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Novel chlorine-containing curcumin analogue CAK06 promotes neuroprotection and rapid antidepressant through Nrf2-induced anti-inflammatory and antioxidant effects
Published 2025-07-01“…Currently, conventional antidepressants are often limited by poor efficacy and delayed onset, and there is an urgent need for the development of rapid acting antidepressant alternatives. …”
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424
The Choice of the Leader-Manager Behavioral Model (in the Context of Generations’ Cultural Values Change Out in the Twenty-First Century)
Published 2016-12-01“…In such circumstances, the demand for creative professionals with innovative thinking and multi-tasking ability has significantly increased. Currently, leaders of organizations are facing the challenge of maintaining leadership potential, determined by changing out cultural values of new generations of workers belonging to generations Y and Z. …”
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Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage
Published 2025-05-01“…Several small-molecule inhibitors targeting ATM/Chk2 or ATR/Chk1 are currently being tested in preclinical and/or clinical settings, showing promise in cancer models and patients. …”
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Increasing efficiency and sustainability: A comparative analysis of concrete 3D printing and traditional methods based on case studies
Published 2025-01-01“…These are particularly important in the context of the current skilled labour shortage and emphasis on resource efficiency in construction. …”
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Does neoadjuvant chemotherapy increase the survival in patients with locally advanced gastric cancer patients? – A real-world evidence
Published 2020-01-01“…However, these findings were statistically not significant. The current study has contributed an important finding to the existing evidences of clinical practice in an Indian setting. …”
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A Critical Analysis of Cooperative Caching in Ad Hoc Wireless Communication Technologies: Current Challenges and Future Directions
Published 2025-02-01“…In this paper, we discuss the problems and issues in the current wireless ad hoc paradigms as well as spotlight versatile cooperative caching as the potential solution to the increasing complications in ad hoc networks. …”
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Cost–consequence analysis of COPD treatment according to NICE and GOLD recommendations compared with current clinical practice in the UK
Published 2022-06-01“…Savings were achieved overall despite a small increase in the rate of exacerbations due to the redistribution of certain patients currently undergoing triple inhaled therapy to therapies not containing inhaled corticosteroids.Conclusion Redistribution of patients with COPD from current clinical practice to treatment according to published recommendations would provide substantial cost savings over the first year.…”
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Unraveling the Complexity of the Ne/Nc Ratio for Conservation of Large and Widespread Pelagic Fish Species: Current Status and Challenges
Published 2024-10-01“…Secondly, we outline current knowledge about the influence of life history traits on the Ne/Nc ratio in the light of examples drawn from large and abundant pelagic fish species. …”
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Strategic Aspects of Human Capital Development in Ukraine in the Context of Integration of Veterans into the Spheres of Industry 4.0 and 5.0
Published 2024-09-01“…The article is devoted to the topical problem of integration of veterans into high-tech sectors of the Ukrainian economy, in particular into the spheres of Industry 4.0 and 5.0. In the context of a prolonged cyber war and the expected increase in the number of veterans to 5-6 million people, the issue of their effective reintegration into civilian life is of strategic importance for the country. …”
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UE Context Dissemination in Sparse LEO Constellations for 5G/6G Cellular IoT in Store and Forward Operation
Published 2025-01-01“…The rapid expansion of the Internet of Things (IoT) highlights the need for ubiquitous connectivity, especially in remote and underserved areas. As a cornerstone of current 5th Generation (5G) cellular IoT networks, Narrowband IoT (NB-IoT) supports diverse massive Machine-Type Communications (mMTC) applications. …”
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Evaluation of the federal hospital atlas in the context of the hospital reform 2024: a critical analysis of the healthcare provision in German hospitals
Published 2025-06-01“…Abstract Background In the context of the ongoing German hospital reform, the newly introduced Federal Hospital Atlas aims to increase transparency regarding hospital structures and service quality. …”
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A Bibliometric Analysis of Mountain Research Literature on Journal of Mountain Research and Development: Current Situation and Future Directions
Published 2023-12-01“…Academic studies on mountains have increased since the 1990s. The aim of this study is to examine the current situation and development of the international literature on mountainous areas. …”
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Knowledge and Perception of Practicing Anesthetists on Current Techniques, Clinical Applications, and Limitations of Artificial Intelligence in Anesthesiology: An Indian Study
Published 2024-11-01“…Background: Artificial intelligence (AI) is increasingly gaining importance in modern medicine. Yet, there is a dearth of knowledge on what the anesthesiologists know and think about AI in context. …”
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The effectiveness of home-based transcranial direct current stimulation on chronic pain: A systematic review and meta-analysis
Published 2024-11-01“…As pain is highly prevalent and imposes significant burdens, interest in its remote management is steadily increasing. Transcranial Direct Current Stimulation (tDCS) seems promising in this context. …”
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