An overview of drug‐induced sodium channel blockade and changes in cardiac conduction: Implications for drug safety by Khuram W. Chaudhary, Colleen E. Clancy, Pei‐Chi Yang, Jennifer B. Pierson, Alan L. Goldin, John E. Koerner, Todd A. Wisialowski, Jean‐Pierre Valentin, John P. Imredy, Armando Lagrutta, Simon Authier, Robert Kleiman, Philip T. Sager, Peter Hoffmann, Michael K. Pugsley

“…Drug‐dependent block of Nav1.5 current (INa) can lead to significant alterations in cardiac electrophysiology, potentially resulting in conduction slowing and an increased risk of proarrhythmic events. …”
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METHODOLOGY FOR EVALUATING THE EFFECTIVENESS OF ANTI-CORRUPTION ACTIVITIES IN THE MILITARY SECTOR UNDER CONDITIONS OF ENSURING FINANCIAL SECURITY by Myroslav Kryshtanovych, Oleksandr Nazarenko, Serhii Bazyka, Oleksii Vasyliev, Anna Munko, Yaroslav Panas

“…In such circumstances, it is crucial to evaluate current anti-corruption measures to ensure financial security. …”
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Low-cost nano biochar: a sustainable approach for drought stress mitigation in faba bean (Vicia faba L.) by Heba Ibrahim Abd El-Moaty, Heba Ibrahim Abd El-Moaty, Ali El-Dissouky, Amel F. Elhusseiny, Kareem M. Farag, Rasha Abu-Khudir, Rasha Abu-Khudir, Mayyadah Abdullah Alkuwayti, Najla K. Al Abdulsalam, Salwa M. Abdel Rahman

“…Surprisingly, the application of biochar increased soil water holding capacity and organic matter by 66% and 220%, respectively. …”
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Climate change impact on the distribution and priority areas for conservation of Sterculia setigera Delile in Benin, West Africa by Rissicath Foumilayo Djaboutou, Séverin Biaou, Gérard Nounagnon Gouwakinnou, Christine A. I. Nougbodé Ouinsavi

“…Under future climate scenarios SSP 2–4.5 and SSP 5–8.5, SN increased, while SC decreased. The SS subgroups, showed a decrease in suitable conditions under the SSP 2–4.5 scenario but an increase under the SSP 5–8.5 scenario. …”
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Enhancing Gas Fermentation Efficiency via Bioaugmentation with <i>Megasphaera sueciensis</i> and <i>Clostridium carboxidivorans</i> by Clemens Hiebl, Dominik Pinner, Hannes Konegger, Franziska Steger, Dina Mohamed, Werner Fuchs

“…Gas fermentation aims to fix CO₂ into higher-value compounds, such as short or medium-chain fatty acids or alcohols. In this context, the use of mixed microbial consortia presents numerous advantages, including increased resilience and adaptability. …”
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Vaccination against SARS-COV‑2 in oncology by A. A. Polyakov, V. V. Lunin, F. M. Abbaysbeyli, O. L. Timofeeva, V. B. Larionova, P. A. Zeynalova, A. A. Fedenko

“…This paper reflects considerations and recommendations for the vaccination of cancer patients by Russian and foreign specialists in the context of COVID‑19 pandemic. The review presents current recommendations for vaccination against SARS-COV‑2 in patients with solid tumors, hematological malignancies, recipients of hematopoietic stem cells and cell therapy.Conclusion. …”
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Average nutrient and chlorophyll distributions in the western Mediterranean: RADMED project by María del Carmen García-Martínez, Manuel Vargas-Yáñez, Francina Moya, Rocío Santiago, María Muñoz, Andreas Reul, Teodoro Ramírez, Rosa Balbín

“…In this context, the long-term monitoring of the Mediterranean waters is a basic task. …”
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Association Between A1c and Cutaneous Dermatophytosis: A Case–Control Study by Nicole Ufkes, Zachary Hopkins, John Skylar Westerdahl, Scott R. Florell

“…Controls included patients seen in the dermatology department but who had no known diagnosis (past or current) of dermatophyte infection and were seen in a context where tinea could have been identified (i.e., no surgical visits, suture removals, spot checks, and cosmetic visits) and did not have a potentially confounding condition (inflammatory rashes). …”
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A Novel Mutation of VPS33B Gene Associated with Incomplete Arthrogryposis-Renal Dysfunction-Cholestasis Phenotype by Eleni Agakidou, Charalampos Agakidis, Marios Kambouris, Nicoleta Printza, Maria Farini, Elina Vourda, Spyridon Gerou, Kosmas Sarafidis

“…This is the first published VPS33B mutation in an ARC patient of Greek origin. The current case adds to the spectrum of ARC-associated VPS33B mutations and provides evidence supporting the existence of incomplete ARC phenotype. …”
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EQ-5D Based Utility Values for Adults with Chronic Obstructive Pulmonary Disease: A Systematic Review, Meta-Analysis, and Meta-Regression by Natasha Salant, Syed Mohiuddin, Yuanyuan Zhang, Lynda Ayiku, Kusal Lokuge, Paul Jacklin, Lesley Owen

“…Moayeri et al. published a systematic review and meta-analysis of utilities (EQ-5D) in COPD in June 2016. The current study investigated changes in mean utilities in more recent studies thereafter, exploring heterogeneity in utilities across diverse clinical and study characteristics. …”
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Factors Affecting Medical Device-Related Pressure Injuries in Intensive Care Units by Fatma Ali, Sahar Mohammad, Dalia Ameen

“… Context: Medical device-related pressure injuries (MDRPI) are a common complication that can occur in critically ill patients and require medical devices in the intensive care unit. …”
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Analysis of Adaptation of Students Studying under the Flipped Classroom Model to the Conditions of Distance Learning by G. R. Chaynikova

“…At the same time, it is necessary to keep in mind the importance of pedagogical support in the context of e-learning.…”
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Pharmacological and pupillary evidence for the noradrenergic contribution to reinforcement learning in Parkinson’s disease by Claire O’Callaghan, Frank H. Hezemans, Naresh Subramaniam, Rong Ye, Kamen A. Tsvetanov, Alexander G. Murley, Negin Holland, Isabella F. Orlando, Ralf Regenthal, Roger A. Barker, Caroline H. Williams-Gray, Luca Passamonti, Trevor W. Robbins, James B. Rowe

“…Testing the noradrenergic framework of learning in the context of human diseases offers a test bed for current normative neuroscience theories and may also indicate therapeutic potential. …”
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Traumatic Brain Injury and Genetic Risk for Alzheimer’s Disease Impact Cerebrospinal Fluid β-Amyloid Levels in Vietnam War Veterans by Jena N. Moody, Erica Howard, Kate E. Nolan, Sarah Prieto, Mark W. Logue, Jasmeet P. Hayes

“…This relationship may be stronger with increasing TBI severity (p = 0.05). Overall, TBI was associated with lower Aβ42/40, indicating greater amyloid deposition in the brain, in the context of greater polygenic risk for AD. …”
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Insulin Modulates NK Cell Activity in Liver Fibrosis MASH Patients via the STING Pathway by Johnny Amer, Ahmad Salhab, Amiram Ariel, Rifaat Safadi

“…While STING is well-established in various immune cells, its role in natural killer (NK) cells, particularly within the context of liver fibrosis, remains inadequately explored. …”
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Unravelling the myriad physiologic roles of transthyretin: critical considerations for treating transthyretin amyloidosis by Morie A. Gertz, Mandar A. Aras, Nicole Bart, Thomas H. Brannagan, Jan M. Griffin, Amy R. Kontorovich, Andrew M. Rosen

“…While a link between low TTR and severe disease and mortality is well established, it remains unclear whether long-term TTR suppression via ATTR therapies increases risk of disease. Clinical decisions in ATTR, however, should reflect the current understanding of the roles of TTR and the patient’s clinical history.Conclusion TTR serves vital physiologic roles across organ systems. …”
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Climate change adaptation: policy, practice and adaptation gaps in the agriculture sector in Bangladesh, India and Nepal by Shobha Shrestha, Prem Sagar Chapagain, Yili Zhang, Linshan Liu, Jianzhong Yan, Suresh Chand Rai, Md. Nurul Islam, Basanta Paudel

“…Lack of understanding and awareness of CCA in a local sociocultural context among implementation authorities and weak institutional mechanisms are gaps at the institutional front. …”
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Potential protective association of the AA genotype and a allele of CXCR4 rs2228014 polymorphism with COVID-19 severity in adult egyptians by Osama H. Korayem, Amr E. Ahmed, Mohamed H. Meabed, Doaa M. Magdy, Wafaa M. Abdelghany

“…Several genetic factors have been implicated in diverse responses to SARS-CoV-2 infection, such as the C-X-C chemokine receptor 4 (CXCR4) rs2228014 polymorphism, which has been previously studied in various diseases but has not been explored in the context of COVID-19 severity. The current study aimed to assess the association between the rs2228014 polymorphism in the CXCR4 gene and the severity of COVID-19, which has not been previously reported. …”
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Quantitative systems toxicology modeling in pharmaceutical research and development: An industry‐wide survey and selected case study examples by Kylie A. Beattie, Meghna Verma, Richard J. Brennan, Diana Clausznitzer, Valeriu Damian, Derek Leishman, Mary E. Spilker, Britton Boras, Zhenhong Li, Elias Oziolor, Theodore R. Rieger, Anna Sher

“…Abstract Quantitative systems toxicology (QST) models are increasingly being applied for predicting and understanding toxicity liabilities in pharmaceutical research and development. …”
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Private, non-profit, and plantation: Oil palm smallholders in management-assistance programs vary in socio-demographics, attitudes, and management practices. by Valentine J Reiss-Woolever, Wakhid Wakhid, Muhammad Ikhsan, Jean-Pierre Caliman, Muhammad Naim, Elfina N Azmi, Sharyn Shufiyan, John Howes, Reza Azmi, Ying Ying Lim, Siti Zulaikah Abdul Jan, Isaac Barrock, Badrul Azhar, Julia Drewer, Caroline Ward, Joshua A Jones, Sarah H Luke, Edgar C Turner, Purnama Hidayat, Damayanti Buchori

“…Awareness of the effects of palm oil production on ecosystems and human communities has increased drastically in recent years, with ever louder calls for the private and public sector to develop programs to support sustainable cultivation by smallholder farmers. …”
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