Biological and mechanical challenges in the endodontic treatment of immature teeth with pulp necrosis: insights based on a Series of Atypical Clinical Cases by Julian Gregoire Leprince, Motoki Okamoto, Matthias Widbiller, Julien Beauquis, Simon Mariano Pedano, Kerstin M. Galler, Yusuke Takahashi

“… Over the past two decades, dental pulp regeneration has become a major focus in endodontology. The currently applied clinical strategies are referred to as ‘revitalisation’ procedures. …”
Get full text

Converse effects of warming and reclamation on methane uptake in alpine meadows by Jing Huang, Guozheng Hu, Hasbagan Ganjurjav, Qingzhu Gao, Yubao Sha, Zheng Li, Guoxu Ji, Huihui Liu, Ling Han, Shicheng He, Jun Yan, Youxia Wang, Wendong Xie, Elise S. Gornish

“…Warming promoted CH4 uptake by increasing soil nutrient content and increasing the activities of methane monooxygenase and soil sucrase. …”
Get full text

Teucrium polium induces apoptosis in peripheral blood lymphocytes isolated from human chronic lymphocytic leukemia by Zarić Milan, Živković-Zarić Radica, Mitrović Marina, Nikolić Ivana, Čanović Petar, Milosavljević Zoran, Jovanović Danijela, Zelen Ivanka

“…The activation of apoptosis is one of the main molecular mechanisms responsible for anti-cancer activities of most of the currently studied potential anti-cancer agents, including natural compounds. …”
Get full text

SETup automotive: a Method for Systems Engineering Transformation in automotive industry by Iris Graessler, Benedikt Grewe

“…With this in mind, systems engineering (SE) is currently being introduced on a large scale into the automotive industry. …”
Get full text

Exploring the Role of EU Subsidies in Enhancing the Competitiveness of Slovak Farms by Ivana Kravčáková Vozárová, Rastislav Kotulič

“…The competitiveness of Slovak farms is currently strongly influenced not only by internal factors such as productivity, innovation, and management, but also by external factors, especially political and economic decisions at the EU level. …”
Get full text

Learner Engagement in Using Kahoot! within a University English Proficiency Course by Mohd Zulfadli Mat Husin, Ruhil Amal Azmuddin

“…Background/purpose – Game-based learning is becoming increasingly popular among educators in higher institutions. …”
Get full text

Detecting and Responding to a Dengue Outbreak: Evaluation of Existing Strategies in Country Outbreak Response Planning by Julia Harrington, Axel Kroeger, Silvia Runge-Ranzinger, Tim O'Dempsey

“…Dengue outbreaks are occurring with increasing frequency and intensity. Evidence-based epidemic preparedness and effective response are now a matter of urgency. …”
Get full text

Flood Risk Mitigation by Spatial Planning—Lessons Learned From Municipal Consultation by Stefan Greiving, Stefanie Wolf, Daniela Michalski, Mark Fleischhauer

“…The flood event that hit the German states of Rhineland‐Palatinate and North Rhine‐Westphalia in mid‐July 2021 increased municipal awareness for flood‐sensitive planning. …”
Get full text

Anatomic and mechanical considerations in restoring volume of the face with use of hyaluronic acid fillers with a novel layered technique by Mohan K Thomas, James A Dsilva, Ateesh J Borole, Sudhir M Naik, Soma G Sarkar

“…Context: Facial fillers have revolutionized the field of cosmetic facial rejuvenation as it has become the prime sought - after rejuvenation procedure offering youthful, 3-dimensional look with minimal invasiveness. …”
Get full text

Counterfactual choice and learning in a neural network centered on human lateral frontopolar cortex. by Erie D Boorman, Timothy E Behrens, Matthew F Rushworth

“…Although the neural system responsible for tracking the value of choices actually taken is increasingly well understood, whether a neural system tracks counterfactual information is currently unclear. …”
Get full text

Enhancing Smart Cities with IoT and Cloud Computing: A Study on Integrating Wireless Ad Hoc Networks for Efficient Communication by Haider Mohammed Abdulhadi, Yousra Abdul Alsahib S. Aldeen, Maryam A. Yousif, Mays jalal jaseem, Syed Hamid Hussain Madni

“…IoT data is first collected in the context of smart cities. The data that is gathered is uniform. …”
Get full text

Demographic responses of hybridizing cinquefoils to changing climate in the Colorado Rocky Mountains by Kelly A. Carscadden, Daniel F. Doak, Meagan F. Oldfather, Nancy C. Emery

“…Our findings demonstrate that hybrids in this system are neither intrinsically unfit nor universally more vigorous than parents, suggesting that the demographic consequences of hybridization are context‐dependent. Our results also imply that shifts to warmer and drier conditions could have particularly negative repercussions for P. pulcherrima, which is currently the most abundant taxon in the study area, possibly as a legacy of more favorable historical climates. …”
Get full text

Are interventions for environmentally sustainable dietary behaviours effective? A review by Y Ran, U M Persson, T Lindahl, M Jonell, A Brons, B Macura, J Candel, A Abu Hatab, E Röös

“…In the face of growing environmental pressures, understanding how governance can promote more sustainable dietary behaviours is increasingly critical. However, a synthesis of available intervention strategies for behavioural change is currently missing. …”
Get full text

Efficiency and heat transport processes of low-temperature aquifer thermal energy storage systems: new insights from global sensitivity analyses by Luka Tas, Niels Hartog, Martin Bloemendal, David Simpson, Tanguy Robert, Robin Thibaut, Le Zhang, Thomas Hermans

“…Thick productive aquifer layers have been targeted first, as these are the most promising hydrogeological context for ATES. Regardless, there is currently an increasing trend to target more complex aquifers such as low-transmissivity and alluvial aquifers or fractured rock formations. …”
Get full text

iPSC models of mitochondrial diseases by Sonja Heiduschka, Alessandro Prigione

“…Consequently, most mitochondrial diseases are currently untreatable. Human induced pluripotent stem cells (iPSCs) represent a promising approach for developing human model systems and assessing therapeutic avenues in a patient- and tissue-specific context. iPSCs are being increasingly used to investigate mitochondrial diseases, either for dissecting mutation-specific defects within two-dimensional (2D) or three-dimensional (3D) progenies or for unveiling the impact of potential treatment options. …”
Get full text

In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington’s Disease by Luis C. Morales, Luv Modi, Saba Abbasi Dezfouli, Amarnath Praphakar Rajendran, Remant Kc, Vaibhavi Kadam, Simonetta Sipione, Hasan Uludağ

“…<b>Methods:</b> This study aims to investigate the efficacy of siRNA-containing nano-engineered lipopolymers in selectively silencing the <i>HTT</i> expression in a neuronal model expressing a chimeric protein formed by the human mutated exon 1 of the <i>HTT</i> gene, tagged with GFP. …”
Get full text

Development of an easy non‐destructive particle isolation protocol for quality control of red blood cell concentrates by Marine Ghodsi, Anne‐Sophie Cloos, Anaïs Lotens, Marine De Bueger, Patrick Van Der Smissen, Patrick Henriet, Nicolas Cellier, Christophe E. Pierreux, Tomé Najdovski, Donatienne Tyteca

“…Nevertheless, there is currently no standardized isolation protocol. In a previous publication, we developed a reproducible ultracentrifugation‐based protocol (20,000 × g protocol) that allows to classify red blood cell concentrates into three cohorts according to their vesiculation level. …”
Get full text

The implementation of safer drug consumption facilities in Scotland: a mixed methods needs assessment and feasibility study for the city of Edinburgh by James Nicholls, Wendy Masterton, Danilo Falzon, Andrew McAuley, Hannah Carver, Kathryn Skivington, Josh Dumbrell, Andy Perkins, Samantha Steele, Kirsten Trayner, Tessa Parkes

“…Abstract Background Scotland currently has amongst the highest rates of drug-related deaths in Europe, leading to increased advocacy for safer drug consumption facilities (SDCFs) to be piloted in the country. …”
Get full text

The challenges of reproducibility for research based on geodata web services by M. Cannata, M. Collombin, O. Ertz, G. Giuliani, J. Ingensand, C. Primerano, D. Strigaro

“…Additionally, we assess the currently available tools that support data versioning for databases, files and log-structured tables. …”
Get full text

Lipidomic markers of obesity and their dynamics after bariatric surgery by T. V. Saprina, A. S. Bashirova, V. V. Ivanov, S. I. Pekov, I. A. Popov, S. R. Bashirov, E. A. Vasilyeva, O. A. Pavlenko, D. V. Krinitskii, M. Chen

“…Currently available studies and their results suggest that we are only at the very start of studying this promising biomedical field.…”
Get full text