Combining the RCAS/tv-a retrovirus and CRISPR/Cas9 gene editing systems to generate primary mouse models of diffuse midline glioma by Sophie R. Wu, Julianne Sharpe, Joshua Tolliver, Abigail J. Groth, Reid Chen, María E. Guerra García, Vennesa Valentine, Nerissa T. Williams, Sheeba Jacob, Zachary J. Reitman

“…Genetically engineered mouse models (GEMMs) are critical to studying tumorigenesis and tumor-immune interactions, which may inform new treatment approaches. However, current midline glioma GEMM approaches are limited in their ability to multiplex perturbations and/or target specific cell lineages in the brain for genetic manipulation. …”
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Development of a Long-Acting Follicle-Stimulating Hormone Using Serum Albumin Fab-Associated Technology for Female Infertility by Daham Kim, Yoon Hee Cho, Min Jeong Kang, So Jeong Lee, Soohyun Lee, Bo Hyon Yun, Hyunjin Chi, Jeongsuk An, Kyungsun Lee, Jaekyu Han, Susan Chi, Moo Young Song, Sang-Hoon Cha, Eun Jig Lee

“…Conclusion These findings suggest that SAFA-FSH presents a promising alternative to current rhFSH treatments for female infertility. However, further research is essential to thoroughly assess its safety and efficacy in clinical contexts.…”
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A comprehensive item bank of internal validity issues of relevance to in vitro toxicology studies by Gunn E. Vist, Heather M. R. Ames, Gro H. Mathisen, Trine Husøy, Camilla Svendsen, Anna Beronius, Emma Di Consiglio, Ingrid L. Druwe, Thomas Hartung, Sebastian Hoffmann, Carlijn R. Hooijmans, Kyriaki Machera, Pilar Prieto, Joshua F. Robinson, Erwin Roggen, Andrew A. Rooney, Nicolas Roth, Eliana Spilioti, Anastasia Spyropoulou, Olga Tcheremenskaia, Emanuela Testai, Mathieu Vinken, Paul Whaley

“…Context In vitro toxicology studies are increasingly being included as evidence in systematic reviews and chemical risk assessments. …”
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Electronic cigarette use in relation to changes in smoking status and respiratory symptoms by Linnéa Hedman<sup>+<sup>, Gustaf Lyytinen<sup>+<sup>, Helena Backman, Magnus Lundbäck, Caroline Stridsman, Anne Lindberg, Hannu Kankaanranta, Lina Rönnebjerg, Eva Rönmark, Linda Ekerljung

“…A validated postal questionnaire containing identical questions was used in OLIN and WSAS at baseline in 2006–2008 and at follow-up in 2016. …”
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The attenuated African swine fever vaccine HLJ/18-7GD provides protection against emerging prevalent genotype II variants in China by Zilong Wang, Jiwen Zhang, Fang Li, Zhenjiang Zhang, Weiye Chen, Xianfeng Zhang, Encheng Sun, Yuanmao Zhu, Renqiang Liu, Xijun He, Zhigao Bu, Dongming Zhao

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Home Health Care Providers’ Readiness to Care for Children and Youth With Complex Medical Conditions: Protocol for a Scoping Review by Joanne Tay, Margaret Saari, Adam Mulcaster, Edward Cruz

“…However, families continue providing the bulk of care, often at great personal costs. As care complexity increases, so does the reliance on home care providers. …”
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Research status and prospects of treatment for malignant pleural mesothelioma by ZHAO Kaile, WANG Lei, GENG Jianxiong, CUI Chengwei, YU Yan

“…Malignant pleural mesothelioma (MPM) is strongly associated with a history of asbestos exposure and is characterized by high malignancy, high mortality, and poor prognosis. Current treatments for MPM are limited and generally suboptimal, resulting in a median overall survival (OS) of approximately one year for MPM patients. …”
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Student Mental Health in UK Higher Education Institutions: Protocol for a Scoping Review of Trends, Gaps, and Research Directions by Nicola Cogan, Aja Murray, Emily Long, Maria Gardani, Michelle O'Toole, Menchie Leung, Stella Kyratzi, Jelena Milicev, Katie Dryburgh, Chloe Bolota, Lacey Ho

“…Current literature remains fragmented, with limited synthesis comparing national contexts. …”
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Intelligent beehive monitoring system based on internet of things and colony state analysis by Yiyao Zheng, Xiaoyan Cao, Shaocong Xu, Shihui Guo, Rencai Huang, Yingjiao Li, Yijie Chen, Liulin Yang, Xiaoyu Cao, Zainura Idrus, Hongting Sun

“…Moreover, our counting algorithm also achieved excellent results, with root mean square error (RMSE) of 1.3 ± 0.1, 0.2 ± 0.0, and 1.6 ± 0.1 in counting the number of bees current, entry, and out scene in an episode, respectively. …”
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An animal model study of simplified optical navigation system-assisted percutaneous lumbar transforaminal puncture by B. N. Wenxiu Chai, Yuqing Chen, Li Sheng, Yong Huang

“…The system significantly improves puncture accuracy while markedly decreasing both the number of puncture attempts and fluoroscopy exposures compared to conventional techniques.…”
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The Bioethics-CSR Divide by Caio Caesar Dib

“…This includes investments, entrepreneurship models, and its relationship to stakeholders, leading to an increasing operationalization and globalization of the concept.[6] At first sight, these two movements seem to stem from different contexts. …”
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Artificial intelligence in Anatomy: Potential uses and challenges by Lubna Faisal

“…One more example of AI in anatomy teaching is ChatGPT. No doubt it increases students’ engagement, and ability to learn and has strong text analysis. …”
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Synergistic Effects of Mannan Oligosaccharides and Onion Peels on In Vitro Batch Culture Fermentation of High Concentrate and Forage Diets by Lydia K. Olagunju, Oludotun O. Adelusi, Peter A. Dele, Yasmine Shaw, Rosetta M. Brice, Oluteru E. Orimaye, Jorge A. Villarreal-González, Hye Won Kang, Ahmed E. Kholif, Uchenna Y. Anele

“…The administration of MOS, OP, and MOS:2OP to the HC diet decreased methane production at 24 h of incubation. …”
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Contribution of the TRPM4 Channel to Osteogenic Differentiation of Human Aortic Valve Interstitial Cells by Margaux Aize, Arthur Boilève, Benoit D. Roussel, Laura Brard, Harlyne Mpweme Bangando, Corentin Kerevel, Alexandre Lebrun, Hind Messaoudi, Vladimir Saplacan, Alain Manrique, Romain Guinamard, Christophe Simard

“…Mineralization and osteogenic markers (bone morphogenetic protein 2, runt‐related transcription factor 2) were decreased when pro‐calcifying media contained 9‐phenanthrol or small hairpin RNA–TRPM4. …”
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Bifidobacterium animalis ssp. lactis BX-245-fermented milk alleviates tumor burden in mice with colorectal cancer by Chengcong Yang, Musu Zha, Lu Li, Jiaqi Qiao, Lai-Yu Kwok, Dandan Wang, Yongfu Chen

“…Collectively, our data suggest that administering probiotic fermented milk containing specific functional strains such as BX245 could result in a reduction in tumor burden in CRC mice. …”
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Assessment of the phenolic profile and biological activities of aqueous date seed extracts: A comparative analysis by Tareq M. Osaili, Aseel Swaidan, Anas Al-Nabulsi, Amin Olaimat, Susanne Neugart, Layla Engelhardt, Tuba Esatbeyoglu, Mutamed Ayyash, Leila Cheikh Ismail, Maher M Al-Dabbas, Reyad S. Obaid, Nada El Darra

“…Date palm fruit (Phoenix dactylifera L.) is a well-known fruit that has become increasingly popular among consumers due to its pleasant flavor, nutrient-dense content, and nutraceutical characteristics. …”
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Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…This has the potential to affect fetal brain development, increase infant reactivity to stress, and impair sensitive mother–infant bonds from developing. …”
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Effects of coix seed polyphenol extract on rumen fermentation, milk production, fatty acid profile, antioxidant activity, and polyphenol content in dairy goats by X.Z. Tian, Y.Q. Xu, J.X. Qin, X. Wang, S.L. Xie, R. Chen, Q. Lu, X. Chen

“…Overall, the appropriate supplemental level of CSE was 1.5 g/kg in dairy goats under the conditions of the current experiment.…”
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STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma by Dingheng Lu, Yuxiao Li, Xinyang Niu, Jiazhu Sun, Weitao Zhan, Yuchen Shi, Kai Yu, Suyuelin Huang, Xiaoyan Liu, Liping Xie, Xueyou Ma, Ben Liu

“…While tyrosine kinase inhibitors (TKIs) are currently the first-line treatments for advanced/metastatic ccRCC, patients often develop resistance after TKI therapy. …”
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A Framework for Cervical Cancer Elimination in Low-and-Middle-Income Countries: A Scoping Review and Roadmap for Interventions and Research Priorities by Michelle B. Shin, Gui Liu, Nelly Mugo, Nelly Mugo, Patricia J. Garcia, Patricia J. Garcia, Darcy W. Rao, Darcy W. Rao, Cara J. Broshkevitch, Linda O. Eckert, Linda O. Eckert, Leeya F. Pinder, Leeya F. Pinder, Judith N. Wasserheit, Judith N. Wasserheit, Judith N. Wasserheit, Ruanne V. Barnabas, Ruanne V. Barnabas, Ruanne V. Barnabas, Ruanne V. Barnabas

“…Using these data, we developed a logic model to summarize the current state of science and identified evidence gaps and priority research questions for each prevention strategy. …”
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