Pharmacological and pupillary evidence for the noradrenergic contribution to reinforcement learning in Parkinson’s disease by Claire O’Callaghan, Frank H. Hezemans, Naresh Subramaniam, Rong Ye, Kamen A. Tsvetanov, Alexander G. Murley, Negin Holland, Isabella F. Orlando, Ralf Regenthal, Roger A. Barker, Caroline H. Williams-Gray, Luca Passamonti, Trevor W. Robbins, James B. Rowe

“…Testing the noradrenergic framework of learning in the context of human diseases offers a test bed for current normative neuroscience theories and may also indicate therapeutic potential. …”
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Traumatic Brain Injury and Genetic Risk for Alzheimer’s Disease Impact Cerebrospinal Fluid β-Amyloid Levels in Vietnam War Veterans by Jena N. Moody, Erica Howard, Kate E. Nolan, Sarah Prieto, Mark W. Logue, Jasmeet P. Hayes

“…This relationship may be stronger with increasing TBI severity (p = 0.05). Overall, TBI was associated with lower Aβ42/40, indicating greater amyloid deposition in the brain, in the context of greater polygenic risk for AD. …”
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Unravelling the myriad physiologic roles of transthyretin: critical considerations for treating transthyretin amyloidosis by Morie A. Gertz, Mandar A. Aras, Nicole Bart, Thomas H. Brannagan, Jan M. Griffin, Amy R. Kontorovich, Andrew M. Rosen

“…While a link between low TTR and severe disease and mortality is well established, it remains unclear whether long-term TTR suppression via ATTR therapies increases risk of disease. Clinical decisions in ATTR, however, should reflect the current understanding of the roles of TTR and the patient’s clinical history.Conclusion TTR serves vital physiologic roles across organ systems. …”
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Climate change adaptation: policy, practice and adaptation gaps in the agriculture sector in Bangladesh, India and Nepal by Shobha Shrestha, Prem Sagar Chapagain, Yili Zhang, Linshan Liu, Jianzhong Yan, Suresh Chand Rai, Md. Nurul Islam, Basanta Paudel

“…Lack of understanding and awareness of CCA in a local sociocultural context among implementation authorities and weak institutional mechanisms are gaps at the institutional front. …”
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Potential protective association of the AA genotype and a allele of CXCR4 rs2228014 polymorphism with COVID-19 severity in adult egyptians by Osama H. Korayem, Amr E. Ahmed, Mohamed H. Meabed, Doaa M. Magdy, Wafaa M. Abdelghany

“…Several genetic factors have been implicated in diverse responses to SARS-CoV-2 infection, such as the C-X-C chemokine receptor 4 (CXCR4) rs2228014 polymorphism, which has been previously studied in various diseases but has not been explored in the context of COVID-19 severity. The current study aimed to assess the association between the rs2228014 polymorphism in the CXCR4 gene and the severity of COVID-19, which has not been previously reported. …”
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Quantitative systems toxicology modeling in pharmaceutical research and development: An industry‐wide survey and selected case study examples by Kylie A. Beattie, Meghna Verma, Richard J. Brennan, Diana Clausznitzer, Valeriu Damian, Derek Leishman, Mary E. Spilker, Britton Boras, Zhenhong Li, Elias Oziolor, Theodore R. Rieger, Anna Sher

“…Abstract Quantitative systems toxicology (QST) models are increasingly being applied for predicting and understanding toxicity liabilities in pharmaceutical research and development. …”
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Private, non-profit, and plantation: Oil palm smallholders in management-assistance programs vary in socio-demographics, attitudes, and management practices. by Valentine J Reiss-Woolever, Wakhid Wakhid, Muhammad Ikhsan, Jean-Pierre Caliman, Muhammad Naim, Elfina N Azmi, Sharyn Shufiyan, John Howes, Reza Azmi, Ying Ying Lim, Siti Zulaikah Abdul Jan, Isaac Barrock, Badrul Azhar, Julia Drewer, Caroline Ward, Joshua A Jones, Sarah H Luke, Edgar C Turner, Purnama Hidayat, Damayanti Buchori

“…Awareness of the effects of palm oil production on ecosystems and human communities has increased drastically in recent years, with ever louder calls for the private and public sector to develop programs to support sustainable cultivation by smallholder farmers. …”
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Inferential misconceptions and replication crisis by Norbert Hirschauer, Oliver Mußhoff, Sven Gruener, Ulrich Frey, Insa Theesfeld, Peter Wagner

“…Nonetheless, they seem to have persisted in empirical research, and criticisms of p value misuses have increased in the recent past due to the non-replicability of many studies. …”
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Mapping the status of global taxonomic knowledge of Orthoptera (Arthropoda, Insecta) by Rodrigo Antônio Castro-Souza, Juliana Stropp, Luiz Felipe Moretti Iniesta, Richard J. Ladle, Neucir Szinwelski, Geiziane Tessarolo, José Alexandre Diniz-Filho, Thadeu Sobral-Souza, Joaquín Hortal

“…Our analyses show that the descriptions of currently valid species increased exponentially since the 19th century, with a temporary decline following World War II, while synonyms outpaced the number of valid species until the 1980s. …”
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The impact of e-marketing orientation, technological orientation and learning capacity on online SME performance by Ahmed Al Asheq, Khadiza Rahman Tanchi, Md. Kamruzzaman, Md. Mobarak Karim

“…Currently, Internet penetration is accelerating across the country in Bangladesh, which, in particular, has led to the simultaneous development and growth of online businesses. …”
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Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity by Bhavani Sowndharya Balamurugan, Mathan Muthu Chinnakannu Marimuthu, Vickram Agaram Sundaram, Bharath Saravanan, Prasanth Chandrababu, Hitesh Chopra, Tabarak Malik

“…For example, it points out the modulatory effects of vitamin D on both innate and adaptive immunity, with a specific focus on its ability to suppress pro-inflammatory cytokines synthesis while enhancing regulatory T-cell function. In the same context, also zinc is described as important nutrient for thymic function and T-cell differentiation but exhibits immunomodulatory functions by decreasing inflammation. …”
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Japanese Model of Attracting Foreign Youth in the Higher Education System by S. V. Ryazantsev, T. K. Rostovskaya, N. S. Ryazantsev

“…National education and science systems are increasingly integrated into the international scientific and educational space in the context of increasing globalisation. …”
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Administration of aspirin and risk of pancreatic ductal adenocarcinoma by Arooba Noor Abbasi, Fatimah Bismah Athar, Arooba Lakho

“…While Aspirin shows major benefits in other contexts, its role in PDAC risk reduction appears limited. …”
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Citizens’ Perceptions of Public Administration Ethics, Public Service Quality and Politicization of Public Organizations: A Study in Diyarbakır by Müslüm Kayacı

“…Field studies in different contexts can provide evidence for new public management scholars to expand theory and for governments to improve current policies and operations in the bureaucracy. …”
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The existing state of knowledge about sleep health in community-dwelling older persons – a scoping review by Sandra Öberg, Christina Sandlund, Björn Westerlind, Deborah Finkel, Lennarth Johansson

“…Few reviews have described current knowledge about the holistic concept of sleep health of community-dwelling older people.Aim This study aimed to describe the current state of knowledge and identify research gaps concerning sleep health among community-dwelling older persons.Method We conducted a scoping review. …”
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Cost-benefit analysis of craniocerebral surgical site infection control in tertiary hospitals in China by Jiong Zhou, Xiaojun Ma

“…This study aimed to determine the cost of SSIs and to evaluate whether SSI control can reduce medical costs under the current medical payment system and wage rates in China. …”
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Burnout and its Factors in Healthcare Workers Involved in Providing Health Care for Patients With COVID-19 at Different Stages of the Pandemic by A. B. Kholmogorova, S. S. Petrikov, A. Y. Suroyegina, O. Y. Mikita, A. A. Rakhmanina, A. P. Roy

“…Abstract. In the context of the pandemic, when healthcare professionals are forced to work under extreme stress and an increased threat of infection, research on professional burnout and emotional maladjustment of medical workers is gaining particular relevance around the world.Aim of study. …”
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Comparison of Bone Mineral Density in Lumbar Spine and Fracture Rate among Eight Drugs in Treatments of Osteoporosis in Men: A Network Meta-Analysis. by Ling-Xiao Chen, Zhi-Rui Zhou, Yu-Lin Li, Guang-Zhi Ning, Tian-Song Zhang, Di Zhang, Shi-Qing Feng

“…Zoledronate ranked first for increasing the BMD in LS, and teriparatide (20mg) was ranked first for decreasing the fracture rate.…”
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Integrating the international medical graduate by Julia McLaughlin, Katherine Baker, Tracy Sandell, Shirly Mathias, Subramaniam Nagasayi, Ilona Schmidt, Christopher James

“…Introduction: The growing utilisation of international medical graduate (IMG) doctors in the UK has uncovered a need for hospitals to establish induction programmes that harness supportive environments for these doctors to learn within the specific context of the NHS. Currently, IMGs are under-supported at local and national levels. …”
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New Developments in the EU Internal Market – Harmonisation vs. Mutual Recognition by Ljubica Dzabirova

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