Optimizing enzyme thermostability by combining multiple mutations using protein language model by Jiahao Bian, Pan Tan, Ting Nie, Liang Hong, Guang‐Yu Yang

“…It showed a 10.19°C increase in the melting temperature and an ~655‐fold increase in the half‐life at 58°C. …”
Get full text

Military and political security in the Arctic before and amidst the Ukrainian crisis by I. A. Arzhanov

“…This course has been reflected in a whole series of alliance’s military exercises, which, as shown in the article, are becoming increasingly extensive and regular year by year. The author concludes that the Ukrainian crisis has only laid bare the true aspirations of the NATO countries seeking to contain Russia in the Far North and refusing to consider its interests and build a constructive dialogue in the field of military and political security. …”
Get full text

UML/OCL based design and the transition towards temporal object relational database with bitemporal data by Soumiya Ain El Hayat, Fouad Toufik, Mohamed Bahaj

“…In software modeling, UML (Unified modeling language) receives increasing attention from designers of real-time systems in software development. …”
Get full text

Improvement of RT-DETR model for ground glass pulmonary nodule detection. by Siyuan Tang, Qiangqiang Bao, Qingyu Ji, Tong Wang, Naiyu Wang, Min Yang, Yu Gu, Jinliang Zhao, Yuhan Qu, Siriguleng Wang

“…Currently, pulmonary nodules detection work mostly focus on recognition and diagnosis of solid nodules. …”
Get full text

Melt‐Processable and Electrospinnable Shape‐Memory Hydrogels by Turdimuhammad Abdullah, Cagatay Altınkok, Oguz Okay

“…Abstract Due to their ability to adapt to subtle changes in response to various external and internal stimuli, smart hydrogels have become increasingly popular in research and industry. However, many currently available hydrogels suffer from poor processability and inferior mechanical properties. …”
Get full text

Investigation of hydrogen embrittlement in steel alloys: mechanism, factors, advanced methods and materials, applications, challenges, and future directions: A review by Umme Javeria, Sung Jin Kim

“…Hydrogen embrittlement (HE) remains a critical challenge in structural metals, particularly steels, compromising their mechanical integrity in hydrogen-containing environments. The process typically initiates with crack nucleation and progresses to fracture due to a reduction in ductility and an increase in brittleness. …”
Get full text

The role of non-antibacterial agents in the prevention of recurrent urinary tract infections by E. V. Shikh, O. V. Zhukova

“…Currently, European recommendations for the prevention of recurrent urinary tract infections include non-antibacterial agents such as D-mannose; preparations containing cranberries and/or products of its processing. …”
Get full text

Study of nicotine content in the aerosols of ENDS of various designs by T. A. Zaitseva, T. A. Perezhogina, S. N. Medvedeva, L. V. Kokorina

“…Currently, a unified approach to the regulation of NCP and control of the content of toxic substances in the aerosol has not been developed, which leads to the use of various modes of aerosol collection on laboratory smoking machines. …”
Get full text

Mapping the global distribution and conservation status of oases—ecosystems of pivotal biocultural relevance by Juan Antonio Hernández-Agüero, Mechthilde Falkenhahn, Jessica Hetzer, Karsten Wesche, Christiane Zarfl, Klement Tockner

“…However, less than 0.5% of their total area is currently under protection, making oases one of the least conserved ecosystems worldwide. …”
Get full text

Investigation of neuromodulation of the endbulb of Held synapse in the cochlear nucleus by serotonin and norepinephrine by Maria Groshkova, Maria Groshkova, Maria Groshkova, Maria Groshkova, Maria Groshkova, Theocharis Alvanos, Theocharis Alvanos, Theocharis Alvanos, Yumeng Qi, Fangfang Wang, Carolin Wichmann, Carolin Wichmann, Carolin Wichmann, Carolin Wichmann, Yunfeng Hua, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser

“…Patch-clamp recordings from BCs revealed an increase in frequency of miniature excitatory postsynaptic currents (mEPSCs) upon application of NE but not 5-HT. …”
Get full text

<i>MAGE-C1</i> gene and mage-c1 protein expression comparison in primary multiple myeloma patients by E. A. Makunina, L. P. Mendeleeva, V. L. Surin, M. V. Soloviev, M. V. Firsova, A. M. Kovrigina, A. A. Sherstnev, I. V. Gal’tseva, Y. O. Davydova, S. M. Kulikov

“…Single factor analysis showed that patients with decreased MAGE-C1 gene and mage-c1 protein expression levels achieved a significantly higher antitumor response to bortezomib-containing regimens, while high expression was accompanied by refractoriness to bortezomib.…”
Get full text

Forensic Investigation of Stainless Steel 316 Hydrogen-Membrane and Ammonia-Cracking Reactors Through Mechanical Testing by Alexander Ilyushechkin, Veronica Gray, Riley Ingle, Lachlan Carter, Liezl Schoeman

“…We examined samples of reactor walls exposed to hydrogen-containing atmospheres for >100 and ~1000 h at elevated temperatures during hydrogen separation and ammonia cracking. …”
Get full text

Tax planning: organization features at enterprise by Grabchuk I.L., Laichuk S.M.

“…The research determines the need for studying the «cloud» technologies as the method of saving company’s resources and increasing the efficiency of processing accounting data. …”
Get full text

Optimization procedure for conformance control by Konstantin M. Fedorov, Rodion M. Ganopolsky, Alexander Ya. Gilmanov, Alexander P. Shevelev

“…The article is devoted to the development of an optimization procedure for conformance control treatment. Currently, due to the significant share of reservoirs with high water cut, it is relevant to use methods that allow reducing the rate of production water cut increase. …”
Get full text

Trial in absentia and the modern international criminal procedure by A. B. Mezyaev

“…The practice of these courts demonstrates a very inconsistent application and not always convincing interpretation of the rights of the accused in general and the right to be tried in his presence. Currently, this practice is trying to change the previously formed trend towards increasingly severe restrictions on exceptions to the right of the accused to be tried in his presence.…”
Get full text

Ginseng and its functional components in non-alcoholic fatty liver disease: therapeutic effects and multi-target pharmacological mechanisms by Ping Xiao, Zhaorui Ye, Xiuyan Li, Quansheng Feng, Yue Su

“…BackgroundNon-alcoholic fatty liver disease (NAFLD) is a common type of chronic liver disease and its incidence is increasing. Its disease progression is closely related to non-alcoholic steatohepatitis and liver fibrosis. …”
Get full text

Direct and Indirect Methods for Studying Human Gut Microbiota by V. T. Ivashkin, O. S. Medvedev, E. A. Poluektova, A. V. Kudryavtseva, I. R. Bakhtogarimov, A. E. Karchevskaya

“…Aim: To review the main methods of intestinal microbiota studying.Key points. Currently, molecular genetic methods are used mainly for basic research and do not have a unified protocol for data analysis, which makes it difficult to implement them in clinical practice. …”
Get full text

T cell epitope content comparison using EpiCC correlates with vaccine efficacy against heterologous porcine reproductive and respiratory syndrome virus type 2 strains by J. Mark Hammer, Andres H. Gutierrez, Lucas Huntimer, Benjamin Gabriel, William D. Martin, Sabine E. Hammer, Tobias Käser, Anne S. De Groot

“…While vaccines are available, they are not entirely effective, and the introduction of modified live virus vaccines (MLV) has contributed to an increase in the rate of viral evolution. While vaccines induce humoral responses that may contribute to immunity against PRRSV, vaccines containing T cell epitopes that are well-matched to circulating strains are believed to be more likely to induce protective effects upon challenge or field exposure. …”
Get full text

A Mechanistic Approach to Replacing Antibiotics with Natural Products in the Treatment of Bacterial Diarrhea by Mingbang Wei, Huaizhi Liu, Zhefan Hu, Peixiao Wen, Yourong Ye, Yangzom Chamba, Hongliang Zhang, Peng Shang

“…Natural products have emerged as potential alternatives to antibiotics in the treatment of bacterial diarrhea, due to their multi-targeting effects, low potential for inducing resistance, and favorable safety profiles. Currently, the search for natural product-based therapies has become an emerging focus in medical research. …”
Get full text

Hybrid surface layers with antibacterial and anti-inflammatory activity for implants materials by Mariia A. Piatkova, Konstantine V. Nadaraia, Arina I. Ponomarenko, Igor V. Manzhulo, Mariia S. Gerasimenko, Arina I. Pleshkova, Evgeny A. Belov, Igor M. Imshinetskiy, Ksenia A. Fomenko, Ivan S. Osmushko, Aleksey G. Kozlov, Sergey V. Gnedenkov, Dmitry V. Mashtalyar

“…Currently, there is an essential need for bioresorbable bone implants with antibacterial, anti-inflammatory properties as well as osteoinductivity. …”
Get full text