Efficacy and safety of compound glycyrrhizin combined with topical minoxidil for alopecia areata: a systematic review and meta-analysis of randomized controlled trials by Chenqi Guo, Xiangru Gu, Junchen Li, Yingdong Wang, Xiaoya Liu, Guojing Yang, Min Zhang, Yu Zhang

“…The SALT score (MD = −10.09, 95% CI [−12.89, −7.30], p < 0.00001), serum TNF-α levels (MD = −0.99, 95% CI [−1.19, −0.39], p < 0.00001), serum IL-12 levels (MD = −8.84, 95% CI [−11.20, −6.47], p < 0.00001) and serum IFN-γ levels (MD = −7.44, 95% CI [−11.51, −3.37], p = 0.0003) were reduced, and the serum TGF-β1 levels (MD = 2.40, 95% CI [1.24, 3.57], p < 0.0001) were increased. There were no significant differences in reported adverse events, including irritant contact dermatitis (RR = 0.51, 95% CI [0.25, 1.01], p = 0.05),’ gastrointestinal reactions (RR = 2.47, 95% CI [0.49, 12.55], p = 0.28), lower limb edema (RR = 2.60, 95% CI [0.61, 11.06], p = 0.20), facial edema (RR = 2.33, 95% CI [0.61, 8.93], p = 0.22), or localized itching (RR = 0.56, 95% CI [0.18, 1.75], p = 0.32), between the two groups.Conclusion The current evidence indicates that CG combined with topical minoxidil therapy is effective and safe for AA. …”
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Synergistic Effects of Mannan Oligosaccharides and Onion Peels on In Vitro Batch Culture Fermentation of High Concentrate and Forage Diets by Lydia K. Olagunju, Oludotun O. Adelusi, Peter A. Dele, Yasmine Shaw, Rosetta M. Brice, Oluteru E. Orimaye, Jorge A. Villarreal-González, Hye Won Kang, Ahmed E. Kholif, Uchenna Y. Anele

“…The administration of MOS, OP, and MOS:2OP to the HC diet decreased methane production at 24 h of incubation. …”
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Thermal Rejection Assessment: New Strategies for Early Detection by Irina Filz von Reiterdank, Irina Filz von Reiterdank, Irina Filz von Reiterdank, Irina Filz von Reiterdank, Rohil Jain, Rohil Jain, Eloi de Clermont-Tonnerre, Eloi de Clermont-Tonnerre, Eloi de Clermont-Tonnerre, Eloi de Clermont-Tonnerre, Alexandra Tchir, Alexandra Tchir, Curtis L. Cetrulo, Curtis L. Cetrulo, Alexandre G. Lellouch, Alexandre G. Lellouch, J. Henk Coert, Aebele B. Mink van der Molen, Shannon N. Tessier, Shannon N. Tessier, Korkut Uygun, Korkut Uygun

“…This approach may reduce the need for invasive biopsies, thereby improving patient comfort and reducing potential complications associated with current diagnostic methods.…”
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Epidemiological Situation on Cholera in the Russian Federation in 2023 and Forecast for 2024 by A. Yu. Popova, A. K. Noskov, E. B. Ezhlova, V. D. Kruglikov, E. V. Monakhova, O. S. Chemisova, A. A. Lopatin, S. M. Ivanova, O. A. Podoynitsyna, A. S. Vodop’yanov, D. A. Levchenko, I. V. Savina

“…The risks of epidemic manifestations of cholera are especially high in the territories of the constituent entities of the Russian Federation which are under ongoing emergency, due to migration processes, and the impact of other risk-forming factors that contribute to an increase in the degree of contact of the population with water bodies contaminated with cholera vibrios. …”
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Contribution of the TRPM4 Channel to Osteogenic Differentiation of Human Aortic Valve Interstitial Cells by Margaux Aize, Arthur Boilève, Benoit D. Roussel, Laura Brard, Harlyne Mpweme Bangando, Corentin Kerevel, Alexandre Lebrun, Hind Messaoudi, Vladimir Saplacan, Alain Manrique, Romain Guinamard, Christophe Simard

“…Mineralization and osteogenic markers (bone morphogenetic protein 2, runt‐related transcription factor 2) were decreased when pro‐calcifying media contained 9‐phenanthrol or small hairpin RNA–TRPM4. …”
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Bifidobacterium animalis ssp. lactis BX-245-fermented milk alleviates tumor burden in mice with colorectal cancer by Chengcong Yang, Musu Zha, Lu Li, Jiaqi Qiao, Lai-Yu Kwok, Dandan Wang, Yongfu Chen

“…Collectively, our data suggest that administering probiotic fermented milk containing specific functional strains such as BX245 could result in a reduction in tumor burden in CRC mice. …”
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Рreventive efficacy of interferon -2b in the COVID-19 pandemic by Zh. B. Ponezheva, A. A. Grishaeva, I. V. Mannanova, A. N. Kupchenko, S. B. Yatsyshina, S. V. Krasnova, V. V. Malynovskaya, V. G. Akimkin

“…The amount of infected people has already exceeded 48 million, and more than 1 million deaths have been registered. A steady increase of new cases of COVID-19 is currently observed on the territory of the Russian Federation. …”
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Effects of coix seed polyphenol extract on rumen fermentation, milk production, fatty acid profile, antioxidant activity, and polyphenol content in dairy goats by X.Z. Tian, Y.Q. Xu, J.X. Qin, X. Wang, S.L. Xie, R. Chen, Q. Lu, X. Chen

“…Overall, the appropriate supplemental level of CSE was 1.5 g/kg in dairy goats under the conditions of the current experiment.…”
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STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma by Dingheng Lu, Yuxiao Li, Xinyang Niu, Jiazhu Sun, Weitao Zhan, Yuchen Shi, Kai Yu, Suyuelin Huang, Xiaoyan Liu, Liping Xie, Xueyou Ma, Ben Liu

“…While tyrosine kinase inhibitors (TKIs) are currently the first-line treatments for advanced/metastatic ccRCC, patients often develop resistance after TKI therapy. …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…Support for the diversity of carers of eating disorders (fathers, partners, siblings) in different cultural contexts across the spectrum of eating disorders The current model of carers support is designed for parents (particularly mothers) of white, highly educated patients with AN. …”
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The methyl-CpG binding domain 2 regulates peptidylarginine deiminase 4 expression and promotes neutrophil extracellular trap formation via the Janus kinase 2 signaling pathway in e... by Biao Peng, Mu-Yun Yan, Yun-Rong Chen, Fei Sun, Xu-Dong Xiang, Da Liu

“…Objective The prognosis for severe asthma is poor, and the current treatment options are limited. The methyl-CpG binding domain protein 2 (MBD2) participates in neutrophil-mediated severe asthma through epigenetic regulation. …”
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Food Application of Orange Seed Powder through Incorporation in Wheat Flour to Boost Vitamin and Mineral Profiles of Formulated Biscuits by Ashiq Hussain, Salah Laaraj, Tusneem Kausar, Aziz Tikent, Hanane Azzouzi, Samina Kauser, Qurat Ul An, Aqsa Iqbal, Saima Akram, Rizwan Nisar, Ayesha Najam, Haya Fatima, Shazia Yaqub, Kaoutar Elfazazi

“…In the current work, orange seed powder replaced wheat flour at 0, 2.5, 5, 7.5, and 10% levels, to observe changes in physicochemical features of developed biscuits. …”
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Implementation of a digital nurse to improve the use of digital health applications (DiGA) for older people with depressive disorders (DiGA4Aged): a randomized proof of concept stu... by Anna Mai, Magdalena Pape, Theresa Sophie Busse, Katharina Kunde, Jennifer Bosompem, Chantal Giehl, Ina Carola Otte, Stephan Herpertz, Georg Juckel, Ida Haussleiter, Rainer Wirth, Horst Christian Vollmar, Nina Timmesfeld, Jan Dieris-Hirche

“…Discussion In Germany, the approved DiGA are currently little used, especially by people with a low digital affinity. …”
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High-risk pregnancy and risk of breastfeeding failure by Eman S. Salama, Mostafa Hussein, Ahmed N. Fetih, Azza M. A. Abul-Fadl, Shimaa A. Elghazally

“…A pretested and validated questionnaire was used to collect detailed epidemiological, personal, health-related status, medications, hospitalizations, reproductive history, current delivery, and previous breastfeeding experiences. …”
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Web-Based Respondent-Driven Sampling to Assess Biobehavioral Factors Among Men Who Have Sex With Men in Thailand: Cross-Sectional Study by Watcharapol Srinor, Suvimon Tanpradech, Panupit Thiengtham, Samart Karuchit, Charif Naksuk, Thitipong Yingyong, Thananda Naiwatanakul, Sanny Northbrook, Wolfgang Hladik

“… Abstract BackgroundRespondent-driven sampling (RDS) is the current standard for sampling key populations at risk for HIV infections but is usually limited to local implementation in single towns or cities. …”
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Use of ICT to Confront COVID-19 by Yousry Saber El Gamal

“…Supporting a digitized world and staying current in the latest technology will be essential for any country to remain competitive in a post COVID-19 world. …”
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Seismic Performance of Steel Column Base of Disc-spring Self-centering Energy-consuming Damper by SUN Jiateng, LIU Jianming, ZHU Guangzhi

“…When the number of shear energy dissipation plates is increased, the maximum stiffness, maximum residual deformation and energy consumption are increased by 20%, 25% and 20% respectively. …”
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Oral-Delivery Lactococcus lactis expressing cherry fusion lactoferrin peptides against infection of avian pathogenic Escherichia coli in chickens by Zhuoran Li, Xueying Wang, Dianzhong Zheng, Fuzhen Han, Yue Li, Han Zhou, Jiaxuan Li, Wen Cui, Yanping Jiang, Xiaona Wang, Weichun Xie, Lijie Tang

“…Historically, antibiotics and vaccinations currently control APEC infections in poultry, however, antibiotic-resistant strains and heterologous serotypes limit their effectiveness. …”
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Improvement of the perovskite photodiodes performance via advanced interface engineering with polymer dielectric by Andrey P. Morozov, Lev O. Luchnikov, Sergey Yu. Yurchuk, Artur R. Ishteev, Pavel A. Gostishchev, Sergey I. Didenko, Nikita S. Saratovsky, Dmitry O. Balakirev, Ivan V. Dyadishchev, Andrey A. Romanov, Ekaterina A. Ilicheva, Anton A. Vasilev, Sergey S. Kozlov, Dmitry S. Muratov, Yuriy N. Luponosov, Danila S. Saranin

“…IV curve analysis and 2-diode model calculations showed enhanced shunt properties, a decreased non-ideality factor, and reduced saturation dark current. …”
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Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and <i>Trypanosoma cruzi</... by Gabriela Alves de Souza, Lorrane de Souza Chaves, Afonso Santine M. M. Velez, Jorge Lucas F. Lacerda, Paulo Pitasse-Santos, Jayane Clys Conceição dos Santos, Otávio Augusto Chaves, Carlos Serpa, Raphael do Carmo Valente, Leonardo Marques da Fonseca, Marcos André Rodrigues da Costa Santos, Jhenifer Santos dos Reis, Carlos Antônio do Nascimento Santos, Lucia Mendonça-Previato, Jose Osvaldo Previato, Celio Geraldo Freire-de-Lima, Debora Decoté-Ricardo, Leonardo Freire-de-Lima, Marco Edilson Freire de Lima

“…<b>Background: </b>Anticancer therapies represent the primary treatment option for a significant number of cancer patients globally; however, many of these treatments are associated with severe side effects as they target molecular structures present in both cancerous and healthy cells. In a similar context, the treatment of Chagas disease, a neglected tropical illness, is hindered by the high toxicity of the currently available drugs. …”
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