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3561
The Ukraine-Russia conflict: An international humanitarian law review of the involvement of foreign fighters
Published 2025-01-01“…Their involvement on both sides of the conflict between those supporting either Ukrainian forces or Russian-backed groups, presents a complex issue that requires careful consideration within the context of IHL, which currently lacks clear provisions for addressing their legal status. …”
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3562
Review of the hydrological effects of the extreme event Hurricane Eta in the Chiriquí Viejo River basin, November 2020
Published 2025-06-01“…The maximum rainfall recorded on November 4, 2020, reached 223.8 mm, while the flow in Paso Canoa reached 638.03 m³/s, demonstrating the magnitude of the event and the inability of the basin to handle such high volumes of water.Through a detailed analysis, it was observed that soil saturation resulted in direct runoff of up to 70.0 mm that same day, which shows that the infiltration capacity of the soil was quickly exceeded.Despite the damage observed, there are currently no advanced hydrological studies on extreme events in critical basins such as the Chiriquí Viejo River.This lack of research reflects a serious lack of planning and assessment of the risks associated with phenomena of this magnitude.One of the most critical problems found is the lack of specialized hydrology professionals, who are essential to carry out detailed studies and ensure sustainable management of water resources.In a context where climate change increases the frequency and intensity of extreme events, the absence of hydrologists in the region puts the resilience of the basin to future disasters at risk.The basin's hydraulic system demonstrated its inability to handle high flows, underscoring the need to improve flood control and water retention infrastructure.In addition, the lack of effective hydrological planning and coordination in the management of hydraulic infrastructures compromises both the safety of downstream communities and the sustainability of hydroelectric reservoirs, vital for the region.…”
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3563
Promising areas and megatrends in the development of logistics technologies in the future
Published 2025-05-01“…The authors have determined that the key trend is increasing the flexibility of the logistics process, improving its ability to adapt to changing external conditions and continuously improve. …”
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3564
RETRACTED: Recent trends in the use of bacteriophages as replacement of antimicrobials against food-animal pathogens
Published 2023-05-01“…Additionally, bacteria are becoming more resistant to antibiotics, which pose a global threat. Currently, many scientific efforts have been made to develop and implement new technologies to combat bacteria considering the increasing emergence of multidrug-resistant bacteria. …”
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3565
Experience in implementing a patient-centered approach in a private medical organization
Published 2022-09-01“…Currently, taking into account the pronounced competition among modern medical organizations, attracting patients and forming a high degree of their loyalty requires significant efforts both in the field of ensuring the quality of medical services provided, and in the field of full implementation of legally enshrined patient rights, compliance with ethical and deontological norms, the formation of effective communication and integration processes between employees of a medical organization and patients and/ or their relatives, and in the context of the activities of a private medical organization, special work is also largely required to optimize the main business processes. …”
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3566
PO54 | FATTY INFILTRATION AND POTENTIAL ADIPOGENIC SHIFT OF SKELETAL MUSCLE CELLS: MULTIPARAMETRIC HISTOLOGICAL ANALYSIS OF MYOSTEATOSIS
Published 2025-08-01“… Myosteatosis, defined as an ectopic fat accumulation within skeletal muscle, has gained increasing clinical relevance as it fits within the context of metabolic disorders and aging. …”
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3567
Smart Packet Delivery in Mobile Underwater Sensors Networks (M-CTSP)
Published 2025-01-01“…This research is focused on leveraging the Travelling Salesman Problem (TSP) to establish the optimal route of getting from a source node to a destination node in an underwater dynamic location. In this context, all nodes are mobile and slightly adjust their positions due to water currents. …”
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3568
Digital Transformation Strategy of Aerospace Industry
Published 2025-04-01“…The aerospace industry, as an important representative of high-end manufacturing, plays an irreplaceable role in the development of new-quality productivity. In the context of increasingly complex projects and rapid iteration of new technologies, the development model of the aerospace industry is facing significant challenges and urgently requires digital transformation to promote high-quality development of the industry. …”
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3569
Supply Chain Model for Mini Wind Power Systems in Urban Areas
Published 2025-02-01“…The pursuit of energy security has become one of the most important challenges facing modern societies worldwide. The increase in energy consumption and the need to promote sustainability puts pressure on power generation systems. …”
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3570
Effects of wetting events on mass timber surface microbial communities and VOC emissions: implications for building operation and occupant well-being
Published 2025-04-01“…IntroductionHumans have used wood as a construction material throughout history. Currently, mass timber products, such as cross-laminated timber (CLT), are becoming more popular as a structural material, since they are renewable and have a lower carbon footprint than concrete or steel. …”
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3571
Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma
Published 2025-03-01“…It is critical to investigate new biomarkers and prognostic variables because there are currently no early diagnostic indicators. Actin-related proteins (ARPs) are involved in transcriptional regulation, chromatin remodeling, and DNA repair—all processes that have been connected to the development of cancer. …”
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3572
Nanostructured Strategies for Melanoma Treatment—Part I: Design and Optimization of Curcumin-Loaded Micelles for Enhanced Anticancer Activity
Published 2025-02-01“…<b>Background/Objectives</b>: Melanoma is a pathology that affects a large part of the population, and the currently available therapies have many limitations, including the selective targeting of the site of action. …”
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3573
Standardized Outcomes for Randomized Controlled Trials Targeting Early Interventions in Patients With Moderate-to-Severe Traumatic Brain Injury: Protocol for the Development of a C...
Published 2025-01-01“…In the last 20 years, there has been an increase in clinical trials in neurocritical care, leading mostly to negative results. …”
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3574
Oral vs. Outpatient Parenteral Antimicrobial Treatment for Infective Endocarditis: Study Protocol for the Spanish OraPAT-IE GAMES Trial
Published 2025-03-01“…Conclusion In a global context of limited healthcare resources and a sustained increase in elderly and frail patients, it is of great importance to demonstrate the effectiveness and safety of outpatient management strategies that could reduce the duration of conventional hospitalizations with their potential complications and inherent costs. …”
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3575
OPTIMIZATION OF IMID-BASED THERAPIES
Published 2024-12-01“…In this case, it is clear that multiple myeloma treatment optimization cannot be achieved by considering multiple myeloma treatment only as applying the appropriate drug combination.In order to ensure the optimization of IMID-based therapies, it is necessary to take a broad perspective.This perspective should include the correct selection of the patient to be treated with IMID, the development and implementation of IMID forms that will increase patient compliance, the use of techniques to predict the development of resistance, side effect management during treatment, preventing the increase in disease burden with appropriate maneuvers by following the disease burden after treatment, and drug-free follow-up.It is recommended to avoid thalidomide in the presence of peripheral neuropathy, to prefer other agents instead of lenalidomide in the presence of renal function loss, and to avoid pomalidomide in patients with COPD.Nex-20, a once-monthly subcutaneous formulation of lenalidomide, is expected to be an important breakthrough in improving patient compliance.Prediction of which patients will develop resistance will be very useful in order to have the best treatment outcomes.Calculation of miRNA risk scores, measurement of lenalidomide metabolite levels in urine, measurement of cereblon levels in blood, or immunohistochemical detection of cereblon levels are some of the methods currently being tried to predict disease resistance.Patients who develop anemia should be treated with erythropoietin, skin reactions should be treated with steroids and antihistamines, diarrhea should be treated with loperamide and colestyramine, and in general, the drug should be discontinued and the same dose or a lower dose should be insisted upon.An important part of treatment is maintenance therapy with lenalidomide. …”
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3576
Justification of military neutrality of the Republic of Serbia at a time of erosion of neutrality in Europe
Published 2023-01-01“…Increase of NATO members, as well as abandoning neutrality under the influence of globalization and negative experiences of neutral countries in the 20th century, strengthens this assertion. …”
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3577
CircPWWP2A promotes renal interstitial fibrosis through modulating miR-182/ROCK1 axis
Published 2024-12-01“…Despite ongoing research, the mechanisms underlying renal fibrosis are still not well understood, and there is currently a lack of effective treatments available. …”
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3578
A review of private forest owner typologies with potential to contribute to social milieu research in forest policy
Published 2025-06-01“…Furthermore, their broader geographical scope can complement the currently German-centric milieu literature.In conclusion, PFO typology research and social milieu research are mutually beneficial. …”
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3579
Assessing crack formation and strain distribution in concrete structures using externally installed fiber optic sensors
Published 2025-07-01“…The structural integrity of many European bridges is increasingly compromised by rising traffic loads and gradual deterioration. …”
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3580
Bleomycin: A worthy alternative
Published 2011-01-01“…Complications of the therapy were few and far between. 2 patients developed fever after injection, one patients reported a transient increase in size of swelling, 2 patients have developed discoloration of the overlying skin and are currently being followed up for final outcome. …”
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