Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and <i>Trypanosoma cruzi</... by Gabriela Alves de Souza, Lorrane de Souza Chaves, Afonso Santine M. M. Velez, Jorge Lucas F. Lacerda, Paulo Pitasse-Santos, Jayane Clys Conceição dos Santos, Otávio Augusto Chaves, Carlos Serpa, Raphael do Carmo Valente, Leonardo Marques da Fonseca, Marcos André Rodrigues da Costa Santos, Jhenifer Santos dos Reis, Carlos Antônio do Nascimento Santos, Lucia Mendonça-Previato, Jose Osvaldo Previato, Celio Geraldo Freire-de-Lima, Debora Decoté-Ricardo, Leonardo Freire-de-Lima, Marco Edilson Freire de Lima

“…<b>Background: </b>Anticancer therapies represent the primary treatment option for a significant number of cancer patients globally; however, many of these treatments are associated with severe side effects as they target molecular structures present in both cancerous and healthy cells. In a similar context, the treatment of Chagas disease, a neglected tropical illness, is hindered by the high toxicity of the currently available drugs. …”
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Effects of temporary erosion control blanket and grass cover on the rates of runoff and sediment in the cut and fill slopes of forest roads using a rainfall simulation test by Behnaz Askari, Mehran Nasiri, Majid Lotfalian

“…The use of erosion control blankets is a soil bio-engineering method that can effectively reduce runoff and sediment and increase slope stability. Therefore, the current research aimed to temporarily stabilize soil using protective covering treatments, such as jute, straw, wood chips, Festuca grass cover, and nano zeolite super absorbent, to reduce the amount of runoff and sediment. …”
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Use of ICT to Confront COVID-19 by Yousry Saber El Gamal

“…Supporting a digitized world and staying current in the latest technology will be essential for any country to remain competitive in a post COVID-19 world. …”
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Safety, Feasibility, and Tolerability of Ten Days of At-Home, Remotely Supervised tDCS During Gamified Attention Training in Children with Acquired Brain Injury: An Open-Label, Dos... by Athena Stein, Justin Riddle, Kevin A. Caulfield, Paul E. Dux, Maximilian A. Friehs, Philipp A. Schroeder, Michael P. Craven, Madeleine J. Groom, Kartik K. Iyer, Karen M. Barlow

“…When delivered daily, transcranial direct current stimulation (tDCS) may improve attention; however, access to daily in-clinic tDCS treatment can be limited by other commitments, including concurrent therapy, school commitments, and caregiver schedules. …”
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“Locality – Adaptation” Research of Hydropower Resettlement Communities in the Jinsha River Basin: A Case Study of Ludila Hydropower Station by Fang WANG, Zhuoqi LI, Haoyi XU, Jiaqi YAN

“…ObjectiveWithin human – environment systems, river basins constitute the earliest geographical units of human activity and currently represent the most critical zones of strained human – environment interactions. …”
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On the added value of sequential deep learning for the upscaling of evapotranspiration by B. Kraft, B. Kraft, B. Kraft, J. A. Nelson, S. Walther, F. Gans, U. Weber, G. Duveiller, M. Reichstein, W. Zhang, M. Rußwurm, D. Tuia, M. Körner, Z. Hamdi, M. Jung

“…In particular, we investigate three questions regarding the performance of the sequential models compared to the non-sequential models in the context of spatial upscaling: (a) whether they lead to more realistic and robust global and regional ET, (b) whether they are able to capture the temporal dynamics of ET better, and (c) how robust they are to the covariate setup and training data subsets.…”
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ROLE OF CYTOXIC T-LYMPHOCYTES IN THE PATHOGENESIS OF PRETERM BIRTH by N. R. Radzhabova, N. Yu. Sotnikova, A. V. Kudryashova, N. Yu. Borzova, A. I. Malyshkina

“…Currently, the existence of a wide range of subpopulations of CD8+T-lymphocytes has been revealed, among which there are subpopulations of naive and effector cells, as well as memory cells. …”
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SOLPS-ITER simulation of W limiter start-up on ITER by Y. Zhang, A.A. Pshenov, R.A. Pitts, X. Bonnin, M. Dubrov, Y. Gribov, A. Kirschner, C. Baumann, S. Brezinsek, J. Romazanov, Chaofeng Sang, Dezhen Wang

“…To assess this impact, a large database of SOLPS-ITER simulations of the hydrogen (H) plasmas in contact with the tungsten (W) limiter has been constituted, including transport of all individual W charge states up to a given cut-off. …”
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Regulatory culture and architectural project by Mario Losasso

“…They are attentive to a quality that does not depend on construction solutions or on techno-typological, morphological or physical-chemical characteristics, but which is linked to a system of needs to be satisfied, the outcome of the interaction between construction and cultural, socio-economic and environmental context. Today’s regulatory landscape has expanded, increasing sensitivities to environmental challenges, health and the qualities of living space. …”
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Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…This has the potential to affect fetal brain development, increase infant reactivity to stress, and impair sensitive mother–infant bonds from developing. …”
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Effectiveness of virtual fencing in a mountain environment and its impact on heifer behaviour and welfare by P. Fuchs, C.M. Pauler, M.K. Schneider, C. Umstätter, C. Rufener, B. Wechsler, R.M. Bruckmaier, M. Probo

“…Video cameras recorded animal reactions upon virtual fence contact. Grass height was measured to estimate forage availability in the currently grazed paddocks. …”
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Herd immunity to hepatitis A virus in the Saint Petersburg and Leningrad Region by A. Yu. Popova, A. Yu. Gorbunova, Yu. V. Ostankova, S. A. Egorova, D. E. Reingardt, A. R. Ivanova, A. N. Schemelev, I. V. Drozd, O. B. Zhimbaeva, E. M. Danilova, A. M. Milichkina, E. B. Ezhlova, A. A. Melnikova, N. S. Bashketova, L. V. Buts, A. A. Totolian

“…Acute HA accounted for the largest share in the structure of acute viral hepatitis morbidity – 61%, and in comparison, with 2010, its specific weight increased 1.3 times (55% – in 2010). Currently, there is no specific treatment for HA. …”
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Structure, conservation and health implications of urban wild meat value chains: A case study of Lagos, Nigeria by Samuel N. Akpan, Pim van Hooft, Anise N. Happi, Ralph Buij, Frank van Langevelde, Elizabeth A.J. Cook, James M. Hassell, Dawn M. Zimmerman, Sherrill P. Masudi, Christian T. Happi, Lian F. Thomas

“…Conservation and public health interventions should be node-specific and gender-sensitive, targeting the dry seasons when actors' activities peak, and risks of human-wild meat contact are greater. There is need for the re-assessment of the conservation statuses of West Africa's wildlife species to reflect current realities foisted by wild meat trade.…”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…This paper describes the current transplant system’s use of subjective evaluation criteria, particularly psychosocial support and compliance. …”
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Insights from UKCTOCS for design, conduct and analyses of large randomised controlled trials by Usha Menon, Aleksandra Gentry-Maharaj, Matthew Burnell, Sophia Apostolidou, Andy Ryan, Jatinderpal K Kalsi, Naveena Singh, Lesley Fallowfield, Alistair J McGuire, Stuart Campbell, Steven J Skates, Anne Dawnay, Mahesh Parmar, Ian J Jacobs

“…Future work There is a pressing need to increase the evidence base to support decision making about all aspects of trial methodology. …”
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Social Networks Link Prediction Based on Incremental Learning by Jian SHU, Zhichen CHEN

“…However, the prediction performance of IL−SNLP on Ask Ubuntu and Super User decreases by only 4.54% and 5.25%, respectively, compared to its performance on Math Overflow. …”
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Growth Toxic Effects of Metal Nanoparticles on Bacillus subtilis and Vibrio parahaemolyticus by Shiyu CHEN, Bin XIA, Lin ZHU, Shuang LI, Qiufen LI, Xuemei SUN, Wei DAI

“…The obtained response values are proportional to the concentration and mobility of the ionic current in culture mediums. Since the uncharged or weakly charged substrate will be converted into highly charged small-molecule substances during the growth and proliferation of bacteria—thus increasing the culture medium conductivity—the bacterial growth process can be recorded quickly and accurately by detecting the change in the conductivity of the culture medium. …”
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The study of Effective and Efficient Organizational Change Processes with an Emphasis on Islamic Management by Fazel Hajizadeh Ebrahimi, Hamid Moakedi

“…AbstractToday, effective and efficient change management has attracted the attention of managers in various organizations and companies from the highest management level to the last levels. In performing the current business, all managers should take into account the fact that making appropriate and effective changes has become one of the fixed features in the administrative system of the society. …”
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Effects of Conditioning Temperature on Pellet Quality, Nutrients Digestibility, and Metabolizable Energy of Broilers Diet by Seyedeh Vajiheh Shakhese Emampour, Abolghasem Golian, Heydar Zarghi, Ali Reza Hesabi Nameghi

“…So that the amount of electricity usage decreased (quadratic, p< 0.001), and increased pellet PDI (quadratic, p<0.001) and pellet hardness (linear, p<0.002) by increasing in conditioning temperature. …”
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Multi-source Data-driven Analysis of Deformation and Influencing Factors for Expansive Soil Canal Slopes by ZHANG Yuhan, HU Jiang, LI Xing

“…Moreover, dense deployment of monitoring points not only increases construction challenges but also significantly raises project costs. …”
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