SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2 by Hyun-Ju Cho, Joy Smith, Christopher H Switzer, Eleni Louka, Rebecca L Charles, Oleksandra Prysyazhna, Ewald Schroder, Mariana Fernandez-Caggiano, Daniel Simoes de Jesus, Seda Eminaga, Xiaoke Yin, Xiaoping Yang, Steven Lynham, Manuel Mayr, Valle Morales, Katiuscia Bianchi, Vinothini Rajeeve, Pedro R Cutillas, Adam J Mead, Philip Eaton

“…SFX-01, an α-cyclodextrin-stabilized sulforaphane complex currently in clinical development, covalently adducts cysteine residues. …”
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Post-pandemic patient safety: have the characteristics of incidents with harm changed? Comparative observational study in primary care via review of medical records with a trigger... by Gerardo Garzón González, Tamara Alonso Safont, Oscar Aguado Arroyo, Cristina Villanueva Sanz, Arancha Luaces Gayán, Esther Zamarrón Fraile, Juan José Jurado Balbuena, Inmaculada Mediavilla Herrera, Research Team “TriggerPrim®”

“…Conclusions No differences were found in the avoidability, severity, place of occurrence, or contributory factors of PSIHs before the pandemic and currently. In terms of the nature of these incidents, the outcomes revealed an increase in diagnostic errors (excluding diagnostic tests), which could be attributed to a greater frequency of remote consultations and a decrease in the longitudinality of care resulting from the shortage of professionals.…”
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The involvement of the synaptic vesicle cycle in homocysteine induced neurotoxicity in vitro and in vivo by Meng Wang, Xiaoshan Liang, Keqing Jin, Yinyue Liu, Suhui Luo, Qiang Zhang, Xuan Wang, Zhiping Dong, Xumei zhang

“…However, there is currently a lack of comprehensive understanding regarding the molecular mechanisms underlying Hcy-induced neurotoxicity. …”
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Role of the Fe₃O₄ mass ratio in Fe₃O₄-Fe nanoparticles with the core-shell structure on their anticancer activity <i>in vitro</i> by O. V. Bakina, A. S. Lozhkomoev, S. O. Kazantsev, A. V. Avgustinovich, S. G. Afanasyev, l. V. Spirina

“…Using the MTT test, it was found that nanoparticles containing 5 wt. Fe3O4, in the presence of which, at a concentration of 1 mg/ml, the number of living cells decreased to 16 % relative to the control. …”
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Monkeypox virus (MPXV) isolation from longitudinal samples of 11 patients to infer risk of onwards transmission by Dr Helen Callaby, Dr Janie Olver, Ms Kirsty Emery, Dr Kevin Richards, Dr Marian Killip, Dr Natalie Groves, Dr Jake Dunning, Professor Malcolm G Semple, Professor J Kenneth Baillie, Dr Tommy Rampling, Dr Catherine F Houlihan

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Effects of wetting events on mass timber surface microbial communities and VOC emissions: implications for building operation and occupant well-being by Gwynne Á. Mhuireach, Susan Collins, Leslie Dietz, Patrick Finn Horve, Aurélie Laguerre, Dale Northcutt, Jason Stenson, Kevin Van Den Wymelenberg, Elliott Gall, Mark Fretz

“…IntroductionHumans have used wood as a construction material throughout history. Currently, mass timber products, such as cross-laminated timber (CLT), are becoming more popular as a structural material, since they are renewable and have a lower carbon footprint than concrete or steel. …”
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Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma by Jing Wang, Meng Song, Jinming Tang, Haoran Yue, Xiaoyang Guo, Zhan Chen, Xiaolan Shen, Mingbo Cao, Mingbo Cao

“…It is critical to investigate new biomarkers and prognostic variables because there are currently no early diagnostic indicators. Actin-related proteins (ARPs) are involved in transcriptional regulation, chromatin remodeling, and DNA repair—all processes that have been connected to the development of cancer. …”
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Nanostructured Strategies for Melanoma Treatment—Part I: Design and Optimization of Curcumin-Loaded Micelles for Enhanced Anticancer Activity by Valentina Paganini, Andrea Cesari, Silvia Tampucci, Patrizia Chetoni, Susi Burgalassi, Michele Lai, Giulia Sciandrone, Silvia Pizzimenti, Fabio Bellina, Daniela Monti

“…<b>Background/Objectives</b>: Melanoma is a pathology that affects a large part of the population, and the currently available therapies have many limitations, including the selective targeting of the site of action. …”
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Analysis of the influence of the microbial load of poultry facilities on the development of keel “mins” in turkeys by R. I. Fedyniak, R. A. Peleno

“…The maximum values of the microbial load were from 60 to 90 days when 1 m3 contained from 5.35 ± 1.20 to 5.41 ± 0.17 lg CFU. From the 91st day until the end of the production cycle, a decrease in the microbial load of poultry houses' air was noted, from 2.5 to 3.9 %. …”
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Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis by Mélanie Bézard, Jean-Sébastien Vartanian-Grimaldi, Julien Henri, Denisa Calin, Amira Zaroui, Mounira Kharoubi, Thibaud Damy, Onnik Agbulut, Ekaterini Kordeli

“…LC-treated hiPSC-CM cultures and LC-containing spheroids presented structural and functional defects including: (1) decreased levels and subcellular disorganization of sarcomeric protein alpha-actinin; (2) abnormal accumulation of calcium handling SERCA2a protein; (3) impaired contractility of spheroids and altered calcium transients. …”
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Mortality impact, risks, and benefits of general population screening for ovarian cancer: the UKCTOCS randomised controlled trial by Usha Menon, Aleksandra Gentry-Maharaj, Matthew Burnell, Andy Ryan, Jatinderpal K Kalsi, Naveena Singh, Anne Dawnay, Lesley Fallowfield, Alistair J McGuire, Stuart Campbell, Steven J Skates, Mahesh Parmar, Ian J Jacobs

“…The no-screening group contained 101,359 women. Those in the blood and scan groups had screening every year until December 2011. …”
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Optimized biosynthesis and performance enhancement of γ-PGA from Bacillus licheniformis: a study on wettability, microstructure, and environmental performance by Mingming Cheng, Shuoshi Zhang, Jianbo Gao, Wenqing Liu, Gang Zhou, Tao Sui, Daoquan Cheng, Cheng Wang, Xiangchuan Wang, Xiaoyan Li, Yuxi Li

“…Infrared spectroscopy analysis showed that the purified product contained typical functional groups of γ-PGA. Changes in the contact angle of γ-PGA solution with coal dust over time demonstrated that brown coal was wetted extremely quickly, with the largest change in contact angle; within 5 min of dropping the fermentation liquid, the contact angle sharply decreased from 69° to 0°, completely wetting the brown coal. …”
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Impact of frailty in older people on health care demand: simulation modelling of population dynamics to inform service planning by Bronagh Walsh, Carole Fogg, Tracey England, Sally Brailsford, Paul Roderick, Scott Harris, Simon Fraser, Andrew Clegg, Simon de Lusignan, Shihua Zhu, Francesca Lambert, Abigail Barkham, Harnish Patel, Vivienne Windle

“…Mean face-to-face appointments were generally similar within frailty categories across age groups, but with a notable decrease in appointments with older age in the severe category. …”
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STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma by Dingheng Lu, Yuxiao Li, Xinyang Niu, Jiazhu Sun, Weitao Zhan, Yuchen Shi, Kai Yu, Suyuelin Huang, Xiaoyan Liu, Liping Xie, Xueyou Ma, Ben Liu

“…While tyrosine kinase inhibitors (TKIs) are currently the first-line treatments for advanced/metastatic ccRCC, patients often develop resistance after TKI therapy. …”
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Training Manual for Prevention of Covid-19 Disease among Hospital Personnel by Ali Poormohammadi, Ghasem Azarian

“…Most respiratory droplets containing viruses are in this size range. Medium droplets (10 to 50μm) remain in the air for several minutes. …”
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Application of biomedical cell products in the treatment of congenital epidermolysis bullosa by Arfenya E. Karamova, Kseniya M. Aulova, Vadim V. Chikin, Аlexey A. Kubanov

“…Congenital epidermolysis bullosa is a phenotypically and genetically heterogeneous group of genodermatoses, which are characterized by decreasing of skin’s structural protein production up to complete absence or violation of the structure as a result of mutation. …”
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Study on Innovative Practices to Promote Girls’ Retention and Transition to Secondary and Higher Learning Institutions in Sub-Saharan Africa. by Ayiga, Natal, Adyanga, Francis Akena, Akello, Jacqueline

“…The economy of the study regions is predominantly agricultural with the majority of the population depending on subsistence farming, living in rural areas, and currently, the poorest in all aspects of development in Uganda. …”
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Study of nicotine content in the aerosols of ENDS of various designs by T. A. Zaitseva, T. A. Perezhogina, S. N. Medvedeva, L. V. Kokorina

“…Currently, a unified approach to the regulation of NCP and control of the content of toxic substances in the aerosol has not been developed, which leads to the use of various modes of aerosol collection on laboratory smoking machines. …”
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Accelerated weathering of PP based nanocomposites: Effect of the presence of maleic anhydryde grafted polypropylene by N. Tz. Dintcheva, M. Morreale, F. P. La Mantia

“…Polymer nanocomposites are currently a topic of great interest. The increasing importance they are gaining also in the standpoint of industrial applications, is giving concerns regarding their environmental stability and, in general, their behaviour in outdoor applications, under direct solar irradiation. …”
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Natural Compounds with Beneficial Effects on Skin Collagen Type I and Mechanisms of Their Action by Wioleta Żynda, Agnieszka Ruczaj, Anna Galicka

“…Currently, when the average life expectancy increases, the esthetic aspect and maintaining healthy skin are particularly important. …”
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