Labor Migration and Its Transformative Effects on Political Landscapes Across Central Asian Nations by Egor V. Fomin, Albert A. Averyanov

“…This study concludes that any reduction in migratory activities, decreased inflows of remittance funds, or diminished organic inclination toward closer ties among migrants would result in both increased political volatility within Central Asia and weakened Russian leverage over the area.…”
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Molecular mechanisms underlying Tao-Hong-Si-Wu decoction treating hyperpigmentation based on network pharmacology, Mendelian randomization analysis, and experimental verification by Jun Chen, Wenyi Ye

“…Context Hyperpigmentation, a common skin condition marked by excessive melanin production, currently has limited effective treatment options.Objective This study explores the effects of Tao-Hong-Si-Wu decoction (THSWD) on hyperpigmentation and to elucidate the underlying mechanisms.Materials and methods We employed network pharmacology, Mendelian randomization, and molecular docking to identify THSWD’s hub targets and mechanisms against hyperpigmentation. …”
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Effect of Clinical Nursing Practice Guidelines regarding Percutaneous Coronary Interventions on Patients' Anxiety and Satisfaction by Ebtisam A. Elhihi, ibrahim A. ibrahim, Faisal A. Alasmari, Awad H. alkhatib, Nahlah A. Alzahrani, Alaa M. Abuhaleimah, Sanaa B. Barnawi, Bayan F. Jilani, Hadeel Y. ALhawsawi, Shatha M. Alsufyani, Amnah Al ahdal, Amr O. Al ahdal

“… Context: The quality of delivery the healthcare must be improved due to the quick changes in the health care. …”
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Revolutionizing brain‒computer interfaces: overcoming biocompatibility challenges in implantable neural interfaces by Weihang Gao, Zineng Yan, Hong Zhou, Yi Xie, Honglin Wang, Jiaming Yang, Jingbo Yu, Changmao Ni, Pengran Liu, Mao Xie, Li Huang, Zhewei Ye

“…Despite significant advancements over the years, conventional neural electrode interfaces remain insufficient for fully achieving these objectives, particularly in the context of long-term implantation. The primary limitation stems from the poor biocompatibility and mechanical mismatch between the interfacing electrodes and neural tissues, which induce a local immune response and scar tissue formation, thus decreasing the performance and useful lifespan. …”
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Modern ideas about the role of the galaninergic system in the pathogenesis of heart failure and myocardial remodeling by A. A. Yafarova, A. R. Kiselev, A. F. Sheptulina, O. M. Drapkina

“…In this regard, the search for new molecules for therapeutic action aimed at preventing myocardial remodeling is of undoubted interest. In this context, the galaninergic system seems to be a promising target. …”
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Financial security of Ukraine in debt burden: Assessment and forecasting by Fedir Zhuravka, Yuriy Petrushenko, Svitlana Chorna, Bohdana Huriy, Inessa Yarova, Olga Pankiv, Wojciech Duranowski

“…Regression modeling demonstrated a clear negative correlation between the amount of external debt and the level of financial security, with each increase in the debt burden being accompanied by a decrease in the integral index. …”
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Surface displacements induced by underground activities from 2014 to 2019 in the former Lorraine coalfield, northeastern France by Modeste Guillaume, Gunzburger Yann, Conin Marianne, Diallo Maniang

“…Given this particular context, combination of historical and recent subsurface activities, it is useful to characterise the current induced surface displacements in the area. …”
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Oral history as a citizen science tool to understand biodiversity loss and environmental changes: on firefly extirpation in Morelia, Michoacán, Mexico by Danna Betsabe Rivera Ramírez, Cisteil X. Pérez-Hernández, Yaayé Arellanes-Cancino, Luis Mendoza-Cuenca

“…Morelians associated these phenomena with increased anthropogenic activities in the city, such as urban growth and a notable increase in pollution and deforestation. …”
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Quality failures in Energy- saving renovation projects in Northern China by Yuting Qi

“…However, in China, building energy renovation projects are subjected to quality failures resulting in energy wastage, a decrease in the energy efficiency of the project, an increase in project cost, and thus negatively affecting the overall performance of the renovation projects. …”
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Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins by Georgy Berezhnoy, Gyuntae Bae, Leonie Wüst, Claudia Schulte, Claire Cannet, Isabel Wurster, Milan Zimmermann, Alexander Jäck, Eike Jakob Spruth, Julian Hellmann-Regen, Sandra Roeske, Dominik Pürner, Wenzel Glanz, Fabian Maass, Felix Hufschmidt, Ingo Kilimann, Elisabeth Dinter, Okka Kimmich, Anna Gamez, Johannes Levin, Josef Priller, Oliver Peters, Michael Wagner, Alexander Storch, Paul Lingor, Emrah Düzel, Christoph van Riesen, Ullrich Wüllner, Stefan Teipel, Björn Falkenburger, Mathias Bähr, Inga Zerr, Gabor C. Petzold, Annika Spottke, Patricia Rizzu, Frederic Brosseron, Hartmut Schäfer, Thomas Gasser, Christoph Trautwein

“…Highlights from these comparisons include increased citrate and dimethylglycine with a decrease of creatinine and methionine in healthy controls and early PD group compared to GBA, PD late and recessive PD. …”
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