Transcriptomic analysis on pancreatic adenocarcinoma patients uncovers KRAS-mediated PPAR pathway alteration by Giuseppe Defazio, Federico Scolari, Sara Fancelli, Simone Polvani, Daniele Lavacchi, Lucia Picariello, Alessandro Tubita, Michaela Luconi, Lorenzo Antonuzzo, Lorenzo Antonuzzo, Andrea Galli, Serena Pillozzi

“…The incidence and mortality of pancreatic adenocarcinoma (PC) are expected to increase in the coming years, with survival rates remaining poor due to limited treatment options. …”
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Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances by Qiu Jiang, Jie Liu, Shan Huang, Xuan-Yue Wang, Xiaowei Chen, Guang-Hui Liu, Keqiang Ye, Weihong Song, Colin L. Masters, Jun Wang, Yan-Jiang Wang

“…Abstract In the context of global ageing, the prevalence of neurodegenerative diseases and dementia, such as Alzheimer’s disease (AD), is increasing. …”
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TRANSFORMING MUSIC EDUCATION IN UKRAINE: OPPORTUNITIES AND CHALLENGES IN CULTURAL AND ARTISTIC EDUCATION REFORM by Ihor ZAKUS, Nataliia LEBEDIEVA, Irma GVINIASHVILI, Viktoriya KORZHENOK, Dennis ADU

“… The article discusses the current challenges and prospects for developing music education in Ukraine while reforming the cultural and artistic sphere. …”
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Assessing Climate Change Impacts on Distribution Dynamics of Lysimachia Christinae in China Through MaxEnt Modeling by Yangzhou Xiang, Yuan Li, Ying Liu, Yingying Yuan, Suhang Li, Qiong Yang, Jinxin Zhang

“…However, in the context of the SSP5‐8.5 pathway, the retention rate significantly decreased to 64.77% by the 2090s, indicating greater habitat instability and expansion needs. …”
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Unraveling the complex role of microglia in Alzheimer’s disease: amyloid β metabolism and plaque formation by Sho Takatori, Mayuna Kondo, Taisuke Tomita

“…Conversely, we explore findings that challenge this view, such as microglial depletion experiments resulting in unchanged or decreased Aβ accumulation. We propose that the contribution of microglia to Aβ metabolism is context-dependent, varying with disease progression, genetic background, and experimental conditions. …”
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CIS Countries Foreign Economic Activity — from Challenges to New Opportunities by M. S. Goncharov

“…Aim and tasks. To identify current trends and issues in foreign trade, the international financial system, and the investment activity of CIS member states, and to provide recommendations that contribute to sustainable economic development and strengthened mutual cooperation.Methods. …”
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Unlocking the hidden forces: deformation and associated stress distribution in the present-day Geneva Basin and Jura fold-and-thrust belt by Sandra Borderie, Jon Mosar, Adeline Marro, Louis Hauvette

“…If current seismicity indicates that the Geneva Basin is tectonically active, few data regarding the state of stress in the area are currently available. …”
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Social Skills Training Program and its Effect on Quality of Life and Stigma among Patients with Schizophrenia by Samah Ali, Amal Awad, Hanaa Ewise, Shimaa Adam

“… Context: Schizophrenia is a severe mental disorder that significantly disrupts an individual's social interactions, work performance, and overall quality of life. …”
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Therapeutic potential of microRNAs in neurological disorders: mechanisms, biomarkers, and emerging therapeutic strategies by Sourav Pal, Subhajit Mandal

“…We also explore the future of miRNA research in the context of precision medicine, highlighting the importance of targeted delivery, safety optimization, and integration of patient-specific molecular profiles. …”
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Rebooting Master’s Programs in an Updated Higher Education System: Management Track by E. A. Kuklina

“…The article substantiates proposals that contribute to updating the Russian model of master’s training in the management track in the direction of increasing its efficiency, competitiveness and relevance.Research objectives: to consider the role of the master’s degree institute in the context of value creation by universities; justify one of the possible approaches to the design of a master’s program, which is based on the implementation of new principles for the creation and implementation of an educational product (using the example of direction 38.04.01 — Economics); consider the “double degree” format as part of a package proposal for the implementation of an MBA program and a master’s program (in the direction of 04/38/02 — Management); justify the need to include disciplines on venture financing and risk management of technological projects in the structure of the master’s training curriculum. …”
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Tax regulation of enterprise R&D expenditures: special aspects and problems of regulation by T. A. Loginova

“…As a second step authors are performing the analysis of current rules related to tax accounting of R&D costs and intangibles in accordance with Tax Code of Russian Federation. …”
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From bench to bedside: nanomedicine development for intracerebral hemorrhage – exploring microenvironment, innovation, and translation by Gui Wan, Lingui Gu, Yangyang Chen, Yiqing Wang, Ye Sun, Zhenwei Li, Wenbin Ma, Xinjie Bao, Renzhi Wang

“…Finally, the progress of nanomedicines in clinical translation is analyzed, highlighting the challenges, opportunities, and future prospects for their application in the context of ICH. Graphical abstract…”
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Dynamic Analysis of the Interconnection of a Set of FPSO Units to an Onshore System via HVDC by Johnny Orozco Nivelo, Carlos A. Villegas Guerrero, Lúcio José da Motta, Marcos R. de Paula Júnior, José M.d. Carvalho Filho, Alex Reis, José Carlos Oliveira, José Mauro T. Marinho, Vinicius Z. Silva, Carlos A. C. Cavaliere

“…In this context, the oil industry, which contributes to indirect GHG emissions, is seeking ways to develop solutions to this issue. …”
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A novel in vitro system for simultaneous infections with hepatitis B, C, D and E viruses by Roxanne Fouillé, Eloi R. Verrier, Amse De Meyer, Lieven Verhoye, Maud Michelet, Romain Barnault, Caroline Pons, Olivier Diaz, Michel Rivoire, Guillaume Passot, Eike Steinmann, Heiner Wedemeyer, Anna Salvetti, Nicole Pavio, Virginie Doceul, Raphaël Darteil, Philip Meuleman, David Durantel, Julie Lucifora

“…Using HEV-infected HuHep mice, we confirmed the antiviral effect of vonafexor, an FXR agonist, that is currently being tested clinically against HBV/HDV. …”
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PROBLEM ISSUES IN THE IMPLEMENTATION OF INNOVATIONS AND DIGITAL TECHNOLOGIES IN AGRICULTURAL PRODUCTION IN THE CONDITIONS OF NBIC CONVERGENCE by Marianna VASILCHENKO, Elena DERUNOVA, Anton VORONOV, Maria RGEVSKAYA

“…Currently, in the agro-industrial complex, the problem of import substitution of key technological solutions, innovative resources and digital technologies is becoming increasingly important for increasing agricultural production. …”
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Overview on the development and application of the key concepts for decision-making in health care by Nicolás Flores Uribe, Diego Grandi Pincheira, Roberto Garnham Parra, Eva Madrid Aris, Nicolas Meza Concha

“…In this context, promoting knowledge dissemination through reliable sources and fostering health literacy among the general population is crucial. …”
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Presenting the agility model of the organization in order to improve the productivity of human resources by Asie Mohmedi, Rashid Zolfaghari, Mahsa Gholam hossein zadeh

“…In terms of purpose, the current research is applicable in the quantitative part, fundamental-exploratory in the qualitative part, and mixed (qualitative-quantitative) in terms of implementation. …”
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Protocol for implementation of intraoperative adverse event recording during WHO checklist sign-out by Guy Haller, Lauren Clack, Christian Schindler, Luzius A Steiner, Salome Dell-Kuster, Dieter Hahnloser, Jörn-Markus Gass, Christoph S Burkhart, Andreas P Vogt, Katrin Burri-Winkler, Anne C Auderset, Valentin Neuhaus, Giorgio Prouse, Judith Winkens, Amanda Van Vegten, Zuzanna Kita, Monika Finsterwald, Nico Streit, Lisa M Willms

“…Introduction & aim Intraoperative adverse events (iAEs) increase postoperative complications, which are devastating to patients and costly to healthcare systems. …”
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Marketing Logistics and its Digitalization by Iryna Polishchuk, Yuriy Dovhan, Iryna Kramar, Larysa Dovhan, Oksana Yakushevska

“…The purpose of the article is to highlight the historical process of forming marketing logistics as a modern management concept and the current trends in its digitalization. The theoretical foundations of marketing logistics summarized in this work will facilitate the integration of digital technologies into marketing logistics, improve business processes, and support the sustainable development of companies in the context of dynamic changes in the global market. …”
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The Direction of Indonesia’s Legal Policy on the ASEAN Mutual Legal Assistance Treaty in Criminal Matters: A Path to Law Reform in Cross-Border Crime Enforcement in Southeast Asia... by Ridwan Arifin, Rodiyah Rodiyah, Waspiah Waspiah, Asyaffa Ridzqi Amandha, Elizabeth Yunita Krisnawati, Tirta Sandi, Michael Timothy Napitupulu

“…First, it provides a comprehensive analysis of the current state of Indonesia’s legal policy on AMLAT, highlighting key areas for legal reform. …”
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