A multi-omic dissection of molecular hallmarks of accelerated aging in schizophrenia by DongDong Qi, Peng Liu, YiMeng Wang, XuGuang Tai, ShiFa Ma, Yue Wang

“…The intricate interplay of schizophrenia with the aging process is characterized by a shortened lifespan, underscoring the urgent need for an in-depth exploration of the underlying biological mechanisms that contribute to the unique aging trajectory within this specific patient population. Currently, this crucial aspect remains largely unexplored. …”
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Optimized biosynthesis and performance enhancement of γ-PGA from Bacillus licheniformis: a study on wettability, microstructure, and environmental performance by Mingming Cheng, Shuoshi Zhang, Jianbo Gao, Wenqing Liu, Gang Zhou, Tao Sui, Daoquan Cheng, Cheng Wang, Xiangchuan Wang, Xiaoyan Li, Yuxi Li

“…Infrared spectroscopy analysis showed that the purified product contained typical functional groups of γ-PGA. Changes in the contact angle of γ-PGA solution with coal dust over time demonstrated that brown coal was wetted extremely quickly, with the largest change in contact angle; within 5 min of dropping the fermentation liquid, the contact angle sharply decreased from 69° to 0°, completely wetting the brown coal. …”
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Selective Separation of Scandium in Acidic Water Using Carboxyl Functionalized Covalent Phosphonitrile Polymers by Yu BAI, Ayinuer WUSHUER, Lei OUYANG, Lijin HUANG, Qin SHUAI

“…However, because the pore size of the vast majority of covalent organic polymers currently synthesized is much larger than those of metal ions, this method is generally applicable to larger sized ions such as hydrated uranium ions. …”
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Anticipating how spatial fishing restrictions in EU waters perform to protect marine species, habitats, and dependent fisheries by François Bastardie, Amaia Astarloa, Logan Binch, Isabella Bitetto, Dimitrios Damalas, Jochen Depestele, Pierre-Yves Hernvann, Sigrid Lehuta, Jonas Letschert, Irida Maina, Stéphanie Mahévas, Georgia Papantoniou, Miriam Püts, Giovanni Romagnoni, Giovanni Romagnoni, Giovanni Romagnoni, Giovanni Romagnoni, Maria Teresa Spedicato, Klaas Sys, Irini Tsikopoulou, Gert Van Hoey, Walter Zupa, Anna Rindorf

“…As the proportion of closed regions increases, potential effects on marine ecosystems can even be damaging in the short term to some sensitive species (such as the endangered, threatened and protected species ETP) and vulnerable habitats (with currently high relative benthic status RBS). …”
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Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and <i>Trypanosoma cruzi</... by Gabriela Alves de Souza, Lorrane de Souza Chaves, Afonso Santine M. M. Velez, Jorge Lucas F. Lacerda, Paulo Pitasse-Santos, Jayane Clys Conceição dos Santos, Otávio Augusto Chaves, Carlos Serpa, Raphael do Carmo Valente, Leonardo Marques da Fonseca, Marcos André Rodrigues da Costa Santos, Jhenifer Santos dos Reis, Carlos Antônio do Nascimento Santos, Lucia Mendonça-Previato, Jose Osvaldo Previato, Celio Geraldo Freire-de-Lima, Debora Decoté-Ricardo, Leonardo Freire-de-Lima, Marco Edilson Freire de Lima

“…<b>Background: </b>Anticancer therapies represent the primary treatment option for a significant number of cancer patients globally; however, many of these treatments are associated with severe side effects as they target molecular structures present in both cancerous and healthy cells. In a similar context, the treatment of Chagas disease, a neglected tropical illness, is hindered by the high toxicity of the currently available drugs. …”
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Understanding data and information needs for palliative cancer care to inform digital health intervention development in Nigeria, Uganda and Zimbabwe: protocol for a multicountry q... by Richard Harding, Bassey Ebenso, Adlight Dandadzi, Eve Namisango, Kehinde Okunade, Kennedy Bashan Nkhoma, Omolola Salako, David Akeju, Olaitan Soyannwo, Elizabeth Namukwaya, Elizabeth Nabirye, Lovemore Mupaza, Emmanuel Luyirika, Henry Ddungu, Z Mike Chirenje, Michael I Bennett, Matthew J Allsop

“…However, there is currently a lack of any theoretical underpinning or data to understand stakeholder drivers for digital health components in this context. …”
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Issues of Interpretation and Application of the Notion of “International Legal Legitimation” by A. M. Korzhenyak

“…Therefore, this phenomenon encapsulates a tremendous applied value in the context of the increasing number of hybrid threats to the national security of our country and the emergence of new sources of such threats.MATERIALS AND METHODS. …”
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Impact on alcohol selection and online purchasing of changing the proportion of available non-alcoholic versus alcoholic drinks: A randomised controlled trial. by Natasha Clarke, Anna K M Blackwell, Jennifer Ferrar, Katie De-Loyde, Mark A Pilling, Marcus R Munafò, Theresa M Marteau, Gareth J Hollands

“…<h4>Background</h4>Increasing the availability of non-alcoholic options is a promising population-level intervention to reduce alcohol consumption, currently unassessed in naturalistic settings. …”
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An in-depth understanding of stakeholders’ experiences about their participation in the co-production of ‘Maze Out’: a serious game for the treatment of eating disorders by Maria Mercedes Guala, Aida Bikic, Kim Bul, David Clinton, Anette Søgaard Nielsen, Helene Nygaard Nielsen, Martina Scarpelli, Luciana Schneider, Regina Christiansen

“…Abstract Background Co-production is increasingly used in mental health research and clinical settings. …”
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Trade-Off Between Growth Regimes in <i>Chlorella vulgaris</i>: Impact on Carotenoid Production by Patrícia Acosta Caetano, Pricila Pinheiro Nass, Mariany Costa Deprá, Tatiele Casagrande do Nascimento, Eduardo Jacob-Lopes, Leila Queiroz Zepka

“…With the increasing awareness of socio-environmental issues, a global trend has emerged emphasizing the valorization of natural ingredients that promote health and well-being within sustainable production systems, such as microalgae-based carotenoids. …”
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Factors Related to Health Resilience in Students Affected by Disaster at Campus Graha Ananda Palu by Sadli Syam, Muhammad Sabri Syahrir, Muhammad Aji Satria, Iin Irawati

“…Follow stages disaster in Palu City, when these are the people affected disaster in Palu City now currently in phase recovery going to resilience, namely restore normal condition and strengthen Power stand public to disaster. …”
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Methods for the health technology assessment of complex interventions: a protocol for a scoping review by Tracy Merlin, Abdolvahab Baghbanian, Drew Carter, Shuhong Wang

“…Introduction In healthcare policy and economic literature, research on the health technology assessment (HTA) of complex interventions (CIs) is becoming increasingly important. In many developed countries, HTA guides decision-making to help achieve greater value for money when funding health care. …”
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A review of coal mine saline mine water treatment and utilization technologies by Weidong MAO, Zhongquan GUO, Yuan FU, Jiuli YANG, Xufeng XU, Yantao WU, Zhipeng TANG, Jun ZHANG, Dongfeng CUI, Junzhao ZHU

“…China’s coal production is dominated by underground mining. With increasing mining depth, there is an observed rise in the proportion of saline mine water emissions. …”
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Fuel cell technologies in the automotive sector: A focus on proton exchange membrane and Alkaline fuel cells by Vijay Bhooshan Kumar, Aakash Collin, M. Gopi Sankar, Kanakasabapathi Subramanian

“…The automotive industry currently relies heavily on internal combustion engine (ICE) technology, which consumes large amounts of fossil fuels and significantly contributes to global environmental degradation and the ongoing energy crisis. …”
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The prognostic value of serum apolipoprotein A1 levels in elderly patients with de novo SARS-CoV-2 omicron infection by Cong Shi, Ruishuang Ma, Miao Zhou, Shujun Yang, Shengping Gong

“…The omicron variant is currently the predominant strain circulating worldwide. …”
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Implementation of a community-based LC-UV drug checking service: promising preliminary findings on feasibility and validity by Nicolas Fabresse, Eurydice Papias, Alma Heckenroth, Victor Martin, Daniel Allemann, Perrine Roux

“…Abstract Background The increasing diversity of psychoactive substances on the unregulated drug market poses significant health, psychological, and social risks to people who use drugs (PWUD). …”
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“If that would have lessened my symptoms, that would have been great...”: a qualitative study about the acceptability of tecovirimat as treatment for mpox by Sara Paparini, Rosalie Hayes, Benjamin Weil, Will Nutland, Ismael Maatouk, Teodora Wi, Chloe M. Orkin, Rosamund Lewis

“…Conclusions This exploratory study suggest that offering tecovirimat (or comparable emergency-licensed treatments) to people with mpox is acceptable, although uptake will depend on knowledge of mpox treatment options, trust in medicine and medical professionals and provision of relevant information and choice. To increase acceptability of such treatments, clinicians should ensure patients are aware of mpox symptom management options, including pain relief; acknowledge and address patient concerns upfront and within the context of non-stigmatising care; and communicate offers in a consistent and supportive manner in line with locally approved eligibility criteria and protocols at the time.…”
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Molecular genetics is on the guard of the law by L. I. Kucherenko, I. V. Pavliuk, O. V. Khromylova

“…In the world, forensic DNA analysis is recognized as one of the most promising areas of development of forensic examinations, and its results are currently one of the most reliable pieces of evidence. …”
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Medical embryology and regenerative medicine: research and applications in clinical practice by Julia Soczyńska, Julia Soczyńska, Wiktor Gawełczyk, Wiktor Gawełczyk, Patrycja Obrycka, Patrycja Obrycka, Mateusz Żołyniak, Mateusz Żołyniak, Adrian Muzyka, Adrian Muzyka, Krzysztof Majcherczyk, Krzysztof Majcherczyk, Julia Papierkowska, Julia Papierkowska, Sławomir Woźniak

“…Taking this progress a step further, the ability to introduce stem cells into damaged tissues, thereby facilitating the formation of functional structures, has led to the growing interest in organoids -three-dimensional models that replicate key functions of real organs. Organoids are currently applied not only in drug screening but are also gaining increasing attention for their role in cancer therapy research. …”
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A comprehensive item bank of internal validity issues of relevance to in vitro toxicology studies by Gunn E. Vist, Heather M. R. Ames, Gro H. Mathisen, Trine Husøy, Camilla Svendsen, Anna Beronius, Emma Di Consiglio, Ingrid L. Druwe, Thomas Hartung, Sebastian Hoffmann, Carlijn R. Hooijmans, Kyriaki Machera, Pilar Prieto, Joshua F. Robinson, Erwin Roggen, Andrew A. Rooney, Nicolas Roth, Eliana Spilioti, Anastasia Spyropoulou, Olga Tcheremenskaia, Emanuela Testai, Mathieu Vinken, Paul Whaley

“…Context In vitro toxicology studies are increasingly being included as evidence in systematic reviews and chemical risk assessments. …”
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