Case Report: Locally invasive thyroid metastases from renal cell carcinoma: surgery after neoadjuvant therapy by Dana M. Hartl, Mohamed-Amine Bani, Abir Al Ghuzlan, Andreea-Elena Simonescu, Ingrid Breuskin, Alix Marhic, Laurence Albiges, Laurence Albiges, Livia Lamartina, Livia Lamartina, Julien Hadoux, Julien Hadoux

“…Patient 1 received lenvatinib and a bispecific anti–Programmed cell Death protein 1/ cytotoxic T-lymphocyte-associated protein 4 (PD-1/CTLA-4) antibody in the context of a clinical trial. The second patient received nivolumab and cabozantinib.ResultsThe observed tumor response in patient 1 showed a decrease in mean surgical complexity score from unresectable (prevertebral fascia invasion) to severe (risk of recurrent nerve paralysis) and in patient 2 from unresectable (prevertebral fascia) to moderate (superficial esophageal invasion). …”
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Development of a hydrogel-based three-dimensional (3D) glioblastoma cell lines culture as a model system for CD73 inhibitor response study by Marjan Bahraminasab, Samira Asgharzade, Ali Doostmohamadi, Atefeh Satari, Farkhonde Hasannejad, Samaneh Arab

“…GBM cells treated with CD73 inhibitors significantly decreased the proliferation rate and expression of VEGF and HIF1-α in the optimal hydrogel. …”
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Investigating the Therapeutic Effects of Albendazole, Mebendazole, and Praziquantel Nanocapsules in Hydatid Cyst-Infected Mice by Nooshinmehr Soleymani, Soheil Sadr, Cinzia Santucciu, Abbas Rahdar, Giovanna Masala, Hassan Borji

“…Drug resistance is the main challenge in treating parasitic diseases, including cystic echinococcosis (CE). Hence, the current study aims to investigate the effect of nanocapsules containing albendazole (ABZ), mebendazole (MBZ), and praziquantel (PZQ) on treating hydatid cysts in mice using these high-potency drugs. …”
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Metabolizable energy and digestible nutrient values of protease-supplemented field pea for broiler chicken by Tofuko A. Woyengo, Anna Rogiewicz, Robert Patterson

“…Results indicate that the protease product used in the current study marginally reduced the SID of AA for both SBM and field pea. …”
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Dietary Erucic Acid Induces Fat Accumulation, Hepatic Oxidative Damage, and Abnormal Lipid Metabolism in Nile Tilapia (Oreochromis niloticus) by Dingfei Ma, Qiangwei Li, Yuanyuan Xie, Youqin Kong, Zhili Ding, Jinyun Ye, Chenglong Wu, Yan Liu

“…Feeding fish with diets containing EA (20 and 27 g/kg diet) significantly increased the malondialdehyde content. …”
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Influence of Age and Neurotoxic HAART Use on Frequency of HIV Sensory Neuropathy by Olajumoke Oshinaike, Akinsegun Akinbami, Oluwadamilola Ojo, Anthonia Ogbera, Njideka Okubadejo, Frank Ojini, Mustapha Danesi

“…Data was collected using structured questionnaires which contained the brief peripheral neuropathy screening tool of AIDS Clinical Trial Group protocol. …”
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The impact of dropouts in scRNAseq dense neighborhood analysis by Alisa Pavel, Manja Gersholm Grønberg, Line H. Clemmensen

“…., cell pairs consistently being in the same cluster) decreases. This implies that sub-populations within cell types are increasingly difficult to identify under increasing dropout rates because observations are not consistently close.Our results challenge the current practice of using default clustering pipelines and the general assumption of identifiable local neighborhoods on high dropout data. …”
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Research on tetrahedral adaptive mesh grading refinement for intersecting faults by CHEN Yingxian, ZHU Zhe, MA Huiru, FU Jiepeng

“…Current tetrahedral adaptive mesh refinement techniques have primarily focused on the 3D reconstruction and analysis of simple stratified geological bodies. …”
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Evaluating the effect of vitamin D3 fortification on physicochemical and sensory properties of yogurt by Saneela Saleem, Zahra Khan, Imtiaz Hussain, Faran Khan, Fahad Al-Asmari, Faima Atta Khan, Alyan Ali Zafar, Muhammad Abdul Rahim, Zongo Eliasse, Mohamed Fawzy Ramadan

“…Although the vitamin D3 content decreased during storage, it could be preserved if fortified yogurt is stored in opaque containers.…”
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Herbicides’ efficiency in a weed control on winter wheat sown in the steppe part of Kabardino-Balkaria by Kh. Sh. Tarchokov, A. I. Sarbasheva, O. Kh. Mataeva

“…The arable (0–20 cm) layer contained 3.0–3.5 % of humus; 100 g of soil contained 1.56–2.87 % of Р2О5 (according to Machigin); 3.61–4.30 mg of K2O (according to Machigin); 6.8–7.0 of pH. …”
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Interleukin-35 impairs human NK cell effector functions and induces their ILC1-like conversion with tissue residency features by Valentin Picant, Lara Revol-Bauz, Laurie Tonon, Timothée Casini, Aurélien Voissière, Dominique Poujol, Emilie Picard, Céline Rodriguez, Cyril Degletagne, Emily Sible, Uzma Hasan, Anthony Ferrari, Christophe Caux, Nathalie Bendriss-Vermare

“…Abstract Natural Killer (NK) cells play pivotal immunological roles including direct cytotoxic effector function and secretion of inflammatory and immunomodulating cytokines. In the context of chronic inflammation, NK cell fitness decreases during disease progression through currently unknown mechanisms. …”
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Development of <i>OptiCon</i>: A Mathematical Model with a Graphical User Interface for Designing Sustainable Portland Cement Concrete Mixes with Budget Constraint by Angie Pineda, Rita Peñabaena-Niebles, Gilberto Martínez-Arguelles, Rodrigo Polo-Mendoza

“…However, designing PCCs with simultaneous contents of SCMs and RCA is not easily manageable because current design procedures fail to adjust all of the variables involved. …”
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Pot Marigold (Calendula officinalis) Powder in Rainbow Trout (Oncorhynchus mykiss) Feed: Effects on Growth, Immunity, and Yersinia ruckeri Resistance by Hamed Ghafarifarsani, Seyed Hossein Hoseinifar, Taravat Molayemraftar, Mahdieh Raeeszadeh, Hien Van Doan

“…The current research investigated the effects of pot marigold (Calendula officinalis) powder on growth, biochemical parameters, digestive enzymes, serum and mucus immune responses, antioxidant defense, and resistance of rainbow trout (Oncorhynchus mykiss) against Yersinia ruckeri. …”
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Novel Nanotechnology of TiO2 Improves Physical-Chemical and Biological Properties of Glass Ionomer Cement by Daniela Dellosso Cibim, Miki Taketomi Saito, Priscila Alves Giovani, Ana Flávia Sanches Borges, Vanessa Gallego Arias Pecorari, Orisson Ponce Gomes, Paulo Noronha Lisboa-Filho, Francisco Humberto Nociti-Junior, Regina Maria Puppin-Rontani, Kamila Rosamilia Kantovitz

“…Furthermore, regardless of TiO2 concentration, no significant effect was found on SR, whereas GIC-containing 7% TiO2 presented decreased SH values. Fluoride release lasted longer for the 5% and 7% TiO2 groups, and cell morphology/spreading and ECM composition were found to be positively affected by TiO2 at 5%. …”
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VigorBaby dietary supplement administration to mice during pregnancy and lactation alleviated ovarian disorders induced by Zearalenone in offsprings by Xuan Liu, Wen-Meng Bian, Yan-Qin Feng, Jia-Tian Tang, Ning Zuo, Jun-Jie Wang, Massimo De Felici, Xin Wang, Wei Shen

“…Remarkably, we found that these deleterious effects of the mycotoxin were almost completely abolished when dams, after ZEN administration, were fed 200 mg/kg of VigorBaby, a dietary supplement containing various vitamins and antioxidants. Moreover, some ovarian defects caused by ZEN in the F1 offsprings, such as decreased numbers of oocytes and PFs in 3 dpp ovaries and altered folliculogenesis in 21 dpp ovaries, were also observed in the F2 generation. …”
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Consequences, costs and cost-effectiveness of workforce configurations in English acute hospitals by Peter Griffiths, Christina Saville, Jane Ball, David Culliford, Jeremy Jones, Francesca Lambert, Paul Meredith, Bruna Rubbo, Lesley Turner, Chiara Dall’Ora

“…Study registration This study is registered as Current Controlled Trials ClinicalTrials.gov NCT04374812. …”
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Artesunate-loaded Fe3O4 nanoparticles: A novel approach for combating 4T1 breast cancer cells in vitro and in vivo by Amirreza Safdarian, Massoumeh Ebtekar, zouhair Mohammad Hassan, Hossein Naderi Manesh, Hashemi Seyed Ali, Saeed Samaeinasab, Danial Habibi, Hossein Khorramdelazad

“…Results: The nanoparticle made in this article had good anticancer effects and caused apoptosis in cancer cells in breast cancer, and also strengthened the cellular immune system and further increased interferon gamma and increased the half-life of mice with cancer, while this nanoparticle It did not have the side effects of chemotherapy drugs.Conclusion: Artesunate-containing nanoparticles decreased 4T1 cell viability and increased apoptosis to a greater extent than nanoparticles without the drug. …”
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Impaired plasma membrane calcium ATPase activity and mitochondrial dysfunction contribute to calcium dysregulation in Fabry disease-related painful neuropathy by Francesco Formaggio, Asia Pizzi, Cecilia Delprete, Davide Pasqualini, Isabella Mataloni, Roberto Rimondini, Ludovica Campolongo, Vincenzo Donadio, Anna Maria Ghelli, Rocco Liguori, Marco Caprini

“…The reduced activity was associated with a decrease of cytosolic pH which weakened the PMCA-dependent calcium extrusion. …”
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Comparison of various feed additives on nutrient digestibility, digestive enzyme activity, blood metabolite levels, and gut microbiota composition in japanese quail chicks by Hassan Saleh, Omid Jangjou, Mohammad Taher Mirakzehi, Seyedeh Hamideh Hosseni

“…In contrast, quail chicks that received diets containing tetracycline antibiotics exhibited a decreased presence of Clostridium species and E. coli in the ileum, as compared to the control group (p < 0.05). …”
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Cervical ripening at home or in hospital during induction of labour: the CHOICE prospective cohort study, process evaluation and economic analysis by Mairead Black, Cassandra Yuill, Mairi Harkness, Sayem Ahmed, Linda Williams, Kathleen A Boyd, Maggie Reid, Amar Bhide, Neelam Heera, Jane Huddleston, Neena Modi, John Norrie, Dharmintra Pasupathy, Julia Sanders, Gordon C S Smith, Rosemary Townsend, Helen Cheyne, Christine McCourt, Sarah Stock

“…Following pilot analysis, the primary comparison was changed to ensure feasibility and to reflect current practice, comparing home cervical ripening using a balloon catheter with in-hospital cervical ripening using any prostaglandin from 37 weeks of gestation. …”
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