Hydroxyapatite-filled osteoinductive and piezoelectric nanofibers for bone tissue engineering by Frederico Barbosa, Fábio F. F. Garrudo, Paola S. Alberte, Leonor Resina, Marta S. Carvalho, Akhil Jain, Ana C. Marques, Francesc Estrany, Frankie J. Rawson, Carlos Aléman, Frederico Castelo Ferreira, João C. Silva

“…The biological cues provided by the HAp nanoparticles enhanced the osteogenic differentiation of seeded human mesenchymal stem/stromal cells (MSCs) as observed by the increased ALP activity, cell-secreted calcium deposition and osteogenic gene expression levels observed for the HAp-containing fibers. …”
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An analysis of data quality and population characteristics of the SIGN online surgical database: A 20 year review by Matthew Roces, Ericka von Kaeppler, Claire Donnelley, Mayur Urva, Abigail Cortez, Kelsey Brown, Michael Flores, Patricia Rodarte, Kian Niknam, Francisco Gomez-Alvarado, Babapelumi Adejuyigbe, Lewis Zirkle, David Shearer

“…However, the quality of data contained in the SOSD is largely unknown. The aim of the current study was to analyze the trend in data quality and follow-up rate of the SOSD over the past two decades. …”
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Enhanced Broad-Spectrum Efficacy of an L2-Based mRNA Vaccine Targeting HPV Types 6, 11, 16, 18, with Cross-Protection Against Multiple Additional High-Risk Types by Kosuke Tsukamoto, Akio Yamashita, Masatoshi Maeki, Manabu Tokeshi, Hirotatsu Imai, Akira Fukao, Toshinobu Fujiwara, Koji Okudera, Nobuhisa Mizuki, Kenji Okuda, Masaru Shimada

“…Results: We identified that a construct containing E01 (a 5′-untranslated region) and SL2.7 (a poly(A) polymerase recruitment sequence) significantly increased protein expression. …”
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Biosensor DNA Elektrokimia untuk Deteksi Makanan Mengandung Babi (Sus scrofa) Menggunakan Screen Printed Carbon Electrode Termodifikasi Emas by Shabarni Gaffar, Annisa Ilma Naviardianti, Santhy Wyantuti, Yeni Wahyuni Hartati

“…Detection of meatball samples by DNA biosensor showed a significant increase of current response for sample that contains 100% swine DNA (3.417 µA). …”
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Accretion of the degenerate Fermi gas onto a Reissner-Nordström black hole by Ping Li, Jiang-he Yang, Siwei Xu

“…Our results indicate that the accretion rate decreases as the charge of the black hole increases, suggesting that our accretion model does not violate the cosmic censorship hypothesis. …”
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Age of tobacco, nicotine and cannabis use initiation in Switzerland: a sequence analysis among adolescents and young adults by Diana Fernandes, Lorraine Chok, Jérémy Cros, Luc Lebon, Karin Zurcher, Alexandre Dubuis, Cathy Berthouzoz, André Berchtold, Yara Barrense-Dias

“…Conclusions Cigarettes remain the first product to be used, but the younger the respondents, the earlier they start using e-cigarettes, and very close to cigarettes. Regarding current consumption patterns, e-cigarettes are becoming increasingly prominent.…”
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EVALUATION OF THE DYNAMICS OF OCCLUSION RATIO DURING ORTHODONTIC TREATMENT OF PATIENTS WITH PERMANENT BITE. by K.M. Lykhota

“…However, this method does not meet current requirements, because it reflects neither such parameters as the strength and timeliness of tooth contacts, nor contains information about the nature of occlusive violations. …”
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Fastest Prostate Cancer Prediction on Whole-Mount Pathological Slides Using Self-Reform Multilayer Transformer by Linjie Xu, Xiaotian Yu, Haoming Luo, Jili Wang, Wenjie Liang, Jing Zhang, Zunlei Feng, Cheng Lu, Xiuming Zhang

“…Moreover, pixels in each whole-mount slide of PCa are increased by approximately <inline-formula> <tex-math notation="LaTeX">$4\sim 9$ </tex-math></inline-formula> times, therefore containing more information for diagnosis. …”
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Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extracts against TCDD-induced hepatocyte damage in Jian carp (Cyprinus carpio var. Jian) by Du Jinliang, Cao Liping, Jia Rui, Liu Yingjuan, Shen Yujin, Yin Guojun

“…Jian).Jian carp were fed with diet containing 3 doses of GGE (0.1, 0.5 and 1.0 g/kg diet) for 60 days before a single intraperitoneal injection of TCDD (0.6 μg/kg), 72 h after TCDD injection, blood and liver samples were taken for biochemical analysis.The results showed that GGE at 1.0 g/kg diet for 60 days prior to TCDD intoxication significantly reduced the elevated activities of ALT, AST, LDH, AKP and increased the reduced levels of total protein (TP), albumin (Alb) in the serum, markedly inhibited the reduction of the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), total antioxidant capacity (T-AOC), and reduced the malondialdehyde (MDA) formation in liver tissue. …”
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Anatomy and function of closing muscle complex of the vagina in health and pelvic organ prolapse by G. B. Dikke, A. D. Makatsariya, A. M. Ziganshin, E. A. Shaikhieva, V. O. Bitsadze

“…In modern literature, the pelvic floor muscles are presented by showing their anatomical location and indicating relevant attachment points, but their combined anatomical, topographic and functional significance is described insufficiently, which the current review was aimed at.Aim: to determine the physiological significance and anatomical units of the vagina occlusor muscle complex, topography and functions in health and in pelvic organ prolapse (POP).Materials and Methods. …”
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Evaluating and Enhancing Japanese Large Language Models for Genetic Counseling Support: Comparative Study of Domain Adaptation and the Development of an Expert-Evaluated Dataset by Takuya Fukushima, Masae Manabe, Shuntaro Yada, Shoko Wakamiya, Akiko Yoshida, Yusaku Urakawa, Akiko Maeda, Shigeyuki Kan, Masayo Takahashi, Eiji Aramaki

“…ObjectiveThis study aims to evaluate the current capabilities and identify challenges in developing a JGCLLM-based dialogue system for genetic counseling. …”
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Antiviral Therapeutics Discovery for Enterovirus D68. by Prof Justin Jang H Chu

“…To date, there are no effective antiviral successfully developed for enterovirus infection and the current understanding on pathogenesis is limited, which has resulted in the persistent circulation and outbreaks across the globe. …”
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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Bispecific antibodies, but not anti-PD-1, significantly increased the abundance of a proliferating natural killer cell subset, which exhibited enrichment for a tissue-residency signature. …”
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Substance P- and Insulin-like Growth Factor 1-derived Tetrapeptides for Neurotrophic Keratopathy Related to Leprosy: A Clinical Trial by Shoko Kondo, MD, Yoshiko Okano, MD, PhD, Satoshi Iraha, MD, PhD, Shoji Tokunaga, PhD

“…Although leprosy is bacteriologically curable, there is currently no efficient treatment. Eye drops containing tetrapeptides, phenylalanine-glycine-leucine-methionine-amide (FGLM-NH2) and serine-serine-serine-arginine (SSSR), derived from substance P and insulin-like growth factor 1, are clinically efficacious in the treatment of corneal epithelial disorders caused by neurotrophic keratopathy. …”
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Transuterine relocation of pregnant uterine horn segment in an exploratory rat model with implications for tubal ectopic pregnancy by Cara Buskmiller, Christina Camilleri, Stephen Sammut

“…Abstract Ectopic pregnancy affects ~ 2% of pregnancies annually in the United States, with no current treatments allowing for the continuation of the pregnancy. …”
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Metal flow behavior and energy consumption model during the extrusion process of a 6063 aluminum alloy profile with complex cross-section by Dewei Zhang, Haijie Xu, Sheng Xu, Fei Tong, Kai Chen, Zixuan Li, Jinrong Zuo, Xuedao Shu

“…The simulation results show that the standard deviation of metal flow velocity (representing the forming quality) was decreased as container temperature decreases, and the extrusion speed, billet temperature and die temperature increase. …”
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The pharmacological management of depression – Update 2017 by Elzbieta Osuch, Andre Marais

“…This article summarizes the currently available antidepressant drugs in South Africa. …”
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Mapping the status of global taxonomic knowledge of Orthoptera (Arthropoda, Insecta) by Rodrigo Antônio Castro-Souza, Juliana Stropp, Luiz Felipe Moretti Iniesta, Richard J. Ladle, Neucir Szinwelski, Geiziane Tessarolo, José Alexandre Diniz-Filho, Thadeu Sobral-Souza, Joaquín Hortal

“…Our analyses show that the descriptions of currently valid species increased exponentially since the 19th century, with a temporary decline following World War II, while synonyms outpaced the number of valid species until the 1980s. …”
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The impact of dropouts in scRNAseq dense neighborhood analysis by Alisa Pavel, Manja Gersholm Grønberg, Line H. Clemmensen

“…This implies that sub-populations within cell types are increasingly difficult to identify under increasing dropout rates because observations are not consistently close.Our results challenge the current practice of using default clustering pipelines and the general assumption of identifiable local neighborhoods on high dropout data. …”
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The PHD transcription factor Cti6 is involved in the fungal colonization and aflatoxin B1 biological synthesis of Aspergillus flavus by Zhang Mengjuan, Lin Guanglan, Pan Xiaohua, Song Weitao, Tan Can, Chen Xuan, Yang Yanling, Zhuang Zhenhong

“…Bioinformatics analysis showed Cti6 is conservative in Aspergillus spp., and mCherry mediated subcellular localization showed that most Cti6 accumulated in the nuclei, which reflected that Cti6 performed its important biological function in the nuclei in Aspergillus spp.. The results of the current study elucidate the roles of PHD domain containing proteins in the mechanism of the infection of crops by A. flavus, and provided a novel target for effectively controlling the contamination of Aspergillus spp. to crops.…”
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