Effects of KCNQ2 gene truncation on M-type Kv7 potassium currents. by Jon Robbins, Gayle M Passmore, Fe C Abogadie, Joanne M Reilly, David A Brown

“…Measurements of tetraethylammonium block did not indicate an increased expression of Kv7.5-containing subunits, implying a compensatory increase in Kv7.2 expression from the remaining KCNQ2 gene. …”
Get full text

Machine learning application to predict binding affinity between peptide containing non-canonical amino acids and HLA-A0201. by Shan Jiang, Zhaoqian Su, Nathaniel Bloodworth, Yunchao Liu, Cristina E Martina, David G Harrison, Jens Meiler

“…However, such modifications are increasingly recognized as critical mediators of peptide immunogenicity. …”
Get full text

Formulation of Topical Drug Delivery Systems Containing a Fixed-Dose Isoniazid–Rifampicin Combination Using the Self-Emulsification Mechanism by Melissa van Deventer, Richard K. Haynes, Marius Brits, Joe M. Viljoen

Get full text

Numerical Simulation Study on the Air/Water Counter- current Flow Limitation in Nuclear Reactors by youssef morghi, Amir Zacarias Mesquita

Get full text

Current Research on Quantifying Cotton Yield Responses to Waterlogging Stress: Indicators and Yield Vulnerability by Long Qian, Yunying Luo, Kai Duan

Get full text

The current state and prospects for the development of the Ukrainian market of veterinary drugs for the treatment of skin diseases by I. V. Bushuieva, M. V. Ohloblina

“…The trend of increasing incidence of skin diseases of various etiologies and the frequency of complications caused by them (dermatitis, allergies, secondary infections, eczema, trichophytosis, dermatophytosis, dermatomycosis, etc.) is increasing in Ukraine. …”
Get full text

The development of the Unobligatory Health Insurance as basic unit of the Russian public system of medical care modernization by O. V. Boyko

Get full text

Policy Formulations to Establish More Dry Port Infrastructures to Increase Seaport Efficiency, Productivity, and Competitiveness in Bangladesh by Razon Chandra Saha, Khairir Bin Khalil

“…In the findings, 82.50% of participants agreed that existing facilities are not enough and need to establish more dry ports to handle current and future volumes of containers. Moreover, the responses reveal a division of opinion on establishing a dry port outside of Chattogram, with a notable inclination towards opposition. …”
Get full text

Concurrent Chemoradiotherapy Increases the Levels of Soluble Immune Checkpoint Proteins in Patients with Locally Advanced Cervical Cancer by Chao Liu, Xiaohui Li, Aijie Li, Wenxue Zou, Rui Huang, Xiaoyu Hu, Jinming Yu, Xiaoling Zhang, Jinbo Yue

“…The levels of soluble T-cell immunoglobulin and mucin-domain containing-3 (sTIM-3) significantly increased during CCRT (P=0.041), while those of the soluble B and T lymphocyte attenuator (sBTLA), sCD40, soluble glucocorticoid-induced tumor necrosis factor receptor ligand (sGITRL), sCD80, sCD86, sPD-1, sPD-L1, sCTLA-4, and soluble inducible T-cell costimulator (sICOS) significantly increased after CCRT (all P<0.05). …”
Get full text

Evaluating the Impact Performance of Environmentally Friendly Asphalt Concrete Slabs Containing Different Proportions of Recycled Concrete Aggregate and Corrugated Steel Fibers by Walid Mansour, Diaa Ashraf, Ali Basha

“…Abstract The current research focuses on recycling construction waste by producing asphalt concrete mixtures containing varying proportions of recycled concrete aggregate (RCA), ranging from 0 to 50%. …”
Get full text

Structure and Electrocatalytic Properties of Sulfur-Containing Multi-Walled Carbon Nanotubes on a Titanium Substrate Modified by a Helium Ion Beam by Petr M. Korusenko, Egor V. Knyazev, Alexander S. Vinogradov, Ksenia A. Kharisova, Sofya S. Filippova, Ulyana M. Rodionova, Oleg V. Levin, Elena V. Alekseeva

“…The results indicate that the ion beam treatment of the S-MWCNT system led to an increase in the level of imperfections on the surface structures of the nanotubes due to the formation of point defects on their outer walls and the appearance of oxygen-containing functional groups, including SO_x groups, near these defects. …”
Get full text

CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients by Molly S. Cook, Ellen King, Katie R. Flaherty, Khadiza Siddika, Sophie Papa, Reuben Benjamin, Anna Schurich

“…The most common CAR-T cell products currently in the clinic for DLBCL differ in their co-stimulation moiety, containing either CD28 or 4-1BB, which initiate distinct signaling pathways. …”
Get full text

Holistic Dynamic Modeling and Simulation of Alkaline Water Electrolysis Systems Based on Heat Current Method by Yi-Chong Jiang, Shi-Meng Dong, Zheng Liang, Xiao-Li Wang, Lei Shi, Bing Yan, Tian Zhao

“…Hydrogen production technology is becoming increasingly important with the rapid development of hydrogen energy. …”
Get full text

Successive increases in the resistance of Drosophila to viral infection through a transposon insertion followed by a Duplication. by Michael M Magwire, Florian Bayer, Claire L Webster, Chuan Cao, Francis M Jiggins

“…This resistant allele has rapidly increased in frequency under directional selection and is now the commonest form of the gene in natural populations. …”
Get full text

Retrospective and current state of forest territories of the border areas of the Bryansk region exposed to radioactive contamination by T. A. Marchenko, A. I. Radin, A. N. Razdaivodin

Get full text

U-SCAD: An Unsupervised Method of System Call-Driven Anomaly Detection for Containerized Edge Clouds by Jiawei Ye, Ming Yan, Shenglin Wu, Jingxuan Tan, Jie Wu

“…Container technology is currently one of the mainstream technologies in the field of cloud computing, yet its adoption in resource-constrained, latency-sensitive edge environments introduces unique security challenges. …”
Get full text

Comparing the Air Abrasion Cutting Efficacy of Dentine Using a Fluoride-Containing Bioactive Glass versus an Alumina Abrasive: An In Vitro Study by Melissa H. X. Tan, Robert G. Hill, Paul Anderson

“…Alumina, while being currently the most common abrasive used for cutting, has controversial health and safety issues and no remineralisation properties. …”
Get full text

Experimental and simulation evaluation of sulfate attack behavior of concrete in sulfate-rich and stray current environment by Yi Xu, Qian Chen, Zhisheng Lv, Li Cao, Yichao Chen, Sheng Jiang, Zhengyu Zhu, Hongqiang Chu, Linhua Jiang

“…The reinforced concrete structures within subway projects are often in a complex environment surrounded by the track's stray current and groundwater containing sulfate and chloride ions. …”
Get full text

Improvement of the sensitivity of circulating tumor DNA-based liquid biopsy: current approaches and future perspectives by Ekaterina S. Kuligina, Grigoriy A. Yanus, Evgeny N. Imyanitov

Get full text

Inquest of Current Situation in Afghanistan Under Taliban Rule Using Sentiment Analysis and Volume Analysis by Ernesto Lee, Furqan Rustam, Imran Ashraf, Patrick Bernard Washington, Manideep Narra, Rahman Shafique

“…LDA is used for topic modeling on two datasets containing tweets about the current situation after the Taliban take control of Afghanistan. …”
Get full text