Prioritization of potential drug targets for diabetic kidney disease using integrative omics data mining and causal inference by Junyu Zhang, Jie Peng, Chaolun Yu, Yu Ning, Wenhui Lin, Mingxing Ni, Qiang Xie, Chuan Yang, Huiying Liang, Miao Lin

“…Diabetic kidney disease (DKD) with increasing global prevalence lacks effective therapeutic targets to halt or reverse its progression. …”
Get full text

Early mental health intervention and supported self-care for LGBTQ+ young people in the UK: a mixed-methods study by Elizabeth McDermott, Rachael Eastham, Elizabeth Hughes, Emily Pattison, Katherine Johnson, Stephanie Davis, Steven Pryjmachuk, Ceu Mateus, Olu Jenzen, Felix McNulty

“…Stage 2: service mapping This stage of the study investigated and mapped current LGBTQ+ youth-specific mental health service provision across the UK. …”
Get full text

Treatment Methods Dry Form of Age Macular Degeneration — History and Prospects. Review by A. N. Kulikov, M. V. Zakharov, A. A. Volozhev

“…The main treatment for wet AMD is the injection of medications called anti-VEGF agents. Currently, treatment of dry age-related macular degeneration includes modification of risk factors (stop smoking, healthy life style and etc) and dietary supplements containing a combination of certain ingredients (vitamin C, vitamin E, zinc, copper, and lutein with zeaxanthin or beta-carotene) may be able to slow the progression of the disease. …”
Get full text

Cryo-EM and cryo-ET reveal the molecular architecture and host interactions of mycobacteriophage Douge by Jitendra Maharana, Chun-Hsiung Wang, Li-An Tsai, Yi-Ting Liao, Cheng-Han Yang, Melvin C. Shen, Lourriel S. Macale, Thang Ngoc Tran, Joemark Narsico, Ronelito J. Perez, Sunil Kumar Tewary, Jian-Li Wu, Hong-You Lin, Shu-Wei Chang, Aaron Franklin, Patrick J. Moynihan, Deborah Jacobs-Sera, Krista G. Freeman, Graham F. Hatfull, Todd L. Lowary, Meng-Chiao Ho

“…Molecular insights into mycobacteriophage architecture and host interactions could allow structure-guided phage engineering to increase efficacy and broaden host range, but such information is currently unavailable. …”
Get full text

Promising opportunities to improve polio vaccines by E. E. Evreinova, L. M. Khantimirova, V. A. Shevtsov, V. A. Merkulov, V. P. Bondarev

“…In order to meet the needs of global health, it is planned to increase the use of traditional and optimised inactivated polio vaccines and introduce new types of vaccines that are being developed based on the current understanding of RNA-containing viruses. …”
Get full text

Sustainable Design of a Tiny House: Using a Life Cycle Assessment Approach to Compare the Environmental Performance of Industrial and Earth-Based Building Systems by Letizia Dipasquale, Giada Giuffrida, Natalia Jorquera Silva, Riccardo Maria Pulselli, Rosa Caponetto

“…The increased concerns about climate change, diminishing natural resources, and environmental degradation call for deep research into new environmentally friendly building systems that use natural or recycled materials. …”
Get full text

The long-term suitability of agrivoltaics as a climate adaptation strategy in the southwestern United States by Talitha H. Neesham-McTiernan, Greg A. Barron-Gafford

“…We evaluate land suitability for agrivoltaics across the southwest using spatially explicit multi-criteria decision analysis, which incorporates biophysical variables that relate to the potential microclimate benefits provided by agrivoltaics under current and future climate conditions. Results show 310,393 km2 of the region is suitable for agrivoltaics, with 20,576 km2 classified as most suitable under current conditions, increasing to 31,712 km2 under 2080 conditions. …”
Get full text

The Impact of Resection Margins in Primary Resection of High-Grade Soft Tissue Sarcomas: How Far Is Far Enough? by Julian Miles Steffens, Tymoteusz Budny, Georg Gosheger, Marieke De Vaal, Anna Maria Rachbauer, Andrea Laufer, Nina Myline Engel, Niklas Deventer

“…<b>Background/Objectives</b>: The World Health Organization’s (WHO) classification of tumors contains around 80 entities of soft tissue sarcomas (STSs). …”
Get full text

FUZZY ALGORITHM TO CONTROL REACTIVE POWER FLOW IN ELECTRIC NETWORK WITH NONLINEAR LOADS by H. B. Guliyev

“…The mentioned results demonstrate that when harmonic components of voltages exceed normative magnitudes, the use of the proposed algorithm eliminates additional loading on the capacitor banks with higher harmonic currents whereas the control procedure acquires quality, the number of commutations is being reduced, the capacitor battery functions longer and the probability of its malfunction decreases.…”
Get full text

Use of nicotine products — a cross-sectional survey of adolescents in Poland by Piotr Korczyński, Stanisław Surma, Agnieszka Jankowska-Zduńczyk, Sebastian Szmit, Piotr Wierzbiński, Janusz Sytnik-Czetwertyński, Krzysztof J. Filipiak

“…INTRODUCTION: Cigarette smoking has been a significant health problem in the world for decades. Currently, new forms of smoking are becoming increasingly popular — e-cigarettes and tobacco heating systems (HnB, heat-not-burn), whose impact on the human body is not indifferent. …”
Get full text

Hygienic requirements to the design of the positron-emission tomography centers and departments by O. V. Minonenko, T. B. Baltrukova, N. S. Bashketova, G. A. Gorskiy, T. V. Kryukova, E. A. Fedorova

“…The aim of the current study is to provide a critical analysis of the current hygienic requirements to the design of the PET, PET/CT and PET/MRI centers and departments. …”
Get full text

Evaluation of the applicability of the X-ray room technical passports in the medical facilities and approval of the X-ray department technical plans by the local radiological autho... by I. I. Berezin, S. S. Somov, К. V. Yakusheva

“…The purpose of this work was to assess the relevance and necessity of issuing a technical passport for the X-ray room and to coordinate the project of the X-ray room with the X-ray department in the light of the current sanitary legislation. Registration of a technical passport by organizations that have special permits for these types of work, and not only by the X-ray and radiological department, would increase the legal value of the technical passport. …”
Get full text

Impact of Iron Supplementation on Growth Performance, Iron Homeostasis and Redox Balance of Suckling Piglets by Qingwei Meng, Qing Wu, Qiang Zhou, Jiayong Tang, Yong Zhuo, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Lun Hua, Xuemei Jiang, De Wu, Lianqiang Che

“…Piglets in the CON group had lower body weight on PND 21 compared with piglets in the FeDex, FeOra, and FeDPO groups (0.46–1.05 kg decrease, <i>p</i> < 0.05), while piglets in the FeDPO group had the highest weaning weight across all groups (<i>p</i> < 0.05). …”
Get full text

Optimizing Antibiotic Use: Addressing Resistance Through Effective Strategies and Health Policies by Maurizio Capuozzo, Andrea Zovi, Roberto Langella, Alessandro Ottaiano, Marco Cascella, Manlio Scognamiglio, Francesco Ferrara

“…<b>Main text:</b> This review analyzes current strategies and health policies adopted in the European Union (EU) and Italy to manage AMR, presenting an in-depth examination of approaches for containment and mitigation. …”
Get full text

Research progress on nanotoxicity and detoxification of cobalt in metal-based implants by Wentao Fan, Mingxin Guo

“…While mechanisms are increasingly understood, further research is crucial to fully elucidate the long-term systemic consequences and to develop effective clinical detoxification and preventative strategies for patients with cobalt-containing implants.…”
Get full text

An analysis of McMurdo Dry Valleys’ lotic habitats within Antarctica’s protected area network and addressing gaps in biodiversity protection by Anna Wright, Cassandra Brooks, Michael Gooseff, Adrian Howkins, Stephen Chignell

“…However, with sustained human presence within the MDV, increasing human activity across Antarctica, and aquatic ecosystems subject to environmental change, the effectiveness of current protections for biodiversity conservation requires evaluation. …”
Get full text

Surveillance of Unregulated Caffeine Health Claims on Coffee and Other Foods—A Market Analysis by Katharina Höfflin, Veronika Kurz, Yvonne Köder, Kristina Schmied, Verena Bock, Ann-Kathrin Kull, Dirk W. Lachenmeier

“…To investigate how these are currently used on the market, internet research (n = 188) was carried out. …”
Get full text

CFD Simulation of Hydrodynamic Properties of Perforated Triangular Corrugated Plate Filler Under Reduced Pressure by Yang QIN, Zheng-yu ZOU, Shi-sheng LI, Xiao-hong XIONG, Chang-da LI, Zhi-wei ZHANG, Qing-zhao LIU, Guo-bing LI

“…As the perforation aperture increases, the flow rate decreases overall and the low flow rate area increases. …”
Get full text

Synthesis of magnetite nanoparticles using electrochemical oxidation by Ye. Ya. Levitin, I. D. Roy, O. S. Kryskiv, T. M. Chan

“…To intensify the anodic process it is necessary to apply the mixing that reduces the thickness of the diffusion layer near the electrode and allows oxidation at a current density of 0.7-1.2 A/dm2. Under appropriate conditions of electrolysis (high current density of the cathode, acidification of the solution) loss of iron Fe2+ is avoided at the expense of cathodic discharge, as mainly at the cathode the reducing of cations H+ occurs. …”
Get full text

Blend of low cost electrode material for energy storage device under DC glow discharge plasma exposed ESAC by Vijayalakshmi K.A, Judith Fennila, K T Maheswari

“…More oxygen-containing functional groups are present, according to an FTIR analysis. …”
Get full text