Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review. by John Danesh, Stephen Kaptoge, Andrea G Mann, Nadeem Sarwar, Angela Wood, Sara B Angleman, Frances Wensley, Julian P T Higgins, Lucy Lennon, Gudny Eiriksdottir, Ann Rumley, Peter H Whincup, Gordon D O Lowe, Vilmundur Gudnason

“…An updated systematic review of electronic databases and other sources identified 15 relevant previous population-based prospective studies of IL-6 and clinical coronary outcomes (i.e., MI or coronary death). Including the two current studies, the 17 available prospective studies gave a combined odds ratio of 1.61 (95% CI 1.42-1.83) per 2 SD increase in baseline IL-6 (corresponding to an odds ratio of 3.34 [95% CI 2.45-4.56] per 2 SD increase in usual [long-term average] IL-6 levels).…”
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Challenges in modelling the impact of frost and heat stress on the yield of cool-season annual grain crops by Jonathan Richetti, Victor Oscar Sadras, Victor Oscar Sadras, Victor Oscar Sadras, Di He, Brenton Leske, Pengcheng Hu, Yacob Beletse, C. Mariano Cossani, C. Mariano Cossani, C. Mariano Cossani, Ha Nguyen, Bangyou Zheng, David Matthews Deery, M. Fernanda Dreccer, Jeremy Whish, Julianne Lilley

“…These temperature extremes are increasing in frequency and intensity due to climate change in many parts of the broadacre cropping regions globally, presenting challenges to food production. …”
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Matching action to need: an analysis of Global Burden of Disease 2017 and population health data to focus adolescent health policy and actions in Myanmar by Karly I. Cini, Phone Myint Win, Zay Yar Swe, Kyu Kyu Than, Thin Mar Win, Ye Win Aung, Aye Aye Myint, Nisaa R. Wulan, Lia J. Burns, Elissa C. Kennedy, Kate L. Francis, Sanda, Su Mon Myat, Sithu Swe, Aung Ko Ko, Yadanar, Margaret Hellard, Chad L. Hughes, George C. Patton, Ali H. Mokdad, Peter S. Azzopardi

“…Conclusions: These results highlight the need to focus current efforts on addressing disease and mortality experienced by adolescents in Myanmar, with a specific focus on injury, mental health and non-communicable disease.…”
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Apple phenotyping using deep learning and 3D depth analysis: An experimental study on fruitlet sizing during early development by Giorgio Checola, Damiano Moser, Paolo Sonego, Cristian Iob, Franco Micheli, Pietro Franceschi

“…Current research in apple-growing focuses on collecting extensive biometric data to better understand physiological processes, improve orchard productivity and predict yields. …”
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Kyrgyz SSR During the Great Patriotic War: Demographic Processes and Challenges by Shaiyrkul Batyrbaeva, Anara Karyeva

“…By 1943, natural growth became negative, which was accompanied by an increase in migration losses caused by the return of evacuees and a general increase in mortality. …”
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Reduction of Ascites Susceptibility in Broiler Chickens under Cold Stress by Guanidinoacetic Acid Supplementation by Mousa Ezatikia, parviz Farhoomand, Sina Payvastegan, Bahram Pirooz, Negin Delfani

“…Additionally, increasing the level of guanidinoacetic acid supplementation linearly increased breast muscle yield and decreased relative weights of the small intestine, duodenum, and ileum. …”
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Bone marrow mesenchymal stem cell-derived exosomes alleviate DSS-induced inflammatory bowel disease in mice through inhibiting intestinal epithelial cell pyroptosis via delivery of... by Bihua Wu, Shuangyan Su, Xianyu Wang, Yuwei Li, Zhenghao Mei, Fenglin Lou, Le Guo

“…BackgroundInflammatory bowel disease (IBD), characterized by chronic intestinal inflammation and epithelial barrier dysfunction, remains a therapeutic challenge due to the limitations of current treatments, including drug resistance and invasive surgical risks. …”
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Quantitative characterization of adsorbed and free shale oil microscopic distribution based on nuclear magnetic resonance: a case study of Chang 7 member of Triassic Yanchang Forma... by Fei LIU, Jinliang DU, Lin SUN, Ruiliang GUO, Bofei HAO, Peng LIU

“…Adsorbed oil mainly exist in micropores (< 100 nm), and the amount of free oil in micropores, mesopores, and macropores sequentially decreases. Organic-matter-rich shale generally contain higher amount of free oil and lower amount of adsorbed oil due to the existence of hydrocarbon generation-induced microfractures and less developed organic pores. …”
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Efficacy and Safety of Various Intravenous Thrombolytics for Acute Ischemic Stroke (AIS) at Various Dosages: A Systematic Review and Network Meta-Analysis by Yibin Hu, Shengxian Wu, Haixuan Zhang, Kangfeng Wang, Lijuan Zhang, Yizheng Ma, He Li

“…Abstract Background Currently, there is limited evidence on the efficacy and safety of various thrombolytic drugs at different dosages for the treatment of acute ischemic stroke (AIS). …”
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Optimizing in vitro slow-growth conservation media for garlic under ambient conditions: further implications for core set accessions by Ashwini Prashant Benke, DalasanuruChandregowda ManjunathaGowda, Vijay Mahajan, Digambar N. Mokat

“…Therefore, maintaining the crop’s genetic diversity in a suitable alternative form is crucial. The current study standardized the protocol for slow-growth conservation of garlic (in vitro) at an ambient temperature. …”
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Sustainable agriculture through nano-priming: Evaluating the role of biogenic manganese oxide nanoparticles in mitigating wastewater-induced stress in wheat (Triticum aestivum) by Aneeza ISHFAQ, Sabir HUSSAIN, Tanvir SHAHZAD, Muhammed SHAHID, Faisal MAHMOOD, Syed Raza HUSSAIN, Irfan HAIDRI, Imran KHAN, Mahmoud F. SELEIMAN, Muhammad Ahsan ASGHAR, Muhammad Fuad ANSHORI

“…Control included seeds without MnO-NP priming. The wastewater contained contaminants such as heavy metals and organic pollutants. …”
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Finerenone attenuates downregulation of the kidney GLP-1 receptor and glucagon receptor and cardiac GIP receptor in mice with comorbid diabetes by Duc Tin Tran, Emily S. H. Yeung, Lisa Y. Q. Hong, Harmandeep Kaur, Suzanne L. Advani, Youan Liu, Madiha Zahra Syeda, Sri Nagarjun Batchu, Andrew Advani

“…After 26 weeks, mice were fed a high fat diet containing finerenone (100 mg/kg diet) or high fat diet alone for a further 2 weeks. …”
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EDUCATIONAL AUTONOMY AS AN IMPORTANT PREREQUISITE FOR THE FORMATION OF FUTURE PHDS’ RESEARCH COMPETENCE IN THE CONDITIONS OF POSTGRADUATE STUDIES by Oliinyk Iryna

“…The purpose of this research is to examine the concept of “learning autonomy” as an effective method of increasing the awareness of future PhD candidates in the process of developing research competence in terms of postgraduate studies. …”
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New radar altimetry datasets of Greenland and Antarctic surface elevation, 1991–2012 by M. R. Suryawanshi, M. R. Suryawanshi, M. McMillan, J. Maddalena, F. Piras, J. Aublanc, J.-A. Daguzé, C. Grau, Q. Huang

“…To reliably constrain multi-decadal trends in ice sheet imbalance, and to place current observations within a longer-term context, requires continued efforts to optimise the processing of data acquired by the older historical missions and to evaluate the accuracy of these measurements. …”
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Access to veterinary care in Canada: a cross-sectional survey of animal healthcare organizations and interventions by Quinn Rausch, Maryam Alhamdan, Shane Bateman, Michelle Evason, Valli Fraser-Celin, Courtney Graham, Jamie Saad, Michelle Tuma, Karen Ward, Lauren Van Patter

“…IntroductionMany Canadians struggle to access healthcare for their animals, but little data is available from the Canadian context on how barriers to care are being addressed, and with what effects.MethodsThe aim of this research was to characterize service providing organizations, barrier mitigation tools, community partnerships, and evaluation metrics used by organizations attempting to increase access to animal healthcare in Canada. …”
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The substance use profiles of adults who sought mental health and addiction services through a centralized intake process in Nova Scotia (2020–2021) by Matiwos Soboka, Philip G. Tibbo, Sherry H. Stewart, Sherry H. Stewart, Sherry H. Stewart, Patryk Simon, JianLi Wang, JianLi Wang

“…BackgroundDespite the increasing substance use in Canada, our understanding of how substance use varies based on the intersections of gender, ethnicity/race, and income sources among preclinical populations remains limited. …”
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MOTIVATIONAL COMPONENT AS A SUCCESS TO ORGANIZE AN INDEPENDENT WORK OF STUDENTS AT THE DEPATMENT OF THERAPEUTIC DENTISTRY by Yu. V. Sidash

“…The process of the study isto create a sincere atmosphere of communication in the audience, establish contact with students, achieve mutual understanding and form a sense of confidence in the student. …”
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Towards a sustainable rare disease and orphan drug ecosystem in Saudi Arabia: policy insights from a multi-stakeholder workshop by Ghada Mohammed Abozaid, Ghada Mohammed Abozaid, Hussain Abdulrahman Al-Omar, Abdulaziz Alrabiah, Asma AlMuaither, Amy Jayne McKnight

“…Through a series of presentations, educational sessions, and plenary discussions, participants examined the current landscape of RDs in SA, identified barriers to accessing ODs, and recommended strategies and initiatives to improve the accessibility, innovation, and sustainability of ODs.ResultsThe workshop highlighted key challenges recognized by a diverse group of 59 participants, including the absence of a national strategy, absent of local RDs and ODs definitions in the Saudi context, limited awareness and understanding of RDs among healthcare professionals, delayed diagnoses, scarcity of treatment and diagnosis centers for RDs, insufficient screening and prevention programs, regulatory hurdles in approving and importing ODs, and financial constraints. …”
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‘It was a joint plan we worked out together’. How the I-WOTCH programme enabled people with chronic non-malignant pain to taper their opioids: a process evaluation by Martin Underwood, Kate Seers, Charles Abraham, Harbinder Kaur Sandhu, Vivien P Nichols, Sam Eldabe, Alleyne Sharisse, Balasubramanian Shyam, Betteley Lauren, Booth Katie, Carnes Dawn, D Furlan Andrea, Haywood Kirstie, Iglesias Urrutia C Paola, Lall Ranjit, Manca Andrea, Mistry Dipesh, Noyes Jennifer, Rahman Anisur, Shaw Jane, KY Tang Nicole, Taylor Stephanie, Tysall Colin, Underwood Martin, J Withers Emma

“…It provided people with a forum in which to learn about the current thinking about opioid usage and its effects. …”
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‘Communities are attempting to tackle the crisis’: a scoping review on community plans to prevent and reduce opioid-related harms by Carol Strike, Michael Parkinson, Nimitha Paul, Sue Keller-Olaman, Susan Massarella, Jayne Caldwell, Greg Penney, Rita Henderson

“…Stakeholders identified three key implications to our findings: addressing equity and stigma-related barriers towards people with lived experience of substance use; improving data collection to facilitate evaluation; and enhancing community partnerships by involving people with lived experience of substance use.Conclusion Current understanding of the implementation and context of community opioid-related plans demonstrates a need for evaluation to advance the evidence base. …”
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