Insulin Modulates NK Cell Activity in Liver Fibrosis MASH Patients via the STING Pathway by Johnny Amer, Ahmad Salhab, Amiram Ariel, Rifaat Safadi

“…While STING is well-established in various immune cells, its role in natural killer (NK) cells, particularly within the context of liver fibrosis, remains inadequately explored. …”
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Unravelling the myriad physiologic roles of transthyretin: critical considerations for treating transthyretin amyloidosis by Morie A. Gertz, Mandar A. Aras, Nicole Bart, Thomas H. Brannagan, Jan M. Griffin, Amy R. Kontorovich, Andrew M. Rosen

“…While a link between low TTR and severe disease and mortality is well established, it remains unclear whether long-term TTR suppression via ATTR therapies increases risk of disease. Clinical decisions in ATTR, however, should reflect the current understanding of the roles of TTR and the patient’s clinical history.Conclusion TTR serves vital physiologic roles across organ systems. …”
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Climate change adaptation: policy, practice and adaptation gaps in the agriculture sector in Bangladesh, India and Nepal by Shobha Shrestha, Prem Sagar Chapagain, Yili Zhang, Linshan Liu, Jianzhong Yan, Suresh Chand Rai, Md. Nurul Islam, Basanta Paudel

“…Lack of understanding and awareness of CCA in a local sociocultural context among implementation authorities and weak institutional mechanisms are gaps at the institutional front. …”
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Potential protective association of the AA genotype and a allele of CXCR4 rs2228014 polymorphism with COVID-19 severity in adult egyptians by Osama H. Korayem, Amr E. Ahmed, Mohamed H. Meabed, Doaa M. Magdy, Wafaa M. Abdelghany

“…Several genetic factors have been implicated in diverse responses to SARS-CoV-2 infection, such as the C-X-C chemokine receptor 4 (CXCR4) rs2228014 polymorphism, which has been previously studied in various diseases but has not been explored in the context of COVID-19 severity. The current study aimed to assess the association between the rs2228014 polymorphism in the CXCR4 gene and the severity of COVID-19, which has not been previously reported. …”
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Quantitative systems toxicology modeling in pharmaceutical research and development: An industry‐wide survey and selected case study examples by Kylie A. Beattie, Meghna Verma, Richard J. Brennan, Diana Clausznitzer, Valeriu Damian, Derek Leishman, Mary E. Spilker, Britton Boras, Zhenhong Li, Elias Oziolor, Theodore R. Rieger, Anna Sher

“…Abstract Quantitative systems toxicology (QST) models are increasingly being applied for predicting and understanding toxicity liabilities in pharmaceutical research and development. …”
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Private, non-profit, and plantation: Oil palm smallholders in management-assistance programs vary in socio-demographics, attitudes, and management practices. by Valentine J Reiss-Woolever, Wakhid Wakhid, Muhammad Ikhsan, Jean-Pierre Caliman, Muhammad Naim, Elfina N Azmi, Sharyn Shufiyan, John Howes, Reza Azmi, Ying Ying Lim, Siti Zulaikah Abdul Jan, Isaac Barrock, Badrul Azhar, Julia Drewer, Caroline Ward, Joshua A Jones, Sarah H Luke, Edgar C Turner, Purnama Hidayat, Damayanti Buchori

“…Awareness of the effects of palm oil production on ecosystems and human communities has increased drastically in recent years, with ever louder calls for the private and public sector to develop programs to support sustainable cultivation by smallholder farmers. …”
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Modelling of wax deposition for waxy crude oil by ANSYS fluent by Salman Hadi Dahwal, Zarana Patel, Ashish Nagar

“…The crude oil utilized for the study contains 38% wax and has pour point of 36 °C. The fluid flow was 1 GPM and the inlet temperature was 333.15 K which decreases up to 298.15 K. …”
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Preventive and therapeutic effects of Nasturtium officinale hydroalcoholic extract on cyclophosphamide-induced testicular toxicity in rats by Hamideh Aboutalebi, fatemeh alipour, Alireza Ebrahimzadeh-Bideskan

“…Since the Nasturtium officinale L. hydroalcoholic extract (NOE) contains a wide range of phytochemicals with various biological functions, the current study was designed to explore the protective potential of NOE on testicular toxicity caused by Cy in rats.Materials and Methods: Forty-eight adult male Wistar rats were randomly allocated into eight groups (n=6): control, Cy [received a single dose of 75 mg/kg, intraperitoneal (i.p)], NOE+Cy (Prevention): received NOE 500 and 1000 mg/kg/day, orally for 21 consecutive days and on the last day received Cy, Cy+NOE (Treatment): received NOE 500 and 1000 mg/kg/day, orally for 7 days after Cy administration for 21 consecutive days, and NOE (500 and 1000 mg/kg/day). …”
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Antifungal and anti-biofilm effects of hydrazone derivatives on Candida spp by Pierre Popczyk, Alina Ghinet, Clovis Bortolus, Laure Kamus, Marc F. Lensink, Jérôme de Ruyck, Boualem Sendid, Faustine Dubar

“…Worldwide, invasive candidiasis are a burden for the health system due to difficulties to manage patients, to the increasing of the resistance of the current therapeutics and the emergence of naturally resistant species of Candida. …”
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Part B: Innovative Data Augmentation Approach to Boost Machine Learning for Hydrodynamic Purposes—Computational Efficiency by Hamed Majidiyan, Hossein Enshaei, Damon Howe, Eric Gubesch

“…The significance of the current study extends beyond the maritime context and can be utilized for ML applications in intrinsically stochastic data.…”
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MENTORING AND TRAINING OF UNIVERSITY TEACHING STAFF by Alexandrina Mihaela POPESCU, Andreea Aurora Maria BUGA

“…The transition to an academic career represents a critical stage in the professional development of young teaching staff, characterized by complex challenges that require specialized support and professional guidance. In the current context of higher education, marked by structural transformations and increasing pressures, mentoring must be viewed as a fundamental necessity for ensuring the success and retention of new members of the university teaching staff. …”
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Advertising in the marketing communications system: analysis and directions of improvement by Alevtina Pakulina, Vitalii Blahoi

“…Based on the identified trends and current market requirements, the article substantiates ways to improve the enterprise's advertising strategy. …”
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Assessing the Quality of Concrete Tunnel Lining Exposed to Tunnel Fire through Residual Compressive Strength by Husen Alhawat, R. Hamid, Shahrizan Baharom, M. R. Azmi, A. B. M. A. Kaish

“…Another concrete tunnel lining segment was constructed using concrete containing silica fume normally used in the current construction, coded as SPC concrete. …”
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Effects of complex whole-body movements on EEG activity: a scoping review by Gabriel Müller, Atef Salem, Wolfgang I. Schöllhorn

“…This issue is currently being increasingly investigated using movements in which metabolism is not increased accordingly. …”
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African New Towns by Rachel Keeton

“…Building on the arguments that (1) equal access to resources is a key component of sustainable development and that (2) urban planning benefits from new linkages between critical social theory and environmental science, this research proposes that applying adaptive urban planning principles to New Towns in the African context can increase ecological sustainability and social inclusivity (WCED 1987; Fainstein and Campbell 2012). …”
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Waste-to-Taste: Transforming Wet Byproducts of the Food Industry into New Nutritious Foods by Anna Koptelova, Aurélien Ducrey, Bénédicte Lunven, Léa Köller, Natalia Nagornova, Edouard W. Appenzeller, Tiffany Abitbol

“…Indeed, the end-of-life of our food crops is increasingly important to consider in the context of circularity, ensuring that land, water, and chemical inputs to agriculture are sustainable. …”
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A holistic approach to sustain and support lifelong practices of wellness among healthcare professionals: generating preliminary solid steps towards a culture of wellness by Beverley Argus-Calvo, Deborah J. Clegg, Maureen D. Francis, Alok Kumar Dwivedi, Paul A. Carrola, Marie Leiner

“…This approach facilitates the establishment of a sustainable culture of wellness that benefits both current and subsequent generations of healthcare professionals. …”
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Targeted reproductive management for lactating Holstein cows: Economic return by Ricardo C. Chebel, Tomas Gonzalez, Ana B. Montevecchio, Klibs N. Galvão, Albert de Vries, Rafael S. Bisinotto

“…Under the conditions of the current experiment, the TRM treatment improved the gross profit of Holstein cows because the increased hazard of pregnancy changed culling dynamics, reducing replacement cost and cow sales and increasing calf value. …”
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Development of a High Resolution Imaging Radar for Automotive Applications in Critical Visibility Conditions by S. Vitale, A. Collaro, S. Franceschini, G. Schirinzi, W. Yang, V. Pascazio

“…To address this limitation, radar sensors—particularly imaging radars—are gaining prominence within the context of Driver Assistance Systems. A key challenge in current radar signal processing techniques is their limited ability to distinguish multiple targets along the same line of sight. …”
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Ergonomic challenges and culturally-adapted aesthetic strategies in Tunisian university libraries: Insights from Daciano da Costa and contemporary design frameworks in the digital... by Malek Nouri, Ph.D.

“…Through field observations (N=3 evaluators per site), user surveys (N=120), and focus groups (N=24 participants), it systematically examines the current challenges faced by these libraries in meeting the diverse physical and functional needs of their users, particularly in an era increasingly dominated by digital resources. …”
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