Evaluating and Enhancing Japanese Large Language Models for Genetic Counseling Support: Comparative Study of Domain Adaptation and the Development of an Expert-Evaluated Dataset by Takuya Fukushima, Masae Manabe, Shuntaro Yada, Shoko Wakamiya, Akiko Yoshida, Yusaku Urakawa, Akiko Maeda, Shigeyuki Kan, Masayo Takahashi, Eiji Aramaki

“…ObjectiveThis study aims to evaluate the current capabilities and identify challenges in developing a JGCLLM-based dialogue system for genetic counseling. …”
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Antiviral Therapeutics Discovery for Enterovirus D68. by Prof Justin Jang H Chu

“…To date, there are no effective antiviral successfully developed for enterovirus infection and the current understanding on pathogenesis is limited, which has resulted in the persistent circulation and outbreaks across the globe. …”
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Promising opportunities to improve polio vaccines by E. E. Evreinova, L. M. Khantimirova, V. A. Shevtsov, V. A. Merkulov, V. P. Bondarev

“…In order to meet the needs of global health, it is planned to increase the use of traditional and optimised inactivated polio vaccines and introduce new types of vaccines that are being developed based on the current understanding of RNA-containing viruses. …”
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Cryo-EM and cryo-ET reveal the molecular architecture and host interactions of mycobacteriophage Douge by Jitendra Maharana, Chun-Hsiung Wang, Li-An Tsai, Yi-Ting Liao, Cheng-Han Yang, Melvin C. Shen, Lourriel S. Macale, Thang Ngoc Tran, Joemark Narsico, Ronelito J. Perez, Sunil Kumar Tewary, Jian-Li Wu, Hong-You Lin, Shu-Wei Chang, Aaron Franklin, Patrick J. Moynihan, Deborah Jacobs-Sera, Krista G. Freeman, Graham F. Hatfull, Todd L. Lowary, Meng-Chiao Ho

“…Molecular insights into mycobacteriophage architecture and host interactions could allow structure-guided phage engineering to increase efficacy and broaden host range, but such information is currently unavailable. …”
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SEED DORMANCY BREAKING OF AN ENDANGERED MEDICINAL TREE SPECIES (TAXUS BACCATA L.) USING EMBRYO CULTURE by Mohamed BEKHOUCHE, Abdelkader MORSLI, Majda KHELIFI-SLAOUI, Roukia BENYAMMI, Hayette ZAOUT, Lakhdar KHELIFI

“…These results indicated that the protocol developed during the current study will be useful to overcome seed dormancy and for multiplication and conservation of the species T. baccata L. …”
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Parathyroid hormone administration improves bone marrow microenvironment and partially rescues haematopoietic defects in Bmi1-null mice. by Ruinan Lu, Qian Wang, Yongli Han, Jianyong Li, Xiang-Jiao Yang, Dengshun Miao

“…The mice were treated with PTH1-34 (containing the first 34 residues of mature PTH), an anabolic drug currently used for treating osteoporosis, and compared with the vehicle-treated Bmi1-/- and wild-type littermates in terms of skeletal and haematopoietic phenotypes. …”
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THE RADIO WAVES PROPAGATION CHARACTERISTICS IN THE GLIDESLOPE AXES OF THE GROUND CONTROLLED APPROACH SYSTEMS IN THE ARCTIC REGIONS by G. S. Nakhmanson, D. V. Buchnev, A. V. Bunin

“…Information about the location of the aircraft, with a decrease along a predetermined path, the carriages, the floor-fer with the use of radio landing systems. …”
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Optimizing Antibiotic Use: Addressing Resistance Through Effective Strategies and Health Policies by Maurizio Capuozzo, Andrea Zovi, Roberto Langella, Alessandro Ottaiano, Marco Cascella, Manlio Scognamiglio, Francesco Ferrara

“…<b>Main text:</b> This review analyzes current strategies and health policies adopted in the European Union (EU) and Italy to manage AMR, presenting an in-depth examination of approaches for containment and mitigation. …”
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Evaluation of the applicability of the X-ray room technical passports in the medical facilities and approval of the X-ray department technical plans by the local radiological autho... by I. I. Berezin, S. S. Somov, К. V. Yakusheva

“…The purpose of this work was to assess the relevance and necessity of issuing a technical passport for the X-ray room and to coordinate the project of the X-ray room with the X-ray department in the light of the current sanitary legislation. Registration of a technical passport by organizations that have special permits for these types of work, and not only by the X-ray and radiological department, would increase the legal value of the technical passport. …”
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Research progress on nanotoxicity and detoxification of cobalt in metal-based implants by Wentao Fan, Mingxin Guo

“…While mechanisms are increasingly understood, further research is crucial to fully elucidate the long-term systemic consequences and to develop effective clinical detoxification and preventative strategies for patients with cobalt-containing implants.…”
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Ozonation of 4-aminotoluene as a new method of synthesis of 4-aminobenzaldehyde – an intermediate for the production of anti-tuberculosis drugs by A. H. Halstian, A. S. Вushuiev, Ye. Yu. Vasylenko

“…Continuous control of the current ozone concentration and recording the results in the form of a kinetic curve was carried out when passing ozone-containing gas through the container of the spectrophotometer “SF-46 LOMO” at a certain wavelength of a monochromatic light source. …”
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The Adaptability of Salicornia bigelovii to Salinity and Nutrient Levels in Aquaculture Effluent by Saisai CHI, Qiufen LI, Zijun LUO, Bo SUN, Wenjie TIAN, Ying MA, Zhiguo DONG, Zhengguo CUI

“…Therefore, the effective treatment and resource utilization of aquaculture effluents have become urgent considerations. The current methods for treating aquaculture effluents include physical, chemical, and biological approaches. …”
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Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis by Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen

“…Abstract Facet joint osteoarthritis (FJOA) is a prevalent degenerative condition in the aging population; however, the underlying pathophysiological mechanisms remain poorly understood and current therapeutic strategies remain limited to palliative pain management. …”
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STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma by Dingheng Lu, Yuxiao Li, Xinyang Niu, Jiazhu Sun, Weitao Zhan, Yuchen Shi, Kai Yu, Suyuelin Huang, Xiaoyan Liu, Liping Xie, Xueyou Ma, Ben Liu

“…While tyrosine kinase inhibitors (TKIs) are currently the first-line treatments for advanced/metastatic ccRCC, patients often develop resistance after TKI therapy. …”
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Hygienic requirements to the design of the positron-emission tomography centers and departments by O. V. Minonenko, T. B. Baltrukova, N. S. Bashketova, G. A. Gorskiy, T. V. Kryukova, E. A. Fedorova

“…The aim of the current study is to provide a critical analysis of the current hygienic requirements to the design of the PET, PET/CT and PET/MRI centers and departments. …”
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The long-term suitability of agrivoltaics as a climate adaptation strategy in the southwestern United States by Talitha H. Neesham-McTiernan, Greg A. Barron-Gafford

“…We evaluate land suitability for agrivoltaics across the southwest using spatially explicit multi-criteria decision analysis, which incorporates biophysical variables that relate to the potential microclimate benefits provided by agrivoltaics under current and future climate conditions. Results show 310,393 km2 of the region is suitable for agrivoltaics, with 20,576 km2 classified as most suitable under current conditions, increasing to 31,712 km2 under 2080 conditions. …”
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LRRC8A in endothelial cells contributes to the aberrant blood-brain barrier integrity in ischaemic stroke by Yan Wang, Yan Zhang, Chang Liu, Xiaoyu Zhang, Bo Wang, Yue Kong, Hailin Zhang, Yanfei Tian, Yupeng Zhao, Zhenghui Wu, Huaxing Zhang, Xiaona Du, Huiran Zhang

“…Background The increased permeability of the blood-brain barrier (BBB) is a critical contributor to the high mortality following ischaemic stroke. …”
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Exploration of the breast ductal carcinoma in situ signature and its prognostic implications by Jiao Zhang, Hui Lin, Lei Hou, Hui Xiao, Xilong Gong, Xuhui Guo, Xuchen Cao, Zhenzhen Liu

“…A unique six‐gene signature (containing GAPDH, CDH2, BIRC5, NEK2, IDH2, and MELK) was developed for DCIS prognostic prediction. …”
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Blend of low cost electrode material for energy storage device under DC glow discharge plasma exposed ESAC by Vijayalakshmi K.A, Judith Fennila, K T Maheswari

“…More oxygen-containing functional groups are present, according to an FTIR analysis. …”
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An analysis of McMurdo Dry Valleys’ lotic habitats within Antarctica’s protected area network and addressing gaps in biodiversity protection by Anna Wright, Cassandra Brooks, Michael Gooseff, Adrian Howkins, Stephen Chignell

“…However, with sustained human presence within the MDV, increasing human activity across Antarctica, and aquatic ecosystems subject to environmental change, the effectiveness of current protections for biodiversity conservation requires evaluation. …”
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